Yvette van Kooyk

PROF.DR., (Principal Investigator)

1989 …2019
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Research Output 1989 2019

2011

C-type Lectin Receptors for Tumor Eradication: Future Directions

Streng-Ouwehand, I., Unger, W. W. J. & Van Kooyk, Y., 8 Aug 2011, In : Cancers. 3, 3, p. 3169-88 20 p.

Research output: Contribution to journalArticleAcademicpeer-review

DC-SIGN mediated antigen-targeting using glycan-modified liposomes: Formulation considerations

Joshi, M. D., Unger, W. W. J., van Beelen, A. J., Bruijns, S. C. M., Litjens, M., van Bloois, L., Kalay, H., van Kooyk, Y. & Storm, G., 2011, In : International journal of pharmaceutics. 416, 2, p. 426-432

Research output: Contribution to journalArticleAcademicpeer-review

Designing polymeric particles for antigen delivery

De Koker, S., Lambrecht, B. N., Willart, M. A., van Kooyk, Y., Grooten, J., Vervaet, C., Remon, J. P. & De Geest, B. G., 2011, In : Chemical Society Reviews. 40, 1, p. 320-339

Research output: Contribution to journalArticleAcademicpeer-review

Design of neo-glycoconjugates that target the mannose receptor and enhance TLR-independent cross-presentation and Th1 polarization

Singh, S. K., Ouwehand, I., Litjens, M., Kalay, H., Burgdorf, S., Saeland, E., Kurts, C., Unger, W. W. J. & van Kooyk, Y., 2011, In : European Journal of Immunology. 41, 4, p. 916-925

Research output: Contribution to journalArticleAcademicpeer-review

'Dressed for success' C-type lectin receptors for the delivery of glyco-vaccines to dendritic cells

Unger, W. W. J. & van Kooyk, Y., 2011, In : Current Opinion in Immunology. 23, 1, p. 131-137

Research output: Contribution to journalArticleAcademicpeer-review

37 Downloads (Pure)

Galactosaminogalactan, a New Immunosuppressive Polysaccharide of Aspergillus fumigatus

Fontaine, T., Delangle, A., Simenel, C., Coddeville, B., van Vliet, S. J., van Kooyk, Y., Bozza, S., Moretti, S., Schwarz, F., Trichot, C., Aebi, M., Delepierre, M., Elbim, C., Romani, L. & Latge, J. P., 2011, In : PLoS Pathogens. 7, 11, e1002372.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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Highly glycosylated tumour antigens: interactions with the immune system

Saeland, E. & van Kooyk, Y., 2011, In : Biochemical Society Transactions. 39, p. 388-392

Research output: Contribution to journalArticleAcademicpeer-review

State of the union: glycobiology and immunology in the Canadian Rockies

Cobb, B. A., Rabinovich, G. A. & van Kooyk, Y., May 2011, In : Glycobiology. 21, 5, p. 545-546 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

Tumour-associated glycan modifications of antigen enhance MGL2 dependent uptake and MHC class I restricted CD8 T cell responses

Singh, S. K., Ouwehand, I., Litjens, M., Kalay, H., Saeland, E. & van Kooyk, Y., 2011, In : International Journal of Cancer. 128, 6, p. 1371-1383

Research output: Contribution to journalArticleAcademicpeer-review

2010

A Potential Role for Galectins in Immune Modulation Upon Exposure of Human Intestinal Epithelial Cells to Non-Digestible Carbohydrates and Tlr Ligands

de Kivit, S., Saeland, E., Kraneveld, A., van Kooyk, Y., Garssen, J. & Willemsen, L., 2010, In : Journal of Pediatric Gastroenterology and Nutrition. 50, p. E87-E88

Research output: Contribution to journalMeeting AbstractOther research output

15 Downloads (Pure)

Glycan-lectin duet. A novel strategy for DC targeting.

Singh, S. K., 2010

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

File
15 Downloads (Pure)

Langerhans cells and dendritic cells in innate defense against pathogens

de Jong, M. A. W. P., 2010

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

File

Schistosoma mansoni worm glycolipids induce an inflammatory phenotype in human dendritic cells by cooperation of TLR4 and DC-SIGN

van Stijn, C. M. W., Meyer, S., van den Broek, M., Bruijns, S. C. M., van Kooyk, Y., Geyer, R. & van Die, I. M., 2010, In : Molecular Immunology. 47, 7-8, p. 1544-1552

Research output: Contribution to journalArticleAcademicpeer-review

Targeting Siglec-e on Murine Dendritic Cells Inhibits Antigen Presentation and Cd4 and Cd8 T Cell Responses

Bax, M., Unger, W. W. J., Singh, S. K., McKenzie, E. J., Litjens, M., Garcia Vallejo, J. J., Saeland, E., van Vliet, S. J., Crocker, P. R. & van Kooyk, Y., 2010, In : Annals of the Rheumatic Diseases. 69, p. A106

Research output: Contribution to journalMeeting AbstractOther research output

93 Downloads (Pure)

The functional consequences of glycosylation on dendritic cell biology.

