Wiesje van der Flier

PROF.DR., (Principal Investigator)

20002020

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2020

A clinical-radiological framework of the right temporal variant of frontotemporal dementia

Ulugut Erkoyun, H., Groot, C., Heilbron, R., Nelissen, A., van Rossum, J., Jutten, R., Koene, T., van der Flier, W. M., Wattjes, M. P., Scheltens, P., Ossenkoppele, R., Barkhof, F. & Pijnenburg, Y., 1 Sep 2020, In : Brain. 143, 9, p. 2831-2843

Research output: Contribution to journalArticleAcademicpeer-review

Arylesterase activity of paraoxonase-1 in serum and cerebrospinal fluid of patients with alzheimer’s disease and vascular dementia

Romani, A., Trentini, A., Flier, W. M. V. D., Bellini, T., Zuliani, G., Cervellati, C. & Teunissen, C. E., May 2020, In : Antioxidants. 9, 5, 456.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A Suboptimal Diet is Associated with Poorer Cognition: The NUDAD Project

Fieldhouse, J. L. P., Doorduijn, A. S., de Leeuw, F. A., Verhaar, B. J. H., Koene, T., Wesselman, L. M. P., Schueren, M. D. V. D., Visser, M., Rest, O. V. D., Scheltens, P., Kester, M. I. & Flier, W. M. V. D., 6 Mar 2020, In : Nutrients. 12, 3, 703.

Research output: Contribution to journalArticleAcademicpeer-review

Author response: Clinical relevance of acute cerebral microinfarcts in vascular cognitive impairment

Ferro, D. A., van den Brink, H., Exalto, L. G., Boomsma, J. M. F., Barkhof, F., Prins, N. D., van der Flier, W. M. & Biessels, G. J., 18 Feb 2020, In : Neurology. 94, 7, p. 330 1 p.

Research output: Contribution to journalArticleAcademicpeer-review

CCL23: A Chemokine Associated with Progression from Mild Cognitive Impairment to Alzheimer's Disease

Faura, J., Bustamante, A., Penalba, A., Giralt, D., Simats, A., Martínez-Sáez, E., Alcolea, D., Fortea, J., Lleó, A., Teunissen, C. E., Van Der Flier, W. M., Ibañez, L., Harari, O., Cruchaga, C., Hernández-Guillamón, M., Delgado, P. & Montaner, J., 1 Jan 2020, In : Journal of Alzheimer's Disease. 73, 4, p. 1585-1595 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

CDH6 and HAGH protein levels in plasma associate with Alzheimer’s disease in APOE ε4 carriers

Ahmad, S., Milan, M. D. C., Hansson, O., Demirkan, A., Agustin, R., Sáez, M. E., Giagtzoglou, N., Cabrera-Socorro, A., Bakker, M. H. M., Ramirez, A., Hankemeier, T., Stomrud, E., Mattsson-Carlgren, N., Scheltens, P., van der Flier, W. M., Ikram, M. A., Malarstig, A., Teunissen, C. E., Amin, N. & van Duijn, C. M., 1 Dec 2020, In : Scientific Reports. 10, 1, 8233.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cerebral blood flow and cognitive functioning in patients with disorders along the heart–brain axis: Cerebral blood flow and the heart–brain axis

Leeuwis, A. E., Hooghiemstra, A. M., Bron, E. E., Kuipers, S., Oudeman, E. A., Kalay, T., Brunner-La Rocca, H. P., Kappelle, L. J., van Oostenbrugge, R. J., Greving, J. P., Niessen, W. J., van Buchem, M. A., van Osch, M. J. P., van Rossum, A. C., Prins, N. D., Biessels, G. J., Barkhof, F., van der Flier, W. M. & Heart–Brain Connection consortium, 1 Jan 2020, (Accepted/In press) In : Alzheimer's and Dementia: Translational Research and Clinical Interventions.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Circulating metabolites are associated with brain atrophy and white matter hyperintensities

de Leeuw, F. A., Karamujić-Čomić, H., Tijms, B. M., Peeters, C. F. W., Kester, M. I., Scheltens, P., Ahmad, S., Vojinovic, D., Adams, H. H. H., Hankemeier, T., Bos, D., van der Lugt, A., Vernooij, M. W., Ikram, M. A., Amin, N., Barkhof, F., Teunissen, C. E., van Duijn, C. M. & van der Flier, W. M., 2020, In : Alzheimer's and Dementia.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Clinicians’ communication with patients receiving a MCI diagnosis: The ABIDE project

