S.M. Lougheed

20022019
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Research Output 2002 2019

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Article

The effect of everolimus and low-dose cyclophosphamide on immune cell subsets in patients with metastatic renal cell carcinoma: results from a phase I clinical trial

Dutch WIN-O Consortium, 2019, In : Cancer Immunology, Immunotherapy. 68, 3, p. 503-515

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Phase 1 study of everolimus and low-dose oral cyclophosphamide in patients with metastatic renal cell carcinoma

Dutch WIN-O Consortium, 9 Nov 2018, In : Cancer Immunology, Immunotherapy.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

A bispecific nanobody approach to leverage the potent and widely applicable tumor cytolytic capacity of Vγ9Vδ2-T cells

de Bruin, R. C. G., Veluchamy, J. P., Lougheed, S. M., Schneiders, F. L., Lopez-Lastra, S., Lameris, R., Stam, A. G., Sebestyen, Z., Kuball, J., Molthoff, C. F. M., Hooijberg, E., Roovers, R. C., Santo, J. P. D., van Bergen en Henegouwen, P. M. P., Verheul, H. M. W., de Gruijl, T. D. & van der Vliet, H. J., 17 Oct 2017, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticleAcademicpeer-review

Blocking tumor-educated MSC paracrine activity halts osteosarcoma progression

Baglio, S. R., Lagerweij, T., Pérez-Lanzón, M., Ho, X. D., Léveillé, N., Melo, S. A., Cleton-Jansen, A. M., Jordanova, E. S., Roncuzzi, L., Greco, M., Van Eijndhoven, M. A. J., Grisendi, G., Dominici, M., Bonafede, R., Lougheed, S. M., De Gruijl, T. D., Zini, N., Cervo, S., Steffan, A., Canzonieri, V. & 6 othersMartson, A., Maasalu, K., Köks, S., Wurdinger, T., Baldini, N. & Pegtel, D. M., 15 Jul 2017, In : Clinical Cancer Research. 23, 14, p. 3721-3733 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

High Levels of EBV-Encoded RNA 1 (EBER1) Trigger Interferon and Inflammation-Related Genes in Keratinocytes Expressing HPV16 E6/E7

Aromseree, S., Middeldorp, J. M., Pientong, C., van Eijndhoven, M., Ramayanti, O., Lougheed, S. M., Pegtel, D. M., Steenbergen, R. D. M. & Ekalaksananan, T., 2017, In : PLoS ONE. 12, 1, p. e0169290

Research output: Contribution to journalArticleAcademicpeer-review

Long survival of patients with locally advanced breast cancer on combined neoadjuvant chemotherapy and immune potentiation: Modern lessons from an old study

Pohlmann, P. R., van Cruijsen, H., Stam, A. G. M., Lougheed, S. M., van den Eertwegh, A. J. M., Hoekman, K., Scheper, R., Buter, J., van der Hoeven, J. J. M., van der Wall, E., Pinedo, H. M. & de Gruij, T. D., Feb 2017, In : Cancer Research. 77

Research output: Contribution to journalArticleAcademicpeer-review

2016

Highly specific and potently activating V gamma 9V delta 2-T cell specific nanobodies for diagnostic and therapeutic applications

de Bruin, R. C. G., Lougheed, S. M., van der Kruk, L., Stam, A. G., Hooijberg, E., Roovers, R. C., Henegouwen, P. M. P. V. B. E., Verheul, H. M. W., de Gruijl, T. D. & van der Vliet, H. J., Aug 2016, In : Clinical Immunology. 169, p. 128-138

Research output: Contribution to journalArticleAcademicpeer-review

Sensing of latent EBV infection through exosomal transfer of 5'pppRNA

Baglio, S. R., van Eijndhoven, M. A. J., Koppers-Lalic, D., Berenguer, J., Lougheed, S. M., Gibbs, S., Leveille, N., Rinkel, R. N. P. M., Hopmans, E. S., Swaminathan, S., Verkuijlen, S. A. W. M., Scheffer, G. L., van Kuppeveld, F. J. M., de Gruijl, T. D., Bultink, I. E. M., Jordanova, E. S., Hackenberg, M., Piersma, S. R., Knol, J. C., Voskuyl, A. E. & 4 othersWurdinger, T., Jimenez, C. R., Middeldorp, J. M. & Pegtel, D. M., 2 Feb 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 5, p. E587-E596

