Roderick Slieker

MSC.

20122020

Research output per year

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Research Output

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Article
2020

Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease

Giacomelli, E., Meraviglia, V., Campostrini, G., Cochrane, A., Cao, X., van Helden, R. W. J., Krotenberg Garcia, A., Mircea, M., Kostidis, S., Davis, R. P., van Meer, B. J., Jost, C. R., Koster, A. J., Mei, H., Míguez, D. G., Mulder, A. A., Ledesma-Terrón, M., Pompilio, G., Sala, L., Salvatori, D. C. F. & 9 others, Slieker, R. C., Sommariva, E., de Vries, A. A. F., Giera, M., Semrau, S., Tertoolen, L. G. J., Orlova, V. V., Bellin, M. & Mummery, C. L., 4 Jun 2020, In : Cell Stem Cell. 26, 6, p. 862-879.e11

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug–metabolite atlas

Liu, J., Lahousse, L., Nivard, M. G., Bot, M., Chen, L., van Klinken, J. B., Thesing, C. S., Beekman, M., van den Akker, E. B., Slieker, R. C., Waterham, E., van der Kallen, C. J. H., de Boer, I., Li-Gao, R., Vojinovic, D., Amin, N., Radjabzadeh, D., Kraaij, R., Alferink, L. J. M., Murad, S. D. & 29 others, Uitterlinden, A. G., Willemsen, G., Pool, R., Milaneschi, Y., van Heemst, D., Suchiman, H. E. D., Rutters, F., Elders, P. J. M., Beulens, J. W. J., van der Heijden, A. A. W. A., van Greevenbroek, M. M. J., Arts, I. C. W., Onderwater, G. L. J., van den Maagdenberg, A. M. J. M., Mook-Kanamori, D. O., Hankemeier, T., Terwindt, G. M., Stehouwer, C. D. A., Geleijnse, J. M., ‘t Hart, L. M., Slagboom, P. E., van Dijk, K. W., Zhernakova, A., Fu, J., Penninx, B. W. J. H., Boomsma, D. I., Demirkan, A., Stricker, B. H. C. & van Duijn, C. M., 1 Jan 2020, In : Nature Medicine. 26, 1, p. 110-117 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

NACHO: an R package for quality control of NanoString nCounter data

Canouil, M., Bouland, G. A., Bonnefond, A., Froguel, P., 't Hart, L. M. & Slieker, R. C., 1 Feb 2020, In : Bioinformatics. 36, 3, p. 970-971 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Prediction models for development of retinopathy in people with type 2 diabetes: systematic review and external validation in a Dutch primary care setting

van der Heijden, A. A., Nijpels, G., Badloe, F., Lovejoy, H. L., Peelen, L. M., Feenstra, T. L., Moons, K. G. M., Slieker, R. C., Herings, R. M. C., Elders, P. J. M. & Beulens, J. W., 1 Jan 2020, (Accepted/In press) In : Diabetologia. 63, 6, 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

2019

A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody-Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy

Grubb, A. L., McDonald, T. J., Rutters, F., Donnelly, L. A., Hattersley, A. T., Oram, R. A., Palmer, C. N. A., van der Heijden, A. A., Carr, F., Elders, P. J. M., Weedon, M. N., Slieker, R. C., 't Hart, L. M., Pearson, E. R., Shields, B. M. & Jones, A. G., 1 Feb 2019, In : Diabetes Care. 42, 2, p. 208-214 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Visit-to-visit variability of glycemia and vascular complications: the Hoorn Diabetes Care System cohort

Slieker, R. C., van der Heijden, A. A. W. H., Nijpels, G., Elders, P. J. M., 't Hart, L. M. & Beulens, J. W. J., 2019, In : Cardiovascular Diabetology. 18, 1, 170.

Research output: Contribution to journalArticleAcademicpeer-review

2018

Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception

Slieker, R. C., Relton, C. L., Gaunt, T. R., Slagboom, P. E. & Heijmans, B. T., 30 May 2018, In : Epigenetics and Chromatin. 11, 1, 25.