Visser, L. N. C., van Maurik, I. S., Bouwman, F. H., Staekenborg, S., Vreeswijk, R., Hempenius, L., de Beer, M. H., Roks, G., Boelaarts, L., Kleijer, M., van der Flier, W. M. & Smets, E. M. A., 2020, In : PLoS ONE. 15, 1, e0227282.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Comorbid amyloid-β pathology affects clinical and imaging features in VCD

Leijenaar, J. F., Groot, C., Sudre, C. H., Bergeron, D., Leeuwis, A. E., Cardoso, M. J., Carrasco, F. P., Laforce, R., Barkhof, F., van der Flier, W. M., Scheltens, P., Prins, N. D. & Ossenkoppele, R., 1 Feb 2020, In : Alzheimers & Dementia. 16, 2, p. 354-364 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Dietary patterns are related to cognitive functioning in elderly enriched with individuals at increased risk for Alzheimer’s disease

Wesselman, L. M. P., van Lent, D. M., Schröder, A., van de Rest, O., Peters, O., Menne, F., Fuentes, M., Priller, J., Spruth, E. J., Altenstein, S., Schneider, A., Fließbach, K., Roeske, S., Wolfsgruber, S., Kleineidam, L., Spottke, A., Pross, V., Wiltfang, J., Vukovich, R., Schild, A. K. & 16 others, Düzel, E., Metzger, C. D., Glanz, W., Buerger, K., Janowitz, D., Perneczky, R., Tatò, M., Teipel, S., Kilimann, I., Laske, C., Buchmann, M., Ramirez, A., Sikkes, S. A. M., Jessen, F., van der Flier, W. M. & Wagner, M., 1 Jan 2020, (Accepted/In press) In : European Journal of Nutrition.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

BBMRI Metabolomics Consortium, 2020, In : Nature Communications. 11, 1, 39.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Identification of novel cerebrospinal fluid biomarker candidates for dementia with Lewy bodies: a proteomic approach

Van Steenoven, I., Koel-Simmelink, M. J. A., Vergouw, L. J. M., Tijms, B. M., Piersma, S. R., Pham, T. V., Bridel, C., Ferri, G. L., Cocco, C., Noli, B., Worley, P. F., Worley, P. F., Xiao, M. F., Xu, D., Oeckl, P., Otto, M., Van Der Flier, W. M., De Jong, F. J., Jimenez, C. R., Lemstra, A. W. & 1 others, Teunissen, C. E., 18 Jun 2020, In : MOLECULAR NEURODEGENERATION. 15, 1, 36.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Identifying a task-invariant cognitive reserve network using task potency

van Loenhoud, A. C., Habeck, C., van der Flier, W. M., Ossenkoppele, R. & Stern, Y., 15 Apr 2020, In : NeuroImage. 210, 116593.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Latent atrophy factors related to phenotypical variants of posterior cortical atrophy

Groot, C., Yeo, B. T. T., Vogel, J. W., Zhang, X., Sun, N., Mormino, E. C., Pijnenburg, Y. A. L., Miller, B. L., Rosen, H. J., Joie, R. L., Barkhof, F., Scheltens, P., van der Flier, W. M., Rabinovici, G. D. & Ossenkoppele, R., 16 Jul 2020, In : Neurology.

Research output: Contribution to journalArticleAcademicpeer-review

Methylphenidate and galantamine in patients with vascular cognitive impairment-the proof-of-principle study STREAM-VCI

Leijenaar, J. F., Groeneveld, G. J., Klaassen, E. S., Leeuwis, A. E., Scheltens, P., Weinstein, H. C., van Gerven, J. M. A., Barkhof, F., van der Flier, W. M. & Prins, N. D., 2020, In : Alzheimer's Research & Therapy. 12, 1, p. 10 10.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Multi-tracer model for staging cortical amyloid deposition using PET imaging

Collij, L. E., Heeman, F., Salvadó, G., Ingala, S., Altomare, D., Wilde, A., Konijnenberg, E., van Buchem, M., Yaqub, M., Markiewicz, P., Golla, S. S. V., Wottschel, V., Wink, A. M., Visser, P. J., Teunissen, C. E., Lammertsma, A. A., Scheltens, P., van der Flier, W. M., Boellaard, R., van Berckel, B. N. M. & 6 others, Molinuevo, J. L., Gispert, J. D., Schmidt, M. E., Bsarkhof, F., Alves, I. L. & ALFA Study; for the Alzheimer’s Disease Neuroimaging Initiative;on behalf of the AMYPAD Consortium, 16 Jul 2020, In : Neurology. 95, 11

Research output: Contribution to journalArticleAcademicpeer-review

Non-memory cognitive symptom development in Alzheimer's disease

Blenkinsop, A., van der Flier, W. M., Wolk, D., Lehmann, M., Howard, R., Frost, C. & Barnes, J., 1 Jan 2020, (Accepted/In press) In : European Journal of Neurology.

