25-Hydroxyvitamin D concentrations, asthma and eczema in childhood: The generation R study

Ilse I. M. Tromp, Oscar H. Franco, Edith H. van den Hooven, Annemieke C. Heijboer, Vincent W. V. Jaddoe, Liesbeth Duijts, Johan C. de Jongste, Henriëtte A. Moll, Jessica C. Kiefte-de Jong

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background & aims: A role of vitamin D in the development of respiratory and allergic disease in children remains unclear. It may be likely that vitamin D has an effect on airway inflammation, but only few studies examined the effect in children. We aimed to examine whether serum 25-hydroxyvitamin D (25(OH) vitamin D) concentrations are associated with the fraction of exhaled nitric oxide (FeNO), airway interrupter resistance (Rint), physician diagnosed asthma ever, wheezing and eczema in a population-based cohort study in 6 year old children. Methods: Serum 25(OH) vitamin D concentration was assessed in 3815 children. 25(OH) vitamin D concentrations ≥75 nmol/L were considered as sufficient, between 50 and 75 nmol/L as insufficient, and <50 nmol/L as deficient. FeNO and Rint were measured at the research center. Data on physician diagnosed asthma, wheezing, and eczema were obtained by parent-reported questionnaires. Results: In comparison with sufficient 25(OH) vitamin D concentration, deficient concentrations were associated with elevated FeNO of ≥25 ppb (OR: 2.54; 95% CI: 1.34–4.80). In addition, deficient and insufficient 25(OH) vitamin D concentrations were associated with a lower Rint (Z-score: −1.26; 95% CI: −1.66 to −0.85) (ß: −0.75; 95% CI: −1.08 to −0.42), and increased risks of eczema (OR: 1.65; 95% CI: 1.13–2.41) (OR: 1.44; 95% CI: 1.06–1.95). Insufficient 25(OH) vitamin D concentration were associated with a decreased risk of physician diagnosed asthma ever (OR: 0.59; 95% CI: 0.38–0.94). Conclusions: Our results indicate that lower 25(OH) vitamin D levels are associated with elevated FeNO levels, but lower Rint values. Lower 25(OH) vitamin D levels are also associated with a decreased risk for asthma diagnoses but an increased risk for eczema.
LanguageEnglish
Pages169-176
JournalClinical Nutrition
Volume37
Issue number1
DOIs
StatePublished - 2018

Cite this

Tromp, I. I. M., Franco, O. H., van den Hooven, E. H., Heijboer, A. C., Jaddoe, V. W. V., Duijts, L., ... Kiefte-de Jong, J. C. (2018). 25-Hydroxyvitamin D concentrations, asthma and eczema in childhood: The generation R study. Clinical Nutrition, 37(1), 169-176. DOI: 10.1016/j.clnu.2016.11.019
Tromp, Ilse I. M. ; Franco, Oscar H. ; van den Hooven, Edith H. ; Heijboer, Annemieke C. ; Jaddoe, Vincent W. V. ; Duijts, Liesbeth ; de Jongste, Johan C. ; Moll, Henriëtte A. ; Kiefte-de Jong, Jessica C./ 25-Hydroxyvitamin D concentrations, asthma and eczema in childhood: The generation R study. In: Clinical Nutrition. 2018 ; Vol. 37, No. 1. pp. 169-176
@article{604721a624e8493e87982075377b4fde,
title = "25-Hydroxyvitamin D concentrations, asthma and eczema in childhood: The generation R study",
abstract = "Background & aims: A role of vitamin D in the development of respiratory and allergic disease in children remains unclear. It may be likely that vitamin D has an effect on airway inflammation, but only few studies examined the effect in children. We aimed to examine whether serum 25-hydroxyvitamin D (25(OH) vitamin D) concentrations are associated with the fraction of exhaled nitric oxide (FeNO), airway interrupter resistance (Rint), physician diagnosed asthma ever, wheezing and eczema in a population-based cohort study in 6 year old children. Methods: Serum 25(OH) vitamin D concentration was assessed in 3815 children. 25(OH) vitamin D concentrations ≥75 nmol/L were considered as sufficient, between 50 and 75 nmol/L as insufficient, and <50 nmol/L as deficient. FeNO and Rint were measured at the research center. Data on physician diagnosed asthma, wheezing, and eczema were obtained by parent-reported questionnaires. Results: In comparison with sufficient 25(OH) vitamin D concentration, deficient concentrations were associated with elevated FeNO of ≥25 ppb (OR: 2.54; 95{\%} CI: 1.34–4.80). In addition, deficient and insufficient 25(OH) vitamin D concentrations were associated with a lower Rint (Z-score: −1.26; 95{\%} CI: −1.66 to −0.85) ({\ss}: −0.75; 95{\%} CI: −1.08 to −0.42), and increased risks of eczema (OR: 1.65; 95{\%} CI: 1.13–2.41) (OR: 1.44; 95{\%} CI: 1.06–1.95). Insufficient 25(OH) vitamin D concentration were associated with a decreased risk of physician diagnosed asthma ever (OR: 0.59; 95{\%} CI: 0.38–0.94). Conclusions: Our results indicate that lower 25(OH) vitamin D levels are associated with elevated FeNO levels, but lower Rint values. Lower 25(OH) vitamin D levels are also associated with a decreased risk for asthma diagnoses but an increased risk for eczema.",
author = "Tromp, {Ilse I. M.} and Franco, {Oscar H.} and {van den Hooven}, {Edith H.} and Heijboer, {Annemieke C.} and Jaddoe, {Vincent W. V.} and Liesbeth Duijts and {de Jongste}, {Johan C.} and Moll, {Henri{\"e}tte A.} and {Kiefte-de Jong}, {Jessica C.}",
year = "2018",
doi = "10.1016/j.clnu.2016.11.019",
language = "English",
volume = "37",
pages = "169--176",
journal = "Clinical Nutrition",
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}

