Wilma van de Berg

, PhD, (Principal Investigator)

20002019
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Research Output 2000 2019

2019

7T MRI allows detection of disturbed cortical lamination of the medial temporal lobe in patients with Alzheimer's disease

Kenkhuis, B., Jonkman, L. E., Bulk, M., Buijs, M., Boon, B. D. C., Bouwman, F. H., Geurts, J. J. G., van de Berg, W. D. J. & van der Weerd, L., 1 Jan 2019, In : NeuroImage: Clinical. 21, 1 p., 101665.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Axonal degeneration as substrate of fractional anisotropy abnormalities in multiple sclerosis cortex

Preziosa, P., Kiljan, S., Steenwijk, M. D., Meani, A., van de Berg, W. D. J., Schenk, G. J., Rocca, M. A., Filippi, M., Geurts, J. J. G. & Jonkman, L. E., 1 Jul 2019, In : Brain. 142, 7, p. 1921-1937

Research output: Contribution to journalArticleAcademicpeer-review

Axonal degeneration as substrate of fractional anisotropy abnormalities in Multiple sclerosis cortex

Preziosa, P., Kiljan, S., Steenwijk, M. D., Meani, A., Van de Berg, W. D., Schenk, G., Rocca, M. A., Filippi, M., Geurts, J. & Jonkman, L. E., Jul 2019, In : European Journal of Neurology. 26, p. 107-107

Research output: Contribution to journalMeeting AbstractAcademic

Characterization of Brain Lysosomal Activities in GBA-Related and Sporadic Parkinson’s Disease and Dementia with Lewy Bodies

Moors, T. E., Paciotti, S., Ingrassia, A., Quadri, M., Breedveld, G., Tasegian, A., Chiasserini, D., Eusebi, P., Duran-Pacheco, G., Kremer, T., Calabresi, P., Bonifati, V., Parnetti, L., Beccari, T. & van de Berg, W. D. J., 1 Feb 2019, In : Molecular Neurobiology. 56, 2, p. 1344-1355 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

CSF alpha-synuclein does not discriminate dementia with Lewy bodies from Alzheimer's disease (vol 22, pg 87, 2010)

van Steenoven, I., Majbour, N. K., Vaikath, N. N., Berendse, H. W., van der Flier, W. M., van de Berg, W. D. J., Teunissen, C. E., Lemstra, A. W. & El-Agnaf, O. M. A., Jan 2019, In : Movement Disorders. 34, 1, p. 159-159

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Dementia with Lewy Bodies: A Clinicopathologic Series of False-positive Cases

Vergouw, L. J. M., Marler, L. P., Van De Berg, W. D. J., Rozemuller, A. J. M., De Jong, F. J. & Netherlands Brain Bank, 24 Apr 2019, In : Alzheimer Disease and Associated Disorders.

Research output: Contribution to journalArticleAcademicpeer-review

Demyelination, Inflammation and Axonal Loss Explain Different Patterns of Fractional Anisotropy Abnormalities in MS Cortical Normal Appearing Gray Matter and Lesions

Preziosa, P., Kiljan, S., Steenwijk, M. D., Meani, A., van de Berg, W., Schenk, G., Rocca, M., Filippi, M., Geurts, J. J. G. & Jonkman, L., 9 Apr 2019, In : Neurology. 92, 15

Research output: Contribution to journalMeeting AbstractAcademic

Demyelination, Inflammation and Axonal Loss Explain Different Patterns of Fractional Anisotropy Abnormalities in MS Cortical Normal Appearing Gray Matter and Lesions (P5.2-024)

Preziosa, P., Kiljan, S., Steenwijk, M. D., Meani, A., van de Berg, W., Schenk, G., Rocca, M., Filippi, M., Geurts, J. J. G. & Jonkman, L., 2019, In : Neurology. 92, 15 Supplement, p. P5.2-024

Research output: Contribution to journalArticleAcademic

Open Access

Differential insular cortex subregional vulnerability to α-synuclein pathology in Parkinson's disease and dementia with Lewy bodies

Fathy, Y. Y., Jonker, A. J., Oudejans, E., de Jong, F. J. J., van Dam, A. M. W., Rozemuller, A. J. M. & van de Berg, W. D. J., 1 Apr 2019, In : Neuropathology and Applied Neurobiology. 45, 3, p. 262-277 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Exploring the potential role of the protein, Alpha-Synuclein, as diagnostic target for Parkinson's disease

