Research Output per year
Personal profile
Research interests
My lab studies human genome aiming to dissect molecular mechanisms of susceptibility to infections and translate these findings into novel therapies. We have two programmes that focus on (1) primary immunodeficiencies and (2) mechanisms of host-pathogen interaction in tuberculosis.
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Research Output 1997 2019
Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation
Cuchet-Lourenço, D., Eletto, D., Wu, C., Plagnol, V., Papapietro, O., Curtis, J., Ceron-Gutierrez, L., Bacon, C. M., Hackett, S., Alsaleem, B., Maes, M., Gaspar, M., Alisaac, A., Goss, E., AlIdrissi, E., Siegmund, D., Wajant, H., Kumararatne, D., AlZahrani, M. S., Arkwright, P. D. & 3 others, 24 Aug 2018, In : Science. 361, 6404, p. 810-813 4 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage
Angulo, I., Vadas, O., Garçon, F., Banham-Hall, E., Plagnol, V., Leahy, T. R., Baxendale, H., Coulter, T., Curtis, J., Wu, C., Blake-Palmer, K., Perisic, O., Smyth, D., Maes, M., Fiddler, C., Juss, J., Cilliers, D., Markelj, G., Chandra, A., Farmer, G. & 24 others, 15 Nov 2013, In : Science. 342, 6160, p. 866-71 6 p.Research output: Contribution to journal › Article › Academic › peer-review
Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration
Curtis, J., Luo, Y., Zenner, H. L., Cuchet-Lourenço, D., Wu, C., Lo, K., Maes, M., Alisaac, A., Stebbings, E., Liu, J. Z., Kopanitsa, L., Ignatyeva, O., Balabanova, Y., Nikolayevskyy, V., Baessmann, I., Thye, T., Meyer, C. G., Nürnberg, P., Horstmann, R. D., Drobniewski, F. & 3 others, May 2015, In : Nature Genetics. 47, 5, p. 523-527 5 p.Research output: Contribution to journal › Article › Academic › peer-review
Biallelic JAK1 mutations in immunodeficient patient with mycobacterial infection
Eletto, D., Burns, S. O., Angulo, I., Plagnol, V., Gilmour, K. C., Henriquez, F., Curtis, J., Gaspar, M., Nowak, K., Daza-Cajigal, V., Kumararatne, D., Doffinger, R., Thrasher, A. J. & Nejentsev, S., 23 Dec 2016, In : Nature Communications. 7, p. 13992Research output: Contribution to journal › Article › Academic › peer-review
Immunodeficiency and disseminated mycobacterial infection associated with homozygous nonsense mutation of IKKβ
Burns, S. O., Plagnol, V., Gutierrez, B. M., Al Zahrani, D., Curtis, J., Gaspar, M., Hassan, A., Jones, A. M., Malone, M., Rampling, D., McLatchie, A., Doffinger, R., Gilmour, K. C., Henriquez, F., Thrasher, A. J., Gaspar, H. B. & Nejentsev, S., Jul 2014, In : Journal of Allergy and Clinical Immunology. 134, 1, p. 215-8 4 p.Research output: Contribution to journal › Article › Academic › peer-review
Activities 2014 2019
Understanding susceptibility to mycobacterial infection
Sergey Nezhentsev (Speaker)25 Oct 2019
Activity: Talk or presentation › Invited talk
Primary immunodeficiencies: lessons from rare diseases and therapeutic implications
Sergey Nezhentsev (Speaker)3 May 2019
Activity: Talk or presentation › Invited talk
Primary immunodeficiencies: lessons from rare diseases and therapeutic implications
Sergey Nezhentsev (Speaker)13 Jun 2019
Activity: Talk or presentation › Invited talk
Primary immunodeficiencies: lessons from rare diseases and therapeutic implications
Sergey Nezhentsev (Speaker)13 Apr 2018
Activity: Talk or presentation › Invited talk
Screening human genome to dissect mechanisms of susceptibility to mycobacterial infection and tuberculosis
Sergey Nezhentsev (Speaker)1 Jun 2018
Activity: Talk or presentation › Invited talk
Press / Media
Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation
21/07/2018
1 item of media coverage
Press/Media: Research