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Research Output 1989 2019

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2015

Trypanosoma cruzi Infection Imparts a Regulatory Program in Dendritic Cells and T Cells via Galectin-1-Dependent Mechanisms

Poncini, C. V., Ilarregui, J. M., Batalla, E. I., Engels, S., Cerliani, J. P., Cucher, M. A., van Kooyk, Y., Gonzalez-Cappa, S. M. & Rabinovich, G. A., 2015, In : Journal of Immunology. 195, 7, p. 3311-3324

Research output: Contribution to journalArticleAcademicpeer-review

2014

CNS myelin induces regulatory functions of DC-SIGN-expressing, antigen-presenting cells via cognate interaction with MOG

Garcia-Vallejo, J. J., Ilarregui, J. M., Kalay, H., Chamorro, S., Koning, N., Unger, W. W. J., Ambrosini, M., Montserrat, V., Fernandes, R. J., Bruijns, S. C. M., van Weering, J. R. T., Paauw, N. J., O'Toole, T. G., van Horssen, J., van der Valk, P., Nazmi, K., Bolscher, J. G., Bajramovic, J., Dijkstra, C. D., 't Hart, B. A. & 1 othersvan Kooyk, Y., 2014, In : Journal of Experimental Medicine. 211, 7, p. 1465-1483

Research output: Contribution to journalArticleAcademicpeer-review

DCIR interacts with ligands from both endogenous and pathogenic origin

Bloem, K., Vuist, I. M., van den Berk, M., Klaver, E. J., van Die, I. M., Knippels, L. M., Garssen, J., Garcia Vallejo, J. J., van Vliet, S. J. & van Kooyk, Y., 2014, In : Immunology Letters. 158, 1-2, p. 33-41

Research output: Contribution to journalArticleAcademicpeer-review

Effective Targeting of DC-SIGN by alpha-Fucosylamide Functionalized Gold Nanoparticles

Arosio, D., Chiodo, F., Reina, J. J., Marelli, M., Penades, S., van Kooyk, Y., Garcia Vallejo, J. J. & Bernardi, A., 2014, In : Bioconjugate chemistry. 25, 12, p. 2244-2251

Research output: Contribution to journalArticleAcademicpeer-review

Effects of Antigen-Expressing Immunostimulatory Liposomes on Chemotaxis and Maturation of Dendritic Cells In Vitro and in Human Skin Explants

Lanzi, A., Fehres, C. M., de Gruijl, T. D., van Kooyk, Y. & Mastrobattista, E., 2014, In : Pharmaceutical Research. 31, 2, p. 516-526

Research output: Contribution to journalArticleAcademicpeer-review

Topical rather than intradermal application of the TLR7 ligand imiquimod leads to human dermal dendritic cell maturation and CD8(+) T-cell cross-priming

Fehres, C. M., Bruijns, S. C. M., van Beelen, A. J., Kalay, H., Ambrosini, M., Hooijberg, E., Unger, W. W. J., de Gruijl, T. D. & van Kooyk, Y., 2014, In : European Journal of Immunology. 44, 8, p. 2415-2424

Research output: Contribution to journalArticleAcademicpeer-review

Understanding the biology of antigen cross-presentation for the design of vaccines against cancer

Fehres, C. M., Unger, W. W. J., Garcia Vallejo, J. J. & van Kooyk, Y., 2014, In : Frontiers in Microbiology. 5, 149.

Research output: Contribution to journalArticleAcademicpeer-review

2013

Glycan-based DC-SIGN targeting to enhance antigen cross-presentation in anticancer vaccines

Garcia Vallejo, J. J., Unger, W. W. J., Kalay, H. & van Kooyk, Y., 2013, In : OncoImmunology. 2, 2, e23040.

Research output: Contribution to journalArticleAcademicpeer-review

Glycan-based DC-SIGN targeting vaccines to enhance antigen cross-presentation

van Kooyk, Y., Unger, W. W. J., Fehres, C. M., Kalay, H. & Garcia Vallejo, J. J., 2013, In : Molecular Immunology. 55, 2, p. 143-145

Research output: Contribution to journalArticleAcademicpeer-review

Glycodendrimers prevent HIV transmission via DC-SIGN on dendritic cells

Garcia Vallejo, J. J., Koning, N., Ambrosini, M., Kalay, H., Vuist, I., Sarrami-Forooshani, R., Geijtenbeek, T. B. H. & van Kooyk, Y., 2013, In : International Immunology. 25, 4, p. 221-233

Research output: Contribution to journalArticleAcademicpeer-review

Intestinal Epithelium-Derived Galectin-9 Is Involved in the Immunomodulating Effects of Nondigestible Oligosaccharides

de Kivita, S., Kraneveld, A. D., Knippels, L. M. J., van Kooyk, Y., Garssen, J. & Willemsen, L. E. M., 2013, In : Journal of innate immunity. 5, 6, p. 625-638

