1H magnetic resonance spectroscopy in human hydrocephalus

Kees P J Braun, Rob H J M Gooskens, W Peter Vandertop, Cees A F Tulleken, Jeroen van der Grond

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

PURPOSE: To evaluate cerebral metabolism in clinical hydrocephalus with (1)H magnetic resonance spectroscopy (MRS).

MATERIALS AND METHODS: In 24 children and adults with progressive, arrested, or normal pressure hydrocephalus, long-echo time (1)H MR spectra were acquired from periventricular white matter and intraventricular cerebrospinal fluid (CSF). Metabolite ratios, and the presence of lactate, were compared with 38 age-matched controls.

RESULTS: Metabolite ratios of patients were within the 95% confidence interval (CI) of controls. A small lactate resonance was detected in 20% of control and hydrocephalic subjects. Lactate was consistently visible in CSF spectra, though lactate concentrations were normal. The CSF lactate T(2) was long in comparison with the known intracellular metabolite T(2) relaxation times. In three neonates with hydrocephalus and spina bifida, 3-hydroxybutyrate was detected in CSF in vivo.

CONCLUSION: Within the limits of the present methods, (1)H MRS could not detect cerebral metabolic abnormalities in human hydrocephalus and provided no additional diagnostic information. The long T(2) of lactate in CSF explains its high visibility. Hence, the detection of lactate in spectra acquired from voxels that contain CSF does not necessarily imply cerebral ischemia.

Original languageEnglish
Pages (from-to)291-9
Number of pages9
JournalJournal of Magnetic Resonance Imaging
Volume17
Issue number3
DOIs
Publication statusPublished - Mar 2003

Cite this

Braun, K. P. J., Gooskens, R. H. J. M., Vandertop, W. P., Tulleken, C. A. F., & van der Grond, J. (2003). 1H magnetic resonance spectroscopy in human hydrocephalus. Journal of Magnetic Resonance Imaging, 17(3), 291-9. https://doi.org/10.1002/jmri.10270