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Research Output 1996 2019

2019

Chemically engineered glycan-modified cancer vaccines to mobilize skin dendritic cells

Duinkerken, S., Li, RJE., van Haften, F. J., de Gruijl, TD., Chiodo, F., Schetters, STT. & van Kooyk, Y., 1 Dec 2019, In : Current Opinion Chemical Biology. 53, p. 167-172 6 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Glycan-modified melanoma-derived apoptotic extracellular vesicles as antigen source for anti-tumor vaccination

Horrevorts, S. K., Stolk, D. A., van de Ven, R., Hulst, M., van Het Hof, B., Duinkerken, S., Heineke, M. H., Ma, W., Dusoswa, S. A., Nieuwland, R., Garcia-Vallejo, J. J., van de Loosdrecht, A. A., de Gruijl, T. D., van Vliet, S. J. & van Kooyk, Y., 1 Sep 2019, In : Cancers. 11, 9, 1266.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Glyco-dendrimers as intradermal anti-tumor vaccine targeting multiple skin DC subsets

Duinkerken, S., Horrevorts, S. K., Kalay, H., Ambrosini, M., Rutte, L., de Gruijl, T. D., Garcia-Vallejo, J. J. & van Kooyk, Y., 1 Jan 2019, In : Theranostics. 9, 20, p. 5797-5809

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Metronomic cyclophosphamide attenuates mTOR-mediated expansion of regulatory T cells, but does not impact clinical outcome in patients with metastatic renal cell cancer treated with everolimus

Werter, I. M., Huijts, C. M., Lougheed, S. M., Hamberg, P., Polee, M. B., Tascilar, M., Los, M., Haanen, J. B. A. G., Helgason, H. H., Verheul, H. M., de Gruijl, T. D., van der Vliet, H. J. & Dutch WIN-O Consortium, 1 May 2019, In : Cancer Immunology, Immunotherapy. 68

Research output: Contribution to journalArticleAcademicpeer-review

Neoadjuvant systemic therapy in melanoma: recommendations of the International Neoadjuvant Melanoma Consortium

Amaria, R. N., Menzies, A. M., Burton, E. M., Scolyer, R. A., Tetzlaff, M. T., Antdbacka, R., Ariyan, C., Bassett, R., Carter, B., Daud, A., Faries, M., Fecher, L. A., Flaherty, K. T., Gershenwald, J. E., Hamid, O., Hong, A., Kirkwood, J. M., Lo, S., Margolin, K., Messina, J. & 64 othersPostow, M. A., Rizos, H., Ross, M. I., Rozeman, E. A., Saw, R. P. M., Sondak, V., Sullivan, R. J., Taube, J. M., Thompson, J. F., van de Wiel, B. A., Eggermont, A. M., Davies, M. A., Andrews, M. C., Berry, D. A., Block, M. S., Boland, G. M., Bollin, K. B., Carlino, M. S., Carvajal, R. D., Cohen, J., Davar, D., Delman, K. A., Dummer, R., Farwell, M. D., Fisher, D. E., Fusi, A., Glitza, I. C., de Gruijl, T. D., Gyorki, D. E., Hauschild, A., Hieken, T. J., Larkin, J., Lawson, D. H., Lebbe, C., Lee, J. E., Lowe, M. C., Luke, J. J., McArthur, G. A., McDermott, D. F., McQuade, J. L., Mitchell, T. C., Petrella, T. M., Prieto, P. A., Puzanov, I., Robert, C., Salama, A. K., Sandhu, S., Schadendorf, D., Shoushtari, A. N., Sosman, J. A., Swetter, S. M., Tanabe, K. K., Turajlic, S., Tyler, D. S., Woodman, S. E., Wright, F. C., Zager, J. S., Ascierto, P. A., Spillane, A. J., van Akkooi, A. C. J., Wargo, J. A., Blank, C. U., Tawbi, H. A. & Long, G. V., 1 Jul 2019, In : The Lancet Oncology. 20, 7, p. e378-e389

Research output: Contribution to journalReview articleAcademicpeer-review

Phase 1 study of everolimus and low-dose oral cyclophosphamide in patients with metastatic renal cell carcinoma

Dutch WIN-O Consortium, Feb 2019, In : Cancer Immunology, Immunotherapy. 68, 2, p. 319-329

