[11C]flumazenil-PET: De benzodiazepinereceptor in beeld

Y. P. Dijstelbloem; H. Verschoor; A. D. Windhorst; G. Luurtsema; A. A. Lammertsma; E. J F Franssen

[11C]flumazenil-PET: De benzodiazepinereceptor in beeld

Translated title of the contribution: [11C]flumazenil-PET. An image of the benzodiazepine receptor

Y. P. Dijstelbloem^*, H. Verschoor, A. D. Windhorst, G. Luurtsema, A. A. Lammertsma, E. J F Franssen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Positron emission tomography (PET) is an imaging technology with clinical applications in diagnostics and pharmacological research. [¹¹C]flumazenil is a PET-radiopharmaceutical suitable for identification of binding sites for benzodiazepines in the brain. [¹¹C]flumazenil is a radiopharmaceutical with a short shelf-life, due to the short physical half-life of the carbon-II isotope (20 minutes). For this reason, a rapid radionuclide production, chemical synthesis, formulation, quality control and release procedure are required. PET using [¹¹C]flumazenil is clinically applied to localise epileptic foci in the brain. In research, it is used to investigate changes in benzodiazepine receptor concentration and drug binding to receptors.

Translated title of the contribution	[11C]flumazenil-PET. An image of the benzodiazepine receptor
Original language	Dutch
Pages (from-to)	416-422
Number of pages	7
Journal	Pharmaceutisch Weekblad
Volume	138
Issue number	12
Publication status	Published - 21 Mar 2003

Cite this

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title = "[11C]flumazenil-PET: De benzodiazepinereceptor in beeld",

abstract = "Positron emission tomography (PET) is an imaging technology with clinical applications in diagnostics and pharmacological research. [11C]flumazenil is a PET-radiopharmaceutical suitable for identification of binding sites for benzodiazepines in the brain. [11C]flumazenil is a radiopharmaceutical with a short shelf-life, due to the short physical half-life of the carbon-II isotope (20 minutes). For this reason, a rapid radionuclide production, chemical synthesis, formulation, quality control and release procedure are required. PET using [11C]flumazenil is clinically applied to localise epileptic foci in the brain. In research, it is used to investigate changes in benzodiazepine receptor concentration and drug binding to receptors.",

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author = "Dijstelbloem, {Y. P.} and H. Verschoor and Windhorst, {A. D.} and G. Luurtsema and Lammertsma, {A. A.} and Franssen, {E. J F}",

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T2 - De benzodiazepinereceptor in beeld

AU - Dijstelbloem, Y. P.

AU - Verschoor, H.

AU - Windhorst, A. D.

AU - Luurtsema, G.

AU - Lammertsma, A. A.

AU - Franssen, E. J F

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AB - Positron emission tomography (PET) is an imaging technology with clinical applications in diagnostics and pharmacological research. [11C]flumazenil is a PET-radiopharmaceutical suitable for identification of binding sites for benzodiazepines in the brain. [11C]flumazenil is a radiopharmaceutical with a short shelf-life, due to the short physical half-life of the carbon-II isotope (20 minutes). For this reason, a rapid radionuclide production, chemical synthesis, formulation, quality control and release procedure are required. PET using [11C]flumazenil is clinically applied to localise epileptic foci in the brain. In research, it is used to investigate changes in benzodiazepine receptor concentration and drug binding to receptors.

KW - Drug compounding

KW - Emission-computed

KW - Flumazenil

KW - Radioisotopes

KW - Receptors, GABA-A

KW - Tomography

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JF - Pharmaceutisch Weekblad

SN - 0031-6911

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ER -

[11C]flumazenil-PET: De benzodiazepinereceptor in beeld

Abstract

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