Research output: Contribution to journalArticleAcademicpeer-review

TLR2 ligand-synthetic long peptide conjugates effectively stimulate tumor-draining lymph node T cells of cervical cancer patients

Zom, G. G., Welters, M. J. P., Loof, N. M., Goedemans, R., Lougheed, S., Valentijn, R. R. P. M., Zandvliet, M. L., Meeuwenoord, N. J., Melief, C. J. M., de Gruijl, T. D., Van der Marel, G. A., Filippov, D. V., Ossendorp, F. & Van der Burg, S. H., 11 Oct 2016, In : Oncotarget. 7, 41, p. 67087-67100

Research output: Contribution to journalArticleAcademicpeer-review

2014

Induction of dendritic cell maturation in the skin microenvironment by soluble factors derived from colon carcinoma

Lindenberg, J. J., van de Ven, R., Oosterhoff, D., Sombroek, C. C., Lougheed, S. M., Stam, A. G. M., Koenen, H. J. P. M., van den Eertwegh, A. J. M., Scheper, R. J. & de Gruijl, T. D., 2014, In : Human Vaccines & Immunotherapeutics. 10, 6, p. 1622-1632

Research output: Contribution to journalArticleAcademicpeer-review

Myeloid derived suppressor and dendritic cell subsets are related to clinical outcome in prostate cancer patients treated with prostate GVAX and ipilimumab

Santegoets, S. J. A. M., Stam, A. G. M., Lougheed, S. M., Gall, H., Jooss, K., Sacks, N., Hege, K., Lowy, I., Scheper, R. J., Gerritsen, W. R., van den Eertwegh, A. J. M. & de Gruijl, T. D., 2014, In : Journal for Immunotherapy of Cancer. 2, 31.

Research output: Contribution to journalArticleAcademicpeer-review

2013

Functional characterization of a STAT3-dependent dendritic cell-derived CD14(+) cell population arising upon IL-10-driven maturation

Lindenberg, J. J., van de Ven, R., Lougheed, S. M., Zomer, A., Santegoets, S. J. A. M., Griffioen, A. W., Hooijberg, E., van den Eertwegh, A. J. M., Thijssen, V. L., Scheper, R. J., Oosterhoff, D. & de Gruijl, T. D., 2013, In : OncoImmunology. 2, 4, e23837.

Research output: Contribution to journalArticleAcademicpeer-review

IL-10 conditioning of human skin affects the distribution of migratory dendritic cell subsets and functional T cell differentiation

Lindenberg, J. J., Oosterhoff, D., Sombroek, C. C., Lougheed, S. M., Hooijberg, E., Stam, A. G. M., Santegoets, S. J. A. M., Tijssen, H. J., Buter, J., Pinedo, H. M., van den Eertwegh, A. J. M., Scheper, R. J., Koenen, H. J. P. M., van de Ven, R. & de Gruijl, T. D., 2013, In : PLoS ONE. 8, 7, e70237.

Research output: Contribution to journalArticleAcademicpeer-review

Intradermal Delivery of TLR Agonists in a Human Explant Skin Model: Preferential Activation of Migratory Dendritic Cells by Polyribosinic-Polyribocytidylic Acid and Peptidoglycans

Oosterhoff, D., Heusinkveld, M., Lougheed, S. M., Kosten, I., Lindstedt, M., Bruijns, S. C. M., van Es, T., van Kooyk, Y., van der Burg, S. H. & de Gruijl, T. D., 2013, In : Journal of Immunology. 190, 7, p. 3338-3345

Research output: Contribution to journalArticleAcademicpeer-review

T cell profiling reveals high CD4(+)CTLA-4(+) T cell frequency as dominant predictor for survival after Prostate GVAX/ipilimumab treatment

Santegoets, S. J. A. M., Stam, A. G. M., Lougheed, S. M., Gall, H., Scholten, P. E. T., Reijm, M., Jooss, K., Sacks, N., Hege, K., Lowy, I., Cuillerot, J. M., von Blomberg, B. M. E., Scheper, R. J., van den Eertwegh, A. J. M., Gerritsen, W. R. & de Gruijl, T. D., 2013, In : Cancer Immunology and Immunotherapy. 62, 2, p. 245-256