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node

van Pul, K. M., Vuylsteke, R. J. C. L. M., van de Ven, R., Te Velde, E. A., Rutgers, E. J. T., van den Tol, P. M., Stockmann, H. B. A. C. & de Gruijl, T. D., 22 May 2019, In : Journal for Immunotherapy of Cancer. 7, 1, p. 133

Research output: Contribution to journalArticleAcademicpeer-review

Stereotactic ablative radiotherapy for the comprehensive treatment of 4-10 oligometastatic tumors (SABR-COMET-10): study protocol for a randomized phase III trial

Palma, D. A., Olson, R., Harrow, S., Correa, R. J. M., Schneiders, F., Haasbeek, C. J. A., Rodrigues, G. B., Lock, M., Yaremko, B. P., Bauman, G. S., Ahmad, B., Schellenberg, D., Liu, M., Gaede, S., Laba, J., Mulroy, L., Senthi, S., Louie, A. V., Swaminath, A., Chalmers, A. & 5 othersWarner, A., Slotman, B. J., de Gruijl, T. D., Allan, A. & Senan, S., 2019, In : BMC Cancer. 19, 1, 816.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The effect of everolimus and low-dose cyclophosphamide on immune cell subsets in patients with metastatic renal cell carcinoma: results from a phase I clinical trial

Huijts, C. M., Lougheed, S. M., Bodalal, Z., van Herpen, C. M., Hamberg, P., Tascilar, M., Haanen, J. B., Verheul, H. M., de Gruijl, T. D., van der Vliet, H. J. & Dutch WIN-O Consortium, 13 Mar 2019, In : Cancer Immunology, Immunotherapy. 68, 3, p. 503-515

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Translational studies on the therapeutic control of regulatory T cells in renal cell cancer: suppressing the suppressors

Huijts, C. M., 2019, 206 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

Open Access

Unlocking the therapeutic potential of primary tumor-draining lymph nodes

Rotman, J., Koster, B. D., Jordanova, E. S., Heeren, A. M. & de Gruijl, T. D., 1 Oct 2019, In : Cancer Immunology, Immunotherapy. 68, 10, p. 1681-1688 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
2018

A novel allogeneic off-the-shelf dendritic cell vaccine for post-remission treatment of elderly patients with acute myeloid leukemia

van de Loosdrecht, A. A., van Wetering, S., Santegoets, S. J. A. M., Singh, S. K., Eeltink, C. M., den Hartog, Y., Koppes, M., Kaspers, J., Ossenkoppele, G. J., Kruisbeek, A. M. & de Gruijl, T. D., 1 Oct 2018, In : Cancer Immunology and Immunotherapy. 67, 10, p. 1505-1518 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A safety and immunogenicity study of immunization with hVEGF/RFASE in cynomolgus monkeys

Wentink, M. Q., Verheul, H. M. W., Griffioen, A. W., Schafer, K. A., McPherson, S., Early, R. J., van der Vliet, H. J. & de Gruijl, T. D., 5 Apr 2018, In : Vaccine. 36, 15, p. 2025-2032 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

CD40L coding oncolytic adenovirus allows long-term survival of humanized mice receiving dendritic cell therapy

Zafar, S., Sorsa, S., Siurala, M., Hemminki, O., Havunen, R., Cervera-Carrascon, V., Santos, J. M., Wang, H., Lieber, A., de Gruijl, T., Kanerva, A. & Hemminki, A., 2018, In : OncoImmunology. 7, 10, e1490856.

Research output: Contribution to journalArticleAcademicpeer-review

Enhanced Dendritic Cell Development Through Long-Term Proteasome Inhibition

van de Ven, R., Verbrugge, S. E., Al, M., Dekker, H., Verheul, HMW., Anderl, J. L., Chan, E. T., Dijkmans, BAC., Lems, WF., Scheper, RJ., Jansen, G. & de Gruijl, TD., 18 Jan 2018, In : Journal of Molecular and Clinical Medicine. 1, 1, p. 37-46 10 p., DOI: 10.31083/j.jmcm.2018.01.005.

