Sergey Nezhentsev

, (Principal Investigator)

19972019
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Personal profile

Research interests

My lab studies human genome aiming to dissect molecular mechanisms of susceptibility to infections and translate these findings into novel therapies. We have two programmes that focus on (1) primary immunodeficiencies and (2) mechanisms of host-pathogen interaction in tuberculosis.

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Research Output 1997 2019

  • 64 Article
  • 3 Review article
  • 2 Research external, graduation external
  • 1 Erratum

Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation

Cuchet-Lourenço, D., Eletto, D., Wu, C., Plagnol, V., Papapietro, O., Curtis, J., Ceron-Gutierrez, L., Bacon, C. M., Hackett, S., Alsaleem, B., Maes, M., Gaspar, M., Alisaac, A., Goss, E., AlIdrissi, E., Siegmund, D., Wajant, H., Kumararatne, D., AlZahrani, M. S., Arkwright, P. D. & 3 othersAbinun, M., Doffinger, R. & Nejentsev, S., 24 Aug 2018, In : Science. 361, 6404, p. 810-813 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage

Angulo, I., Vadas, O., Garçon, F., Banham-Hall, E., Plagnol, V., Leahy, T. R., Baxendale, H., Coulter, T., Curtis, J., Wu, C., Blake-Palmer, K., Perisic, O., Smyth, D., Maes, M., Fiddler, C., Juss, J., Cilliers, D., Markelj, G., Chandra, A., Farmer, G. & 24 othersKielkowska, A., Clark, J., Kracker, S., Debré, M., Picard, C., Pellier, I., Jabado, N., Morris, J. A., Barcenas-Morales, G., Fischer, A., Stephens, L., Hawkins, P., Barrett, J. C., Abinun, M., Clatworthy, M., Durandy, A., Doffinger, R., Chilvers, E. R., Cant, A. J., Kumararatne, D., Okkenhaug, K., Williams, R. L., Condliffe, A. & Nejentsev, S., 15 Nov 2013, In : Science. 342, 6160, p. 866-71 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration

Curtis, J., Luo, Y., Zenner, H. L., Cuchet-Lourenço, D., Wu, C., Lo, K., Maes, M., Alisaac, A., Stebbings, E., Liu, J. Z., Kopanitsa, L., Ignatyeva, O., Balabanova, Y., Nikolayevskyy, V., Baessmann, I., Thye, T., Meyer, C. G., Nürnberg, P., Horstmann, R. D., Drobniewski, F. & 3 othersPlagnol, V., Barrett, J. C. & Nejentsev, S., May 2015, In : Nature Genetics. 47, 5, p. 523-527 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Biallelic JAK1 mutations in immunodeficient patient with mycobacterial infection

Eletto, D., Burns, S. O., Angulo, I., Plagnol, V., Gilmour, K. C., Henriquez, F., Curtis, J., Gaspar, M., Nowak, K., Daza-Cajigal, V., Kumararatne, D., Doffinger, R., Thrasher, A. J. & Nejentsev, S., 23 Dec 2016, In : Nature Communications. 7, p. 13992

Research output: Contribution to journalArticleAcademicpeer-review

Immunodeficiency and disseminated mycobacterial infection associated with homozygous nonsense mutation of IKKβ

Burns, S. O., Plagnol, V., Gutierrez, B. M., Al Zahrani, D., Curtis, J., Gaspar, M., Hassan, A., Jones, A. M., Malone, M., Rampling, D., McLatchie, A., Doffinger, R., Gilmour, K. C., Henriquez, F., Thrasher, A. J., Gaspar, H. B. & Nejentsev, S., Jul 2014, In : Journal of Allergy and Clinical Immunology. 134, 1, p. 215-8 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Activities 2014 2019

  • 6 Invited talk
  • 2 Editorial work

Primary immunodeficiencies: lessons from rare diseases and therapeutic implications

Sergey Nezhentsev (Speaker)
13 Jun 2019

Activity: Talk or presentationInvited talk

Primary immunodeficiencies: lessons from rare diseases and therapeutic implications

Sergey Nezhentsev (Speaker)
3 May 2019

Activity: Talk or presentationInvited talk

Understanding susceptibility to mycobacterial infection

Sergey Nezhentsev (Speaker)
25 Oct 2019

Activity: Talk or presentationInvited talk

Variant or disease-causing

Sergey Nezhentsev (Speaker)
25 Oct 2018

Activity: Talk or presentationInvited talk

Primary immunodeficiencies: lessons from rare diseases and therapeutic implications

Sergey Nezhentsev (Speaker)
13 Apr 2018

Activity: Talk or presentationInvited talk