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Research Output 1983 2019

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2019

Methylglyoxal-Derived Advanced Glycation Endproducts Accumulate in Multiple Sclerosis Lesions

Wetzels, S., Vanmierlo, T., Scheijen, J. L. J. M., van Horssen, J., Amor, S., Somers, V., Schalkwijk, C. G., Hendriks, J. J. A. & Wouters, K., 2019, In : Frontiers in Immunology. 10, p. 855

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Oligodendrocyte degeneration and concomitant microglia activation directs peripheral immune cells into the forebrain

Chrzanowski, U., Bhattarai, S., Scheld, M., Clarner, T., Fallier-Becker, P., Beyer, C., Rohr, S. O., Schmitz, C., Hochstrasser, T., Schweiger, F., Amor, S., Horn-Bochtler, A., Denecke, B., Nyamoya, S. & Kipp, M., 2019, In : Neurochemistry International. 126, p. 139-153

Research output: Contribution to journalArticleAcademicpeer-review

Heat shock protein expression in cerebral X-linked adrenoleukodystrophy reveals astrocyte stress prior to myelin loss

Görtz, A. L., Peferoen, L. A. N., Gerritsen, W. H., van Noort, J. M., Bugiani, M. & Amor, S., 1 Jun 2018, In : Neuropathology and Applied Neurobiology. 44, 4, p. 363-376 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Heat shock proteins are differentially expressed in brain and spinal cord: implications for multiple sclerosis

Gorter, R. P., Nutma, E., Jahrei, M-C., de Jonge, J. C., Quinlan, R. A., van der Valk, P., van Noort, J. M., Baron, W. & Amor, S., Nov 2018, In : Clinical and Experimental Immunology. 194, 2, p. 137-152 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

MMP7 cleaves remyelination-impairing fibronectin aggregates and its expression is reduced in chronic multiple sclerosis lesions

Wang, P., Gorter, R. P., de Jonge, J. C., Nazmuddin, M., Zhao, C., Amor, S., Hoekstra, D. & Baron, W., 1 Aug 2018, In : GLIA. 66, 8, p. 1625-1643 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Phosphatidylcholine 36:1 concentration decreases along with demyelination in the cuprizone animal model and in post-mortem multiple sclerosis brain tissue

Trépanier, M-O., Hildebrand, K. D., Nyamoya, S. D., Amor, S., Bazinet, R. P. & Kipp, M., 1 Jun 2018, In : Journal of Neurochemistry. 145, p. 504-515 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Rapidly progressive amyotrophic lateral sclerosis is associated with microglial reactivity and small heat shock protein expression in reactive astrocytes

Gorter, R. P., Stephenson, J., Nutma, E., Anink, J., de Jonge, J. C., Baron, W., Jahreiβ, M. C., Belien, J. A. M., van Noort, J. M., Mijnsbergen, C., Aronica, E. & Amor, S., 2018, In : Neuropathology and Applied Neurobiology.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Visualization of the Breakdown of the Axonal Transport Machinery: a Comparative Ultrastructural and Immunohistochemical Approach

Rühling, S., Kramer, F., Schmutz, S., Amor, S., Jiangshan, Z., Schmitz, C., Kipp, M. & Hochstrasser, T., 2018, In : Molecular Neurobiology.

Research output: Contribution to journalArticleAcademicpeer-review

2017

Heat Shock Proteins: Old and Novel Roles in Neurodegenerative Diseases in the Central Nervous System

van Noort, J. M., Bugiani, M. & Amor, S., 2017, In : CNS and Neurological Disorders. Drug Targets. 16, 3, p. 244-256 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Identification of highly connected hub genes in the protective response program of human macrophages and microglia activated by alpha B-crystallin

Holtman, I. R., Bsibsi, M., Gerritsen, W. H., Boddeke, H. W. G. M., Eggen, B. J. L., van der Valk, P., Kipp, M., van Noort, J. M. & Amor, S., 1 Mar 2017, In : GLIA. 65, 3, p. 460-473 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Increased White Matter Inflammation in Aging- and Alzheimer's Disease Brain

