Find Research Outputs

1989

A comparison of the cardioprotective effects of calcium antagonists from different classes upon ischaemic damage in the guinea-pig working heart

Hugtenburg, J. G., Mathy, M. J., Veldsema-Currie, R. D., Boddeke, H. W. G. M., Beekeringh, J. J. & van Zwieten, P. A., 1 Jan 1989, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 340, 1, p. 126-134 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

A controlled trial of methionyl growth hormone therapy in prepubertal children with short stature, subnormal growth rate and normal growth hormone response to secretagogues

Wit, J. M., Rietveld, D. H. F., Drop, S. L. S., Oostdijk, W., Gons, M., Otten, B. J., Delemarre-Van de Waal, H. A., Reeser, M., Waelkens, J. J. J. & Bot, A., 1 Jan 1989, In : Acta Paediatrica Scandinavica. 78, 3, p. 426-435 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Activity of the folate analog 10-ethyl, 10-deaza-aminopterin (10-EdAM) against human head and neck cancer xenografts

Brown, D. H., Braakhuis, B. J. M., Van Dongen, G. A. M. S., Van Walsum, M., Bagnay, M. & Snow, G. B., 1 Dec 1989, In : Anticancer Research. 9, 6, p. 1549-1552 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Alpha 2-adrenoceptor-mediated modulation of noradrenaline release is decreased in vas deferens but not in cerebral cortex of diabetic rats

Drukarch, B., Schepens, E., Heimans, J. J. & Stoof, J. C., Jul 1989, In : Journal of the Neurological Sciences. 91, 3, p. 293-9 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Anti‐tumor and differentiation‐inducing activity of n,n‐dimethylformamide (dmf) in head‐and‐neck cancer xenografts

Van Dongen, G. A. M. S., Braakhuis, B. J. M., Leyva, A., Hendriks, H. R., Kipp, B. B. A., Bagnay, M. & Snow, G. B., 1 Jan 1989, In : International Journal of Cancer. 43, 2, p. 285-292 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

A peptidoglycan protein complex purified from M. leprae cell walls contains most or all immunodominant M. leprae T-cell antigens

Mutis, T., Van Schooten, W. C. A. & De Vries, R. R. P., 1 Jan 1989, In : International Journal of Leprosy. 57, 4, p. 788-793 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

17 Downloads (Pure)

A progress report of a phase I study of interferon-gamma and interleukin-2 and some comments on the mechanism of the toxicity due to Interleukin-2

Wagstaff, J., Vermorken, J. B., Schwartsmann, G., Scheper, R. J., Hack, C. E., Nuijens, J. H., Eerenberg-Belmer, A. J. M. & Pinedo, H. M., 1989, In : Cancer Treatment Reviews. 16, Suppl. A, p. 105-109

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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A theoretical and experimental investigation of acid catalyzed rearrangements of small [n]cyclophanes

Kostermans, G. B. M., Kwakman, P. J., Pouwels, P. J. W., Somsen, G., De Wolf, W. H. & Bicklehaupt, F., 1 Jan 1989, In : Journal of Physical Organic Chemistry. 2, 4, p. 331-348 18 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cardioprotective effect of trimetazidine and nifedipine in guinea-pig hearts subjected to ischaemia

Hugtenburg, J. G., Jap, T. J. W., Mathy, M. J., Van Heiningen, P. N. M., Bohnenn, V. A., Heijnis, J. B., Boddeke, H. W. G. M. & Van Zwieten, P. A., 1 Jan 1989, In : Archives Internationales de Pharmacodynamie et de Therapie. 300, p. 186-208 23 p.

Research output: Contribution to journalArticleAcademicpeer-review

26 Downloads (Pure)

Chemotherapy in advanced soft tissue sarcomas

Verwey, J., van Groeningen, C. J. & Pinedo, H. M., 1989, Treatment of soft tissue sarcomas. Kluwer Academic Publishers, p. 75-92

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Open Access
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Cloning and expression in Escherichia coli of Haemophilus influenzae fimbrial genes establishes adherence to oropharyngeal epithelial cells

Van Ham, S. M., Mooi, F. R., Sindhunata, M. G., Maris, W. R. & Van Alphen, L., 1 Jan 1989, In : EMBO Journal. 8, 11, p. 3535-3540 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Collaboration between general practitioners and specialists in patients with cancer

Van der Wouden, J. C. & Dokter, H. J., 1 Jan 1989, In : Huisarts en Wetenschap. 32, 2, p. 51-55 5 p.

