Research output per year
Research output per year
DR.IR., (Principal Investigator)
Research activity per year
My group is interested in deciphering the molecular response mechanisms to clinical schedules of fractionated radiotherapy. The overarching goal is to understand how tumor cells and the tumor micro-environment respond during longer periods of fractionated radiotherapy in order to optimize dose-scheduling of combination therapies.
Over the last decade, we have used different approaches to determine the role of the tumor microenvironment in the response to radiotherapy and to monitor the cellular response(s) of the tumor microenvironment to radiotherapy. This includes studies in cultured cell in vitro, in tumor models in vivo as well as in tumor tissues derived from cancer patients.
Regarding the modulation of the tumor micro-environment, we are particularly interested in the role of galectins, a family of carbohydrate (sugar) binding proteins that are linked to blood vessel growth as well as to regulation of the immune response. We study how galectins contribute to tumor progression and how targeting galectins can be exploited for cancer therapy.
Angiogenesis
Radiobiology
Molecular Cell Biology
Glycobiology
Postdoc, Maastricht UMC
2002 → 2009
PhD student, Maastricht UMC
1997 → 2002
Research output: Contribution to journal › Article › Academic › peer-review
Research output: Contribution to journal › Article › Academic › peer-review
Research output: Contribution to journal › Comment/Letter to the editor › Academic
Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review
Research output: Contribution to journal › Review article › Academic › peer-review
Victor Thijssen (Examiner)
Activity: Examination
Victor Thijssen (Member of editorial board)
Activity: Publication peer-review and editorial work › Editorial work
Victor Thijssen (Examiner)
Activity: Examination
Victor Thijssen (Chair)
Activity: Membership › Membership of board
Victor Thijssen (Examiner)
Activity: Examination