Raj, D., Yin, Z., Breur, M., Doorduin, J., Holtman, I. R., Olah, M., Mantingh-Otter, I. J., Van Dam, D., De Deyn, P. P., den Dunnen, W., Eggen, B. J. L., Amor, S. & Boddeke, E., 2017, In : Frontiers in Behavioral Neuroscience. 10, p. 206

Research output: Contribution to journalArticleAcademicpeer-review

Neurofilament light as an immune target for pathogenic antibodies

Puentes, F., van der Star, B. J., Boomkamp, S. D., Kipp, M., Boon, L., Bosca, I., Raffel, J., Gnanapavan, S., van der Valk, P., Stephenson, J., Barnett, S. C., Baker, D. & Amor, S., Dec 2017, In : Immunology. 152, 4, p. 580-588 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans

Owen, D. R., Narayan, N., Wells, L., Healy, L., Smyth, E., Rabiner, E. A., Galloway, D., Williams, J. B., Lehr, J., Mandhair, H., Peferoen, L. A., Taylor, P. C., Amor, S., Antel, J. P., Matthews, P. M. & Moore, C. S., Aug 2017, In : Journal of Cerebral Blood Flow and Metabolism. 37, 8, p. 2679-2690 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Synaptophysin Is a Reliable Marker for Axonal Damage

Gudi, V., Gai, L., Herder, V., Tejedor, L. S., Kipp, M., Amor, S., Sühs, K-W., Hansmann, F., Beineke, A., Baumgärtner, W., Stangel, M. & Skripuletz, T., 1 Jan 2017, In : Journal of Neuropathology and Experimental Neurology. 76, 2, p. 109-125 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Ageing and recurrent episodes of neuroinflammation promote progressive experimental autoimmune encephalomyelitis in Biozzi ABH mice

Peferoen, L. A. N., Breur, M., van de Berg, S., Peferoen-Baert, R., Boddeke, E. H. W. G. M., van der Valk, P., Pryce, G., van Noort, J. M., Baker, D. & Amor, S., Oct 2016, In : Immunology. 149, 2, p. 146-156

Research output: Contribution to journalArticleAcademicpeer-review

CD20 therapies in multiple sclerosis and experimental autoimmune encephalomyelitis - Targeting T or B cells?

Agahozo, M. C., Peferoen, L., Baker, D. & Amor, S., Sep 2016, In : Multiple Sclerosis and Related Disorders. 9, p. 110-7 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Expression of IL-1 beta in rhesus EAE and MS lesions is mainly induced in the CNS itself

Burm, S. M., Peferoen, L. A. N., Zuiderwijk-Sick, E. A., Haanstra, K. G., 't Hart, B. A., van der Valk, P., Amor, S., Bauer, J. & Bajramovic, J. J., 6 Jun 2016, In : Journal of Neuroinflammation. 13, 138.

Research output: Contribution to journalArticleAcademicpeer-review

Human endogenous retrovirus W in brain lesions: Rationale for targeted therapy in multiple sclerosis

van Horssen, J., van der Pol, S., Nijland, P., Amor, S. & Perron, H., Jul 2016, In : Multiple Sclerosis and Related Disorders. 8, p. 11-18

Research output: Contribution to journalArticleAcademicpeer-review

Lesion Expansion in Experimental Demyelination Animal Models and Multiple Sclerosis Lesions

Grosse-Veldmann, R., Becker, B., Amor, S., van der Valk, P., Beyer, C. & Kipp, M., Sep 2016, In : Molecular Neurobiology. 53, 7, p. 4905-4917

Research output: Contribution to journalArticleAcademicpeer-review

Metal ions potentiate microglia responsiveness to endotoxin

Rachmawati, D., Peferoen, L. A. N., Vogel, D. Y. S., Alsalem, I. W. A., Amor, S., Bontkes, H. J., von Blomberg, BME., Scheper, R. J. & van Hoogstraten, I. M. W., 15 Feb 2016, In : Journal of Neuroimmunology. 291, p. 89-95 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Non-neuronal cells in ALS: Role of glial, immune cells and blood-CNS barriers

