If you made any changes in Pure these will be visible here soon.

Research Output

2015

A new cellular target for Yersinia pestis

Garcia Vallejo, J. J. & van Kooyk, Y., 2015, In : Immunology and cell biology. 93, 9, p. 769-770

Research output: Contribution to journalArticleAcademicpeer-review

Antibody-Opsonized Bacteria Evoke an Inflammatory Dendritic Cell Phenotype and Polyfunctional Th Cells by Cross-Talk between TLRs and FcRs

Bakema, J. E., Tuk, C. W., van Vliet, S. J., Bruijns, S. C., Vos, J. B., Letsiou, S., Dijkstra, C. D., van Kooyk, Y., Brenkman, A. B. & van Egmond, M., 2015, In : Journal of Immunology. 194, 4, p. 1856-1866

Research output: Contribution to journalArticleAcademicpeer-review

Antigen targeting reveals splenic CD169(+) macrophages as promoters of germinal center B-cell responses

Veninga, H., Borg, E. G. F., Vreeman, K., Taylor, P. R., Kalay, H., van Kooyk, Y., Kraal, G., Martinez-Pomares, L. & den Haan, J. M. M., 2015, In : European Journal of Immunology. 45, 3, p. 747-757

Research output: Contribution to journalArticleAcademicpeer-review

Antigen targeting to dendritic cells combined with transient regulatory T cell inhibition results in long-term tumor regression

Unger, W. W. J., Mayer, C. T., Engels, S., Hesse, C., Perdicchio, M., Puttur, F., Streng-Ouwehand, I., Litjens, M., Kalay, H., Berod, L., Sparwasser, T. & van Kooyk, Y., 2015, In : OncoImmunology. 4, 8, e970462.

Research output: Contribution to journalArticleAcademicpeer-review

Controlled release of a model vaccine by nanoporous ceramic microneedle arrays

Boks, M. A., Unger, W. W. J., Engels, S., Ambrosini, M., van Kooyk, Y. & Luttge, R., 2015, In : International journal of pharmaceutics. 491, 1-2, p. 375-383

Research output: Contribution to journalArticleAcademicpeer-review

Cross-presentation through langerin and DC-SIGN targeting requires different formulations of glycan-modified antigens

Fehres, C. M., Kalay, H., Bruijns, S. C. M., Musaafir, S. A. M., Ambrosini, M., van Bloois, L., van Vliet, S. J., Storm, G., Garcia Vallejo, J. J. & van Kooyk, Y., 2015, In : Journal of Controlled Release. 203, p. 67-76

Research output: Contribution to journalArticleAcademicpeer-review

DC-SIGN: The Strange Case of Dr. Jekyll and Mr. Hyde

Garcia Vallejo, J. J. & van Kooyk, Y., 2015, In : Immunity. 42, 6, p. 983-985

Research output: Contribution to journalArticleAcademicpeer-review

DC-SIGN. C-Type Lectin with Prominent Role in Immune System

Garcia-Vallejo, J. J. & van Kooyk, Y., 2015, Glycoscience: Biology and Medicine. p. 649-659

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Human milk blocks DC-SIGN-pathogen interaction via MUC1

Koning, N., Kessen, S. F. M., van der Voorn, J. P., Appelmelk, B. J., Jeurink, P. V., Knippels, L. M. J., Garssen, J. & van Kooyk, Y., 2015, In : Frontiers in Immunology: Molecular Innate Immunity. 6, 112.

Research output: Contribution to journalArticleAcademicpeer-review

In situ Delivery of Antigen to DC-SIGN(+)D14(+) Dermal Dendritic Cells Results in Enhanced CD8(+) T-Cell Responses

Fehres, C. M., van Beelen, A. J., Bruijns, S. C. M., Ambrosini, M., Kalay, H., van Bloois, L., Unger, W. W. J., Garcia Vallejo, J. J., Storm, G., de Gruijl, T. D. & van Kooyk, Y., 2015, In : Journal of Investigative Dermatology. 135, 9, p. 2228-2236

Research output: Contribution to journalArticleAcademicpeer-review

In situ Delivery of Tumor Antigen- and Adjuvant-Loaded Liposomes Boosts Antigen-Specific T-Cell Responses by Human Dermal Dendritic Cells

Boks, M. A., Bruijns, S. C. M., Ambrosini, M., Kalay, H., van Bloois, L., Storm, G., de Gruijl, T. D. & van Kooyk, Y., 2015, In : Journal of Investigative Dermatology. 135, 11, p. 2697-2704

Research output: Contribution to journalArticleAcademicpeer-review

MGL ligand expression is correlated to BRAF mutation and associated with poor survival of stage III colon cancer patients

