Theresia Westers

DR.ING.

20042020

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2020

Computational analysis of flow cytometry data in hematological malignancies: future clinical practice?

Duetz, C., Bachas, C., Westers, T. M. & van de Loosdrecht, A. A., Mar 2020, In : Current Opinion in Oncology. 32, 2, p. 162-169 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2019

TCF4 promotes erythroid development

In 't Hout, F. E. M., van Duren, J., Monteferrario, D., Brinkhuis, E., Mariani, N., Westers, T. M., Chitu, D., Nikoloski, G., van de Loosdrecht, A. A., van der Reijden, B. A., Jansen, J. H. & Huls, G., Jan 2019, In : Experimental Hematology. 69, p. 17-21.e1

Research output: Contribution to journalArticleAcademicpeer-review

2018

A novel cryptic CBFB-MYH11 gene fusion present at birth leading to acute myeloid leukemia and allowing molecular monitoring for minimal residual disease

Poddighe, P. J., Veening, M. A., Mansur, M. B., Loonen, A. H., Westers, T. M., Merle, P. A., Wessels, J. W., de Haas, V., Kors, W. A., Bhola, S. L., Wondergem, M. J., Ford, A. M. & Kaspers, G. J. L., 1 Mar 2018, In : Human Pathology: Case Reports. 11, p. 34-38 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

Genomic array as compared to karyotyping in myelodysplastic syndromes in a prospective clinical trial

Stevens-Kroef, M. J., Olde Weghuis, D., ElIdrissi-Zaynoun, N., van der Reijden, B., Cremers, E. M. P., Alhan, C., Westers, T. M., Visser-Wisselaar, H. A., Chitu, D. A., Cunha, S. M., Vellenga, E., Klein, S. K., Wijermans, P., de Greef, G. E., Schaafsma, M. R., Muus, P., Ossenkoppele, G. J., van de Loosdrecht, A. A. & Jansen, J. H., 1 Jul 2017, In : Genes Chromosomes and Cancer. 56, 7, p. 524-534 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Immunophenotypic analysis of erythroid dysplasia in myelodysplastic syndromes. A report from the IMDSFlow working group

Westers, T. M., Cremers, E. M. P., Oelschlaegel, U., Johansson, U., Bettelheim, P., Matarraz, S., Orfao, A., Moshaver, B., Brodersen, L. E., Loken, M. R., Wells, D. A., Subirá, D., Cullen, M., te Marvelde, J. G., van der Velden, V. H. J., Preijers, F. W. M. B., Chu, S. C., Feuillard, J., Guérin, E., Psarra, K. & 10 others, Porwit, A., Saft, L., Ireland, R., Milne, T., Béné, M. C., Witte, B. I., Della Porta, M. G., Kern, W., van de Loosdrecht, A. A. & IMDSFlow Working Group, 2017, In : Haematologica. 102, 2, p. 308-319 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Implementation of erythroid lineage analysis by flow cytometry in diagnostic models for myelodysplastic syndromes

Cremers, E. M. P., Westers, T. M., Alhan, C., Cali, C., Visser-Wisselaar, H. A., Chitu, D. A., van der Velden, V. H. J., te Marvelde, J. G., Klein, S. K., Muus, P., Vellenga, E., de Greef, G. E., Legdeur, M. C. C. J. C., Wijermans, P. W., Stevens-Kroef, M. J. P. L., da Silva-Coelho, P., Jansen, J. H., Ossenkoppele, G. J., van de Loosdrecht, A. A. & HOVON89 study group, 2017, In : Haematologica. 102, 2, p. 320-326 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Transcriptional profiling reveals functional dichotomy between human slan+ non-classical monocytes and myeloid dendritic cells

van Leeuwen-Kerkhoff, N., Lundberg, K., Westers, T. M., Kordasti, S., Bontkes, H. J., de Gruijl, T. D., Lindstedt, M. & van de Loosdrecht, A. A., 1 Oct 2017, In : Journal of Leukocyte Biology. 102, 4, p. 1055-1068 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Validation of and proposals for refinements of the WHO 2016 classification for myelodysplastic syndromes

van Spronsen, M. F., Westers, T. M., Rozema, H., Ossenkoppele, G. J., Kibbelaar, R. E., Hoogendoorn, M. & van de Loosdrecht, A. A., 1 Nov 2017, In : American Journal of Hematology. 92, 11, p. E631-E634

Research output: Contribution to journalArticleAcademicpeer-review

2016

Massive parallel RNA sequencing of highly purified mesenchymal elements in low-risk MDS reveals tissue-context-dependent activation of inflammatory programs

Chen, S., Zambetti, N. A., Bindels, E. M. J., Kenswill, K., Mylona, A. M., Adisty, N. M., Hoogenboezem, R. M., Sanders, M. A., Cremers, E. M. P., Westers, T. M., Jansen, J. H., van de Loosdrecht, A. A. & Raaijmakers, M. H. G. P., Sep 2016, In : Leukemia. 30, 9, p. 1938-+