Research output: Contribution to journalArticleAcademicpeer-review

Intradermal Delivery of TLR Agonists in a Human Explant Skin Model: Preferential Activation of Migratory Dendritic Cells by Polyribosinic-Polyribocytidylic Acid and Peptidoglycans

Oosterhoff, D., Heusinkveld, M., Lougheed, S. M., Kosten, I., Lindstedt, M., Bruijns, S. C. M., van Es, T., van Kooyk, Y., van der Burg, S. H. & de Gruijl, T. D., 2013, In : Journal of Immunology. 190, 7, p. 3338-3345

Research output: Contribution to journalArticleAcademicpeer-review

In vivo targeting of human DC-SIGN drastically enhances CD8(+) T-cell-mediated protective immunity

Hesse, C., Ginter, W., Forg, T., Mayer, C. T., Baru, A. M., Arnold-Schrauf, C., Unger, W. W. J., Kalay, H., van Kooyk, Y., Berod, L. & Sparwasser, T., 2013, In : European Journal of Immunology. 43, 10, p. 2543-2553

Research output: Contribution to journalArticleAcademicpeer-review

Ligand Binding and Signaling of Dendritic Cell Immunoreceptor (DCIR) Is Modulated by the Glycosylation of the Carbohydrate Recognition Domain

Bloem, K., Vuist, I. M., van der Plas, A. J., Knippels, L. M. J., Garssen, J., Garcia Vallejo, J. J., van Vliet, S. J. & van Kooyk, Y., 2013, In : PLoS ONE. 8, 6, e66266.

Research output: Contribution to journalArticleAcademicpeer-review

MGL signaling augments TLR2-mediated responses for enhanced IL-10 and TNF-alpha secretion

van Vliet, S. J., Bay, S., Vuist, I. M., Kalay, H., Garcia Vallejo, J. J., Leclerc, C. & van Kooyk, Y., 2013, In : Journal of Leukocyte Biology. 94, 2, p. 315-323

Research output: Contribution to journalArticleAcademicpeer-review

Multivalent glycopeptide dendrimers for the targeted delivery of antigens to dendritic cells

Garcia Vallejo, J. J., Ambrosini, M., Overbeek, A., van Riel, W. E., Bloem, K., Unger, W. W. J., Chiodo, F., Bolscher, J. G., Nazmi, K., Kalay, H. & van Kooyk, Y., 2013, In : Molecular Immunology. 53, 4, p. 387-397

Research output: Contribution to journalArticleAcademicpeer-review

Notch controls generation and function of human effector CD8+ T cells

Kuijk, L. M., Verstege, M. I., Rekers, N. V., Bruijns, S. C. M., Hooijberg, E., Roep, B. O., de Gruijl, T. D., van Kooyk, Y. & Unger, W. W. J., 2013, In : Blood. 121, 14, p. 2638-2646

Research output: Contribution to journalArticleAcademicpeer-review

Skin-resident antigen-presenting cells: instruction manual for vaccine development

Fehres, C. M., Garcia Vallejo, J. J., Unger, W. W. J. & van Kooyk, Y., 2013, In : Frontiers in Immunology: Molecular Innate Immunity. 4, 157.

Research output: Contribution to journalArticleAcademicpeer-review

The physiological role of DC-SIGN: A tale of mice and men

Garcia Vallejo, J. J. & van Kooyk, Y., 2013, In : Trends in Immunology. 34, 10, p. 482-486

Research output: Contribution to journalArticleAcademicpeer-review

2012

BODIPY-Labeled DC-SIGN-Targeting Glycodendrons Efficiently Internalize and Route to Lysosomes in Human Dendritic Cells

Ribeiro-Viana, R., Garcia Vallejo, J. J., Collado, D., Perez-Inestrosa, E., Bloem, K., van Kooyk, Y. & Rojo, J., 2012, In : Biomacromolecules. 13, 10, p. 3209-3219

Research output: Contribution to journalArticleAcademicpeer-review

Differential glycosylation of MUC1 and CEACAM5 between normal mucosa and tumour tissue of colon cancer patients

Saeland, E., Da Silva Aresta Belo, A. I., Mongera, S., van Die, I. M., Meijer, G. A. & van Kooyk, Y., 2012, In : International Journal of Cancer. 131, 1, p. 117-128

Research output: Contribution to journalArticleAcademicpeer-review

Galectin-9 induced by dietary synbiotics is involved in suppression of allergic symptoms in mice and humans

de Kivit, S., Saeland, E., Kraneveld, A. D., van de Kant, H. J. G., Schouten, B., van Esch, B. C. A. M., Knol, J., Sprikkelman, A. B., van der Aa, L. B., Knippels, L. M. J., Garssen, J., van Kooyk, Y. & Willemsen, L. E. M., 2012, In : Allergy. 67, 3, p. 343-352

