Robert Szulcek

20132019
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Research Output 2013 2019

  • 17 Article
  • 1 Meeting Abstract
  • 1 Research VU University Amsterdam, graduation VU University Amsterdam
2019

Autophagy contributes to BMP type 2 receptor degradation and development of pulmonary arterial hypertension

Gomez-Puerto, M. C., van Zuijen, I., Huang, C. J. Z., Szulcek, R., Pan, X., van Dinther, M. A. H., Kurakula, K., Wiesmeijer, C. C., Goumans, M-J., Bogaard, H-J., Morrell, N. W., Rana, A. A. & ten Dijke, P., 1 Nov 2019, In : Journal of Pathology. 249

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Multicenter Preclinical Validation of BET Inhibition for the Treatment of Pulmonary Arterial Hypertension

Van der Feen, D. E., Kurakula, K., Tremblay, E., Boucherat, O., Bossers, G. PL., Szulcek, R., Bourgeois, A., Lampron, M-C., Habbout, K., Martineau, S., Paulin, R., Kulikowski, E., Jahagirdar, R., Schalij, I., Bogaard, H. J., Bartelds, B., Provencher, S., Berger, R. M. F., Bonnet, S. & Goumans, M-J., 1 Oct 2019, In : American Journal of Respiratory and Critical Care Medicine. 200, 7, p. 910-920 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Nintedanib improves cardiac fibrosis but leaves pulmonary vascular remodelling unaltered in experimental pulmonary hypertension

Rol, N., de Raaf, M. A., Sun, X. Q., Kuiper, V. P., da Silva Gonçalves Bos, D., Happé, C., Kurakula, K., Dickhoff, C., Thuillet, R., Tu, L., Guignabert, C., Schalij, I., Lodder, K., Pan, X., Herrmann, F. E., van Nieuw Amerongen, G. P., Koolwijk, P., Vonk-Noordegraaf, A., de Man, F. S., Wollin, L. & 3 othersGoumans, M-J., Szulcek, R. & Bogaard, H. J., 2019, In : Cardiovascular Research. 115, 2, p. 432-439

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Prevention of progression of pulmonary hypertension by the Nur77 agonist 6-mercaptopurine: role of BMP signalling

Kurakula, K., Sun, X-Q., Happé, C., da Silva Goncalves Bos, D., Szulcek, R., Schalij, I., Wiesmeijer, K. C., Lodder, K., Tu, L., Guignabert, C., de Vries, C. J. M., de Man, F. S., Vonk Noordegraaf, A., ten Dijke, P., Goumans, M-J. & Bogaard, H. J., 2019, In : The European respiratory journal. 54, 3

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Contribution of impaired parasympathetic activity to right ventricular dysfunction and pulmonary vascular remodeling in pulmonary arterial hypertension

Da Silva Gonçalves Bós, D., Van Der Bruggen, C. E. E., Kurakula, K., Sun, X. Q., Casali, K. R., Casali, A. G., Rol, N., Szulcek, R., Dos Remedios, C., Guignabert, C., Tu, L., Dorfmüller, P., Humbert, M., Wijnker, P. J. M., Kuster, D. W. D., Van Der Velden, J., Goumans, M. J., Bogaard, H. J., Vonk-Noordegraaf, A., De Man, F. S. & 1 othersHandoko, M. L., 1 Jan 2018, In : Circulation. 137, 9, p. 910-924 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Endothelial dysfunction in pulmonary arterial hypertension: loss of cilia length regulation upon cytokine stimulation

Dummer, A., Rol, N., Szulcek, R., Kurakula, K., Pan, X., Visser, B. I., Bogaard, H. J., DeRuiter, M. C., Goumans, M-J. & Hierck, B. P., 27 Feb 2018, In : Pulmonary Circulation. 8, 2, p. 2045894018764629

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Stiffness-Induced Endothelial DLC-1 Expression Forces Leukocyte Spreading through Stabilization of the ICAM-1 Adhesome