Research output: Contribution to journalArticleAcademicpeer-review

PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment

Alzheimer’s Disease Neuroimaging Initiative (ADNI), 12 Mar 2020, In : Acta Neuropathologica. 139, 6, 20 p.

Research output: Contribution to journalArticleAcademicpeer-review

Precision prevention of Alzheimer's and other dementias: Anticipating future needs in the control of risk factors and implementation of disease-modifying therapies

Frisoni, G. B., Molinuevo, J. L., Altomare, D., Carrera, E., Barkhof, F., Berkhof, J., Delrieu, J., Dubois, B., Kivipelto, M., Nordberg, A., Schott, J. M., van der Flier, W. M., Vellas, B., Jessen, F., Scheltens, P. & Ritchie, C., 2020, In : Alzheimer's and Dementia.

Research output: Contribution to journalArticleAcademicpeer-review

Prodromal Dementia with Lewy Bodies: Clinical Characterization and Predictors of Progression

van de Beek, M., van Steenoven, I., van der Zande, J. J., Barkhof, F., Teunissen, C. E., van der Flier, W. M. & Lemstra, A. W., 1 Jan 2020, In : Movement Disorders. 35, 5, 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Selection of memory clinic patients for CSF biomarker assessment can be restricted to a quarter of cases by using computerized decision support, without compromising diagnostic accuracy

Rhodius-Meester, H. F. M., van Maurik, I. S., Koikkalainen, J., Tolonen, A., Frederiksen, K. S., Hasselbalch, S. G., Soininen, H., Herukka, S-K., Remes, A. M., Teunissen, C. E., Barkhof, F., Pijnenburg, Y. A. L., Scheltens, P., Lötjönen, J. & van der Flier, W. M., 2020, In : PLoS ONE. 15, 1, p. e0226784 e0226784.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Single-subject gray matter networks predict future cortical atrophy in preclinical Alzheimer's disease

Dicks, E., van der Flier, W. M., Scheltens, P., Barkhof, F., Tijms, B. M. & Alzheimer's Disease Neuroimaging Initiative, 21 May 2020, In : Neurobiology of Aging. 94, p. 71-80 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Specific Nutritional Biomarker Profiles in Mild Cognitive Impairment and Subjective Cognitive Decline Are Associated With Clinical Progression: The NUDAD Project

de Leeuw, F. A., van der Flier, W. M., Tijms, B. M., Scheltens, P., Mendes, V. M., Manadas, B., Bierau, J. R., van Wijk, N., van den Heuvel, E. G. H. M., Mohajeri, M. H., Teunissen, C. E. & Kester, M. I., 27 Jan 2020, In : Journal of the American Medical Directors Association.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Targeting Lifestyle Behavior to Improve Brain Health: User-Experiences of an Online Program for Individuals with Subjective Cognitive Decline

Wesselman, L. M. P., Schild, A. K., Hooghiemstra, A. M., Meiberth, D., Drijver, A. J., Leeuwenstijn-Koopman, M. V., Prins, N. D., Brennan, S., Scheltens, P., Jessen, F., van der Flier, W. M. & Sikkes, S. A. M., 1 Mar 2020, In : Journal of Prevention of Alzheimer's Disease. 7, 3, p. 184-194 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

The Association Between Biomarkers and Neuropsychiatric Symptoms Across the Alzheimer's Disease Spectrum

Banning, L. C. P., Ramakers, I. H. G. B., Köhler, S., Bron, E. E., Verhey, F. R. J., de Deyn, P. P., Claassen, J. A. H. R., Koek, H. L., Middelkoop, H. A. M., van der Flier, W. M., van der Lugt, A., Aalten, P., The Alzheimer's Disease Neuroimaging Initiative & Parelsnoer Institute Neurodegenerative Diseases study group, 1 Jan 2020, In : American Journal of Geriatric Psychiatry. 28, 7, 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

ABIDE Delphi study: Topics to discuss in diagnostic consultations in memory clinics

Fruijtier, A. D., Visser, L. N. C., van Maurik, I. S., Zwan, M. D., Bouwman, F. H., van der Flier, W. M. & Smets, E. M. A., 31 Aug 2019, In : Alzheimer's Research and Therapy. 11, 1, 77.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