Lenos, K. J., Goos, J. A. C. M., Vuist, I. M., den Uil, S. H., Delis-van Diemen, P. M., Belt, E. J. T., Stockmann, H. B. A. C., Bril, H., de Wit, M., Carvalho, B., Giblett, S., Pritchard, C. A., Meijer, G. A., van Kooyk, Y., Fijneman, R. J. A. & van Vliet, S. J., 2015, In : Oncotarget. 6, 28, p. 26278-26290

Research output: Contribution to journalArticleAcademicpeer-review

MPLA incorporation into DC-targeting glycoliposomes favours anti-tumour T cell responses

Boks, M. A., Ambrosini, M., Bruijns, S. C. M., Kalay, H., van Bloois, L., Storm, G., Garcia Vallejo, J. J. & van Kooyk, Y., 2015, In : Journal of Controlled Release. 216, p. 37-46

Research output: Contribution to journalArticleAcademicpeer-review

Novel insights into the immunomodulatory role of the dendritic cell and macrophage-expressed C-type lectin MGL

van Kooyk, Y., Ilarregui, J. M. & van Vliet, S. J., 2015, In : Immunobiology. 220, 2, p. 185-192

Research output: Contribution to journalArticleAcademicpeer-review

Phenotypic and Functional Properties of Human Steady State CD14(+) and CD1a(+) Antigen Presenting Cells and Epidermal Langerhans Cells

Fehres, C. M., Bruijns, S. C. M., Sotthewes, B. N., Kalay, H., Schaffer, L., Head, S. R., de Gruijl, T. D., Garcia Vallejo, J. J. & van Kooyk, Y., 2015, In : PLoS ONE. 10, 11, e0143519.

Research output: Contribution to journalArticleAcademicpeer-review

The primate autoimmune encephalomyelitis model; a bridge between mouse and man

't Hart, B., van Kooyk, Y., Geurts, J. J. G. & Gran, B., 2015, In : Annals of Clinical and Translational Neurology. 2, 5, p. 581-593

Research output: Contribution to journalArticleAcademicpeer-review

Trypanosoma cruzi Infection Imparts a Regulatory Program in Dendritic Cells and T Cells via Galectin-1-Dependent Mechanisms

Poncini, C. V., Ilarregui, J. M., Batalla, E. I., Engels, S., Cerliani, J. P., Cucher, M. A., van Kooyk, Y., Gonzalez-Cappa, S. M. & Rabinovich, G. A., 2015, In : Journal of Immunology. 195, 7, p. 3311-3324

Research output: Contribution to journalArticleAcademicpeer-review

2014

CNS myelin induces regulatory functions of DC-SIGN-expressing, antigen-presenting cells via cognate interaction with MOG

Garcia-Vallejo, J. J., Ilarregui, J. M., Kalay, H., Chamorro, S., Koning, N., Unger, W. W. J., Ambrosini, M., Montserrat, V., Fernandes, R. J., Bruijns, S. C. M., van Weering, J. R. T., Paauw, N. J., O'Toole, T. G., van Horssen, J., van der Valk, P., Nazmi, K., Bolscher, J. G., Bajramovic, J., Dijkstra, C. D., 't Hart, B. A. & 1 others, van Kooyk, Y., 2014, In : Journal of Experimental Medicine. 211, 7, p. 1465-1483

Research output: Contribution to journalArticleAcademicpeer-review

DCIR interacts with ligands from both endogenous and pathogenic origin

Bloem, K., Vuist, I. M., van den Berk, M., Klaver, E. J., van Die, I. M., Knippels, L. M., Garssen, J., Garcia Vallejo, J. J., van Vliet, S. J. & van Kooyk, Y., 2014, In : Immunology Letters. 158, 1-2, p. 33-41

Research output: Contribution to journalArticleAcademicpeer-review

Effective Targeting of DC-SIGN by alpha-Fucosylamide Functionalized Gold Nanoparticles

Arosio, D., Chiodo, F., Reina, J. J., Marelli, M., Penades, S., van Kooyk, Y., Garcia Vallejo, J. J. & Bernardi, A., 2014, In : Bioconjugate chemistry. 25, 12, p. 2244-2251

Research output: Contribution to journalArticleAcademicpeer-review

Effects of Antigen-Expressing Immunostimulatory Liposomes on Chemotaxis and Maturation of Dendritic Cells In Vitro and in Human Skin Explants

Lanzi, A., Fehres, C. M., de Gruijl, T. D., van Kooyk, Y. & Mastrobattista, E., 2014, In : Pharmaceutical Research. 31, 2, p. 516-526

Research output: Contribution to journalArticleAcademicpeer-review

Topical rather than intradermal application of the TLR7 ligand imiquimod leads to human dermal dendritic cell maturation and CD8(+) T-cell cross-priming

Fehres, C. M., Bruijns, S. C. M., van Beelen, A. J., Kalay, H., Ambrosini, M., Hooijberg, E., Unger, W. W. J., de Gruijl, T. D. & van Kooyk, Y., 2014, In : European Journal of Immunology. 44, 8, p. 2415-2424

Research output: Contribution to journalArticleAcademicpeer-review

Understanding the biology of antigen cross-presentation for the design of vaccines against cancer

Fehres, C. M., Unger, W. W. J., Garcia Vallejo, J. J. & van Kooyk, Y., 2014, In : Frontiers in Microbiology. 5, 149.