Research output: Contribution to journalArticleAcademicpeer-review

A SNP panel for identification of DNA and RNA specimens

Yousefi, S., Abbassi-Daloii, T., Kraaijenbrink, T., Vermaat, M., Mei, H., van 't Hof, P., van Iterson, M., Zhernakova, D. V., Claringbould, A., Franke, L., 't Hart, L. M., Slieker, R. C., van der Heijden, A., de Knijff, P. & BIOS Consortium, 25 Jan 2018, In : BMC Genomics. 19, 1, 90.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Blood Metabolomic Measures Associate With Present and Future Glycemic Control in Type 2 Diabetes

't Hart, L. M., Vogelzangs, N., Mook-Kanamori, D. O., Brahimaj, A., Nano, J., van der Heijden, A. A. W. A., Willems van Dijk, K., Slieker, R. C., Steyerberg, E. W., Ikram, M. A., Beekman, M., Boomsma, D. I., van Duijn, C. M., Slagboom, P. E., Stehouwer, C. D. A., Schalkwijk, C. G., Arts, I. C. W., Dekker, J. M., Dehghan, A., Muka, T. & 3 others, van der Kallen, C. J. H., Nijpels, G. & van Greevenbroek, M. M. J., 2018, In : The Journal of clinical endocrinology and metabolism. 103, 12, p. 4569-4579

Research output: Contribution to journalArticleAcademicpeer-review

DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood

Biobank-based Integrative Omics Studies Consortium, 1 Jan 2018, In : Science Advances. 4, 1, eaao4364.

Research output: Contribution to journalArticleAcademicpeer-review

HbA1c is associated with altered expression in blood of cell cycle- and immune response-related genes

Slieker, R. C., van der Heijden, A. A. W. A., van Leeuwen, N., Mei, H., Nijpels, G., Beulens, J. W. J. & ’T Hart, L. M., Jan 2018, In : Diabetologia. 61, 1, p. 1-9 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Disease variants alter transcription factor levels and methylation of their binding sites

Bonder, M. J., Luijk, R., Zhernakova, D. V., Moed, M., Deelen, P., Vermaat, M., Van Iterson, M., Van Dijk, F., Van Galen, M., Bot, J., Slieker, R. C., Jhamai, P. M., Verbiest, M., Suchiman, H. E. D., Verkerk, M., Van Der Breggen, R., Van Rooij, J., Lakenberg, N., Arindrarto, W., Kielbasa, S. M. & 31 others, Jonkers, I., Van't Hof, P., Nooren, I., Beekman, M., Deelen, J., Van Heemst, D., Zhernakova, A., Tigchelaar, E. F., Swertz, M. A., Hofman, A., Uitterlinden, A. G., Pool, R., Van Dongen, J., Hottenga, J. J., Stehouwer, C. D. A., Van Der Kallen, C. J. H., Schalkwijk, C. G., Van Den Berg, L. H., Van Zwet, E. W., Mei, H., Li, Y., Lemire, M., Hudson, T. J., Slagboom, P. E., Wijmenga, C., Veldink, J. H., Van Greevenbroek, M. M. J., Van Duijn, C. M., Boomsma, D. I., Jansen, R. & the BIOS Consortium, 1 Jan 2017, In : Nature Genetics. 49, 1, p. 131-138 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

DNA methylation and transcriptional trajectories during human development and reprogramming of isogenic pluripotent stem cells

Roost, M. S., Slieker, R. C., Bialecka, M., Van Iperen, L., Gomes Fernandes, M. M., He, N., Suchiman, H. E. D., Szuhai, K., Carlotti, F., De Koning, E. J. P., Mummery, C. L., Heijmans, B. T. & Chuva De Sousa Lopes, S. M., 1 Dec 2017, In : Nature Communications. 8, 1, 908.

Research output: Contribution to journalArticleAcademicpeer-review

Early- and late-onset preeclampsia and the tissue-specific epigenome of the placenta and newborn

Herzog, E. M., Eggink, A. J., Willemsen, S. P., Slieker, R. C., Wijnands, K. P. J., Felix, J. F., Chen, J., Stubbs, A., van der Spek, P. J., van Meurs, J. B. & Steegers-Theunissen, R. P. M., 1 Oct 2017, In : Placenta. 58, p. 122-132 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Prolonged high-fat diet induces gradual and fat depot-specific DNA methylation changes in adult mice

Zwamborn, R. A. J., Slieker, R. C., Mulder, P. C. A., Zoetemelk, I., Verschuren, L., Suchiman, H. E. D., Toet, K. H., Droog, S., Slagboom, P. E., Kooistra, T., Kleemann, R. & Heijmans, B. T., 3 Mar 2017, In : Scientific Reports. 7, 43261.

