If you made any changes in Pure these will be visible here soon.

Research Output 1996 2019

Filter
Article
2019
Open Access

Chemically engineered glycan-modified cancer vaccines to mobilize skin dendritic cells

Duinkerken, S., Li, RJE., van Haften, F. J., de Gruijl, TD., Chiodo, F., Schetters, STT. & van Kooyk, Y., Dec 2019, In : Current Opinion Chemical Biology. p. 167-172

Research output: Contribution to journalArticleAcademicpeer-review

Glyco-dendrimers as intradermal anti-tumor vaccine targeting multiple skin DC subsets

Duinkerken, S., Horrevorts, S. K., Kalay, H., Ambrosini, M., Rutte, L., de Gruijl, T. D., Garcia-Vallejo, J. J. & van Kooyk, Y., 2019, In : Theranostics. 9, 20, p. 5797-5809

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node

van Pul, K. M., Vuylsteke, R. J. C. L. M., van de Ven, R., Te Velde, E. A., Rutgers, E. J. T., van den Tol, P. M., Stockmann, H. B. A. C. & de Gruijl, T. D., 22 May 2019, In : Journal for Immunotherapy of Cancer. 7, 1, p. 133

Research output: Contribution to journalArticleAcademicpeer-review

Stereotactic ablative radiotherapy for the comprehensive treatment of 4-10 oligometastatic tumors (SABR-COMET-10): study protocol for a randomized phase III trial

Palma, D. A., Olson, R., Harrow, S., Correa, R. J. M., Schneiders, F., Haasbeek, C. J. A., Rodrigues, G. B., Lock, M., Yaremko, B. P., Bauman, G. S., Ahmad, B., Schellenberg, D., Liu, M., Gaede, S., Laba, J., Mulroy, L., Senthi, S., Louie, A. V., Swaminath, A., Chalmers, A. & 5 othersWarner, A., Slotman, B. J., de Gruijl, T. D., Allan, A. & Senan, S., 2019, In : BMC Cancer. 19, 1, 816.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The effect of everolimus and low-dose cyclophosphamide on immune cell subsets in patients with metastatic renal cell carcinoma: results from a phase I clinical trial

Dutch WIN-O Consortium, 2019, In : Cancer Immunology, Immunotherapy. 68, 3, p. 503-515

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

A novel allogeneic off-the-shelf dendritic cell vaccine for post-remission treatment of elderly patients with acute myeloid leukemia

van de Loosdrecht, A. A., van Wetering, S., Santegoets, S. J. A. M., Singh, S. K., Eeltink, C. M., den Hartog, Y., Koppes, M., Kaspers, J., Ossenkoppele, G. J., Kruisbeek, A. M. & de Gruijl, T. D., 1 Oct 2018, In : Cancer Immunology and Immunotherapy. 67, 10, p. 1505-1518 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A safety and immunogenicity study of immunization with hVEGF/RFASE in cynomolgus monkeys

Wentink, M. Q., Verheul, H. M. W., Griffioen, A. W., Schafer, K. A., McPherson, S., Early, R. J., van der Vliet, H. J. & de Gruijl, T. D., 5 Apr 2018, In : Vaccine. 36, 15, p. 2025-2032 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

CD40L coding oncolytic adenovirus allows long-term survival of humanized mice receiving dendritic cell therapy

Zafar, S., Sorsa, S., Siurala, M., Hemminki, O., Havunen, R., Cervera-Carrascon, V., Santos, J. M., Wang, H., Lieber, A., de Gruijl, T., Kanerva, A. & Hemminki, A., 2018, In : OncoImmunology. 7, 10, e1490856.

Research output: Contribution to journalArticleAcademicpeer-review

Enhanced Dendritic Cell Development Through Long-Term Proteasome Inhibition

van de Ven, R., Verbrugge, S. E., Al, M., Dekker, H., Verheul, HMW., Anderl, J. L., Chan, E. T., Dijkmans, BAC., Lems, WF., Scheper, RJ., Jansen, G. & de Gruijl, TD., 18 Jan 2018, In : Journal of Molecular and Clinical Medicine. 1, 1, p. 37-46 10 p., DOI: 10.31083/j.jmcm.2018.01.005.