Research output: Contribution to journalArticleAcademicpeer-review

2013

Antigen-Presenting Cells in the Central Nervous System

Koning, N., Ilarregui, J. M., Garcia Vallejo, J. J. & van Kooyk, Y., 2013, Multiple Sclerosis Immunology. p. 71-94

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Glycan-based DC-SIGN targeting to enhance antigen cross-presentation in anticancer vaccines

Garcia Vallejo, J. J., Unger, W. W. J., Kalay, H. & van Kooyk, Y., 2013, In : OncoImmunology. 2, 2, e23040.

Research output: Contribution to journalArticleAcademicpeer-review

Glycan-based DC-SIGN targeting vaccines to enhance antigen cross-presentation

van Kooyk, Y., Unger, W. W. J., Fehres, C. M., Kalay, H. & Garcia Vallejo, J. J., 2013, In : Molecular Immunology. 55, 2, p. 143-145

Research output: Contribution to journalArticleAcademicpeer-review

Glycodendrimers prevent HIV transmission via DC-SIGN on dendritic cells

Garcia Vallejo, J. J., Koning, N., Ambrosini, M., Kalay, H., Vuist, I., Sarrami-Forooshani, R., Geijtenbeek, T. B. H. & van Kooyk, Y., 2013, In : International Immunology. 25, 4, p. 221-233

Research output: Contribution to journalArticleAcademicpeer-review

How mucins shape antigen-presenting cells to modify immune responses

van Vliet, S. J. & van Kooyk, Y., 2013, Mucins and Cancer. p. 108-122

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Intestinal Epithelium-Derived Galectin-9 Is Involved in the Immunomodulating Effects of Nondigestible Oligosaccharides

de Kivita, S., Kraneveld, A. D., Knippels, L. M. J., van Kooyk, Y., Garssen, J. & Willemsen, L. E. M., 2013, In : Journal of innate immunity. 5, 6, p. 625-638

Research output: Contribution to journalArticleAcademicpeer-review

Intradermal Delivery of TLR Agonists in a Human Explant Skin Model: Preferential Activation of Migratory Dendritic Cells by Polyribosinic-Polyribocytidylic Acid and Peptidoglycans

Oosterhoff, D., Heusinkveld, M., Lougheed, S. M., Kosten, I., Lindstedt, M., Bruijns, S. C. M., van Es, T., van Kooyk, Y., van der Burg, S. H. & de Gruijl, T. D., 2013, In : Journal of Immunology. 190, 7, p. 3338-3345

Research output: Contribution to journalArticleAcademicpeer-review

In vivo targeting of human DC-SIGN drastically enhances CD8(+) T-cell-mediated protective immunity

Hesse, C., Ginter, W., Forg, T., Mayer, C. T., Baru, A. M., Arnold-Schrauf, C., Unger, W. W. J., Kalay, H., van Kooyk, Y., Berod, L. & Sparwasser, T., 2013, In : European Journal of Immunology. 43, 10, p. 2543-2553

Research output: Contribution to journalArticleAcademicpeer-review

Ligand Binding and Signaling of Dendritic Cell Immunoreceptor (DCIR) Is Modulated by the Glycosylation of the Carbohydrate Recognition Domain

Bloem, K., Vuist, I. M., van der Plas, A. J., Knippels, L. M. J., Garssen, J., Garcia Vallejo, J. J., van Vliet, S. J. & van Kooyk, Y., 2013, In : PLoS ONE. 8, 6, e66266.