Bax, M., 2010

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

File

TLR4-Mediated Sensing of Campylobacter jejuni by Dendritic Cells Is Determined by Sialylation

Kuijf, M. L., Samsom, J. N., van Rijs, W., Bax, M., Huizinga, R., Heikema, A. P., van Doorn, P. A., van Belkum, A., van Kooyk, Y., Burgers, P. C., Luider, T. M., Endtz, H. P., Nieuwenhuis, E. E. S. & Jacobs, B. C., 2010, In : Journal of Immunology. 185, 1, p. 748-755

Research output: Contribution to journalArticleAcademicpeer-review

2009

Characterization of murine MGL1 and MGL2 C-type lectins: Distinct glycan specificities and tumor binding properties

Singh, S. K., Ouwehand, I., Litjens, M., Weelij, D. R., Garcia Vallejo, J. J., van Vliet, S. J., Saeland, E. & van Kooyk, Y., 2009, In : Molecular Immunology. 46, 6, p. 1240-1249

Research output: Contribution to journalArticleAcademicpeer-review

5 Downloads (Pure)

C-type lectin signaling in response to pathogens

den Dunnen, J., 2009, S.l.: Wöhrmann Print Service.

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

File

Endogenous ligands for C-type lectin receptors: the true regulators of immune homeostasis

Garcia Vallejo, J. J. & van Kooyk, Y., 2009, In : Immunological Reviews. 230, p. 22-37

Research output: Contribution to journalArticleAcademicpeer-review

17 Downloads (Pure)

Helminth glycans and their interaction with the immune system

van Stijn, C. M. W., 2009, S.l.: s.n..

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

File

Identification of pathogen receptors on dendritic cells to understand their function and to identify new drug targets

de Witte, L. D., de Jong, M. A. W. P., den Dunnen, J., van Kooyk, Y. & Geijtenbeek, T. B. H., 2009, In : Methods in Molecular Biology. 531, p. 267-285

Research output: Contribution to journalArticleAcademic

36 Downloads (Pure)

Interaction of Polysialic Acid with CCL21 Regulates the Migratory Capacity of Human Dendritic Cells

Bax, M., van Vliet, S. J., Litjens, M., Garcia Vallejo, J. J. & van Kooyk, Y., 2009, In : PLoS ONE. 4, 9, p. e6987 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells

Saeland, E., de Jong, M. A. W. P., Nabatov, A., Kalay, H., van Kooyk, Y. & Geijtenbeek, T. B. H., 2009, In : Molecular Immunology. 46, 11-12, p. 2309-2316

Research output: Contribution to journalArticleAcademicpeer-review

N-glycosylated proteins and distinct lipooligosaccharide glycoforms of Campylobacter jejuni target the human C-type lectin receptor MGL

van Sorge, N. M., Bleumink, N. M. C., van Vliet, S. J., Saeland, E., van der Pol, W. L., van Kooyk, Y. & van Putten, J. W., 2009, In : Cellular Microbiology. 11, 12, p. 1768-1781

Research output: Contribution to journalArticleAcademicpeer-review

Polyelectrolyte Microcapsules as Antigen Delivery Vehicles To Dendritic Cells: Uptake, Processing, and Cross-Presentation of Encapsulated Antigens

De Koker, S., De Geest, B. G., Singh, S. K., De Rycke, R., Naessens, T., van Kooyk, Y., Demeester, J., De Smedt, S. C. & Grooten, J., 2009, In : Angewandte Chemie International Edition in English. 48, 45, p. 8485-8489

Research output: Contribution to journalArticleAcademicpeer-review

Targeting glycan modified OVA to murine DC-SIGN transgenic dendritic cells enhances MHC class I and II presentation

Singh, S. K., Stephani, J., Schaefer, M., Kalay, H., Garcia Vallejo, J. J., den Haan, J. M. M., Saeland, E., Sparwasser, T. & van Kooyk, Y., 2009, In : Molecular Immunology. 47, 2-3, p. 164-174

Research output: Contribution to journalArticleAcademicpeer-review

TLR Triggering on Tolerogenic Dendritic Cells Results in TLR2 Up-Regulation and a Reduced Proinflammatory Immune Program