Research output: Contribution to journalArticleAcademicpeer-review

Evaluation of explant responses to STING ligands: Personalized immunosurgical therapy for head and neck squamous cell carcinoma

Baird, J. R., Bryan Bell, R., Troesch, V., Friedman, D., Bambina, S., Kramer, G., Blair, T. C., Medler, T., Wu, Y., Sun, Z., de Gruijl, T. D., van de Ven, R., Leidner, R. S., Crittenden, M. R. & Gough, M. J., 2018, In : Cancer Research. 78, 21, p. 6308-6319

Research output: Contribution to journalArticleAcademicpeer-review

Improved Induction of Anti-Melanoma T Cells by Adenovirus-5/3 Fiber Modification to Target Human DCs

Chondronasiou, D., Eisden, T-J. T. H. D., Stam, A. G. M., Matthews, Q. L., Icyuz, M., Hooijberg, E., Dmitriev, I., Curiel, D. T., de Gruijl, T. D. & van de Ven, R., 18 Jul 2018, In : Vaccines. 6, 3

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Improving CLL Vγ9Vδ2-T-cell fitness for cellular therapy by ex vivo activation and ibrutinib

de Weerdt, I., Hofland, T., Lameris, R., Endstra, S., Jongejan, A., Moerland, P. D., de Bruin, R. C. G., Remmerswaal, E. B. M., Ten Berge, I. J. M., Liu, N., van der Stelt, M., Faber, L. M., Levin, M-D., Eldering, E., Tonino, S. H., de Gruijl, T. D., van der Vliet, H. J. & Kater, A. P., 22 Nov 2018, In : Blood. 132, 21, p. 2260-2272 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Indoleamine 2,3-dioxygenase expression pattern in the tumor microenvironment predicts clinical outcome in early stage cervical cancer

Heeren, A. M., van Dijk, I., Berry, D. R. A. I., Khelil, M., Ferns, D., Kole, J., Musters, R. J. P., Thijssen, V. L., Mom, C. H., Kenter, G. G., Bleeker, M. C. G., de Gruijl, T. D. & Jordanova, E. S., 11 Jul 2018, In : Frontiers in Immunology. 9, JUL, 1598.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Phase 1 study of everolimus and low-dose oral cyclophosphamide in patients with metastatic renal cell carcinoma

Dutch WIN-O Consortium, 9 Nov 2018, In : Cancer Immunology, Immunotherapy.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer

Niemeijer, A. N., Leung, D., Huisman, M. C., Bahce, I., Hoekstra, O. S., van Dongen, G. A. M. S., Boellaard, R., Du, S., Hayes, W., Smith, R., Windhorst, A. D., Hendrikse, N. H., Poot, A., Vugts, D. J., Thunnissen, E., Morin, P., Lipovsek, D., Donnelly, D. J., Bonacorsi, S. J., Velasquez, L. M. & 3 othersde Gruijl, T. D., Smit, E. F. & de Langen, A. J., 1 Dec 2018, In : Nature Communications. 9, 1, 4664.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

A bispecific nanobody approach to leverage the potent and widely applicable tumor cytolytic capacity of Vγ9Vδ2-T cells

de Bruin, R. C. G., Veluchamy, J. P., Lougheed, S. M., Schneiders, F. L., Lopez-Lastra, S., Lameris, R., Stam, A. G., Sebestyen, Z., Kuball, J., Molthoff, C. F. M., Hooijberg, E., Roovers, R. C., Santo, J. P. D., van Bergen en Henegouwen, P. M. P., Verheul, H. M. W., de Gruijl, T. D. & van der Vliet, H. J., 17 Oct 2017, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticleAcademicpeer-review

Blocking tumor-educated MSC paracrine activity halts osteosarcoma progression

Baglio, S. R., Lagerweij, T., Pérez-Lanzón, M., Ho, X. D., Léveillé, N., Melo, S. A., Cleton-Jansen, A. M., Jordanova, E. S., Roncuzzi, L., Greco, M., Van Eijndhoven, M. A. J., Grisendi, G., Dominici, M., Bonafede, R., Lougheed, S. M., De Gruijl, T. D., Zini, N., Cervo, S., Steffan, A., Canzonieri, V. & 6 othersMartson, A., Maasalu, K., Köks, S., Wurdinger, T., Baldini, N. & Pegtel, D. M., 15 Jul 2017, In : Clinical Cancer Research. 23, 14, p. 3721-3733 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Comparative phenotypic and functional analysis of migratory dendritic cell subsets from human oral mucosa and skin

Kosten, I. J., Van De Ven, R., Thon, M., Gibbs, S. & De Gruijl, T. D., 1 Jul 2017, In : PLoS ONE. 12, 7, e0180333.