Puentes, F., Malaspina, A., Van Noort, J. M. & Amor, S., 1 Mar 2016, In : Brain Pathology. 26, 2, p. 248-257 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pentraxin-3 is upregulated in the central nervous system during MS and EAE, but does not modulate experimental neurological disease

Ummenthum, K., Peferoen, L. A. N., Finardi, A., Baker, D., Pryce, G., Mantovani, A., Bsibsi, M., Bottazzi, B., Peferoen-Baert, R., van der Valk, P., Garlanda, C., Kipp, M., Furlan, R., van Noort, J. M. & Amor, S., Mar 2016, In : European Journal of Immunology. 46, 3, p. 701-711

Research output: Contribution to journalArticleAcademicpeer-review

2015

Activation Status of Human Microglia Is Dependent on Lesion Formation Stage and Remyelination in Multiple Sclerosis

Peferoen, L. A. N., Vogel, D. Y. S., Ummenthum, K., Breur, M., Heijnen, P. D. A. M., Gerritsen, W. H., Peferoen-Baert, R. M. B., van der Valk, P., Dijkstra, C. D. & Amor, S., 2015, In : Journal of Neuropathology and Experimental Neurology. 74, 1, p. 48-63

Research output: Contribution to journalArticleAcademicpeer-review

Can MS lesion stages be distinguished with MRI? A postmortem MRI and histopathology study

Jonkman, L. E., Lopez Soriano, A., Amor, S., Barkhof, F., van der Valk, P., Vrenken, H. & Geurts, J. J. G., 2015, In : Journal of Neurology. 262, 4, p. 1074-1080

Research output: Contribution to journalArticleAcademicpeer-review

CXCL10 Triggers Early Microglial Activation in the Cuprizone Model

Clarner, T., Janssen, K., Nellessen, L., Stangel, M., Skripuletz, T., Krauspe, B., Hess, F. M., Denecke, B., Beutner, C., Linnartz-Gerlach, B., Neumann, H., Vallieres, L., Amor, S., Ohl, K., Tenbrock, K., Beyer, C. & Kipp, M., 2015, In : Journal of Immunology. 194, 7, p. 3400-3413

Research output: Contribution to journalArticleAcademicpeer-review

Disease origin and progression in amyotrophic lateral sclerosis: an immunology perspective

Malaspina, A., Puentes, F. & Amor, S., 2015, In : International Immunology. 27, 3, p. 117-129

Research output: Contribution to journalArticleAcademicpeer-review

GM-CSF promotes migration of human monocytes across the blood brain barrier

Vogel, D. Y. S., Kooij, G., Heijnen, P. D. A. M., Breur, M., Peferoen, L. A. N., van der Valk, P., de Vries, H. E., Amor, S. & Dijkstra, C. D., 2015, In : European Journal of Immunology. 45, 6, p. 1808-1819

Research output: Contribution to journalArticleAcademicpeer-review

Small heat shock proteins are induced during multiple sclerosis lesion development in white but not grey matter

Peferoen, L. A. N., Gerritsen, W. H., Breur, M., Ummenthum, K. M. D., Peferoen-Baert, R. M. B., van der Valk, P., van Noort, J. M. & Amor, S., 2015, In : Acta Neuropathologica Communinications. 3, 1, 87.

Research output: Contribution to journalArticleAcademicpeer-review

The sphingosine 1-phosphate receptor agonist FTY720 is neuroprotective after cuprizone-induced CNS demyelination

Slowik, A., Schmidt, T., Beyer, C., Amor, S., Clarner, T. & Kipp, M., 2015, In : British Journal of Pharmacology. 172, 1, p. 80-92

Research output: Contribution to journalArticleAcademicpeer-review

2014

Affinity Proteomic Profiling of Plasma, Cerebrospinal Fluid, and Brain Tissue within Multiple Sclerosis

