Willem de Haan

DR., PhD

20082018
If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

The aim of my research is to better understand the relation between brain network activity and dementia. It is my strong conviction that this topic deserves a much more prominent place in dementia research. Having been among the first to describe specific patterns of brain network damage in dementia, during the past five years I have developed a computational network model of AD. This approach helps to understand both the cause and course of the disease, and a recent insight is that it can also guide treatment selection by solving how to modulate abnormal brain activity in order to optimize network function. I published a proof-of-concept study and perspective article about this approach in 2017.  Currently, I am testing a method to detect abnormal hippocampal activity in MCI patients for early identification of individuals who can benefit from activity-based treatment. My ideal future occupation would be an academic position focusing on neurophysiology and Alzheimer, integrating computational brain network analysis and cognitive neurology.

Research Output 2008 2018

Graph theoretical analysis of magnetoencephalographic functional connectivity in Alzheimers disease

Stam, C. J., de Haan, W., Daffertshofer, A., Jones, B. F., Manshanden, I., Walsum, A. M., Montez, T., Verbunt, J. P. A., de Munck, J. C., van Dijk, B. W., Berendse, H. W. & Scheltens, P., 2009, In : Brain. 132, p. 213-224

Research output: Contribution to journalArticleAcademicpeer-review

Functional network disruption in the degenerative dementias

Pievani, M., de Haan, W., Wu, T., Seeley, W. W. & Frisoni, G. B., 2011, In : Lancet Neurology. 10, 9, p. 829-843

Research output: Contribution to journalArticleAcademicpeer-review

In a network state of mind

de Haan, W., 2012

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

File

Hersenweb; wat moderne netwerktheorie ons leert over de werking van de hersenen

Stam, K., Douw, L. & de Haan, W., 2010, Amsterdam: Uitgeverij Bert Bakker. 288 p.

Research output: Book/ReportBookAcademicpeer-review