Research output: Contribution to journalArticleAcademicpeer-review

DNA injectie lijkt effectief middel tegen huidkanker.

de Gruijl, TD., 2017, In : Algemeen Dagblad.

Research output: Contribution to journalArticleProfessional

Immunological effects of everolimus in patients with metastatic renal cell cancer

Huijts, C. M., Santegoets, S. J., de Jong, T. D., Verheul, H. M., de Gruijl, T. D. & van der Vliet, H. J., 1 Dec 2017, In : International Journal of Immunopathology and Pharmacology. 30, 4, p. 341-352 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

In Vivo efficacy of umbilical cord blood stem cell-derived NK cells in the treatment of metastatic colorectal cancer

Veluchamy, J. P., Lopez-Lastra, S., Spanholtz, J., Bohme, F., Kok, N., Heideman, D. A. M., Verheul, H. M. W., Di Santo, J. P., de Gruijl, T. D. & van der Vliet, H. J., 6 Feb 2017, In : Frontiers in Immunology. 8, FEB, 87.

Research output: Contribution to journalArticleAcademicpeer-review

Local adjuvant treatment with low-dose CpG-B offers durable protection against disease recurrence in clinical stage I–II melanoma: Data from two randomized phase II trials

Koster, B. D., Van Den Hout, M. F. C. M., Sluijter, B. J. R., Molenkamp, B. G., Vuylsteke, R. J. C. L. M., Baars, A., Van Leeuwen, P. A. M., Scheper, R. J., Petrousjka van den Tol, M., Van Den Eertwegh, A. J. M. & De Gruijl, T. D., 1 Oct 2017, In : Clinical Cancer Research. 23, 19, p. 5679-5686 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Melanoma sequentially suppresses different DC subsets in the sentinel lymph node, affecting disease spread and recurrence

Van Den Hout, M. F. C. M., Koster, B. D., Sluijter, B. J. R., Molenkamp, B. G., Van De Ven, R., Van Den Eertwegh, A. J. M., Scheper, R. J., Van Leeuwen, P. A. M., Van Den Tol, M. P. & De Gruijl, T. D., 1 Nov 2017, In : Cancer Immunology Research. 5, 11, p. 969-977 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Prevention of V gamma 9V delta 2 T cell activation by a V gamma 9V delta 2 TCR nanobody (vol 198, pg 308, 2017)

de Bruin, R. C. G., Stam, A. G. M., Vangone, A., Henegouwen, P. M. P. V. B. E., Verheul, H. M. W., Sebestyen, Z., Kuball, J., Bonvin, A. M. J. J., de Gruijl, T. D. & van der Vliet, H. J., 1 May 2017, In : Journal of Immunology. 198, 9, p. 3759-3759

Research output: Contribution to journalArticleAcademicpeer-review

Prevention of Vγ9Vδ2 T cell activation by a Vγ9Vδ2 TCR nanobody

De Bruin, R. C. G., Stam, A. G. M., Vangone, A., Van Bergen En Henegouwen, P. M. P., Verheul, H. M. W., Sebestyén, Z., Kuball, J., Bonvin, A. M. J. J., De Gruijl, T. D. & Van Der Vliet, H. J., 1 Jan 2017, In : Journal of Immunology. 198, 1, p. 308-317 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Standardized and flexible eight colour flow cytometry panels harmonized between different laboratories to study human NK cell phenotype and function

Veluchamy, J. P., Delso-Vallejo, M., Kok, N., Bohme, F., Seggewiss-Bernhardt, R., Van Der Vliet, H. J., De Gruijl, T. D., Huppert, V. & Spanholtz, J., 10 Mar 2017, In : Scientific Reports. 7, 43873.