Research output: Contribution to journalArticleAcademicpeer-review

MGL signaling augments TLR2-mediated responses for enhanced IL-10 and TNF-alpha secretion

van Vliet, S. J., Bay, S., Vuist, I. M., Kalay, H., Garcia Vallejo, J. J., Leclerc, C. & van Kooyk, Y., 2013, In : Journal of Leukocyte Biology. 94, 2, p. 315-323

Research output: Contribution to journalArticleAcademicpeer-review

Multivalent glycopeptide dendrimers for the targeted delivery of antigens to dendritic cells

Garcia Vallejo, J. J., Ambrosini, M., Overbeek, A., van Riel, W. E., Bloem, K., Unger, W. W. J., Chiodo, F., Bolscher, J. G., Nazmi, K., Kalay, H. & van Kooyk, Y., 2013, In : Molecular Immunology. 53, 4, p. 387-397

Research output: Contribution to journalArticleAcademicpeer-review

Notch controls generation and function of human effector CD8+ T cells

Kuijk, L. M., Verstege, M. I., Rekers, N. V., Bruijns, S. C. M., Hooijberg, E., Roep, B. O., de Gruijl, T. D., van Kooyk, Y. & Unger, W. W. J., 2013, In : Blood. 121, 14, p. 2638-2646

Research output: Contribution to journalArticleAcademicpeer-review

Skin-resident antigen-presenting cells: instruction manual for vaccine development

Fehres, C. M., Garcia Vallejo, J. J., Unger, W. W. J. & van Kooyk, Y., 2013, In : Frontiers in Immunology: Molecular Innate Immunity. 4, 157.

Research output: Contribution to journalArticleAcademicpeer-review

The physiological role of DC-SIGN: A tale of mice and men

Garcia Vallejo, J. J. & van Kooyk, Y., 2013, In : Trends in Immunology. 34, 10, p. 482-486

Research output: Contribution to journalArticleAcademicpeer-review

2012

BODIPY-Labeled DC-SIGN-Targeting Glycodendrons Efficiently Internalize and Route to Lysosomes in Human Dendritic Cells

Ribeiro-Viana, R., Garcia Vallejo, J. J., Collado, D., Perez-Inestrosa, E., Bloem, K., van Kooyk, Y. & Rojo, J., 2012, In : Biomacromolecules. 13, 10, p. 3209-3219

Research output: Contribution to journalArticleAcademicpeer-review

Differential glycosylation of MUC1 and CEACAM5 between normal mucosa and tumour tissue of colon cancer patients

Saeland, E., Da Silva Aresta Belo, A. I., Mongera, S., van Die, I. M., Meijer, G. A. & van Kooyk, Y., 2012, In : International Journal of Cancer. 131, 1, p. 117-128

Research output: Contribution to journalArticleAcademicpeer-review

Galectin-9 induced by dietary synbiotics is involved in suppression of allergic symptoms in mice and humans

de Kivit, S., Saeland, E., Kraneveld, A. D., van de Kant, H. J. G., Schouten, B., van Esch, B. C. A. M., Knol, J., Sprikkelman, A. B., van der Aa, L. B., Knippels, L. M. J., Garssen, J., van Kooyk, Y. & Willemsen, L. E. M., 2012, In : Allergy. 67, 3, p. 343-352

Research output: Contribution to journalArticleAcademicpeer-review

Glycan-modified liposomes boost CD4(+) and CD8(+) T-cell responses by targeting DC-SIGN on dendritic cells

Unger, W. W. J., van Beelen, A. J., Bruijns, S. C. M., Joshi, M., Fehres, C. M., van Bloois, L., Verstege, M. I., Ambrosini, M., Kalay, H., Nazmi, K., Bolscher, J. G., Hooijberg, E., de Gruijl, T. D., Storm, G. & van Kooyk, Y., 2012, In : Journal of Controlled Release. 160, 1, p. 88-95

Research output: Contribution to journalArticleAcademicpeer-review

Glycobiology of immune responses

Rabinovich, G. A., van Kooyk, Y. & Cobb, B. A., 2012, In : Annals of the New York Academy of Sciences. 1253, p. 1-15

Research output: Contribution to journalArticleAcademicpeer-review

Online nanoliquid chromatography-mass spectrometry and nanofluorescence detection for high-resolution quantitative N-glycan analysis

Kalay, H., Ambrosini, M., van Berkel, P. H. C., Parren, P. W. H. I., van Kooyk, Y. & Garcia Vallejo, J. J., 2012, In : Analytical Biochemistry. 423, 1, p. 153-162

Research output: Contribution to journalArticleAcademicpeer-review

Specific glycan elements determine differential binding of individual egg glycoproteins of the human parasite Schistosoma mansoni by host C-type lectin receptors

Meevissen, M. H. J., Driessen, N. N., Smits, H. H., Versteegh, R., van Vliet, S. J., van Kooyk, Y., Schramm, G., Deelder, A. M., de Haas, H., Yazdanbakhsh, M. & Hokke, C. H., 2012, In : International Journal for Parasitology. 42, 3, p. 269-277

Research output: Contribution to journalArticleAcademicpeer-review

Targeting tumor antigens to dendritic cells using particulate carriers

Joshi, M. D., Unger, W. W. J., Storm, G., van Kooyk, Y. & Mastrobattista, E., 2012, In : Journal of Controlled Release. 161, 1, p. 25-37

Research output: Contribution to journalArticleAcademicpeer-review