Rik Ossenkoppele

DR., (Principal Investigator)

20112020

Research output per year

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Research Output

2020

Amyloid-β-independent regulators of tau pathology in Alzheimer disease

van der Kant, R., Goldstein, L. S. B. & Ossenkoppele, R., Jan 2020, In : Nature Reviews Neuroscience. 21, 1, p. 21-35 15 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Assessment of Demographic, Genetic, and Imaging Variables Associated with Brain Resilience and Cognitive Resilience to Pathological Tau in Patients with Alzheimer Disease

Ossenkoppele, R., Lyoo, C. H., Jester-Broms, J., Sudre, C. H., Cho, H., Ryu, Y. H., Choi, J. Y., Smith, R., Strandberg, O., Palmqvist, S., Kramer, J., Boxer, A. L., Gorno-Tempini, M. L., Miller, B. L., La Joie, R., Rabinovici, G. D. & Hansson, O., 1 Jan 2020, (Accepted/In press) In : JAMA Neurology. 77, 5, 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer's disease

Mattsson-Carlgren, N., Andersson, E., Janelidze, S., Ossenkoppele, R., Insel, P., Strandberg, O., Zetterberg, H., Rosen, H. J., Rabinovici, G., Chai, X., Blennow, K., Dage, J. L., Stomrud, E., Smith, R., Palmqvist, S. & Hansson, O., Apr 2020, In : Science Advances. 6, 16, eaaz2387.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Comorbid amyloid-β pathology affects clinical and imaging features in VCD

Leijenaar, J. F., Groot, C., Sudre, C. H., Bergeron, D., Leeuwis, A. E., Cardoso, M. J., Carrasco, F. P., Laforce, R., Barkhof, F., van der Flier, W. M., Scheltens, P., Prins, N. D. & Ossenkoppele, R., 1 Feb 2020, In : Alzheimers & Dementia. 16, 2, p. 354-364 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Diagnostic Performance of RO948 F 18 Tau Positron Emission Tomography in the Differentiation of Alzheimer Disease from Other Neurodegenerative Disorders

Leuzy, A., Smith, R., Ossenkoppele, R., Santillo, A., Borroni, E., Klein, G., Ohlsson, T., Jögi, J., Palmqvist, S., Mattsson-Carlgren, N., Strandberg, O., Stomrud, E. & Hansson, O., 1 Jan 2020, (Accepted/In press) In : JAMA Neurology.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Functional brain architecture is associated with the rate of tau accumulation in Alzheimer's disease

Franzmeier, N., Neitzel, J., Rubinski, A., Smith, R., Strandberg, O., Ossenkoppele, R., Hansson, O., Ewers, M. & Alzheimer’s Disease Neuroimaging Initiative (ADNI), 2020, In : Nature Communications. 11, 1, 347.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Identifying a task-invariant cognitive reserve network using task potency

van Loenhoud, A. C., Habeck, C., van der Flier, W. M., Ossenkoppele, R. & Stern, Y., 15 Apr 2020, In : NeuroImage. 210, 116593.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Latent atrophy factors related to phenotypical variants of posterior cortical atrophy

Groot, C., Yeo, B. T. T., Vogel, J. W., Zhang, X., Sun, N., Mormino, E. C., Pijnenburg, Y. A. L., Miller, B. L., Rosen, H. J., Joie, R. L., Barkhof, F., Scheltens, P., van der Flier, W. M., Rabinovici, G. D. & Ossenkoppele, R., 16 Jul 2020, In : Neurology.

Research output: Contribution to journalArticleAcademicpeer-review

Medial temporal lobe connectivity and its associations with cognition in early Alzheimer's disease

Berron, D., van Westen, D., Ossenkoppele, R., Strandberg, O. & Hansson, O., 1 Apr 2020, In : Brain : a journal of neurology. 143, 4, p. 1233-1248 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Parametric methods for [18F]flortaucipir PET

Golla, S. S. V., Wolters, E. E., Timmers, T., Ossenkoppele, R., van der Weijden, C. W. J., Scheltens, P., Schwarte, L., Mintun, M. A., Devous Sr, M. D., Schuit, R. C., Windhorst, A. D., Lammertsma, A. A., Yaqub, M., van Berckel, B. N. M. & Boellaard, R., 1 Feb 2020, In : Journal of Cerebral Blood Flow and Metabolism. 40, 2, p. 365-373 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2019

Amyloid and tau accumulate across distinct spatial networks and are differentially associated with brain connectivity

Pereira, J. B., Ossenkoppele, R., Palmqvist, S., Strandberg, T. O., Smith, R., Westman, E. & Hansson, O., 2019, In : eLife. 8, e50830.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Applying the ATN scheme in a memory clinic population: The ABIDE project

Altomare, D., de Wilde, A., Ossenkoppele, R., Pelkmans, W., Bouwman, F., Groot, C., van Maurik, I., Zwan, M., Yaqub, M., Barkhof, F., van Berckel, B. N., Teunissen, C. E., Frisoni, G. B., Scheltens, P. & van der Flier, W. M., 22 Oct 2019, In : Neurology. 93, 17, p. e1635-e1646