Tromp, IIM, Franco, OH, van den Hooven, EH, Heijboer, AC, Jaddoe, VWV, Duijts, L, de Jongste, JC, Moll, HA & Kiefte-de Jong, JC 2018, '25-Hydroxyvitamin D concentrations, asthma and eczema in childhood: The generation R study' Clinical Nutrition, vol. 37, no. 1, pp. 169-176. DOI: 10.1016/j.clnu.2016.11.019

25-Hydroxyvitamin D concentrations, asthma and eczema in childhood: The generation R study. / Tromp, Ilse I. M.; Franco, Oscar H.; van den Hooven, Edith H.; Heijboer, Annemieke C.; Jaddoe, Vincent W. V.; Duijts, Liesbeth; de Jongste, Johan C.; Moll, Henriëtte A.; Kiefte-de Jong, Jessica C.

In: Clinical Nutrition, Vol. 37, No. 1, 2018, p. 169-176.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - 25-Hydroxyvitamin D concentrations, asthma and eczema in childhood: The generation R study

AU - Tromp,Ilse I. M.

AU - Franco,Oscar H.

AU - van den Hooven,Edith H.

AU - Heijboer,Annemieke C.

AU - Jaddoe,Vincent W. V.

AU - Duijts,Liesbeth

AU - de Jongste,Johan C.

AU - Moll,Henriëtte A.

AU - Kiefte-de Jong,Jessica C.

PY - 2018

Y1 - 2018

N2 - Background & aims: A role of vitamin D in the development of respiratory and allergic disease in children remains unclear. It may be likely that vitamin D has an effect on airway inflammation, but only few studies examined the effect in children. We aimed to examine whether serum 25-hydroxyvitamin D (25(OH) vitamin D) concentrations are associated with the fraction of exhaled nitric oxide (FeNO), airway interrupter resistance (Rint), physician diagnosed asthma ever, wheezing and eczema in a population-based cohort study in 6 year old children. Methods: Serum 25(OH) vitamin D concentration was assessed in 3815 children. 25(OH) vitamin D concentrations ≥75 nmol/L were considered as sufficient, between 50 and 75 nmol/L as insufficient, and <50 nmol/L as deficient. FeNO and Rint were measured at the research center. Data on physician diagnosed asthma, wheezing, and eczema were obtained by parent-reported questionnaires. Results: In comparison with sufficient 25(OH) vitamin D concentration, deficient concentrations were associated with elevated FeNO of ≥25 ppb (OR: 2.54; 95% CI: 1.34–4.80). In addition, deficient and insufficient 25(OH) vitamin D concentrations were associated with a lower Rint (Z-score: −1.26; 95% CI: −1.66 to −0.85) (ß: −0.75; 95% CI: −1.08 to −0.42), and increased risks of eczema (OR: 1.65; 95% CI: 1.13–2.41) (OR: 1.44; 95% CI: 1.06–1.95). Insufficient 25(OH) vitamin D concentration were associated with a decreased risk of physician diagnosed asthma ever (OR: 0.59; 95% CI: 0.38–0.94). Conclusions: Our results indicate that lower 25(OH) vitamin D levels are associated with elevated FeNO levels, but lower Rint values. Lower 25(OH) vitamin D levels are also associated with a decreased risk for asthma diagnoses but an increased risk for eczema.

AB - Background & aims: A role of vitamin D in the development of respiratory and allergic disease in children remains unclear. It may be likely that vitamin D has an effect on airway inflammation, but only few studies examined the effect in children. We aimed to examine whether serum 25-hydroxyvitamin D (25(OH) vitamin D) concentrations are associated with the fraction of exhaled nitric oxide (FeNO), airway interrupter resistance (Rint), physician diagnosed asthma ever, wheezing and eczema in a population-based cohort study in 6 year old children. Methods: Serum 25(OH) vitamin D concentration was assessed in 3815 children. 25(OH) vitamin D concentrations ≥75 nmol/L were considered as sufficient, between 50 and 75 nmol/L as insufficient, and <50 nmol/L as deficient. FeNO and Rint were measured at the research center. Data on physician diagnosed asthma, wheezing, and eczema were obtained by parent-reported questionnaires. Results: In comparison with sufficient 25(OH) vitamin D concentration, deficient concentrations were associated with elevated FeNO of ≥25 ppb (OR: 2.54; 95% CI: 1.34–4.80). In addition, deficient and insufficient 25(OH) vitamin D concentrations were associated with a lower Rint (Z-score: −1.26; 95% CI: −1.66 to −0.85) (ß: −0.75; 95% CI: −1.08 to −0.42), and increased risks of eczema (OR: 1.65; 95% CI: 1.13–2.41) (OR: 1.44; 95% CI: 1.06–1.95). Insufficient 25(OH) vitamin D concentration were associated with a decreased risk of physician diagnosed asthma ever (OR: 0.59; 95% CI: 0.38–0.94). Conclusions: Our results indicate that lower 25(OH) vitamin D levels are associated with elevated FeNO levels, but lower Rint values. Lower 25(OH) vitamin D levels are also associated with a decreased risk for asthma diagnoses but an increased risk for eczema.

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UR - https://www.ncbi.nlm.nih.gov/pubmed/28017448

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Tromp IIM, Franco OH, van den Hooven EH, Heijboer AC, Jaddoe VWV, Duijts L et al. 25-Hydroxyvitamin D concentrations, asthma and eczema in childhood: The generation R study. Clinical Nutrition. 2018;37(1):169-176. Available from, DOI: 10.1016/j.clnu.2016.11.019