Majbour, N. K., 2019, 168 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

Open Access

Imaging of post-mortem human brain tissue using electron and X-ray microscopy

Lewis, A. J., Genoud, C., Pont, M. L., van de Berg, W. D. J., Frank, S., Stahlberg, H., Shahmoradian, S. H. & Al-Amoudi, A., 1 Oct 2019, In : Current Opinion in Structural Biology. 58, p. 138-148 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes

Shahmoradian, S. H., Lewis, A. J., Genoud, C., Hench, J. R., Moors, T. E., Navarro, P. P., Castaño-Díez, D., Schweighauser, G., Graff-Meyer, A., Goldie, K. N., Sütterlin, R., Huisman, E., Ingrassia, A., Gier, Y. D., Rozemuller, A. J. M., Wang, J., Paepe, A. D., Erny, J., Staempfli, A., Hoernschemeyer, J. & 13 othersGroßerüschkamp, F., Niedieker, D., el-Mashtoly, S. F., Quadri, M., van IJcken, W. F. J., Bonifati, V., Gerwert, K., Bohrmann, B., Frank, S., Britschgi, M., Stahlberg, H., van de Berg, W. D. J. & Lauer, M. E., 2019, In : Nature Neuroscience. 22, 7, p. 1099-1109

Research output: Contribution to journalArticleAcademicpeer-review

Local GM Demyelination and Remote Microstructural Damage in Connected WM Tracts both Contribute to Cortical Neurodegeneration in MS

Preziosa, P., Kiljan, S., Jonkman, L., van de Berg, W., Schenk, G., Rocca, M., Filippi, M., Geurts, J. J. G. & Steenwijk, M. D., 9 Apr 2019, In : Neurology. 92, 15

Research output: Contribution to journalMeeting AbstractAcademic

Neuropathological and genetic characteristics of a post-mortem series of cases with dementia with Lewy bodies clinically suspected of Creutzfeldt-Jakob's disease

Geut, H., Vergouw, L. J. M., Galis, Y., Ingrassia, A., de Jong, F. J., Quadri, M., Bonifati, V., Lemstra, A. W., Rozemuller, A. J. M. & van de Berg, W. D. J., 1 Jun 2019, In : Parkinsonism and Related Disorders. 63, p. 162-168 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Path mediation analysis reveals GBA impacts Lewy body disease status by increasing α-synuclein levels

Gündner, A. L., Duran-Pacheco, G., Zimmermann, S., Ruf, I., Moors, T., Baumann, K., Jagasia, R., van de Berg, W. D. J. & Kremer, T., 1 Jan 2019, In : Neurobiology of Disease. 121, p. 205-213 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Post-Mortem MRI and Histopathology in Neurologic Disease: A Translational Approach

Jonkman, L. E., Kenkhuis, B., Geurts, J. J. G. & van de Berg, W. D. J., 2 Apr 2019, In : Neuroscience Bulletin. 35, 2, p. 229-243 15 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Transcriptome and proteome profiling of neural stem cells from the human subventricular zone in Parkinson's disease

Donega, V., Burm, S. M., van Strien, M. E., van Bodegraven, E. J., Paliukhovich, I., Geut, H., van de Berg, W. D. J., Li, K. W., Smit, A. B., Basak, O. & Hol, E. M., 3 Jun 2019, In : Acta Neuropathologica Communinications. 7, 1, p. 4

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Transcriptomic signatures of brain regional vulnerability to Parkinson’s disease

Keo, A., Mahfouz, A., Ingrassia, A. M. T., Meneboo, J-P., Villenet, C., Mutez, E., Comptdaer, T., Lelieveldt, B. P. F., Figeac, M., Chartier-Harlin, M-C., Berg, W. D. J. V. D., Hilten, J. J. V. & Reinders, M. J. T., 11 Jun 2019, In : Biorxiv.

Research output: Contribution to journalArticleAcademicpeer-review

2018

A comprehensive analysis of SNCA-related genetic risk in sporadic parkinson disease

the International Parkinson Disease Genomics Consortium & the North American Brain Expression Consortium, 1 Jul 2018, In : Annals of Neurology. 84, 1, p. 117-129 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cerebral Corpora amylacea are dense membranous labyrinths containing structurally preserved cell organelles

Navarro, P. P., Genoud, C., Castaño-Díez, D., Graff-Meyer, A., Lewis, A. J., de Gier, Y., Lauer, M. E., Britschgi, M., Bohrmann, B., Frank, S., Hench, J., Schweighauser, G., Rozemuller, A. J. M., van de Berg, W. D. J., Stahlberg, H. & Shahmoradian, S. H., 1 Dec 2018, In : Scientific Reports. 8, 1, 18046.