Research output: Contribution to journalArticleAcademicpeer-review

Evaluation of explant responses to STING ligands: Personalized immunosurgical therapy for head and neck squamous cell carcinoma

Baird, J. R., Bryan Bell, R., Troesch, V., Friedman, D., Bambina, S., Kramer, G., Blair, T. C., Medler, T., Wu, Y., Sun, Z., de Gruijl, T. D., van de Ven, R., Leidner, R. S., Crittenden, M. R. & Gough, M. J., 2018, In : Cancer Research. 78, 21, p. 6308-6319

Research output: Contribution to journalArticleAcademicpeer-review

Improved Induction of Anti-Melanoma T Cells by Adenovirus-5/3 Fiber Modification to Target Human DCs

Chondronasiou, D., Eisden, T-J. T. H. D., Stam, A. G. M., Matthews, Q. L., Icyuz, M., Hooijberg, E., Dmitriev, I., Curiel, D. T., de Gruijl, T. D. & van de Ven, R., 18 Jul 2018, In : Vaccines. 6, 3

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Improving CLL Vγ9Vδ2-T-cell fitness for cellular therapy by ex vivo activation and ibrutinib

de Weerdt, I., Hofland, T., Lameris, R., Endstra, S., Jongejan, A., Moerland, P. D., de Bruin, R. C. G., Remmerswaal, E. B. M., Ten Berge, I. J. M., Liu, N., van der Stelt, M., Faber, L. M., Levin, M-D., Eldering, E., Tonino, S. H., de Gruijl, T. D., van der Vliet, H. J. & Kater, A. P., 22 Nov 2018, In : Blood. 132, 21, p. 2260-2272 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Indoleamine 2,3-dioxygenase expression pattern in the tumor microenvironment predicts clinical outcome in early stage cervical cancer

Heeren, A. M., van Dijk, I., Berry, D. R. A. I., Khelil, M., Ferns, D., Kole, J., Musters, R. J. P., Thijssen, V. L., Mom, C. H., Kenter, G. G., Bleeker, M. C. G., de Gruijl, T. D. & Jordanova, E. S., 11 Jul 2018, In : Frontiers in Immunology. 9, JUL, 1598.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Natural Killer cells from Umbilical Cord blood stem cells: A novel immunotherapy platform for solid tumors

Veluchamy, J. P., 2018, 180 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

Positive & negative roles of innate effector cells in controlling cancer progression

Stolk, D., van der Vliet, H. J., de Gruijl, T. D., van Kooyk, Y. & Exley, M. A., 2018, In : Frontiers in Immunology. 9, SEP, 1990.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
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Translating immune characteristics of metastatic tumors into therapeutic targets for cervical cancer

Heeren, AM., 2018, 213 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

Open Access
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Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer

Niemeijer, A. N., Leung, D., Huisman, M. C., Bahce, I., Hoekstra, O. S., van Dongen, G. A. M. S., Boellaard, R., Du, S., Hayes, W., Smith, R., Windhorst, A. D., Hendrikse, N. H., Poot, A., Vugts, D. J., Thunnissen, E., Morin, P., Lipovsek, D., Donnelly, D. J., Bonacorsi, S. J., Velasquez, L. M. & 3 othersde Gruijl, T. D., Smit, E. F. & de Langen, A. J., 1 Dec 2018, In : Nature Communications. 9, 1, 4664.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

A bispecific nanobody approach to leverage the potent and widely applicable tumor cytolytic capacity of Vγ9Vδ2-T cells

de Bruin, R. C. G., Veluchamy, J. P., Lougheed, S. M., Schneiders, F. L., Lopez-Lastra, S., Lameris, R., Stam, A. G., Sebestyen, Z., Kuball, J., Molthoff, C. F. M., Hooijberg, E., Roovers, R. C., Santo, J. P. D., van Bergen en Henegouwen, P. M. P., Verheul, H. M. W., de Gruijl, T. D. & van der Vliet, H. J., 17 Oct 2017, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticleAcademicpeer-review

Blocking tumor-educated MSC paracrine activity halts osteosarcoma progression

Baglio, S. R., Lagerweij, T., Pérez-Lanzón, M., Ho, X. D., Léveillé, N., Melo, S. A., Cleton-Jansen, A. M., Jordanova, E. S., Roncuzzi, L., Greco, M., Van Eijndhoven, M. A. J., Grisendi, G., Dominici, M., Bonafede, R., Lougheed, S. M., De Gruijl, T. D., Zini, N., Cervo, S., Steffan, A., Canzonieri, V. & 6 othersMartson, A., Maasalu, K., Köks, S., Wurdinger, T., Baldini, N. & Pegtel, D. M., 15 Jul 2017, In : Clinical Cancer Research. 23, 14, p. 3721-3733 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Comparative phenotypic and functional analysis of migratory dendritic cell subsets from human oral mucosa and skin

Kosten, I. J., Van De Ven, R., Thon, M., Gibbs, S. & De Gruijl, T. D., 1 Jul 2017, In : PLoS ONE. 12, 7, e0180333.

