Positron emission tomography (PET) is an imaging technology with clinical applications in diagnostics and pharmacological research. [11C]flumazenil is a PET-radiopharmaceutical suitable for identification of binding sites for benzodiazepines in the brain. [11C]flumazenil is a radiopharmaceutical with a short shelf-life, due to the short physical half-life of the carbon-II isotope (20 minutes). For this reason, a rapid radionuclide production, chemical synthesis, formulation, quality control and release procedure are required. PET using [11C]flumazenil is clinically applied to localise epileptic foci in the brain. In research, it is used to investigate changes in benzodiazepine receptor concentration and drug binding to receptors.
|Number of pages||7|
|Publication status||Published - 21 Mar 2003|