18 F-Flortaucipir in TDP-43 associated frontotemporal dementia

R. Smith, A. F. Santillo, M. Landqvist Waldö, O. Strandberg, D. Berron, S. Vestberg, D. van Westen, J. van Swieten, M. Honer, O. Hansson

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Retention of 18 F-Flortaucipir is reportedly increased in the semantic variant of primary progressive aphasia (svPPA), which is dominated by TDP-43 pathology. However, it is unclear if 18 F-Flortaucipir is also increased in other TDP-43 diseases, such as bvFTD caused by a C9orf72 gene mutation. We therefore recruited six C9orf72 expansion carriers, six svPPA patients, and 54 healthy controls. All underwent 18 F-Flortaucipir PET and MRI scanning. Data from 39 Alzheimer’s Disease patients were used for comparison. PET tracer retention was assessed both at the region-of-interest (ROI) and at the voxel-level. Further, autoradiography using 3 H-Flortaucipir was performed. SvPPA patients exhibited higher 18 F-Flortaucipir retention in the lateral temporal cortex bilaterally according to ROI- and voxel-based analyses. In C9orf72 patients, 18 F-Flortaucipir binding was slightly increased in the inferior frontal lobes in the ROI based analysis, but these results were not replicated in the voxel-based analysis. Autoradiography did not show specific binding in svPPA cases or in C9orf72-mutation carriers. In conclusion, temporal lobe 18 F-Flortaucipir retention was observed in some cases of svPPA, but the uptake was of a lower magnitude compared to AD dementia. C9orf72-mutation carriers exhibited none or limited 18 F-Flortaucipir retention, indicating that 18 F-Flortaucipir binding in TDP-43 proteinopathies is not a general TDP-43 related phenomenon.
Original languageEnglish
Article number6082
JournalScientific Reports
Volume9
Issue number1
DOIs
Publication statusPublished - 2019
Externally publishedYes

Cite this

Smith, R., Santillo, A. F., Waldö, M. L., Strandberg, O., Berron, D., Vestberg, S., ... Hansson, O. (2019). 18 F-Flortaucipir in TDP-43 associated frontotemporal dementia. Scientific Reports, 9(1), [6082]. https://doi.org/10.1038/s41598-019-42625-9
Smith, R. ; Santillo, A. F. ; Waldö, M. Landqvist ; Strandberg, O. ; Berron, D. ; Vestberg, S. ; van Westen, D. ; van Swieten, J. ; Honer, M. ; Hansson, O. / 18 F-Flortaucipir in TDP-43 associated frontotemporal dementia. In: Scientific Reports. 2019 ; Vol. 9, No. 1.
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abstract = "Retention of 18 F-Flortaucipir is reportedly increased in the semantic variant of primary progressive aphasia (svPPA), which is dominated by TDP-43 pathology. However, it is unclear if 18 F-Flortaucipir is also increased in other TDP-43 diseases, such as bvFTD caused by a C9orf72 gene mutation. We therefore recruited six C9orf72 expansion carriers, six svPPA patients, and 54 healthy controls. All underwent 18 F-Flortaucipir PET and MRI scanning. Data from 39 Alzheimer’s Disease patients were used for comparison. PET tracer retention was assessed both at the region-of-interest (ROI) and at the voxel-level. Further, autoradiography using 3 H-Flortaucipir was performed. SvPPA patients exhibited higher 18 F-Flortaucipir retention in the lateral temporal cortex bilaterally according to ROI- and voxel-based analyses. In C9orf72 patients, 18 F-Flortaucipir binding was slightly increased in the inferior frontal lobes in the ROI based analysis, but these results were not replicated in the voxel-based analysis. Autoradiography did not show specific binding in svPPA cases or in C9orf72-mutation carriers. In conclusion, temporal lobe 18 F-Flortaucipir retention was observed in some cases of svPPA, but the uptake was of a lower magnitude compared to AD dementia. C9orf72-mutation carriers exhibited none or limited 18 F-Flortaucipir retention, indicating that 18 F-Flortaucipir binding in TDP-43 proteinopathies is not a general TDP-43 related phenomenon.",
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Smith, R, Santillo, AF, Waldö, ML, Strandberg, O, Berron, D, Vestberg, S, van Westen, D, van Swieten, J, Honer, M & Hansson, O 2019, '18 F-Flortaucipir in TDP-43 associated frontotemporal dementia' Scientific Reports, vol. 9, no. 1, 6082. https://doi.org/10.1038/s41598-019-42625-9

18 F-Flortaucipir in TDP-43 associated frontotemporal dementia. / Smith, R.; Santillo, A. F.; Waldö, M. Landqvist; Strandberg, O.; Berron, D.; Vestberg, S.; van Westen, D.; van Swieten, J.; Honer, M.; Hansson, O.

In: Scientific Reports, Vol. 9, No. 1, 6082, 2019.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Santillo, A. F.

AU - Waldö, M. Landqvist

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AU - Berron, D.

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AU - van Swieten, J.

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AU - Hansson, O.

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Smith R, Santillo AF, Waldö ML, Strandberg O, Berron D, Vestberg S et al. 18 F-Flortaucipir in TDP-43 associated frontotemporal dementia. Scientific Reports. 2019;9(1). 6082. https://doi.org/10.1038/s41598-019-42625-9