If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

Brain white matter integrity is crucial for motor coordination and cognitive functioning, and its disruption is strongly implicated in neurodevelopmental and neuropsychiatric disorders, including autism spectrum disorders. We need better understanding of how cellular interactions in white matter regions contribute to brain network dysfunctions. My lab advanced induced pluripotent stem cell (iPSC) tools to develop human iPSC-based model system for several neurological disorders to address basic and translational research questions in collaboration with on- and off-site partners. Our goal is to identify and describe glial defects in neurodevelopmental disorders, and to perform proof-of-concept studies for glial-targeted therapy strategies using advanced stem cell technologies.

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output

Astrocyte Subtype Vulnerability in Stem Cell Models of Vanishing White Matter

Leferink, P. S., Dooves, S., Hillen, A. E. J., Watanabe, K., Jacobs, G., Gasparotto, L., Cornelissen-Steijger, P., van der Knaap, M. S. & Heine, V. M., 1 Nov 2019, In : Annals of Neurology. 86, 5, p. 780-792 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cell Replacement Therapy Improves Pathological Hallmarks in a Mouse Model of Leukodystrophy Vanishing White Matter

Dooves, S., Leferink, P. S., Krabbenborg, S., Breeuwsma, N., Bots, S., Hillen, A. E. J., Jacobs, G., van der Knaap, M. S. & Heine, V. M., 5 Mar 2019, In : Stem Cell Reports. 12, 3, p. 441-450

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Neuron-Glia Interactions Increase Neuronal Phenotypes in Tuberous Sclerosis Complex Patient iPSC-Derived Models

G. Nadadhur, A., Alsaqati, M., Gasparotto, L., Cornelissen-Steijger, P., van Hugte, E., Dooves, S., Harwood, A. J. & Heine, V. M., 8 Jan 2019, In : Stem Cell Reports. 12, 1, p. 42-56

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The Healthy and Diseased Microenvironments Regulate Oligodendrocyte Properties: Implications for Regenerative Medicine

Leferink, P. S. & Heine, V. M., 1 Jan 2018, In : American Journal of Pathology. 188, 1, p. 39-52 14 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Quantitative proteomic analysis of Rett iPSC-derived neuronal progenitors

Varderidou-Minasian, S., Hinz, L., Hagemans, D., Posthuma, D., Altelaar, M. & Heine, V. M., 27 May 2020, In : Molecular Autism. 11, 1, p. 38 38.

Research output: Contribution to journalArticleAcademicpeer-review