ADDED DIAGNOSTIC VALUE OF 18F-FLUTEMETAMOL PET SCANNING IN YOUNG PATIENTS WITH DEMENTIA

Handels, R., Zwan, M. D., Pelkmans, W., Bouwman, F. H., Biessels, G. J., Roks, G., Schoonenboom, N. S. M., Verwey, N. A., Van Berckel, B. N. M., van der Flier, W. M., Verhey, F. R. J. & Scheltens, P., Jul 2019, In : Alzheimers & Dementia. 15, 7, p. P740

Research output: Contribution to journalArticleAcademicpeer-review

A meta-analysis of genome-wide association studies identifies multiple longevity genes

Deelen, J., Evans, D. S., Arking, D. E., Tesi, N., Nygaard, M., Liu, X., Wojczynski, M. K., Biggs, M. L., van der Spek, A., Atzmon, G., Ware, E. B., Sarnowski, C., Smith, A. V., Seppälä, I., Cordell, H. J., Dose, J., Amin, N., Arnold, A. M., Ayers, K. L., Barzilai, N. & 64 others, Becker, E. J., Beekman, M., Blanché, H., Christensen, K., Christiansen, L., Collerton, J. C., Cubaynes, S., Cummings, S. R., Davies, K., Debrabant, B., Deleuze, J. F., Duncan, R., Faul, J. D., Franceschi, C., Galan, P., Gudnason, V., Harris, T. B., Huisman, M., Hurme, M. A., Jagger, C., Jansen, I., Jylhä, M., Kähönen, M., Karasik, D., Kardia, S. L. R., Kingston, A., Kirkwood, T. B. L., Launer, L. J., Lehtimäki, T., Lieb, W., Lyytikäinen, L. P., Martin-Ruiz, C., Min, J., Nebel, A., Newman, A. B., Nie, C., Nohr, E. A., Orwoll, E. S., Perls, T. T., Province, M. A., Psaty, B. M., Raitakari, O. T., Reinders, M. J. T., Robine, J. M., Rotter, J. I., Sebastiani, P., Smith, J., Sørensen, T. I. A., Taylor, K. D., Uitterlinden, A. G., van der Flier, W., van der Lee, S. J., van Duijn, C. M., van Heemst, D., Vaupel, J. W., Weir, D., Ye, K., Zeng, Y., Zheng, W., Holstege, H., Kiel, D. P., Lunetta, K. L., Slagboom, P. E. & Murabito, J. M., 1 Dec 2019, In : Nature Communications. 10, 1, 3669.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

van der Lee, S. J., Conway, O. J., Jansen, I., Carrasquillo, M. M., Kleineidam, L., van den Akker, E., Hernández, I., van Eijk, K. R., Stringa, N., Chen, J. A., Zettergren, A., Andlauer, T. F. M., Diez-Fairen, M., Simon-Sanchez, J., Lleó, A., Zetterberg, H., Nygaard, M., Blauwendraat, C., Savage, J. E., Mengel-From, J. & 37 others, Moreno-Grau, S., Wagner, M., Fortea, J., Keogh, M. J., Blennow, K., Skoog, I., Friese, M. A., Pletnikova, O., Zulaica, M., Lage, C., de Rojas, I., Riedel-Heller, S., Illán-Gala, I., Wei, W., Jeune, B., Hulsman, M., Beker, N., Tesi, N., Collij, L. E., van Berckel, B. N. M., Reinders, M. J. T., van Schoor, N. M., Lemstra, A. W., Pijnenburg, Y. A. L., Scheltens, P., Huisman, M. A., Heutink, P., Posthuma, D., van der Flier, W. M., Holstege, H., DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank), EADB (Alzheimer Disease European DNA biobank), IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia), Netherlands Brain Bank (NBB) & The GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group, 1 Aug 2019, In : Acta Neuropathologica. 138, 2, p. 237-250

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Applying the ATN scheme in a memory clinic population: The ABIDE project

Altomare, D., de Wilde, A., Ossenkoppele, R., Pelkmans, W., Bouwman, F., Groot, C., van Maurik, I., Zwan, M., Yaqub, M., Barkhof, F., van Berckel, B. N., Teunissen, C. E., Frisoni, G. B., Scheltens, P. & van der Flier, W. M., 22 Oct 2019, In : Neurology. 93, 17, p. e1635-e1646

Research output: Contribution to journalArticleAcademicpeer-review

Open Access