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Research Output 1989 2019

2019

Activation of CD8⁺ T Cell Responses after Melanoma Antigen Targeting to CD169⁺ Antigen Presenting Cells in Mice and Humans

van Dinther, D., Lopez Venegas, M., Veninga, H., Olesek, K., Hoogterp, L., Revet, M., Ambrosini, M., Kalay, H., Stöckl, J., van Kooyk, Y. & den Haan, J. M. M., 5 Feb 2019, In : Cancers. 11, 2

Research output: Contribution to journalArticleAcademicpeer-review

Outer membrane vesicles engineered to express membrane-bound antigen program dendritic cells for cross-presentation to CD8 + T cells

Schetters, S. T. T., Jong, W. S. P., Horrevorts, S. K., Kruijssen, L. J. W., Engels, S., Stolk, D., Daleke-Schermerhorn, M. H., Garcia-Vallejo, J., Houben, D., Unger, W. W. J., den Haan, J. M. M., Luirink, J. & van Kooyk, Y., 2019, In : Acta Biomaterialia.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Subcutaneous immunotherapy using modified Phl p5a-derived peptides efficiently alleviates allergic asthma in mice

Hesse, L., Feenstra, R., Ambrosini, M., de Jager, W. A., Petersen, A., Vietor, H., Unger, W. W. J., van Kooyk, Y. & Nawijn, M. C., 2019, In : Allergy: European Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalComment/Letter to the editorAcademic

Open Access
2018

Comparison of Protein and Peptide Targeting for the Development of a CD169-Based Vaccination Strategy Against Melanoma

van Dinther, D., Veninga, H., Revet, M., Hoogterp, L., Olesek, K., Grabowska, J., Borg, E. G. F., Kalay, H., van Kooyk, Y. & den Haan, J. M. M., 2018, In : Frontiers in Immunology. 9, p. 1997

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Disruption of sialic acid metabolism drives tumor growth by augmenting CD8+ T cell apoptosis

Cornelissen, L. A. M., Blanas, A., van der Horst, J. C., Kruijssen, L., Zaal, A., O'Toole, T., Wiercx, L., van Kooyk, Y. & van Vliet, S. J., 22 Dec 2018, In : International Journal of Cancer.

Research output: Contribution to journalArticleAcademicpeer-review

Fucosylated Antigens in Cancer: An Alliance toward Tumor Progression, Metastasis, and Resistance to Chemotherapy

Blanas, A., Sahasrabudhe, N. M., Rodríguez, E., van Kooyk, Y. & van Vliet, S. J., 2018, In : Frontiers in Oncology. 8, p. 39

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Functional CD169 on Macrophages Mediates Interaction with Dendritic Cells for CD8+ T Cell Cross-Priming

van Dinther, D., Veninga, H., Iborra, S., Borg, E. G. F., Hoogterp, L., Olesek, K., Beijer, M. R., Schetters, S. T. T., Kalay, H., Garcia-Vallejo, J. J., Franken, K. L., Cham, L. B., Lang, K. S., van Kooyk, Y., Sancho, D., Crocker, P. R. & den Haan, J. M. M., 6 Feb 2018, In : Cell Reports. 22, 6, p. 1484-1495 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Glycans to reprogram the immune response

Li, RJE., van Kooyk, Y. & van Vliet, SJ., 22 Oct 2018, Atlas of Science. 1 p.

Research output: Book/ReportReportAcademic

Open Access

Glycosylated extracellular vesicles released by glioblastoma cells are decorated by CCL18 allowing for cellular uptake via chemokine receptor CCR8

Berenguer, J., Lagerweij, T., Zhao, X. W., Dusoswa, S., van der Stoop, P., Westerman, B., de Gooijer, M. C., Zoetemelk, M., Zomer, A., Crommentuijn, M. H. W., Wedekind, L. E., López-López, À., Giovanazzi, A., Bruch-Oms, M., Meulen-Muileman, I. H. V. D., Reijmers, R. M., van Kuppevelt, T. H., García-Vallejo, J. J., van Kooyk, Y., Tannous, B. A. & 9 othersWesseling, P., Koppers-Lalic, D., Vandertop, W. P., Noske, D. P., van Beusechem, V. W., van Rheenen, J., Pegtel, D. M., van Tellingen, O. & Wurdinger, T., 13 Mar 2018, In : Journal of Extracellular Vesicles. 7, 1, 1446660.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Modulation of Immune Tolerance via Siglec-Sialic Acid Interactions