Research output: Contribution to journalArticleAcademicpeer-review

Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia

Zambetti, N. A., Ping, Z., Chen, S., Kenswil, K. J. G., Mylona, M. A., Sanders, M. A., Hoogenboezem, R. M., Bindels, E. M. J., Adisty, M. N., Van Strien, P. M. H., van der Leije, C. S., Westers, T. M., Cremers, E. M. P., Milanese, C., Mastroberardino, P. G., van Leeuwen, J. P. T. M., van der Eerden, B. C. J., Touw, I. P., Kuijpers, T. W., Kanaar, R. & 3 others, van de Loosdrecht, A. A., Vogl, T. & Raaijmakers, M. H. G. P., 3 Nov 2016, In : Stem Cell Research. 19, 5, p. 613-627 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

The myelodysplastic syndromes flow cytometric score: a three-parameter prognostic flow cytometric scoring system

Alhan, C., Westers, T. M., Cremers, E. M. P., Cali, C., Witte, B. I., Ossenkoppele, G. J. & van de Loosdrecht, A. A., Mar 2016, In : Leukemia. 30, 3, p. 658-665

Research output: Contribution to journalArticleAcademicpeer-review

2015

A Human Cell Line Model for Interferon-alpha Driven Dendritic Cell Differentiation

Ruben, J. M., Visser, L. L., Heinhuis, K. M., O'Toole, T. G., Bontkes, H. J., Westers, T. M., Ossenkoppele, G. J., de Gruijl, T. D. & van de Loosdrecht, A. A., 2015, In : PLoS ONE. 10, 8, e0135219.

Research output: Contribution to journalArticleAcademicpeer-review

Immunophenotyping for diagnosis and prognosis in MDS: Ready for general application?

Cremers, E. M. P., Westers, T. M., Ossenkoppele, G. J. & van de Loosdrecht, A. A., 2015, In : Best practice & research clinical haematology. 28, 1, p. 14-21

Research output: Contribution to journalArticleAcademicpeer-review

Myelodysplastic syndromes with a deletion 5q display a characteristic immunophenotypic profile suitable for diagnostics and response monitoring

Oelschlaegel, U., Westers, T. M., Mohr, B., Kramer, M., Parmentier, S., Sockel, K., Thiede, C., Bornhauser, M., Ehninger, G., van de Loosdrecht, A. A. & Platzbecker, U., 2015, In : Haematologica. 100, 3, p. E93-E96

Research output: Contribution to journalArticleAcademicpeer-review

Use of Flow Cytometry Immunophenotyping for Diagnosis of Acute Leukemia at Moi Teaching and Referral Hospital, Eldoret, Kenya

Patel, K., Lotodo, T., Njuguna, F., Emonyi, W., Mining, S., Buziba, N. G., Czader, M., Chite, A., Vik, T., Kaspers, G. J. L., Westers, T. M., de Haas, V., Abbink, F. C. H., Skiles, J. & Kigen, N., 2015, In : American Scientific Research Journal for Engineering, Technology, and Sciences. 13, 1, p. 72-80

Research output: Contribution to journalArticleAcademic

Genomic amplification of MYC as double minutes in a patient with APL-like leukemia

Poddighe, P. J., Wessels, H., Merle, P., Westers, T. M., Bhola, S. L., Loonen, A., Zweegman, S., Ossenkoppele, G. J. & Wondergem, M. J., 2014, In : Molecular cytogenetics. 7, 67.

Research output: Contribution to journalArticleAcademicpeer-review

High class II-associated invariant chain peptide expression on residual leukemic cells is associated with increased relapse risk in acute myeloid leukemia

van den Ancker, W., van Luijn, M. M., Chamuleau, M. E. D., Kelder, A., Feller, N., Terwijn, M., Zevenbergen, A., Schuurhuis, G. J., van Ham, S. M., Westers, T. M., Ossenkoppele, G. J. & van de Loosdrecht, A. A., 2014, In : Leukemia Research. 38, 6, p. 691-693

Research output: Contribution to journalArticleAcademicpeer-review

Revisiting guidelines for integration of flow cytometry results in the WHO classification of myelodysplastic syndromes-proposal from the International/European LeukemiaNet Working Group for Flow Cytometry in MDS

Porwit, A., van de Loosdrecht, A. A., Bettelheim, P., Brodersen, L. E., Burbury, K., Cremers, E., la Porta, M. G., Ireland, R., Johansson, U., Matarraz, S., Ogata, K., Orfao, A., Preijers, F., Psarra, K., Subiraa, D., Valent, P., van der Velden, V. H. J., Wells, D., Westers, T. M., Kern, W. & 1 others, Bene, M. C., 2014, In : Leukemia. 28, 9, p. 1793-1798

Research output: Contribution to journalArticleAcademicpeer-review

ZAP70 in B-CLL Cells Related to the Expression in NK Cells is a Surrogate Marker for Mutational Status