Research output: Contribution to journalArticleAcademicpeer-review

Demyelination, inflammation and axonal loss explain different patterns of fractional anisotropy abnormalities in MS cortical normal appering gray matter and lesions.

Preziosa, P., Kiljan, S., Steenwijk, M. D., Meani, A. G. M., van de Berg, W. D. J., Rocca, M. A., Filippi, M., Geurts, J. J. G. & Jonkman, L. E., Oct 2018, In : Multiple Sclerosis Journal. 24, p. 14-15

Research output: Contribution to journalMeeting AbstractAcademic

Detailed structural orchestration of Lewy pathology in Parkinson's disease as revealed by 3D multicolor STED microscopy

Moors, T. E., Maat, C. A., Niedieker, D., Mona, D., Petersen, D., Timmermans-Huisman, E., Kole, J., El-Mashtoly, S. F., Zago, W., Barbour, R., Mundigl, O., Kaluza, K., Huber, S., Hug, M. N., Kremer, T., Ritter, M., Dziadek, S., Geurts, J. J. G., Gerwert, K., Britschgi, M. & 1 othersBerg, W. D. J. V. D., 2018, In : Biorxiv. p. 470476

Research output: Contribution to journalArticleAcademicpeer-review

Do you see what I see? Visual hallucinations and dementia in Parkinson's disease: a search for neuropsychological, neuroimaging and neuropathological determinants

Hepp, D. H., 2018, 143 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

Local GM demyelination and remote microstructural damage in connected WM tracts both contribute to cortical neurodegeneration in MS

Kiljan, S., Preziosa, P., Jonkman, L. E., van de Berg, W. D. J., Schenk, G. J., Rocca, M. A., Filippi, M., Geurts, J. J. G. & Steenwijk, M. D., Oct 2018, In : Multiple Sclerosis Journal. 24, p. 605-606

Research output: Contribution to journalMeeting AbstractAcademic

LRP10 genetic variants in familial Parkinson's disease and dementia with Lewy bodies: a genome-wide linkage and sequencing study

International Parkinsonism Genetics Network, 1 Jul 2018, In : The Lancet Neurology. 17, 7, p. 597-608 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

α-Synuclein species as potential cerebrospinal fluid biomarkers for dementia with lewy bodies

van Steenoven, I., Majbour, N. K., Vaikath, N. N., Berendse, H. W., van der Flier, W. M., van de Berg, W. D. J., Teunissen, C. E., Lemstra, A. W. & el-Agnaf, O. M. A., 29 Nov 2018, In : Movement Disorders. 33, 11, p. 1724-1733 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

An update on the genetics of dementia with Lewy bodies

Vergouw, L. J. M., van Steenoven, I., van de Berg, W. D. J., Teunissen, C. E., van Swieten, J. C., Bonifati, V., Lemstra, A. W. & de Jong, F. J., 1 Oct 2017, In : Parkinsonism and Related Disorders. 43, p. 1-8 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

CROSS-DISEASE CHARACTERIZATION OF ALPHA-SYNUCLEIN PATHOLOGY IN HUMAN POSTMORTEM BRAIN TISSUE USING EPITOPE-SPECIFIC ANTIBODIES

Maat, C., Moors, T., R, B., Zago, W., Britschgi, M. & van de Berg, WDJ., 10 Sep 2017, CROSS-DISEASE CHARACTERIZATION OF ALPHA-SYNUCLEIN PATHOLOGY IN HUMAN POSTMORTEM BRAIN TISSUE USING EPITOPE-SPECIFIC ANTIBODIES .

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Do you see what I see? Visual hallucinations and dementia in Parkinson’s disease: a search for neuropsychological, neuroimaging and neuropathological determinants

Hepp, DH. & van de Berg, WDJ., 15 Dec 2017, 143 p.

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

Open Access

Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer's disease

Majbour, N. K., Chiasserini, D., Vaikath, N. N., Eusebi, P., Tokuda, T., Van De Berg, W., Parnetti, L., Calabresi, P. & El-Agnaf, O. M. A., 10 Jan 2017, In : Scientific Reports. 7, 40263.

Research output: Contribution to journalArticleAcademicpeer-review

Lewy pathology in Parkinson's disease consists of a crowded organellar membranous medley

Sharamoradian, S., Britschgi, M., Stahlberg, H., van de Berg, WDJ. & Lauer, M., 28 Jun 2017, In : Biorxiv. doi: https://doi.org/10.1101/137976 .