Lübbers, J., Rodríguez, E. & van Kooyk, Y., Dec 2018, In : Frontiers in Immunology. 9, p. 2807-2820 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Mouse DC-SIGN/CD209a as Target for Antigen Delivery and Adaptive Immunity

Schetters, S. T. T., Kruijssen, L. J. W., Crommentuijn, M. H. W., Kalay, H., Ochando, J., den Haan, J. M. M., Garcia-Vallejo, J. J. & van Kooyk, Y., 7 May 2018, In : Frontiers in Immunology. 9, p. 990

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Neuroinflammation: Microglia and T Cells Get Ready to Tango

Schetters, S. T. T., Gomez-Nicola, D., Garcia-Vallejo, J. J. & van Kooyk, Y., 2018, In : Frontiers in Immunology. 8, JAN, 1905.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Positive & negative roles of innate effector cells in controlling cancer progression

Stolk, D., van der Vliet, H. J., de Gruijl, T. D., van Kooyk, Y. & Exley, M. A., 2018, In : Frontiers in Immunology. 9, SEP, 1990.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Targeting Mycobacterium tuberculosis antigens to dendritic cells via the DC-specific-ICAM3-grabbing-nonintegrin receptor induces strong T-helper 1 immune responses

Velasquez, L. N., Stüve, P., Gentilini, M. V., Swallow, M., Bartel, J., Lycke, N. Y., Barkan, D., Martina, M., Lujan, H. D., Kalay, H., van Kooyk, Y., Sparwasser, T. D. & Berod, L., 2018, In : Frontiers in Immunology. 9, MAR, p. 471 471.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The tumour glyco-code as a novel immune checkpoint for immunotherapy

RodrÍguez, E., Schetters, S. T. T. & van Kooyk, Y., Mar 2018, In : Nature Reviews Immunology. 18, 3, p. 204-211 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Using the glycan toolbox for pathogenic interventions and glycan immunotherapy

Li, R. E., van Vliet, S. J. & van Kooyk, Y., 1 Jun 2018, In : Current opinion in biotechnology. 51, p. 24-31 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

2017

Fasciola hepatica glycoconjugates immuneregulate dendritic cells through the Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin inducing T cell anergy

Rodríguez, E., Kalay, H., Noya, V., Brossard, N., Giacomini, C., van Kooyk, Y., García-Vallejo, J. J. & Freire, T., 24 Apr 2017, In : Scientific Reports. 7, p. 46748

Research output: Contribution to journalArticleAcademicpeer-review

Fasciola hepatica Immune Regulates CD11c+ Cells by Interacting with the Macrophage Gal/GalNAc Lectin

Rodríguez, E., Carasi, P., Frigerio, S., da Costa, V., van Vliet, S., Noya, V., Brossard, N., van Kooyk, Y., García-Vallejo, J. J. & Freire, T., 2017, In : Frontiers in Immunology: Molecular Innate Immunity. 8, p. 264

Research output: Contribution to journalArticleAcademicpeer-review

Improved cancer specificity in PSA assay using Aleuria aurantia lectin coated Eu-nanoparticles for detection

Kekki, H., Peltola, M., van Vliet, S., Bangma, C., van Kooyk, Y. & Pettersson, K., Jan 2017, In : Clinical Biochemistry. 50, 1-2, p. 54-61 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Optical clearing and fluorescence deep-tissue imaging for 3D quantitative analysis of the brain tumor microenvironment

Lagerweij, T., Dusoswa, S. A., Negrean, A., Hendrikx, E. M. L., de Vries, H. E., Kole, J., Garcia-Vallejo, J. J., Mansvelder, H. D., Vandertop, W. P., Noske, D. P., Tannous, B. A., Musters, R. J. P., van Kooyk, Y., Wesseling, P., Zhao, X. W. & Wurdinger, T., 1 Nov 2017, In : Angiogenesis. 20, 4, p. 533-546 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Synergistic effects of dendritic cell targeting and laser-microporation on enhancing epicutaneous skin vaccination efficacy

Machado, Y., Duinkerken, S., Hoepflinger, V., Mayr, M., Korotchenko, E., Kurtaj, A., Pablos, I., Steiner, M., Stoecklinger, A., Lübbers, J., Schmid, M., Ritter, U., Scheiblhofer, S., Ablinger, M., Wally, V., Hochmann, S., Raninger, A. M., Strunk, D., van Kooyk, Y., Thalhamer, J. & 1 othersWeiss, R., 28 Nov 2017, In : Journal of Controlled Release. 266, p. 87-99 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Targeting C-type lectin receptors: A high-carbohydrate diet for dendritic cells to improve cancer vaccines

van Dinther, D., Stolk, D. A., van de Ven, R., van Kooyk, Y., de Gruij, T. D. & den Haan, J. M. M., 1 Oct 2017, In : Journal of Leukocyte Biology. 102, 4, p. 1017-1034 18 p.