Research output: Contribution to journalArticleAcademicpeer-review

Glycan-modified liposomes boost CD4(+) and CD8(+) T-cell responses by targeting DC-SIGN on dendritic cells

Unger, W. W. J., van Beelen, A. J., Bruijns, S. C. M., Joshi, M., Fehres, C. M., van Bloois, L., Verstege, M. I., Ambrosini, M., Kalay, H., Nazmi, K., Bolscher, J. G., Hooijberg, E., de Gruijl, T. D., Storm, G. & van Kooyk, Y., 2012, In : Journal of Controlled Release. 160, 1, p. 88-95

Research output: Contribution to journalArticleAcademicpeer-review

Glycobiology of immune responses

Rabinovich, G. A., van Kooyk, Y. & Cobb, B. A., 2012, In : Annals of the New York Academy of Sciences. 1253, p. 1-15

Research output: Contribution to journalArticleAcademicpeer-review

Online nanoliquid chromatography-mass spectrometry and nanofluorescence detection for high-resolution quantitative N-glycan analysis

Kalay, H., Ambrosini, M., van Berkel, P. H. C., Parren, P. W. H. I., van Kooyk, Y. & Garcia Vallejo, J. J., 2012, In : Analytical Biochemistry. 423, 1, p. 153-162

Research output: Contribution to journalArticleAcademicpeer-review

Specific glycan elements determine differential binding of individual egg glycoproteins of the human parasite Schistosoma mansoni by host C-type lectin receptors

Meevissen, M. H. J., Driessen, N. N., Smits, H. H., Versteegh, R., van Vliet, S. J., van Kooyk, Y., Schramm, G., Deelder, A. M., de Haas, H., Yazdanbakhsh, M. & Hokke, C. H., 2012, In : International Journal for Parasitology. 42, 3, p. 269-277

Research output: Contribution to journalArticleAcademicpeer-review

Targeting tumor antigens to dendritic cells using particulate carriers

Joshi, M. D., Unger, W. W. J., Storm, G., van Kooyk, Y. & Mastrobattista, E., 2012, In : Journal of Controlled Release. 161, 1, p. 25-37

Research output: Contribution to journalArticleAcademicpeer-review

2011
34 Downloads (Pure)

Campylobacter jejuni Lipooligosaccharides Modulate Dendritic Cell-Mediated T Cell Polarization in a Sialic Acid Linkage-Dependent Manner

Bax, M., Kuijf, M. L., Heikema, A. P., van Rijs, W., Bruijns, S. C. M., Garcia Vallejo, J. J., Crocker, P. R., Jacobs, B. C., van Vliet, S. J. & van Kooyk, Y., 2011, In : Infection and Immunity. 79, 7, p. 2681-2689

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

C-type Lectin Receptors for Tumor Eradication: Future Directions

Streng-Ouwehand, I., Unger, W. W. J. & Van Kooyk, Y., 8 Aug 2011, In : Cancers. 3, 3, p. 3169-88 20 p.

Research output: Contribution to journalArticleAcademicpeer-review

DC-SIGN mediated antigen-targeting using glycan-modified liposomes: Formulation considerations

Joshi, M. D., Unger, W. W. J., van Beelen, A. J., Bruijns, S. C. M., Litjens, M., van Bloois, L., Kalay, H., van Kooyk, Y. & Storm, G., 2011, In : International journal of pharmaceutics. 416, 2, p. 426-432

Research output: Contribution to journalArticleAcademicpeer-review

Designing polymeric particles for antigen delivery

De Koker, S., Lambrecht, B. N., Willart, M. A., van Kooyk, Y., Grooten, J., Vervaet, C., Remon, J. P. & De Geest, B. G., 2011, In : Chemical Society Reviews. 40, 1, p. 320-339

Research output: Contribution to journalArticleAcademicpeer-review

Design of neo-glycoconjugates that target the mannose receptor and enhance TLR-independent cross-presentation and Th1 polarization

Singh, S. K., Ouwehand, I., Litjens, M., Kalay, H., Burgdorf, S., Saeland, E., Kurts, C., Unger, W. W. J. & van Kooyk, Y., 2011, In : European Journal of Immunology. 41, 4, p. 916-925

Research output: Contribution to journalArticleAcademicpeer-review

'Dressed for success' C-type lectin receptors for the delivery of glyco-vaccines to dendritic cells

Unger, W. W. J. & van Kooyk, Y., 2011, In : Current Opinion in Immunology. 23, 1, p. 131-137

Research output: Contribution to journalArticleAcademicpeer-review

34 Downloads (Pure)

Galactosaminogalactan, a New Immunosuppressive Polysaccharide of Aspergillus fumigatus

