[11C]flumazenil-PET. An image of the benzodiazepine receptor: De benzodiazepinereceptor in beeld

Y. P. Dijstelbloem, H. Verschoor, A. D. Windhorst, G. Luurtsema, A. A. Lammertsma, E. J F Franssen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Positron emission tomography (PET) is an imaging technology with clinical applications in diagnostics and pharmacological research. [11C]flumazenil is a PET-radiopharmaceutical suitable for identification of binding sites for benzodiazepines in the brain. [11C]flumazenil is a radiopharmaceutical with a short shelf-life, due to the short physical half-life of the carbon-II isotope (20 minutes). For this reason, a rapid radionuclide production, chemical synthesis, formulation, quality control and release procedure are required. PET using [11C]flumazenil is clinically applied to localise epileptic foci in the brain. In research, it is used to investigate changes in benzodiazepine receptor concentration and drug binding to receptors.

Translated title of the contribution[11C]flumazenil-PET. An image of the benzodiazepine receptor
Original languageDutch
Pages (from-to)416-422
Number of pages7
JournalPharmaceutisch Weekblad
Volume138
Issue number12
Publication statusPublished - 21 Mar 2003

Cite this

Dijstelbloem, Y. P., Verschoor, H., Windhorst, A. D., Luurtsema, G., Lammertsma, A. A., & Franssen, E. J. F. (2003). [11C]flumazenil-PET: De benzodiazepinereceptor in beeld. Pharmaceutisch Weekblad, 138(12), 416-422.
Dijstelbloem, Y. P. ; Verschoor, H. ; Windhorst, A. D. ; Luurtsema, G. ; Lammertsma, A. A. ; Franssen, E. J F. / [11C]flumazenil-PET : De benzodiazepinereceptor in beeld. In: Pharmaceutisch Weekblad. 2003 ; Vol. 138, No. 12. pp. 416-422.
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Dijstelbloem, YP, Verschoor, H, Windhorst, AD, Luurtsema, G, Lammertsma, AA & Franssen, EJF 2003, '[11C]flumazenil-PET: De benzodiazepinereceptor in beeld' Pharmaceutisch Weekblad, vol. 138, no. 12, pp. 416-422.

[11C]flumazenil-PET : De benzodiazepinereceptor in beeld. / Dijstelbloem, Y. P.; Verschoor, H.; Windhorst, A. D.; Luurtsema, G.; Lammertsma, A. A.; Franssen, E. J F.

In: Pharmaceutisch Weekblad, Vol. 138, No. 12, 21.03.2003, p. 416-422.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - [11C]flumazenil-PET

T2 - De benzodiazepinereceptor in beeld

AU - Dijstelbloem, Y. P.

AU - Verschoor, H.

AU - Windhorst, A. D.

AU - Luurtsema, G.

AU - Lammertsma, A. A.

AU - Franssen, E. J F

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AB - Positron emission tomography (PET) is an imaging technology with clinical applications in diagnostics and pharmacological research. [11C]flumazenil is a PET-radiopharmaceutical suitable for identification of binding sites for benzodiazepines in the brain. [11C]flumazenil is a radiopharmaceutical with a short shelf-life, due to the short physical half-life of the carbon-II isotope (20 minutes). For this reason, a rapid radionuclide production, chemical synthesis, formulation, quality control and release procedure are required. PET using [11C]flumazenil is clinically applied to localise epileptic foci in the brain. In research, it is used to investigate changes in benzodiazepine receptor concentration and drug binding to receptors.

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KW - Radioisotopes

KW - Receptors, GABA-A

KW - Tomography

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Dijstelbloem YP, Verschoor H, Windhorst AD, Luurtsema G, Lammertsma AA, Franssen EJF. [11C]flumazenil-PET: De benzodiazepinereceptor in beeld. Pharmaceutisch Weekblad. 2003 Mar 21;138(12):416-422.