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Association between earliest amyloid uptake and functional connectivity in cognitively unimpaired elderly

Hahn, A., Strandberg, T. O., Stomrud, E., Nilsson, M., van Westen, D., Palmqvist, S., Ossenkoppele, R. & Hansson, O., 1 May 2019, In : Cerebral Cortex. 29, 5, p. 2173-2182

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Associations between tau, Aβ, and cortical thickness with cognition in Alzheimer disease

Ossenkoppele, R., Smith, R., Ohlsson, T., Strandberg, O., Mattsson, N., Insel, P. S., Palmqvist, S. & Hansson, O., 5 Feb 2019, In : Neurology. 92, 6, p. e601-e612

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cognitive reserve and clinical progression in Alzheimer disease: A paradoxical relationship

van Loenhoud, A. C., van der Flier, W. M., Wink, A. M., Dicks, E., Groot, C., Twisk, J., Barkhof, F., Scheltens, P., Ossenkoppele, R. & Alzheimer's Disease Neuroimaging Initiative, 23 Jul 2019, In : Neurology. 93, 4, p. e334-e346

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

COMORBID AMYLOID-β PATHOLOGY AFFECTS NEUROPSYCHIATRIC, NEUROPSYCHOLOGICAL, AND IMAGING FEATURES IN VASCULAR COGNITIVE DISORDERS

Leijenaar, J. F., Groot, C., Sudre, C. H., Bergeron, D., Leeuwis, A. E., Cardoso, J., Carrasco, F. P., Laforce, R., Barkhof, F., van der Flier, W. M., Scheltens, P., Prins, N. D. & Ossenkoppele, R., Jul 2019, In : Alzheimers & Dementia. 15, 7, p. P888-P889

Research output: Contribution to journalMeeting AbstractAcademic

Data-driven approaches for tau-PET imaging biomarkers in Alzheimer's disease

Vogel, J. W., Mattsson, N., Iturria-Medina, Y., Strandberg, O. T., Schöll, M., Dansereau, C., Villeneuve, S., van der Flier, W. M., Scheltens, P., Bellec, P., Evans, A. C., Hansson, O., Ossenkoppele, R. & The Alzheimer's Disease Neuroimaging Initiative, 1 Feb 2019, In : Human Brain Mapping. 40, 2, p. 638-651 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Distinct tau PET patterns in atrophy-defined subtypes of Alzheimer's disease

Ossenkoppele, R., Lyoo, C. H., Sudre, C. H., van Westen, D., Cho, H., Ryu, Y. H., Choi, J. Y., Smith, R., Strandberg, O., Palmqvist, S., Westman, E., Tsai, R., Kramer, J., Boxer, A. L., Gorno-Tempini, M. L., la Joie, R., Miller, B. L., Rabinovici, G. D. & Hansson, O., 2019, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Early recognition and treatment of neuropsychiatric symptoms to improve quality of life in early Alzheimer's disease: Protocol of the BEAT-IT study

Eikelboom, W. S., Singleton, E., van den Berg, E., Coesmans, M., Mattace Raso, F., van Bruchem, R. L., Goudzwaard, J. A., de Jong, F. J., Koopmanschap, M., den Heijer, T., Driesen, J. J. M., Vroegindeweij, L. J. H. M., Thomeer, E. C., Hoogers, S. E., Dijkstra, A. A., Zuidema, S. U., Pijnenburg, Y. A. L., Scheltens, P., van Swieten, J. C., Ossenkoppele, R. & 1 others, Papma, J. M., 24 May 2019, In : Alzheimer's Research and Therapy. 11, 1, 48.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Head-to-Head Comparison among Semi-Quantification Tools of Brain FDG-PET to Aid the Diagnosis of Prodromal Alzheimer's Disease

Brugnolo, A., de Carli, F., Pagani, M., Morbelli, S., Jonsson, C., Chincarini, A., Frisoni, G. B., Galluzzi, S., Perneczky, R., Drzezga, A., van Berckel, B. N. M., Ossenkoppele, R., Didic, M., Guedj, E., Arnaldi, D., Massa, F., Grazzini, M., Pardini, M., Mecocci, P., Dottorini, M. E. & 3 others, Bauckneht, M., Sambuceti, G. & Nobili, F., 1 Jan 2019, In : Journal of Alzheimer's Disease. 68, 1, p. 383-394 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Intrinsic connectivity networks in posterior cortical atrophy: A role for the pulvinar?