Research output: Contribution to journalReview articleAcademicpeer-review

2016

A Nanoparticle-Lectin Immunoassay Improves Discrimination of Serum CA125 from Malignant and Benign Sources

Gidwani, K., Huhtinen, K., Kekki, H., van Vliet, S., Hynninen, J., Koivuviita, N., Perheentupa, A., Poutanen, M., Auranen, A., Grenman, S., Lamminmaki, U., Carpen, O., van Kooyk, Y. & Pettersson, K., Oct 2016, In : Clinical Chemistry. 62, 10, p. 1390-1400

Research output: Contribution to journalArticleAcademicpeer-review

Apoptotic vesicles as tumor vaccine

Horrevorts, S. K., Garcia-Vallejo, J. J., van Vliet, S. J., van de Loosdrecht, A. A., van Kooyk, Y. & de Gruijl, T. D., 2016, In : Immunotherapy. 8, 1, p. 5-8

Research output: Contribution to journalArticleAcademicpeer-review

Glycan modification of antigen alters its intracellular routing in dendritic cells, promoting priming of T cells

Streng-Ouwehand, I., Ho, N. I., Litjens, M., Kalay, H., Boks, M. A., Cornelissen, L. A. M., Singh, S. K., Saeland, E., Garcia-Vallejo, J. J., Ossendorp, F. A., Unger, W. W. J. & van Kooyk, Y., 21 Mar 2016, In : eLife. 5

Research output: Contribution to journalArticleAcademicpeer-review

Human cytomegalovirus-based immunotherapy to treat glioblastoma: Into the future

Duinkerken, S., van Kooyk, Y. & Garcia-Vallejo, J. J., 2016, In : OncoImmunology. 5, 9

Research output: Contribution to journalArticleAcademicpeer-review

Internalization and presentation of myelin antigens by the brain endothelium guides antigen-specific T cell migration

Lopes Pinheiro, M., Kamermans, A., Garcia-Vallejo, J. J., Hof, B. V. H., Wierts, L., O'Toole, T., Boeve, D., Verstege, M., van der Pol, S. M. A., Van Kooyk, Y., de Vries, H. E. & Unger, W. W. J., 23 Jun 2016, In : eLife. 5, e13149.

Research output: Contribution to journalArticleAcademicpeer-review

New roles for CD14 and IL-beta linking inflammatory dendritic cells to IL-17 production in memory CD4(+) T cells

Ilarregui, J. M., van Beelen, A. J., Fehres, C. M., Bruijns, S. C. M., Garcia-Vallejo, J. J. & van Kooyk, Y., 2016, In : Immunology and cell biology. 94, 10, p. 907-916

Research output: Contribution to journalArticleAcademicpeer-review

Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells

Perdicchio, M., Ilarregui, J. M., Verstege, M. I., Cornelissen, L. A. M., Schetters, S. T. T., Engels, S., Ambrosini, M., Kalay, H., Veninga, H., den Haan, JMM., van Berkel, L. A., Samsom, J. N., Crocker, P. R., Sparwasser, T., Berod, L., Garcia-Vallejo, J. J., van Kooyk, Y. & Unger, W. W. J., 22 Mar 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 12, p. 3329-3334

Research output: Contribution to journalArticleAcademicpeer-review

Sialic acid removal from dendritic cells improves antigen cross presentation and boosts anti-tumor immune responses

Silva, M., Silva, Z., Marques, G., Ferro, T., Goncalves, M., Monteiro, M., van Vliet, S. J., Mohr, E., Lino, A. C., Fernandes, A. R., Lima, F. A., van Kooyk, Y., Matos, T., Tadokoro, C. E. & Videira, P. A., 5 Jul 2016, In : Oncotarget. 7, 27, p. 41053-41066

Research output: Contribution to journalArticleAcademicpeer-review

The Human Glycoprotein Salivary Agglutinin Inhibits the Interaction of DC-SIGN and Langerin with Oral Micro-Organisms

Boks, M. A., Gunput, S. T. G., Kosten, I., Gibbs, S., van Vliet, S. J., Ligtenberg, A. J. M. & van Kooyk, Y., 2016, In : Journal of innate immunity. 8, 4, p. 350-361