Chamorro, S., Garcia Vallejo, J. J., Unger, W. W. J., Fernandes, R. J., Bruijns, S. C. M., Laban, S., Roep, B. O., 't Hart, B. O. & van Kooyk, Y., 2009, In : Journal of Immunology. 183, 5, p. 2984-2994

Research output: Contribution to journalArticleAcademicpeer-review

33 Downloads (Pure)

Variation of Neisseria gonorrhoeae Lipooligosaccharide Directs Dendritic Cell-Induced T Helper Responses

van Vliet, S. J., Steeghs, L., Bruijns, S. C. M., Vaezirad, M. M., Blok, C. S., Busto, J. A. A., Deken, M., van Putten, J. W. & van Kooyk, Y., 2009, In : PLoS Pathogens. 5, 10, p. e1000625 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2008

Activation of human monocyte-derived dendritic cells by Burkholderia pseudomallei does not require binding to the C-type lectin DC-SIGN

Charoensap, J., Engering, A., Utaisincharoen, P., van Kooyk, Y. & Sirisinha, S., Dec 2008, In : Transactions of the Royal Society of Tropical Medicine and Hygiene. 102 Suppl 1, p. S76-81

Research output: Contribution to journalArticleAcademicpeer-review

C-type lectins on dendritic cells: key modulators for the induction of immune responses

van Kooyk, Y., Dec 2008, In : Biochemical Society Transactions. 36, 6, p. 1478-81 4 p.

Research output: Contribution to journalReview articleAcademicpeer-review

DC-SIGN mediates adhesion and rolling of dendritic cells on primary human umbilical vein endothelial cells through LewisY antigen expressed on ICAM-2

Garcia Vallejo, J. J., Liempt, P. A. G., da Costa Martins, P., Beckers, C. M. L., van het Hof, B., Gringhuis, S. I., Zwaginga, JJ., van Dijk, W., Geijtenbeek, T. B. H., van Kooyk, Y. & van Die, I. M., 2008, In : Molecular Immunology. 45, 8, p. 2359-2369

Research output: Contribution to journalArticleAcademicpeer-review

Dendritic cells and C-type lectin receptors: coupling innate to adaptive immune responses

van Vliet, S. J., Garcia Vallejo, J. J. & van Kooyk, Y., 2008, In : Immunology and cell biology. 86, 7, p. 580-587

Research output: Contribution to journalArticleAcademicpeer-review

55 Downloads (Pure)

Dendritic cells and lymphotropic viruses: who is fooling whom?

de Witte, L. D., 2008

Research output: ThesisResearch VU University Amsterdam, graduation VU University AmsterdamAcademic

File

Dendritic cells mediate herpes simplex virus infection and transmission through the C-type lectin DC-SIGN

de Jong, M. A. W. P., de Witte, L., Bolmstedt, A., van Kooyk, Y. & Geijtenbeek, T. B. H., 2008, In : Journal of General Virology. 89, Pt 10, p. 2398-2409

Research output: Contribution to journalArticleAcademicpeer-review

Glycan modification of the tumor antigen gp100 targets DC-SIGN to enhance dendritic cell induced antigen presentation to T cells

Aarnoudse, C. A., Bax, M., Sanchez-Hernandez, M., Garcia Vallejo, J. J. & van Kooyk, Y., 2008, In : International Journal of Cancer. 122, 4, p. 839-846

Research output: Contribution to journalArticleAcademicpeer-review

Haematopoietic antigen-presenting cells in the human thymic cortex: evidence for a role in selection and removal of apoptotic thymocytes

Paessens, L. C., Fluitsma, D. M. & van Kooyk, Y., 2008, In : Journal of Pathology. 214, 1, p. 96-103

Research output: Contribution to journalArticleAcademicpeer-review

Interaction of SIGNR1 expressed by marginal zone macrophages with marginal zone B cells is essential to early IgM responses against Streptococcus pneumoniae

Koppel, E. A., Litjens, M., van den Berg, V., van Kooyk, Y. & Geijtenbeek, T. B. H., 2008, In : Molecular Immunology. 45, 10, p. 2881-2887

Research output: Contribution to journalArticleAcademicpeer-review

Leptospira interrogans is recognized through DC-SIGN and induces maturation and cytokine production by human dendritic cells

Gaudart, N., Ekpo, P., Pattanapanyasat, K., van Kooyk, Y. & Engering, A., 2008, In : FEMS Immunology and Medical Microbiology. 53, 3, p. 359-367