Research output: Contribution to journalArticleAcademicpeer-review

Transcriptional profiling reveals functional dichotomy between human slan+ non-classical monocytes and myeloid dendritic cells

van Leeuwen-Kerkhoff, N., Lundberg, K., Westers, T. M., Kordasti, S., Bontkes, H. J., de Gruijl, T. D., Lindstedt, M. & van de Loosdrecht, A. A., 1 Oct 2017, In : Journal of Leukocyte Biology. 102, 4, p. 1055-1068 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

A functional bioassay to determine the activity of anti-VEGF antibody therapy in blood of patients with cancer

Wentink, M. Q., Broxterman, H. J., Lam, S. W., Boven, E., Walraven, M., Griffioen, A. W., Pili, R., van der Vliet, H. J., de Gruijl, T. D. & Verheul, H. M. W., 11 Oct 2016, In : British Journal of Cancer. 115, 8, p. 940-948

Research output: Contribution to journalArticleAcademicpeer-review

Apoptotic vesicles as tumor vaccine

Horrevorts, S. K., Garcia-Vallejo, J. J., van Vliet, S. J., van de Loosdrecht, A. A., van Kooyk, Y. & de Gruijl, T. D., 2016, In : Immunotherapy. 8, 1, p. 5-8

Research output: Contribution to journalArticleAcademicpeer-review

Combination of NK Cells and Cetuximab to Enhance Anti-Tumor Responses in RAS Mutant Metastatic Colorectal Cancer

Veluchamy, J. P., Spanholtz, J., Tordoir, M., Thijssen, V. L., Heideman, D. A. M., Verheul, H. M. W., de Gruijl, T. D. & van der Vliet, H. J., 17 Jun 2016, In : PLoS ONE. 11, 6

Research output: Contribution to journalArticleAcademicpeer-review

Differential effects of inhibitors of the PI3K/mTOR pathway on the expansion and functionality of regulatory T cells

Huijts, C. M., Santegoets, S. J., del Rey, M. Q., de Haas, R. R., Verheul, H. M., de Gruijl, T. D. & van der Vliet, H. J., Jul 2016, In : Clinical Immunology. 168, p. 47-54

Research output: Contribution to journalArticleAcademicpeer-review

Generation and characterization of CD1d-specific single-domain antibodies with distinct functional features

Lameris, R., de Bruin, R. C. G., Henegouwen, P. M. P. V. B. E., Verheul, H. M., Zweegman, S., de Gruijl, T. D. & van der Vliet, H. J., Sep 2016, In : Immunology. 149, 1, p. 111-121

Research output: Contribution to journalArticleAcademicpeer-review

Highly specific and potently activating V gamma 9V delta 2-T cell specific nanobodies for diagnostic and therapeutic applications

de Bruin, R. C. G., Lougheed, S. M., van der Kruk, L., Stam, A. G., Hooijberg, E., Roovers, R. C., Henegouwen, P. M. P. V. B. E., Verheul, H. M. W., de Gruijl, T. D. & van der Vliet, H. J., Aug 2016, In : Clinical Immunology. 169, p. 128-138

Research output: Contribution to journalArticleAcademicpeer-review

Immune-competent human skin disease models

Bergers, L. I. J. C., Reijnders, C. M. A., van den Broek, L. J., Spiekstra, S. W., de Gruijl, T. D., Weijers, E. M. & Gibbs, S., Sep 2016, In : Drug Discovery Today. 21, 9, p. 1479-1488

Research output: Contribution to journalArticleAcademicpeer-review

Improved efficacy of mitoxantrone in patients with castration-resistant prostate cancer after vaccination with GM-CSF-transduced allogeneic prostate cancer cells

van Dodewaard-de Jong, J. M., Santegoets, S. J. A. M., van de Ven, P. M., Versluis, J., Verheul, H. M. W., de Gruijl, T. D., Gerritsen, W. R. & van den Eertwegh, A. J. M., 2016, In : OncoImmunology. 5, 4

Research output: Contribution to journalArticleAcademicpeer-review

Local delivery of CpG-B and GM-CSF induces concerted activation of effector and regulatory T cells in the human melanoma sentinel lymph node

van den Hout, M. F. C. M., Sluijter, B. J. R., Santegoets, S. J. A. M., van Leeuwen, P. A. M., van den Tol, M. P., van den Eertwegh, A. J. M., Scheper, R. J. & de Gruijl, T. D., Apr 2016, In : Cancer Immunology and Immunotherapy. 65, 4, p. 405-415

Research output: Contribution to journalArticleAcademicpeer-review