Abstract

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease with a progressive course characterized by episodically local flare-ups, which often but not always leads to heterotopic bone formation (HO).Recently, we showed that [18F]NaF PET/CT may be the first tool to monitor progression of a posttraumatic flare-up leading to new HO, which was demonstrated in a patient with FOP who underwent a maxillofacial surgery.This paper evaluates [18F]NaF PET/CT as a marker of FOP disease activity, comparing its use with other imaging modalities known in literature. In addition, the follow-up of a spontaneous flare-up in a 19-year old patient is presented showing high muscle [18F]NaF uptake in one defined part within the flare-up area after three weeks. During follow-up [18F]NaF PET /CT scan revealed newly formed heterotopic bone but only in this previously active [18F]NaF region. In conclusion, increased muscle [18F]NaF uptake may predict future HO development in FOP patients. At present [18F]NaF PET/CT appears to be a sensitive imaging modality to serve as a noninvasive marker for bone formation and to monitor disease activity during flare-ups in FOP.

Original languageEnglish
Pages (from-to)143-146
JournalBone
Volume109
DOIs
Publication statusPublished - Apr 2018

Cite this

@article{2238eb857484454187c33e80c6280f9c,
title = "[18F]NaF PET/CT scan as an early marker of heterotopic ossification in fibrodysplasia ossificans progressiva",
abstract = "Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease with a progressive course characterized by episodically local flare-ups, which often but not always leads to heterotopic bone formation (HO).Recently, we showed that [18F]NaF PET/CT may be the first tool to monitor progression of a posttraumatic flare-up leading to new HO, which was demonstrated in a patient with FOP who underwent a maxillofacial surgery.This paper evaluates [18F]NaF PET/CT as a marker of FOP disease activity, comparing its use with other imaging modalities known in literature. In addition, the follow-up of a spontaneous flare-up in a 19-year old patient is presented showing high muscle [18F]NaF uptake in one defined part within the flare-up area after three weeks. During follow-up [18F]NaF PET /CT scan revealed newly formed heterotopic bone but only in this previously active [18F]NaF region. In conclusion, increased muscle [18F]NaF uptake may predict future HO development in FOP patients. At present [18F]NaF PET/CT appears to be a sensitive imaging modality to serve as a noninvasive marker for bone formation and to monitor disease activity during flare-ups in FOP.",
keywords = "Disease marker, Fibrodysplasia ossificans progressiva (FOP), Flare-up, Heterotopic ossification (HO), [18F]NaF PET/CT",
author = "Eekhoff, {E. Marelise W.} and Esm{\'e}e Botman and {Coen Netelenbos}, J. and {de Graaf}, Pim and Nathalie Bravenboer and Dimitra Micha and Gerard Pals and {de Vries}, {Teun J.} and Ton Schoenmaker and Max Hoebink and Lammertsma, {Adriaan A.} and Raijmakers, {Pieter G.H.M.}",
year = "2018",
month = "4",
doi = "10.1016/j.bone.2017.08.012",
language = "English",
volume = "109",
pages = "143--146",
journal = "Bone",
issn = "8756-3282",
publisher = "Elsevier Inc.",

}

[18F]NaF PET/CT scan as an early marker of heterotopic ossification in fibrodysplasia ossificans progressiva. / Eekhoff, E. Marelise W.; Botman, Esmée; Coen Netelenbos, J.; de Graaf, Pim; Bravenboer, Nathalie; Micha, Dimitra; Pals, Gerard; de Vries, Teun J.; Schoenmaker, Ton; Hoebink, Max; Lammertsma, Adriaan A.; Raijmakers, Pieter G.H.M.

In: Bone, Vol. 109, 04.2018, p. 143-146.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - [18F]NaF PET/CT scan as an early marker of heterotopic ossification in fibrodysplasia ossificans progressiva

AU - Eekhoff, E. Marelise W.

AU - Botman, Esmée

AU - Coen Netelenbos, J.

AU - de Graaf, Pim

AU - Bravenboer, Nathalie

AU - Micha, Dimitra

AU - Pals, Gerard

AU - de Vries, Teun J.

AU - Schoenmaker, Ton

AU - Hoebink, Max

AU - Lammertsma, Adriaan A.

AU - Raijmakers, Pieter G.H.M.

PY - 2018/4

Y1 - 2018/4

N2 - Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease with a progressive course characterized by episodically local flare-ups, which often but not always leads to heterotopic bone formation (HO).Recently, we showed that [18F]NaF PET/CT may be the first tool to monitor progression of a posttraumatic flare-up leading to new HO, which was demonstrated in a patient with FOP who underwent a maxillofacial surgery.This paper evaluates [18F]NaF PET/CT as a marker of FOP disease activity, comparing its use with other imaging modalities known in literature. In addition, the follow-up of a spontaneous flare-up in a 19-year old patient is presented showing high muscle [18F]NaF uptake in one defined part within the flare-up area after three weeks. During follow-up [18F]NaF PET /CT scan revealed newly formed heterotopic bone but only in this previously active [18F]NaF region. In conclusion, increased muscle [18F]NaF uptake may predict future HO development in FOP patients. At present [18F]NaF PET/CT appears to be a sensitive imaging modality to serve as a noninvasive marker for bone formation and to monitor disease activity during flare-ups in FOP.

AB - Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease with a progressive course characterized by episodically local flare-ups, which often but not always leads to heterotopic bone formation (HO).Recently, we showed that [18F]NaF PET/CT may be the first tool to monitor progression of a posttraumatic flare-up leading to new HO, which was demonstrated in a patient with FOP who underwent a maxillofacial surgery.This paper evaluates [18F]NaF PET/CT as a marker of FOP disease activity, comparing its use with other imaging modalities known in literature. In addition, the follow-up of a spontaneous flare-up in a 19-year old patient is presented showing high muscle [18F]NaF uptake in one defined part within the flare-up area after three weeks. During follow-up [18F]NaF PET /CT scan revealed newly formed heterotopic bone but only in this previously active [18F]NaF region. In conclusion, increased muscle [18F]NaF uptake may predict future HO development in FOP patients. At present [18F]NaF PET/CT appears to be a sensitive imaging modality to serve as a noninvasive marker for bone formation and to monitor disease activity during flare-ups in FOP.

KW - Disease marker

KW - Fibrodysplasia ossificans progressiva (FOP)

KW - Flare-up

KW - Heterotopic ossification (HO)

KW - [18F]NaF PET/CT

UR - http://www.scopus.com/inward/record.url?scp=85028308739&partnerID=8YFLogxK

U2 - 10.1016/j.bone.2017.08.012

DO - 10.1016/j.bone.2017.08.012

M3 - Article

VL - 109

SP - 143

EP - 146

JO - Bone

JF - Bone

SN - 8756-3282

ER -