[18F]NaF PET/CT scan as an early marker of heterotopic ossification in fibrodysplasia ossificans progressiva

E. Marelise W. Eekhoff, Esmée Botman, J. Coen Netelenbos, Pim de Graaf, Nathalie Bravenboer, Dimitra Micha, Gerard Pals, Teun J. de Vries, Ton Schoenmaker, Max Hoebink, Adriaan A. Lammertsma, Pieter G.H.M. Raijmakers

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease with a progressive course characterized by episodically local flare-ups, which often but not always leads to heterotopic bone formation (HO).Recently, we showed that [18F]NaF PET/CT may be the first tool to monitor progression of a posttraumatic flare-up leading to new HO, which was demonstrated in a patient with FOP who underwent a maxillofacial surgery.This paper evaluates [18F]NaF PET/CT as a marker of FOP disease activity, comparing its use with other imaging modalities known in literature. In addition, the follow-up of a spontaneous flare-up in a 19-year old patient is presented showing high muscle [18F]NaF uptake in one defined part within the flare-up area after three weeks. During follow-up [18F]NaF PET /CT scan revealed newly formed heterotopic bone but only in this previously active [18F]NaF region. In conclusion, increased muscle [18F]NaF uptake may predict future HO development in FOP patients. At present [18F]NaF PET/CT appears to be a sensitive imaging modality to serve as a noninvasive marker for bone formation and to monitor disease activity during flare-ups in FOP.

Original languageEnglish
JournalBone
DOIs
Publication statusPublished - Apr 2018

Cite this

@article{2238eb857484454187c33e80c6280f9c,
title = "[18F]NaF PET/CT scan as an early marker of heterotopic ossification in fibrodysplasia ossificans progressiva",
abstract = "Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease with a progressive course characterized by episodically local flare-ups, which often but not always leads to heterotopic bone formation (HO).Recently, we showed that [18F]NaF PET/CT may be the first tool to monitor progression of a posttraumatic flare-up leading to new HO, which was demonstrated in a patient with FOP who underwent a maxillofacial surgery.This paper evaluates [18F]NaF PET/CT as a marker of FOP disease activity, comparing its use with other imaging modalities known in literature. In addition, the follow-up of a spontaneous flare-up in a 19-year old patient is presented showing high muscle [18F]NaF uptake in one defined part within the flare-up area after three weeks. During follow-up [18F]NaF PET /CT scan revealed newly formed heterotopic bone but only in this previously active [18F]NaF region. In conclusion, increased muscle [18F]NaF uptake may predict future HO development in FOP patients. At present [18F]NaF PET/CT appears to be a sensitive imaging modality to serve as a noninvasive marker for bone formation and to monitor disease activity during flare-ups in FOP.",
keywords = "Disease marker, Fibrodysplasia ossificans progressiva (FOP), Flare-up, Heterotopic ossification (HO), [18F]NaF PET/CT",
author = "Eekhoff, {E. Marelise W.} and Esm{\'e}e Botman and {Coen Netelenbos}, J. and {de Graaf}, Pim and Nathalie Bravenboer and Dimitra Micha and Gerard Pals and {de Vries}, {Teun J.} and Ton Schoenmaker and Max Hoebink and Lammertsma, {Adriaan A.} and Raijmakers, {Pieter G.H.M.}",
year = "2018",
month = "4",
doi = "10.1016/j.bone.2017.08.012",
language = "English",
journal = "Bone",
issn = "8756-3282",
publisher = "Elsevier Inc.",

}

[18F]NaF PET/CT scan as an early marker of heterotopic ossification in fibrodysplasia ossificans progressiva. / Eekhoff, E. Marelise W.; Botman, Esmée; Coen Netelenbos, J.; de Graaf, Pim; Bravenboer, Nathalie; Micha, Dimitra; Pals, Gerard; de Vries, Teun J.; Schoenmaker, Ton; Hoebink, Max; Lammertsma, Adriaan A.; Raijmakers, Pieter G.H.M.

In: Bone, 04.2018.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - [18F]NaF PET/CT scan as an early marker of heterotopic ossification in fibrodysplasia ossificans progressiva

AU - Eekhoff, E. Marelise W.

AU - Botman, Esmée

AU - Coen Netelenbos, J.

AU - de Graaf, Pim

AU - Bravenboer, Nathalie

AU - Micha, Dimitra

AU - Pals, Gerard

AU - de Vries, Teun J.

AU - Schoenmaker, Ton

AU - Hoebink, Max

AU - Lammertsma, Adriaan A.

AU - Raijmakers, Pieter G.H.M.

PY - 2018/4

Y1 - 2018/4

N2 - Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease with a progressive course characterized by episodically local flare-ups, which often but not always leads to heterotopic bone formation (HO).Recently, we showed that [18F]NaF PET/CT may be the first tool to monitor progression of a posttraumatic flare-up leading to new HO, which was demonstrated in a patient with FOP who underwent a maxillofacial surgery.This paper evaluates [18F]NaF PET/CT as a marker of FOP disease activity, comparing its use with other imaging modalities known in literature. In addition, the follow-up of a spontaneous flare-up in a 19-year old patient is presented showing high muscle [18F]NaF uptake in one defined part within the flare-up area after three weeks. During follow-up [18F]NaF PET /CT scan revealed newly formed heterotopic bone but only in this previously active [18F]NaF region. In conclusion, increased muscle [18F]NaF uptake may predict future HO development in FOP patients. At present [18F]NaF PET/CT appears to be a sensitive imaging modality to serve as a noninvasive marker for bone formation and to monitor disease activity during flare-ups in FOP.

AB - Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease with a progressive course characterized by episodically local flare-ups, which often but not always leads to heterotopic bone formation (HO).Recently, we showed that [18F]NaF PET/CT may be the first tool to monitor progression of a posttraumatic flare-up leading to new HO, which was demonstrated in a patient with FOP who underwent a maxillofacial surgery.This paper evaluates [18F]NaF PET/CT as a marker of FOP disease activity, comparing its use with other imaging modalities known in literature. In addition, the follow-up of a spontaneous flare-up in a 19-year old patient is presented showing high muscle [18F]NaF uptake in one defined part within the flare-up area after three weeks. During follow-up [18F]NaF PET /CT scan revealed newly formed heterotopic bone but only in this previously active [18F]NaF region. In conclusion, increased muscle [18F]NaF uptake may predict future HO development in FOP patients. At present [18F]NaF PET/CT appears to be a sensitive imaging modality to serve as a noninvasive marker for bone formation and to monitor disease activity during flare-ups in FOP.

KW - Disease marker

KW - Fibrodysplasia ossificans progressiva (FOP)

KW - Flare-up

KW - Heterotopic ossification (HO)

KW - [18F]NaF PET/CT

UR - http://www.scopus.com/inward/record.url?scp=85028308739&partnerID=8YFLogxK

U2 - 10.1016/j.bone.2017.08.012

DO - 10.1016/j.bone.2017.08.012

M3 - Article

JO - Bone

JF - Bone

SN - 8756-3282

ER -