Research output: Contribution to journalArticleAcademicpeer-review

SMCHD1 regulates a limited set of gene clusters on autosomal chromosomes

Mason, A. G., Slieker, R. C., Balog, J., Lemmers, R. J. L. F., Wong, C. J., Yao, Z., Lim, J. W., Filippova, G. N., Ne, E., Tawil, R., Heijmans, B. T., Tapscott, S. J. & van der Maarel, S. M., 6 Jun 2017, In : Skeletal Muscle. 7, 1, 12.

Research output: Contribution to journalArticleAcademicpeer-review

Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and in Vitro Evidences of a Cell Replication Process

Bacalini, M. G., Deelen, J., Pirazzini, C., De Cecco, M., Giuliani, C., Lanzarini, C., Ravaioli, F., Marasco, E., Van Heemst, D., Suchiman, H. E. D., Slieker, R., Giampieri, E., Recchioni, R., Marcheselli, F., Salvioli, S., Vitale, G., Olivieri, F., Spijkerman, A. M. W., DollCrossed, M. E. T., Sedivy, J. M. & 4 others, Castellani, G., Franceschi, C., Slagboom, P. E. & Garagnani, P., 1 Aug 2017, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 72, 8, p. 1015-1023 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

Slieker, R. C., van Iterson, M., Luijk, R., Beekman, M., Zhernakova, D. V., Moed, M. H., Mei, H., van Galen, M., Deelen, P., Bonder, M. J., Zhernakova, A., Uitterlinden, A. G., Tigchelaar, E. F., Stehouwer, C. D. A., Schalkwijk, C. G., van der Kallen, C. J. H., Hofman, A., van Heemst, D., de Geus, E. J., van Dongen, J. & 14 others, Deelen, J., van den Berg, L. H., van Meurs, J., Jansen, R., 't Hoen, P. A. C., Franke, L., Wijmenga, C., Veldink, J. H., Swertz, M. A., van Greevenbroek, M. M. J., van Duijn, C. M., Boomsma, D. I., Slagboom, P. E. & Heijmans, B. T., 22 Sep 2016, In : Genome Biology. 17

Research output: Contribution to journalArticleAcademicpeer-review

Blood lipids influence DNA methylation in circulating cells

Dekkers, K. F., van Iterson, M., Slieker, R. C., Moed, M. H., Bonder, M. J., van Galen, M., Mei, H., Zhernakova, D. V., van den Berg, L. H., Deelen, J., van Dongen, J., van Heemst, D., Hofman, A., Hottenga, J. J., van der Kallen, C. J. H., Schalkwijk, C. G., Stehouwer, C. D. A., Tigchelaar, E. F., Uitterlinden, A. G., Willemsen, G. & 14 others, Zhernakova, A., Franke, L., 't Hoen, P. A. C., Jansen, R., van Meurs, J., Boomsma, D. I., van Duijn, C. M., van Greevenbroek, M. M. J., Veldink, J. H., Wijmenga, C., van Zwet, E. W., Slagboom, P. E., Jukema, J. W. & Heijmans, B. T., 27 Jun 2016, In : Genome Biology. 17

Research output: Contribution to journalArticleAcademicpeer-review

Epigenomic Analysis of Sézary Syndrome Defines Patterns of Aberrant DNA Methylation and Identifies Diagnostic Markers

van Doorn, R., Slieker, R. C., Boonk, S. E., Zoutman, W. H., Goeman, J. J., Bagot, M., Michel, L., Tensen, C. P., Willemze, R., Heijmans, B. T. & Vermeer, M. H., 1 Sep 2016, In : Journal of Investigative Dermatology. 136, 9, p. 1876-1884 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Neo-cartilage engineered from primary chondrocytes is epigenetically similar to autologous cartilage, in contrast to using mesenchymal stem cells

Bomer, N., den Hollander, W., Suchiman, H., Houtman, E., Slieker, R. C., Heijmans, B. T., Slagboom, P. E., Nelissen, R. G. H. H., Ramos, Y. F. M. & Meulenbelt, I., 1 Aug 2016, In : Osteoarthritis and Cartilage. 24, 8, p. 1423-1430 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2015