Research output: Contribution to journalArticleAcademic

LRRK2 levels and phosphorylation in Parkinson's disease brain and cases with restricted Lewy bodies

Dzamko, N., Gysbers, A. M., Bandopadhyay, R., Bolliger, M. F., Uchino, A., Zhao, Y., Takao, M., Wauters, S., van de Berg, W. D. J., Takahashi-Fujigasaki, J., Nichols, R. J., Holton, J. L., Murayama, S. & Halliday, G. M., 1 Mar 2017, In : Movement Disorders. 32, 3, p. 423-432 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Molecular profiling of adult human neural stem cells in Parkinson's disease

Burm, S. M., van Strien, M. E., Basak, O., Sluijs, J. A., Paliukhovic, I., van de Berg, W. D. J., Li, K. W. & Hol, E. M., Jun 2017, In : GLIA. 65, p. E403-E403

Research output: Contribution to journalMeeting AbstractAcademic

Nitric Oxide Production in the Striatum and Cerebellum of a Rat Model of Preterm Global Perinatal Asphyxia

Barkhuizen, M., van de Berg, WDJ., de Vente, J., Blanco, C., Gavilanes, D. & Steinbusch, H., 30 Apr 2017, In : Neurotoxicity Research. 31, 3, p. 400-409

Research output: Contribution to journalArticleAcademicpeer-review

Origin of α-mannosidase activity in CSF

Tasegian, A., Paciotti, S., Ceccarini, M. R., Codini, M., Moors, T., Chiasserini, D., Albi, E., Winchester, B., van de Berg, W. D. J., Parnetti, L. & Beccari, T., Jun 2017, In : International Journal of Biochemistry & Cell Biology. 87, p. 34-37 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Therapeutic potential of autophagy-enhancing agents in Parkinson's disease

Moors, T. E., Hoozemans, J. J. M., Ingrassia, A., Beccari, T., Parnetti, L., Chartier-Harlin, M. C. & Van De Berg, W. D. J., 25 Jan 2017, In : MOLECULAR NEURODEGENERATION. 12, 1, 11.

Research output: Contribution to journalReview articleAcademicpeer-review

2016

Distribution and Load of Amyloid-beta Pathology in Parkinson Disease and Dementia with Lewy Bodies

Hepp, D. H., Vergoossen, D. L. E., Huisman, E., Lemstra, A. W., Bank, N. B., Berendse, H. W., Rozemuller, A. J., Foncke, E. M. J. & van de Berg, W. D. J., Oct 2016, In : Journal of Neuropathology and Experimental Neurology. 75, 10, p. 936-945

Research output: Contribution to journalArticleAcademicpeer-review

Lysosomal Dysfunction and alpha-Synuclein Aggregation in Parkinson's Disease: Diagnostic Links

Moors, T., Paciotti, S., Chiasserini, D., Calabresi, P., Parnetti, L., Beccari, T. & van de Berg, W. D. J., Jun 2016, In : Movement Disorders. 31, 6, p. 791-801

Research output: Contribution to journalArticleAcademicpeer-review

Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson's disease

Majbour, N. K., Vaikath, N. N., van Dijk, K., Ardah, M. T., Varghese, S., Vesterager, L. B., Montezinho, L. P., Poole, S., Safieh-Garabedian, B., Tokuda, T., Teunissen, C. E., Berendse, H., van de Berg, W. D. J. & El-Agnaf, O. M. A., 19 Jan 2016, In : MOLECULAR NEURODEGENERATION. 11, 7.

Research output: Contribution to journalArticleAcademicpeer-review

Evidence for Immune Response, Axonal Dysfunction and Reduced Endocytosis in the Substantia Nigra in Early Stage Parkinson's Disease.

Dijkstra, A. A., Ingrassia, A., Menezes, R. X., van Kesteren, R. E., Rozemuller, A. J., Heutink, P. & van de Berg, W. D. J., 2015, In : PLoS ONE. 10, 6, e0128651.

Research output: Contribution to journalArticleAcademicpeer-review

Generation and characterization of novel conformation-specific monoclonal antibodies for alpha-synuclein pathology

Vaikath, N. N., Majbour, N. K., Paleologou, K. E., Ardah, M. T., van Dam, E., van de Berg, W. D. J., Forrest, S. L., Parkkinen, L., Gai, W. P., Hattori, N., Takanashi, M., van der Lee, S. J., Mann, D. M. A., Imai, Y., Halliday, G. M., Li, J. Y. & El-Agnaf, O. M. A., 2015, In : Neurobiology of Disease. 79, p. 81-99

Research output: Contribution to journalArticleAcademicpeer-review