Fredericks, C. A., Brown, J. A., Deng, J., Kramer, A., Ossenkoppele, R., Rankin, K., Kramer, J. H., Miller, B. L., Rabinovici, G. D. & Seeley, W. W., 2019, In : NeuroImage: Clinical. 21, 101628.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Predicting diagnosis and cognition with 18F-AV-1451 tau PET and structural MRI in Alzheimer's disease

Mattsson, N., Insel, P. S., Donohue, M., Jögi, J., Ossenkoppele, R., Olsson, T., Schöll, M., Smith, R. & Hansson, O., 1 Apr 2019, In : Alzheimer's and Dementia. 15, 4, p. 570-580 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Prognostic value of Alzheimer's biomarkers in mild cognitive impairment: the effect of age at onset

Altomare, D., Ferrari, C., Caroli, A., Galluzzi, S., Prestia, A., van der Flier, W. M., Ossenkoppele, R., van Berckel, B., Barkhof, F., Teunissen, C. E., Wall, A., Carter, S. F., Schöll, M., Choo, I. H., Grimmer, T., Redolfi, A., Nordberg, A., Scheltens, P., Drzezga, A., Frisoni, G. B. & 1 others, Alzheimer’s Disease Neuroimaging Initiative, 1 Oct 2019, In : Journal of Neurology. 266, 10, p. 2535-2545

Research output: Contribution to journalArticleAcademicpeer-review

2018

Association of Amyloid Positron Emission Tomography With Changes in Diagnosis and Patient Treatment in an Unselected Memory Clinic Cohort: The ABIDE Project

de Wilde, A., van der Flier, W. M., Pelkmans, W., Bouwman, F., Verwer, J., Groot, C., van Buchem, M. M., Zwan, M., Ossenkoppele, R., Yaqub, M., Kunneman, M., Smets, E. M. A., Barkhof, F., Lammertsma, A. A., Stephens, A., van Lier, E., Biessels, G. J., van Berckel, B. N. & Scheltens, P., 1 Sep 2018, In : JAMA Neurology. p. 1062-1070 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia

Amyloid Biomarker Study Group, 1 Jan 2018, In : JAMA Psychiatry. 75, 1, p. 84-95 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Clinical phenotype, atrophy, and small vessel disease in APOEε2 carriers with Alzheimer disease

Groot, C., Sudre, C. H., Barkhof, F., Teunissen, C. E., van Berckel, B. N. M., Seo, S. W., Ourselin, S., Scheltens, P., Cardoso, M. J., van der Flier, W. M. & Ossenkoppele, R., 13 Nov 2018, In : Neurology. 91, 20, p. e1851-e1859

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Discriminative accuracy of [18F]flortaucipir positron emission tomography for Alzheimer disease vs other neurodegenerative disorders

Ossenkoppele, R., Rabinovici, G. D., Smith, R., Cho, H., Scholl, M., Strandberg, O., Palmqvist, S., Mattsson, N., Janelidze, S., Santillo, A., Ohlsson, T., Jogi, J., Tsai, R., la Joie, R., Kramer, J., Boxer, A. L., Gorno-Tempini, M. L., Miller, B. L., Choi, J. Y., Ryu, Y. H. & 2 others, Lyoo, C. H. & Hansson, O., 2018, In : JAMA - Journal of the American Medical Association. 320, 11, p. 1151-1162

Research output: Contribution to journalArticleAcademicpeer-review

Evidence-based Interpretation of Amyloid-β PET Results: A Clinician's Tool

Bergeron, D., Ossenkoppele, R. & Laforce, R., 2018, In : Alzheimer Disease and Associated Disorders. 32, 1, p. 28-34

Research output: Contribution to journalArticleAcademicpeer-review

Greater tau load and reduced cortical thickness in APOE ε4-negative Alzheimer’s disease: a cohort study

Mattsson, N., Ossenkoppele, R., Smith, R., Strandberg, O., Ohlsson, T., Jögi, J., Palmqvist, S., Stomrud, E. & Hansson, O., 2018, In : Alzheimer's Research and Therapy. 10, 1, 45.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Hypometabolism of the posterior cingulate cortex is not restricted to Alzheimer's disease

Scheltens, N. M. E., van der Weijden, K., Adriaanse, S. M., van Assema, D., Oomen, P. P., Krudop, W. A., Lammertsma, A. A., Barkhof, F., Koene, T., Teunissen, C. E., Scheltens, P., van der Flier, W. M., Pijnenburg, Y. A. L., Yaqub, M., Ossenkoppele, R. & van Berckel, B. N. M., 1 Jan 2018, In : NeuroImage: Clinical. 19, p. 625-632 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Is intracranial volume a suitable proxy for brain reserve? Rik Ossenkoppele

Van Loenhoud, A. C., Groot, C., Vogel, J. W., Van Der Flier, W. M. & Ossenkoppele, R., 11 Sep 2018, In : Alzheimer's Research and Therapy. 10, 1, 91.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Local and distant relationships between amyloid, tau and neurodegeneration in Alzheimer's Disease

Iaccarino, L., Tammewar, G., Ayakta, N., Baker, S. L., Bejanin, A., Boxer, A. L., Gorno-Tempini, M. L., Janabi, M., Kramer, J. H., Lazaris, A., Lockhart, S. N., Miller, B. L., Miller, Z. A., O'Neil, J. P., Ossenkoppele, R., Rosen, H. J., Schonhaut, D. R., Jagust, W. J. & Rabinovici, G. D., 2018, In : NeuroImage: Clinical. 17, p. 452-464

Research output: Contribution to journalArticleAcademicpeer-review

Open Access