Wiggers, T. G. H., Westra, G., Westers, T. M., Abbes, A. P., Strunk, A., Kuiper-Kramer, E., Poddighe, P. J., van de Loosdrecht, A. A. & Chamuleau, M. E. D., 2014, In : Cytometry Part B. Clinical Cytometry. 86, 4, p. 280-287

Research output: Contribution to journalArticleAcademicpeer-review

2013

Dendritic cells in myelodysplastic syndromes: from pathogenesis to immunotherapy

Kerkhoff, N., Bontkes, H. J., Westers, T. M., de Gruijl, T. D., Kordasti, S. & van de Loosdrecht, A. A., 2013, In : Immunotherapy. 5, 6, p. 621-637

Research output: Contribution to journalArticleAcademicpeer-review

Procedures for the expansion of CD14(+) precursors from acute myeloid leukemic cells to facilitate dendritic cell-based immunotherapy

van den Ancker, W., Wijnands, P. G. J. B., Ruben, J. M., Westers, T. M., Punt, B., Bachas, C., Ravenshorst, N., van Wetering, S., Kruisbeek, A. M., Bontkes, H. J., Ossenkoppele, G. J., van de Loosdrecht, A. A. & de Gruijl, T. D., 2013, In : Immunotherapy. 5, 11, p. 1183-1190

Research output: Contribution to journalArticleAcademicpeer-review

Implementation of flow cytometry in the diagnostic work-up of myelodysplastic syndromes in a multicenter approach: Report from the Dutch Working Party on Flow Cytometry in MDS

Westers, T. M., van der Velden, V. H. J., Alhan, C., Bekkema, R., Bijkerk, A., Brooimans, R. A., Cali, C., Dräger, A. M., de Haas, V., Homburg, C., de Jong, A., Kuiper-Kramer, P. A., Leenders, M., Lommerse, I., Marvelde, J. G. T., van der Molen-Sinke, J., Moshaver, B., Mulder, A. B., Preijers, F. W. M. B., Schindhelm, R. K. & 4 others, Sluijs, A., van Wering, E. R., Westra, A. H. & van de Loosdrecht, A. A., 2012, In : Leukemia Research. 36, 4, p. 422-430

Research output: Contribution to journalArticleAcademicpeer-review

Multicenter validation of a reproducible flow cytometric score for the diagnosis of low-grade myelodysplastic syndromes: results of a European LeukemiaNET study

la Porta, M. G., Picone, C., Pascutto, C., Malcovati, L., Tamura, H., Handa, H., Czader, M., Freeman, S., Vyas, P., Porwit, A., Saft, L., Westers, T. M., Alhan, C., Cali, C., van de Loosdrecht, A. A. & Ogata, K., 2012, In : Haematologica. 97, 8, p. 1209-1217

Research output: Contribution to journalArticleAcademicpeer-review

Standardization of flow cytometry in myelodysplastic syndromes: a report from an international consortium and the European LeukemiaNet Working Group

Westers, T. M., Ireland, R., Kern, W., Alhan, C., Balleisen, J. S., Bettelheim, P., Burbury, K., Cullen, M., Cutler, J. A., la Porta, M. G., Dräger, A. M., Feuillard, J., Font, P., Germing, U., Haase, D., Johansson, U., Kordasti, S., Loken, M. R., Malcovati, L., te Marvelde, J. G. & 19 others, Matarraz, S., Milne, T., Moshaver, B., Mufti, G. J., Ogata, K., Orfao, A., Porwit, A., Psarra, K., Richards, S. J., Subira, D., Tindell, V., Vallespi, T., Valent, P., van der Velden, V. H. J., de Witte, T. M., Wells, D. A., Zettl, F., Bene, M. C. & van de Loosdrecht, A. A., 2012, In : Leukemia. 26, 7, p. 1730-1741

Research output: Contribution to journalArticleAcademicpeer-review

2011

Flow cytometry in myelodysplastic syndromes: Ready for translation into clinical practice

van de Loosdrecht, A. A. & Westers, T. M., 2011, In : Leukemia Research. 35, 7, p. 850-852

Research output: Contribution to journalArticleAcademicpeer-review

Acute leukemias of ambiguous lineage: diagnostic consequences of the WHO2008 classification

van den Ancker, W., Terwijn, M., Westers, T. M., Merle, PA., van Beckhoven, E., Dräger, A. M., Ossenkoppele, G. J. & van de Loosdrecht, A. A., 2010, In : Leukemia. 24, 7, p. 1392-1396

Research output: Contribution to journalArticleAcademicpeer-review

Class II-associated invariant chain peptide down-modulation enhances the immunogenicity of myeloid leukemic blasts resulting in increased CD4(+) T-cell responses

van Luijn, M. M., Chamuleau, M. E. D., Thompson, J. A., Ostrand-Rosenberg, S., Westers, T. M., Souwer, Y., Ossenkoppele, G. J., van Ham, S. M. & van de Loosdrecht, A. A., 2010, In : Haematologica. 95, 3, p. 485-493

Research output: Contribution to journalArticleAcademicpeer-review

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