Schimmel, L., van der Stoel, M., Rianna, C., van Stalborch, A-M., de Ligt, A., Hoogenboezem, M., Tol, S., van Rijssel, J., Szulcek, R., Bogaard, H. J., Hofmann, P., Boon, R., Radmacher, M., de Waard, V., Huveneers, S. & van Buul, J. D., 18 Sep 2018, In : Cell Reports. 24, 12, p. 3115-3124 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The covalently immobilized antimicrobial peptide LL37 acts as a VEGF mimic and stimulates endothelial cell proliferation

Szulcek, R., Bollensdorff, C., Hordijk, P. & Gabriel, M., 2018, In : Biochemical and Biophysical Research Communications. 496, 3, p. 887-890

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016

Delayed Microvascular Shear Adaptation in Pulmonary Arterial Hypertension Role of Platelet Endothelial Cell Adhesion Molecule-1 Cleavage

Szulcek, R., Happe, C. M., Rol, N., Fontijn, R. D., Dickhoff, C., Hartemink, K. J., Grunberg, K., Tu, L., Timens, W., Nossent, G. D., Paul, M. A., Leyen, T. A., Horrevoets, A. J., de Man, F. S., Guignabert, C., Yu, P. B., Vonk-Noordegraaf, A., van Nieuw Amerongen, G. & Bogaard, H. J., 15 Jun 2016, In : American Journal of Respiratory and Critical Care Medicine. 193, 12, p. 1410-1420

Research output: Contribution to journalArticleAcademicpeer-review

Reconciling paradigms of abnormal pulmonary blood flow and quasi-malignant cellular alterations in pulmonary arterial hypertension

Happe, C. M., Szulcek, R., Voelkel, N. F. & Bogaard, H. J., Aug 2016, In : Vascular Pharmacology. 83, p. 17-25

Research output: Contribution to journalArticleAcademicpeer-review

THSD1 preserves vascular integrity and protects against intraplaque haemorrhaging in ApoE-/- mice

Haasdijk, R. A., Den Dekker, W. K., Cheng, C., Tempel, D., Szulcek, R., Bos, F. L., Hermkens, D. M. A., Chrifi, I., Brandt, M. M., Van Dijk, C., Xu, Y. J., Van De Kamp, E. H. M., Blonden, L. A. J., Van Bezu, J., Sluimer, J. C., Biessen, E. A. L., Van Nieuw Amerongen, G. P. & Duckers, H. J., 2016, In : Cardiovascular Research. 110, 1, p. 129-39 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2015

Transient Intervals of Hyper-Gravity Enhance Endothelial Barrier Integrity: Impact of Mechanical and Gravitational Forces Measured Electrically

Szulcek, R., van Bezu, J., Boonstra, J., van Loon, J. J. W. A. & van Nieuw Amerongen, G. P., 2015, In : PLoS ONE. 10, 12, e0144269.

Research output: Contribution to journalArticleAcademicpeer-review

2014

Electric cell-substrate impedance sensing for the quantification of endothelial proliferation, barrier function, and motility

Szulcek, R., Bogaard, H. J. & van Nieuw Amerongen, G. P., 2014, In : Journal of Visualized Experiments. 85, e51300.

Research output: Contribution to journalArticleAcademicpeer-review

2013

Localized RhoA GTPase activity regulates dynamics of endothelial monolayer integrity

Szulcek, R., Beckers, C. M. L., Hodzic, J., de Wit, J., Chen, Z. L., Grob, T., Musters, R. J. P., Minshall, R. D., van Hinsbergh, V. W. M. & van Nieuw Amerongen, G. P., 2013, In : Cardiovascular Research. 99, 3, p. 471-482

Research output: Contribution to journalArticleAcademicpeer-review

Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension

Bakhshi, F. R., Mao, M., Shajahan, A. N., Piegeler, T., Chen, Z., Chernaya, O., Sharma, T., Elliott, W. M., Szulcek, R., Bogaard, H. J., Comhair, S., Erzurum, S., Van Nieuw Amerongen, G. P., Bonini, M. G. & Minshall, R. D., 1 Dec 2013, In : Pulmonary Circulation. 3, 4, p. 816-830 15 p.

Research output: Contribution to journalArticleAcademicpeer-review