Bystrom, S., Ayoglu, B., Haggmark, A., Mitsios, N., Hong, M. G., Drobin, K., Forsstrom, B., Fredolini, C., Khademi, M., Amor, S., Uhlen, M., Olsson, T., Mulder, J., Nilsson, P. & Schwenk, J. M., 2014, In : Journal of Proteome Research. 13, 11, p. 4607-4619

Research output: Contribution to journalArticleAcademicpeer-review

Control of spasticity in a multiple sclerosis model using central nervous system-excluded CB1 cannabinoid receptor agonists

Pryce, G., Visintin, C., Ramagopalan, S. V., Al-Izki, S., De Faveri, L. E., Nuamah, R. A., Mein, C. A., Montpetit, A., Hardcastle, A. J., Kooij, G., de Vries, H. E., Amor, S., Thomas, S. A., Ledent, C., Marsicano, G., Lutz, B., Thompson, A. J., Selwood, D. L., Giovannoni, G. & Baker, D., 2014, In : FASEB Journal. 28, 1, p. 117-130

Research output: Contribution to journalArticleAcademicpeer-review

Demyelination during multiple sclerosis is associated with combined activation of microglia/macrophages by IFN-gamma and alpha B-crystallin

Bsibsi, M., Peferoen, L. A. N., Holtman, I. R., Nacken, P. J., Gerritsen, W. H., Witte, M. E., van Horssen, J., Eggen, B. J. L., van der Valk, P., Amor, S. & van Noort, J. M., 2014, In : Acta Neuropathologica. 128, 2, p. 215-229

Research output: Contribution to journalArticleAcademicpeer-review

Discrepancy in CCL2 and CCR2 expression in white versus grey matter hippocampal lesions of Multiple Sclerosis patients

Prins, M., Dutta, R., Baselmans, B., Brevé, J. J. P., Bol, J. G. J. M., Deckard, S. A., van der Valk, P., Amor, S., Trapp, B. D., de Vries, H. E., Drukarch, B. & van Dam, A-M., 23 Aug 2014, In : Acta Neuropathologica Communinications. 2, p. 98

Research output: Contribution to journalArticleAcademicpeer-review

Experimental autoimmune encephalomyelitis is a good model of multiple sclerosis if used wisely

Baker, D. & Amor, S., 2014, In : Multiple Sclerosis and Related Disorders. 3, 5, p. 555-564

Research output: Contribution to journalArticleAcademicpeer-review

Human macrophage polarization in vitro: Maturation and activation methods compared

Vogel, D. Y. S., Glim, J. E., Stavenuiter, A. W. D., Breur, M., Heijnen, P., Amor, S., Dijkstra, C. D. & Beelen, R. H. J., 2014, In : Immunobiology. 219, 9, p. 695-703

Research output: Contribution to journalArticleAcademicpeer-review

Immune reactivity to neurofilament proteins in the clinical staging of amyotrophic lateral sclerosis

Puentes, F., Topping, J., Kuhle, J., van der Star, B. J., Douiri, A., Giovannoni, G., Baker, D., Amor, S. & Malaspina, A., 2014, In : Journal of Neurology, Neurosurgery and Psychiatry. 85, 3, p. 274-278

Research output: Contribution to journalArticleAcademicpeer-review

Inflammation in neurodegenerative diseases-an update

Amor, S., Peferoen, L. A. N., Vogel, D. Y. S., Breur, M., van der Valk, P., Baker, D. & van Noort, J. M., 2014, In : Immunology. 142, 2, p. 151-166

Research output: Contribution to journalArticleAcademicpeer-review

Innate and adaptive immune responses in neurodegeneration and repair

Amor, S. & Woodroofe, M. N., 2014, In : Immunology. 141, 3, p. 287-291

Research output: Contribution to journalArticleAcademicpeer-review

Lesional-targeting of neuroprotection to the inflammatory penumbra in experimental multiple sclerosis

