Vanessa Donega

Dr.,

20132022

Research activity per year

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Personal profile

Research interests

I am an Assistant Prof, currently establishing my own research line at the Amsterdam UMC.

I became fascinated in neuroregeneration during my PhD in the lab of Prof. Cobi Heijnen (UMC Utrecht) where I investigated the potential of intranasal administration of mesenchymal stem cells as a novel therapeutic strategy for neonatal brain injury. This work formed the pre-clinical phase of a clinical trial that is currently being run at the UMC Utrecht to assess the potential of intranasal MSC treatment in babies with neonatal encephalopathies. I then joined the INSERM Institute in Lyon, France, as a postdoctoral researcher where I continued working on neonatal brain injury and characterized the neurogenic potential of a population of postnatal glutamatergic progenitors and later in 2018 I worked in the lab of Prof Elly Hol (UMC Utrecht) as a postdoctoral researcher where I started to work on identifying novel therapeutic targets for Parkinson's disease. 

Research in my team focusses on understanding the mechanisms that promote or impair regeneration of the mammalian brain and assessing the capacity of neural stem cells to produce functional neurons to restore brain function. This knowledge will help in the development of tailor-made therapeutic strategies for brain regeneration. To this end we focus on Parkinson’s disease and use both post-mortem human brain tissue and PD mouse model. We combine state-of-the-art methods, including (single-cell) omics and high-end microscopy.

Specialisation

Stem Cell Biology | Neuroregeneration | Translational research |

(single-cell) transcriptomics 

Education/Academic qualification

PhD, University Medical Centre Utrecht, Utrecht, Netherlands

Award Date: 2 Sep 2014

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