Rob Wolthuis

DR., (Principal Investigator)

20002020
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Research Output 2000 2020

  • 16 Article
  • 2 Research external, graduation VU University Amsterdam
  • 1 Review article
2020

Non-redundant roles in sister chromatid cohesion of the DNA helicase DDX11 and the SMC3 acetyl transferases ESCO1 and ESCO2

Faramarz, A., Balk, J. A., van Schie, J. J. M., Oostra, A. B., Ghandour, C. A., Rooimans, M. A., Wolthuis, R. M. F. & de Lange, J., 2020, In : PLoS ONE. 15, 1, p. e0220348

Research output: Contribution to journalArticleAcademicpeer-review

2019

Characterization of a head and neck cancer-derived cell line panel confirms the distinct TP53-proficient copy number-silent subclass

van Harten, A. M., Poell, J. B., Buijze, M., Brink, A., Wells, S. I., René Leemans, C., Wolthuis, R. M. F. & Brakenhoff, R. H., 1 Nov 2019, In : Oral Oncology. 98, p. 53-61

Research output: Contribution to journalArticleAcademicpeer-review

Effective CRISPR/Cas9-mediated correction of a Fanconi anemia defect by error-prone end joining or templated repair

van de Vrugt, H. J., Harmsen, T., Riepsaame, J., Alexantya, G., van Mil, S. E., de Vries, Y., Bin Ali, R., Huijbers, I. J., Dorsman, J. C., Wolthuis, R. M. F. & te Riele, H., 1 Dec 2019, In : Scientific Reports. 9, 1, 768.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Keeping ribosomal DNA intact: a repeating challenge

Warmerdam, D. O. & Wolthuis, R. M. F., 15 Mar 2019, In : Chromosome Research. 27, 1-2, p. 57-72

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Targeting the cell cycle in head and neck cancer by Chk1 inhibition: a novel concept of bimodal cell death

van Harten, A. M., Buijze, M., van der Mast, R., Rooimans, M. A., Martens-de Kemp, S. R., Bachas, C., Brink, A., Stigter-van Walsum, M., Wolthuis, R. M. F. & Brakenhoff, R. H., 1 Jul 2019, In : Oncogenesis. 8, 7, 38.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

CRISPR/Cas: techniek om DNA-fouten te repareren

van de Vrugt, H. J., Cornel, M. C. & Wolthuis, R. M. F., 29 Jun 2018, In : Nederlands Tijdschrift voor Geneeskunde. 162

Research output: Contribution to journalArticleAcademicpeer-review

CRISPR/Cas: Techniek om DNA-fouten te repareren Wanneer komt er een doorbraak richting de kliniek?

Van De Vrugt, H. J., Cornel, M. C. & Wolthuis, R. M. F., 1 Jan 2018, In : Nederlands Tijdschrift voor Geneeskunde. 162, 28, d2461.

Research output: Contribution to journalArticleAcademicpeer-review

Rscreenorm: normalization of CRISPR and siRNA screen data for more reproducible hit selection

Bachas, C., Hodzic, J., van der Mijn, J. C., Stoepker, C., Verheul, H. M. W., Wolthuis, R. M. F., Felley-Bosco, E., van Wieringen, W. N., van Beusechem, V. W., Brakenhoff, R. H. & de Menezes, R. X., 20 Aug 2018, In : BMC Bioinformatics. 19, 1, p. 301

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016

Feedback regulation between atypical E2Fs and APC/CCdh1 coordinates cell cycle progression

Boekhout, M., Yuan, R., Wondergem, A. P., Segeren, H. A., van Liere, E. A., Awol, N., Jansen, I., Wolthuis, R. M. F., de Bruin, A. & Westendorp, B., Mar 2016, In : EMBO Reports. 17, 3, p. 414-27 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

2015

Defective sister chromatid cohesion is synthetically lethal with impaired APC/C function

de Lange, J., Faramarz, A., Oostra, A. B., Menezes, R. X., van der Meulen, I. H., Rooimans, M. A., Rockx, D. A., Brakenhoff, R. H., van Beusechem, V. W., King, R. W., de Winter, J. P. & Wolthuis, R. M. F., 2015, In : Nature Communications. 6, 8399.

Research output: Contribution to journalArticleAcademicpeer-review

105 Downloads (Pure)

Driving Mitosis by Cdk1 and Greatwall

Voets, E., 2015

Research output: ThesisResearch external, graduation VU University AmsterdamAcademic

File

MASTL promotes cyclin B1 destruction by enforcing Cdc20-independent binding of cyclin B1 to the APC/C

Voets, E. & Wolthuis, R. M. F., 2015, In : Biology Open. 4, 4, p. 484-495

Research output: Contribution to journalArticleAcademicpeer-review

Nek2A destruction marks APC/C activation at the prophase-to-prometaphase transition by spindle-checkpoint-restricted Cdc20

Boekhout, M. & Wolthuis, R. M. F., 2015, In : Journal of Cell Science. 128, 8, p. 1639-1653

Research output: Contribution to journalArticleAcademicpeer-review

The lethal response to Cdk1 inhibition depends on sister chromatid alignment errors generated by KIF4 and isoform 1 of PRC1

Voets, E., Marsman, J., Demmers, J., Beijersbergen, R. & Wolthuis, R. M. F., 2015, In : Scientific Reports. 5, 14798.

Research output: Contribution to journalArticleAcademicpeer-review

2014

Inefficient degradation of cyclin B1 re-activates the spindle checkpoint right after sister chromatid disjunction

Clijsters, L., van Zon, W., ter Riet, B., Voets, E., Boekhout, M., Ogink, J., Rumpf-Kienzl, C. & Wolthuis, R. M. F., 2014, In : Cell Cycle. 13, 15, p. 2370-2378

Research output: Contribution to journalArticleAcademicpeer-review

PIP-box-mediated degradation prohibits re-accumulation of Cdc6 during S phase

Clijsters, L. & Wolthuis, R. M. F., 2014, In : Journal of Cell Science. 127, 6, p. 1336-1345

Research output: Contribution to journalArticleAcademicpeer-review

2010
65 Downloads (Pure)

Mitotic entry and exit: the rise and fall of cyclin-Cdk-Cks activity

van Zon, W., 2010

Research output: ThesisResearch external, graduation VU University AmsterdamAcademic

File
2000

The small GTPase, Rap1, mediates CD31-induced integrin adhesion

Reedquist, K. A., Ross, E., Koop, E. A., Wolthuis, R. M., Zwartkruis, F. J., van Kooyk, Y., Salmon, M., Buckley, C. D. & Bos, J. L., 20 Mar 2000, In : Journal of Cell Biology. 148, 6, p. 1151-8 8 p.

Research output: Contribution to journalArticleAcademicpeer-review