Fontaine, T., Delangle, A., Simenel, C., Coddeville, B., van Vliet, S. J., van Kooyk, Y., Bozza, S., Moretti, S., Schwarz, F., Trichot, C., Aebi, M., Delepierre, M., Elbim, C., Romani, L. & Latge, J. P., 2011, In : PLoS Pathogens. 7, 11, e1002372.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

Highly glycosylated tumour antigens: interactions with the immune system

Saeland, E. & van Kooyk, Y., 2011, In : Biochemical Society Transactions. 39, p. 388-392

Research output: Contribution to journalArticleAcademicpeer-review

State of the union: glycobiology and immunology in the Canadian Rockies

Cobb, B. A., Rabinovich, G. A. & van Kooyk, Y., May 2011, In : Glycobiology. 21, 5, p. 545-546 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

Tumour-associated glycan modifications of antigen enhance MGL2 dependent uptake and MHC class I restricted CD8 T cell responses

Singh, S. K., Ouwehand, I., Litjens, M., Kalay, H., Saeland, E. & van Kooyk, Y., 2011, In : International Journal of Cancer. 128, 6, p. 1371-1383

Research output: Contribution to journalArticleAcademicpeer-review

2010

Schistosoma mansoni worm glycolipids induce an inflammatory phenotype in human dendritic cells by cooperation of TLR4 and DC-SIGN

van Stijn, C. M. W., Meyer, S., van den Broek, M., Bruijns, S. C. M., van Kooyk, Y., Geyer, R. & van Die, I. M., 2010, In : Molecular Immunology. 47, 7-8, p. 1544-1552

Research output: Contribution to journalArticleAcademicpeer-review

TLR4-Mediated Sensing of Campylobacter jejuni by Dendritic Cells Is Determined by Sialylation

Kuijf, M. L., Samsom, J. N., van Rijs, W., Bax, M., Huizinga, R., Heikema, A. P., van Doorn, P. A., van Belkum, A., van Kooyk, Y., Burgers, P. C., Luider, T. M., Endtz, H. P., Nieuwenhuis, E. E. S. & Jacobs, B. C., 2010, In : Journal of Immunology. 185, 1, p. 748-755

Research output: Contribution to journalArticleAcademicpeer-review

2009

Characterization of murine MGL1 and MGL2 C-type lectins: Distinct glycan specificities and tumor binding properties

Singh, S. K., Ouwehand, I., Litjens, M., Weelij, D. R., Garcia Vallejo, J. J., van Vliet, S. J., Saeland, E. & van Kooyk, Y., 2009, In : Molecular Immunology. 46, 6, p. 1240-1249

Research output: Contribution to journalArticleAcademicpeer-review

Endogenous ligands for C-type lectin receptors: the true regulators of immune homeostasis

Garcia Vallejo, J. J. & van Kooyk, Y., 2009, In : Immunological Reviews. 230, p. 22-37

Research output: Contribution to journalArticleAcademicpeer-review

Identification of pathogen receptors on dendritic cells to understand their function and to identify new drug targets

de Witte, L. D., de Jong, M. A. W. P., den Dunnen, J., van Kooyk, Y. & Geijtenbeek, T. B. H., 2009, In : Methods in Molecular Biology. 531, p. 267-285

Research output: Contribution to journalArticleAcademic

29 Downloads (Pure)

Interaction of Polysialic Acid with CCL21 Regulates the Migratory Capacity of Human Dendritic Cells

Bax, M., van Vliet, S. J., Litjens, M., Garcia Vallejo, J. J. & van Kooyk, Y., 2009, In : PLoS ONE. 4, 9, p. e6987 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells

Saeland, E., de Jong, M. A. W. P., Nabatov, A., Kalay, H., van Kooyk, Y. & Geijtenbeek, T. B. H., 2009, In : Molecular Immunology. 46, 11-12, p. 2309-2316

Research output: Contribution to journalArticleAcademicpeer-review

N-glycosylated proteins and distinct lipooligosaccharide glycoforms of Campylobacter jejuni target the human C-type lectin receptor MGL

van Sorge, N. M., Bleumink, N. M. C., van Vliet, S. J., Saeland, E., van der Pol, W. L., van Kooyk, Y. & van Putten, J. W., 2009, In : Cellular Microbiology. 11, 12, p. 1768-1781

Research output: Contribution to journalArticleAcademicpeer-review

Polyelectrolyte Microcapsules as Antigen Delivery Vehicles To Dendritic Cells: Uptake, Processing, and Cross-Presentation of Encapsulated Antigens

De Koker, S., De Geest, B. G., Singh, S. K., De Rycke, R., Naessens, T., van Kooyk, Y., Demeester, J., De Smedt, S. C. & Grooten, J., 2009, In : Angewandte Chemie International Edition in English. 48, 45, p. 8485-8489

Research output: Contribution to journalArticleAcademicpeer-review