Research output: Contribution to journalArticleAcademicpeer-review

Protein-glycan interactions in the control of innate and adaptive immune responses

van Kooyk, Y. & Rabinovich, G. A., 2008, In : Nature Immunology. 9, 6, p. 593-601

Research output: Contribution to journalArticleAcademicpeer-review

S layer protein A of Lactobacillus acidophilus NCFM regulates immature dendritic cell and T cell functions

Konstantinov, S. R., Smidt, H., Vos, W. M., Bruijns, S. C., Singh, S. K., Valence, F., Molle, D., Lortal, S., Altermann, E., Klaenhammer, T. R. & van Kooyk, Y., 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 49, p. 19474-19479

Research output: Contribution to journalArticleAcademicpeer-review

Sweet preferences of MGL: carbohydrate specificity and function

van Vliet, S. J., Saeland, E. & van Kooyk, Y., 2008, In : Trends in Immunology. 29, 2, p. 83-90

Research output: Contribution to journalArticleAcademicpeer-review

The C-type lectin macrophage galactose-type lectin impedes migration of immature APCs

van Vliet, S. J., Paessens, L. C., Broks-van den Berg, V. C., Geijtenbeek, T. B. H. & van Kooyk, Y., 2008, In : Journal of Immunology. 181, 5, p. 3148-3155

Research output: Contribution to journalArticleAcademicpeer-review

The mannose cap of mycobacterial lipoarabinomannan does not dominate the Mycobacterium-host interaction

Appelmelk, B. J., den Dunnen, J. T., Driessen, N. N., Ummels, R., Pak, M., Nigou, J., Larrouy-Maumus, G., Gurcha, S. S., Movahedzadeh, F., Geurtsen, J., Brown, E. J., Eysink Smeets, M. M., Besra, G. S., Willemsen, P. T., Lowary, T. L., van Kooyk, Y., Maaskant, J. J., Stoker, N. G., van der Ley, P., Puzo, G. & 6 othersVandenbroucke-Grauls, C. M. J. E., Wieland, C. W., van der Poll, T., Geijtenbeek, T. B. H., van der Sar, A. M. & Bitter, W., 2008, In : Cellular Microbiology. 10, 4, p. 930-944

Research output: Contribution to journalArticleAcademicpeer-review

Vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) provide co-stimulation in positive selection along with survival of selected thymocytes

Paessens, L. C., Singh, S. K., Fernandes, R. J. & van Kooyk, Y., 2008, In : Molecular Immunology. 45, 1, p. 42-48

Research output: Contribution to journalArticleAcademicpeer-review

2007

Binding of human papilloma virus L1 virus-like particles to dendritic cells is mediated through heparan sulfates and induces immune activation

de Witte, L., Zoughlami, Y., Aengeneyndt, B., David, G., van Kooyk, Y., Gissmann, L. & Geijtenbeek, T. B. H., 2007, In : Immunobiology. 212, 9-10, p. 679-91 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB

Gringhuis, S. I., den Dunnen, J., Litjens, M., van Het Hof, B., van Kooyk, Y. & Geijtenbeek, T. B. H., May 2007, In : Immunity. 26, 5, p. 605-16 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Dendritic cell maturation results in pronounced changes in glycan expression affecting recognition by siglecs and galectins

Bax, M., García-Vallejo, J. J., Jang-Lee, J., North, S. J., Gilmartin, T. J., Hernández, G., Crocker, P. R., Leffler, H., Head, S. R., Haslam, S. M., Dell, A. & van Kooyk, Y., 15 Dec 2007, In : Journal of Immunology. 179, 12, p. 8216-24 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Innate signaling and regulation of Dendritic cell immunity

van Vliet, S. J., den Dunnen, J., Gringhuis, S. I., Geijtenbeek, T. B. & van Kooyk, Y., Aug 2007, In : Current Opinion in Immunology. 19, 4, p. 435-40 6 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Langerin is a natural barrier to HIV-1 transmission by Langerhans cells

de Witte, L., Nabatov, A., Pion, M., Fluitsma, D., de Jong, M. A. W. P., de Gruijl, T., Piguet, V., van Kooyk, Y. & Geijtenbeek, T. B. H., Mar 2007, In : Nature Medicine. 13, 3, p. 367-71 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

MGL-mediated internalization and antigen presentation by dendritic cells: a role for tyrosine-5

van Vliet, S. J., Aarnoudse, C. A., Broks-van den Berg, V. C. M., Boks, M., Geijtenbeek, T. B. H. & van Kooyk, Y., Aug 2007, In : European Journal of Immunology. 37, 8, p. 2075-81 7 p.

Research output: Contribution to journalArticleAcademicpeer-review