Al-Izki, S., Pryce, G., Hankey, D. J. R., Lidster, K., von Kutzleben, S. M., Browne, L., Clutterbuck, L., Posada, C., Chan, A. W. E., Amor, S., Perkins, V., Gerritsen, W. H., Ummenthum, K., Peferoen-Baert, R., van der Valk, P., Montoya, A., Joel, S. P., Garthwaite, J., Giovannoni, G., Selwood, D. L. & 1 othersBaker, D., 2014, In : Brain. 137, p. 92-108

Research output: Contribution to journalArticleAcademicpeer-review

Macrophages migrate in an activation-dependent manner to chemokines involved in neuroinflammation

Vogel, D. Y. S., Heijnen, D. A. M., Breur, M., de Vries, H. E., Tool, A. T., Amor, S. & Dijkstra, C. D., 2014, In : Journal of Neuroinflammation. 11, 23.

Research output: Contribution to journalArticleAcademicpeer-review

Neurofilament light antibodies in serum reflect response to natalizumab treatment in multiple sclerosis

Amor, S., van der Star, B. J., Bosca, I., Raffel, J., Gnanapavan, S., Watchorn, J., Kuhle, J., Giovannoni, G., Baker, D., Malaspina, A. & Puentes, F., 2014, In : Multiple Sclerosis. 20, 10, p. 1355-1362

Research output: Contribution to journalArticleAcademicpeer-review

Oligodendrocyte-microglia cross-talk in the central nervous system

Peferoen, L., Kipp, M., van der Valk, P., van Noort, J. M. & Amor, S., 2014, In : Immunology. 141, 3, p. 302-313

Research output: Contribution to journalArticleAcademicpeer-review

The epigenetics of multiple sclerosis and other related disorders

van den Elsen, P. J., van Eggermond, M. C. J. A., Puentes, F., van der Valk, P., Baker, D. & Amor, S., 2014, In : Multiple Sclerosis and Related Disorders. 3, 2, p. 163-175

Research output: Contribution to journalArticleAcademicpeer-review

Two Years Later: Journals Are Not Yet Enforcing the ARRIVE Guidelines on Reporting Standards for Pre-Clinical Animal Studies

Baker, D., Lidster, K., Sottomayor, A. & Amor, S., 2014, In : PloS Biology. 12, 1, p. e1001756 e1001756.

Research output: Contribution to journalArticleAcademicpeer-review

2013

Activation of an immune-regulatory macrophage response and inhibition of lung inflammation in a mouse model of COPD using heat-shock protein alpha B-crystallin-loaded PLGA microparticles

van Noort, J. M., Bsibsi, M., Nacken, P. J., Gerritsen, W. H., Amor, S., Holtman, I. R., Boddeke, E., van Ark, I., Leusink-Muis, T., Folkerts, G., Hennink, W. E. & Amidi, M., 2013, In : Biomaterials. 34, 3, p. 831-839

Research output: Contribution to journalArticleAcademicpeer-review

Alpha-B-crystallin induces an immune-regulatory and antiviral microglial response in preactive multiple sclerosis lesions

Bsibsi, M., Holtman, I. R., Gerritsen, W. H., Eggen, B. J. L., Boddeke, E., van der Valk, P., van Noort, J. M. & Amor, S., 2013, In : Journal of Neuropathology and Experimental Neurology. 72, 10, p. 970-979

Research output: Contribution to journalArticleAcademicpeer-review

Characterization of immune response to neurofilament light in experimental autoimmune encephalomyelitis

Puentes, F., van der Star, B. J., Victor, M., Kipp, M., Beyer, C., Peferoen-Baert, R., Ummenthum, K., Pryce, G., Gerritsen, W. H., Huizinga, R., Reijerkerk, A., van der Valk, P., Baker, D. & Amor, S., 2013, In : Journal of Neuroinflammation. 10, p. 18 18.

Research output: Contribution to journalArticleAcademicpeer-review

Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status

Vogel, D. Y. S., Vereyken, E. J. F., Glim, J. E., Heijnen, D. A. M., Moeton, M., van der Valk, P., Amor, S., Teunissen, C. E., van Horssen, J. & Dijkstra, C. D., 2013, In : Journal of Neuroinflammation. 10, p. 35 35.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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