Research output: Contribution to journalArticleAcademicpeer-review

2012

S-Adenosylhomocysteine induces apoptosis and phosphatidylserine exposure in endothelial cells independent of homocysteine

Sipkens, J. A., Hahn, N. E., Blom, H. J., Lougheed, S. M., Stehouwer, C. D. A., Rauwerda, J. A., Krijnen, P. A. J., van Hinsbergh, V. W. M. & Niessen, H. W. M., Mar 2012, In : Atherosclerosis. 221, 1, p. 48-54 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Tumor-mediated inhibition of human dendritic cell differentiation and function is consistently counteracted by combined p38 MAPK and STAT3 inhibition

Oosterhoff, D., Lougheed, S. M., van de Ven, R., Lindenberg, J. J., van Cruijsen, H., Hiddingh, L., Kroon, J., van den Eertwegh, A. J. M., Hangalapura, B., Scheper, R. J. & de Gruijl, T. D., 2012, In : OncoImmunology. 1, 5, p. 649-658

Research output: Contribution to journalArticleAcademicpeer-review

2011

Characterization of four conventional dendritic cell subsets in human skin-draining lymph nodes in relation to T-cell activation.

van de Ven, R., van den Hout, M. F. C. M., Lindenberg, J. J., Sluijter, B. J. R., van Leeuwen, P. A. M., Lougheed, S. M., Meijer, S., van den Tol, M. P., Scheper, R. J. & de Gruijl, T. D., 2011, In : Blood. 118, 9, p. 2502-2510

Research output: Contribution to journalArticleAcademicpeer-review

Glioblastoma-induced inhibition of Langerhans cell differentiation from CD34(+) precursors is mediated by IL-6 but unaffected by JAK2/STAT3 inhibition.

van Cruijsen, H., Oosterhoff, D., Lindenberg, J. J., Lougheed, S. M., Fehres, C. M., Weijers, K., van Boerdonk, R. A. A., Giaccone, G., Scheper, R. J., Hoekman, K. & de Gruijl, T. D., 2011, In : Immunotherapy. 3, 9, p. 1051-1061

Research output: Contribution to journalArticleAcademicpeer-review

2010

4-1BB-mediated expansion affords superior detection of in vivo primed effector memory CD8(+) T cells from melanoma sentinel lymph nodes

Sluijter, B. J. R., van den Hout, M. F. C. M., Stam, A. G. M., Lougheed, S. M., Suhoski, M. M., van den Eertwegh, A. J. M., van den Tol, M. P., van Leeuwen, P. A. M., Meijer, S., Scheper, R. J., June, C. H., de Gruijl, T. D. & Santegoets, S. J. A. M., 2010, In : Clinical Immunology. 137, 2, p. 221-233

Research output: Contribution to journalArticleAcademicpeer-review

Attenuation of invariant Natural Killer T-cell anergy induction through intradermal delivery of alpha-galactosylceramide

Bontkes, H. J., Moreno Jauge, M., Hangalapura, B. N., Lindenberg, J. J., de Groot, J., Lougheed, S. M., van der Vliet, J. J., van den Eertwegh, A. J. M., de Gruijl, T. D., von Blomberg, B. M. E. & Scheper, R. J., 2010, In : Clinical Immunology. 136, 3, p. 364-374

Research output: Contribution to journalArticleAcademicpeer-review

2006

A postmigrational switch among skin-derived dendritic cells to a macrophage-like phenotype is predetermined by the intracutaneous cytokine balance

de Gruijl, T. D., Sombroek, C. C., Lougheed, S. M., Oosterhoff, D., Buter, J., van den Eertwegh, A. J. M., Scheper, R. J. & Pinedo, H. M., 15 Jun 2006, In : Journal of Immunology. 176, 12, p. 7232-42 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2002

MUTZ-3, a human cell line model for the cytokine-induced differentiation of dendritic cells from CD34+ precursors

Masterson, A. J., Sombroek, C. C., De Gruijl, T. D., Graus, Y. M. F., van der Vliet, H. J. J., Lougheed, S. M., van den Eertwegh, A. J. M., Pinedo, H. M. & Scheper, R. J., 15 Jul 2002, In : Blood. 100, 2, p. 701-3 3 p.

Research output: Contribution to journalArticleAcademicpeer-review