Research output: Contribution to journalArticleAcademicpeer-review

DNA injectie lijkt effectief middel tegen huidkanker.

de Gruijl, TD., 2017, In : Algemeen Dagblad.

Research output: Contribution to journalArticleProfessional

High PD-1 expression on regulatory and effector T cells in lung cancer draining lymph nodes

Van de Ven, R., Niemeijer, A-L. N., Stam, A. G., Hashemi, S. M., Slockers, C. G., Daniels, J. M., Thunnissen, E., Smit, E. F., de Gruijl, T. D. & de langen, A. J., Jul 2017, In : Cancer Research. 77

Research output: Contribution to journalMeeting AbstractAcademic

High PD-1 expression on regulatory and effector T-cells in lung cancer draining lymph nodes

van de Ven, R., Niemeijer, A. L. N., Stam, A. G. M., Hashemi, S. M. S., Slockers, C. G., Daniels, J. M., Thunnissen, E., Smit, E. F., de Gruijl, T. D. & de Langen, A. J., 1 Apr 2017, In : ERS Monograph. 3, 2, 00110-2016.

Research output: Contribution to journalArticleAcademicpeer-review

Immunological effects of everolimus in patients with metastatic renal cell cancer

Huijts, C. M., Santegoets, S. J., de Jong, T. D., Verheul, H. M., de Gruijl, T. D. & van der Vliet, H. J., 1 Dec 2017, In : International Journal of Immunopathology and Pharmacology. 30, 4, p. 341-352 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

In Vivo efficacy of umbilical cord blood stem cell-derived NK cells in the treatment of metastatic colorectal cancer

Veluchamy, J. P., Lopez-Lastra, S., Spanholtz, J., Bohme, F., Kok, N., Heideman, D. A. M., Verheul, H. M. W., Di Santo, J. P., de Gruijl, T. D. & van der Vliet, H. J., 6 Feb 2017, In : Frontiers in Immunology. 8, FEB, 87.

Research output: Contribution to journalArticleAcademicpeer-review

Local adjuvant treatment with low-dose CpG-B offers durable protection against disease recurrence in clinical stage I–II melanoma: Data from two randomized phase II trials

Koster, B. D., Van Den Hout, M. F. C. M., Sluijter, B. J. R., Molenkamp, B. G., Vuylsteke, R. J. C. L. M., Baars, A., Van Leeuwen, P. A. M., Scheper, R. J., Petrousjka van den Tol, M., Van Den Eertwegh, A. J. M. & De Gruijl, T. D., 1 Oct 2017, In : Clinical Cancer Research. 23, 19, p. 5679-5686 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Melanoma sequentially suppresses different DC subsets in the sentinel lymph node, affecting disease spread and recurrence

Van Den Hout, M. F. C. M., Koster, B. D., Sluijter, B. J. R., Molenkamp, B. G., Van De Ven, R., Van Den Eertwegh, A. J. M., Scheper, R. J., Van Leeuwen, P. A. M., Van Den Tol, M. P. & De Gruijl, T. D., 1 Nov 2017, In : Cancer Immunology Research. 5, 11, p. 969-977 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

MICROENVIRONMENT IN TUMOR-DRAINING LYMPH NODES FROM PATIENTS WITH HPV-RELATED VULVAR CANCER

Zijlmans, H., Heeren, M., Samuels, S., Rotman, J., van der Velden, K., Van de Vijver, K., Kenter, G., Jordanova, E., Bleeker, M. & de Gruijl, T., Nov 2017, In : International Journal of Gynecological Cancer. 27, 4, p. 1397-1397 ESGO7-130.

Research output: Contribution to journalMeeting AbstractAcademic

MICROENVIRONMENT IN TUMOR-DRAINING LYMPH NODES FROM PATIENTS WITH HPV-RELATED VULVAR CANCER

Zijlmans, H., Heeren, M., Samuels, S., Rotman, J., van der Velden, K., de Vijver, K. V., Kenter, G., Jordanova, E., Bleeker, M. & de Gruijl, T., Nov 2017, In : International Journal of Gynecological Cancer. 27, p. 499-499

Research output: Contribution to journalMeeting AbstractAcademic

Nanobody based approaches for the therapeutic targeting of conserved T cell subsets in cancer

de Bruin, RCG., 2017, 205 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

Open Access