Research output: Contribution to journalArticleAcademicpeer-review

Tumor sialylation impedes T cell mediated anti-tumor responses while promoting tumor associated-regulatory T cells

Perdicchio, M., Cornelissen, L. A. M., Streng-Ouwehand, I., Engels, S., Verstege, M. I., Boon, L., Geerts, D., van Kooyk, Y. & Unger, W. W. J., 23 Feb 2016, In : Oncotarget. 7, 8, p. 8771-82 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Tumor sialylation impedes T cell mediated anti-tumor responses while promoting tumor associated-regulatory T cells

Perdicchio, M., Cornelissen, L. A. M., Streng-Ouwehand, I., Engels, S., Verstege, M. I., Boon, L., Geerts, D., van Kooyk, Y. & Unger, W. W. J., 23 Feb 2016, In : Oncotarget. 7, 8, p. 8771-8782

Research output: Contribution to journalArticleAcademicpeer-review

2015

A new cellular target for Yersinia pestis

Garcia Vallejo, J. J. & van Kooyk, Y., 2015, In : Immunology and cell biology. 93, 9, p. 769-770

Research output: Contribution to journalArticleAcademicpeer-review

Antibody-Opsonized Bacteria Evoke an Inflammatory Dendritic Cell Phenotype and Polyfunctional Th Cells by Cross-Talk between TLRs and FcRs

Bakema, J. E., Tuk, C. W., van Vliet, S. J., Bruijns, S. C., Vos, J. B., Letsiou, S., Dijkstra, C. D., van Kooyk, Y., Brenkman, A. B. & van Egmond, M., 2015, In : Journal of Immunology. 194, 4, p. 1856-1866

Research output: Contribution to journalArticleAcademicpeer-review

Antigen targeting reveals splenic CD169(+) macrophages as promoters of germinal center B-cell responses

Veninga, H., Borg, E. G. F., Vreeman, K., Taylor, P. R., Kalay, H., van Kooyk, Y., Kraal, G., Martinez-Pomares, L. & den Haan, J. M. M., 2015, In : European Journal of Immunology. 45, 3, p. 747-757

Research output: Contribution to journalArticleAcademicpeer-review

Antigen targeting to dendritic cells combined with transient regulatory T cell inhibition results in long-term tumor regression

Unger, W. W. J., Mayer, C. T., Engels, S., Hesse, C., Perdicchio, M., Puttur, F., Streng-Ouwehand, I., Litjens, M., Kalay, H., Berod, L., Sparwasser, T. & van Kooyk, Y., 2015, In : OncoImmunology. 4, 8, e970462.

Research output: Contribution to journalArticleAcademicpeer-review

Controlled release of a model vaccine by nanoporous ceramic microneedle arrays

Boks, M. A., Unger, W. W. J., Engels, S., Ambrosini, M., van Kooyk, Y. & Luttge, R., 2015, In : International journal of pharmaceutics. 491, 1-2, p. 375-383

Research output: Contribution to journalArticleAcademicpeer-review

Cross-presentation through langerin and DC-SIGN targeting requires different formulations of glycan-modified antigens

Fehres, C. M., Kalay, H., Bruijns, S. C. M., Musaafir, S. A. M., Ambrosini, M., van Bloois, L., van Vliet, S. J., Storm, G., Garcia Vallejo, J. J. & van Kooyk, Y., 2015, In : Journal of Controlled Release. 203, p. 67-76

Research output: Contribution to journalArticleAcademicpeer-review

DC-SIGN: The Strange Case of Dr. Jekyll and Mr. Hyde

Garcia Vallejo, J. J. & van Kooyk, Y., 2015, In : Immunity. 42, 6, p. 983-985

Research output: Contribution to journalArticleAcademicpeer-review

DC-SIGN. C-Type Lectin with Prominent Role in Immune System

Garcia-Vallejo, J. J. & van Kooyk, Y., 2015, Glycoscience: Biology and Medicine. p. 649-659

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

28 Downloads (Pure)

Effects of sialic acids in immunity

Perdicchio, M., 2015

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

File

Human milk blocks DC-SIGN-pathogen interaction via MUC1

Koning, N., Kessen, S. F. M., van der Voorn, J. P., Appelmelk, B. J., Jeurink, P. V., Knippels, L. M. J., Garssen, J. & van Kooyk, Y., 2015, In : Frontiers in Immunology: Molecular Innate Immunity. 6, 112.

Research output: Contribution to journalArticleAcademicpeer-review

32 Downloads (Pure)

Human skin dendritic cells as target for anti-tumor vaccination

Fehres, C. M., 2015

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

File