Alternative Routes to Induce Naïve Pluripotency in Human Embryonic Stem Cells

Duggal, G., Warrier, S., Ghimire, S., Broekaert, D., Van Der Jeught, M., Lierman, S., Deroo, T., Peelman, L., Van Soom, A., Cornelissen, R., Menten, B., Mestdagh, P., Vandesompele, J., Roost, M., Slieker, R. C., Heijmans, B. T., Deforce, D., De Sutter, P., De Sousa Lopes, S. C. & Heindryckx, B., 1 Sep 2015, In : Stem Cells. 33, 9, p. 2686-2698 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Design, measurement and processing of region-specific DNA methylation assays: The mass spectrometry-based method EpiTYPER

Suchiman, H. E. D., Slieker, R. C., Kremer, D., Slagboom, P. E., Heijmans, B. T. & Tobi, E. W., 1 Jan 2015, In : Frontiers in Genetics. 6, SEP, 287.

Research output: Contribution to journalArticleAcademicpeer-review

DNA Methylation Landscapes of Human Fetal Development

Slieker, R. C., Roost, M. S., van Iperen, L., Suchiman, H. E. D., Tobi, E. W., Carlotti, F., de Koning, E. J. P., Slagboom, P. E., Heijmans, B. T. & Chuva de Sousa Lopes, S. M., 1 Jan 2015, In : PLoS Genetics. 11, 10, e1005583.

Research output: Contribution to journalArticleAcademicpeer-review

Early gestation as the critical time-window for changes in the prenatal environment to affect the adult human blood methylome

Tobi, E. W., Slieker, R. C., Stein, A. D., Suchiman, H. E. D., Eline Slagboom, P., Van Zwet, E. W., Heijmans, B. T. & Lumey, L. H., 1 Aug 2015, In : International Journal of Epidemiology. 44, 4, p. 1211-1223 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

2014

DNA methylation signatures link prenatal famine exposure to growth and metabolism

Tobi, E. W., Goeman, J. J., Monajemi, R., Gu, H., Putter, H., Zhang, Y., Slieker, R. C., Stok, A. P., Thijssen, P. E., Müller, F., Van Zwet, E. W., Bock, C., Meissner, A., Lumey, L. H., Eline Slagboom, P. & Heijmans, B. T., 1 Jan 2014, In : Nature Communications. 5, 5592.

Research output: Contribution to journalArticleAcademicpeer-review

Epigenetic variation in monozygotic twins: A genome-wide analysis of DNA methylation in buccal cells

van Dongen, J., Ehli, E. A., Slieker, R. C., Bartels, M., Weber, Z. M., Davies, G. E., Slagboom, P. E., Heijmans, B. T. & Boomsma, D. I., 1 Jan 2014, In : Genes. 5, 2, p. 347-365 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

MethylAid: Visual and interactive quality control of large Illumina 450k datasets

Van Iterson, M., Tobi, E. W., Slieker, R. C., Den Hollander, W., Luijk, R., Slagboom, P. E. & Heijmans, B. T., 1 Jan 2014, In : Bioinformatics. 30, 23, p. 3435-3437 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

2013

Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array

Slieker, R. C., Bos, S. D., Goeman, J. J., Bovée, J. V., Talens, R. P., Van Der Breggen, R., Suchiman, H. E. D., Lameijer, E. W., Putter, H., Van Den Akker, E. B., Zhang, Y., Jukema, J. W., Slagboom, P. E., Meulenbelt, I. & Heijmans, B. T., 9 Aug 2013, In : Epigenetics and Chromatin. 6, 1, 26.

Research output: Contribution to journalArticleAcademicpeer-review

2012

Locomotor activity assay in zebrafish larvae: Influence of age, strain and ethanol

de Esch, C., van der Linde, H., Slieker, R., Willemsen, R., Wolterbeek, A., Woutersen, R. & De Groot, D., 1 Jul 2012, In : Neurotoxicology and Teratology. 34, 4, p. 425-433 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Re-exposure and environmental enrichment reveal NPY-Y1 as a possible target for post-traumatic stress disorder

Hendriksen, H., Bink, D. I., Daniels, E. G., Pandit, R., Piriou, C., Slieker, R., Westphal, K. G. C., Olivier, B. & Oosting, R. S., 1 Sep 2012, In : Neuropharmacology. 63, 4, p. 733-742 10 p.

Research output: Contribution to journalArticleAcademicpeer-review