Research output: Contribution to journalArticleProfessional

3 Downloads (Pure)

Correlation of multidrug distribution, and increased P-glycoprotein expression in cultured SW-1573 human lung tumor cells

Keizer, H. G., Schuurhuis, G. J., Broxterman, H. J., Lankelma, J., Schoonen, W. G. E. J., van Rijn, J., Pinedo, H. M. & Joenje, H., 1989, In : Cancer Research. 49, p. 2988-2993

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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Cytotoxicity of methotrexate and trimetrexate and its reversal by folinic acid in human leukemic CCRF-CEM cells with carrier-mediated and receptor-mediated folate uptake

van der Veer, L. J., Westerhof, G. R., Rijksen, G., Schornagel, J. H. & Jansen, G., 1989, In : Leukemia Research. 13, 11, p. 981-7 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Differences between negative inotropic and vasodilator effects of calcium antagonists acting on extra- and intracellular calcium movements in rat and guinea-pig cardiac preparations

Hugtenburg, J. G., Mathy, M. J., Boddeke, H. W. G. M., Beckeringh, J. J. & van Zwieten, P. A., 1 Jan 1989, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 340, 5, p. 567-575 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Doppler studies in red cell isoimmunization

Bilardo, C. M., Nicolaides, K. H. & Campbell, S., 1989, In : Clinical Obstetrics and Gynecology. 32, 4, p. 719-727

Research output: Contribution to journalArticleAcademicpeer-review

17 Downloads (Pure)

Effect of artificial electron acceptors on the cytotoxicity of mitomycin C and doxorubicin in human lung tumor cells

Keizer, H. G., de Leeuw, J., van Rijn, J., Pinedo, H. M. & Joenje, H., 1989, In : European Journal of Cancer and Clinical Oncology. 25, 7, p. 1113-1118

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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1 Downloads (Pure)

Effect of inhibitors of flavoprotein activity on the cytotoxicity of adriamycin and mitomycin C in human lung tumor cells

Keizer, H. G., de Leeuw, S. J., van Rijn, J., Pinedo, H. M. & Joenje, H., 1989, In : European Journal of Cancer and Clinical Oncology. 25, p. 1113-1119

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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Effects of the pure antiandrogen RU 23.903 (anandron) on sexuality, aggression, and mood in male-to-female transsexuals

van Kemenade, J. F. L. M., Cohen-Kettenis, P. T., Cohen, L. & Gooren, L. J. G., 1 Jun 1989, In : Archives of Sexual Behavior. 18, 3, p. 217-228 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

3 Downloads (Pure)

Enhanced therapeutic efficacy of 5'deoxy-5-fluorouridine in 5-fluorouracil resistant head and neck tumours in relation to 5-fluorouracil metabolic ezymes

Peters, G. J., Braakhuis, B. J. M., de Bruyn, E. A., Laurensse, E. J., van Walsum, M. & Pinedo, H. M., 1989, In : British Journal of Cancer. 59, p. 327-334

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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Enhancement of LFA-1-mediated cell adhesion by triggering through CD2 or CD3 on T lymphocytes

van Kooyk, Y., van de Wiel-van Kemenade, P., Weder, P., Kuijpers, T. W. & Figdor, C. G., 14 Dec 1989, In : Nature. 342, 6251, p. 811-3 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Expression of a folate binding protein in L1210 cells grown in low folate medium

Jansen, G., Kathmann, I., Rademaker, B. C., Braakhuis, B. J., Westerhof, G. R., Rijksen, G. & Schornagel, J. H., 15 Apr 1989, In : Cancer Research. 49, 8, p. 1959-63 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

15 Downloads (Pure)

Fluoropyrimidine metabolism in human head and neck cancer xenografts and murine colon tumors

Laurensse, E., Braakhuis, B. J. M., Pinedo, H. M. & Peters, G. J., 1989, In : Advances in Experimental Medicine and Biology. 253B, p. 327-334

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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Gd-DTPA enhanced MRI in the assessment of myocardial reperfusion

De Roos, A., Doornbos, J., Matheijssen, N., Van der Laarse, A. & Van der Wall, E., 1 Dec 1989, In : MedicaMundi. 34, 3, p. 99-102 4 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Glycolysis in P-glycoprotein overexpressing human tumor cell lines. Effects of resistance modifying and lysosomotropic agents

Broxterman, H. J., Pinedo, H. M., Kuiper, C. M., Schuurhuis, G. J. & Lankelma, J., 1989, In : FEBS Letters. 247, 2, p. 405-410

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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High energy shock waves do not affect either primary tumor growth or metastasis of prostate carcinoma, R3327-MatLyLu

Geldof, A. A., De Voogt, H. J. & Rao, B. R., 1 Jan 1989, In : Urological Research. 17, 1, p. 9-12 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Histopathological changes in the spinal cord after 434 MHz microwave hyperthermia in the cervical region of the rat

Sminia, P., Troost, D. & Haveman, J., 1 Jan 1989, In : International journal of hyperthermia. 5, 1, p. 85-98 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

How to define hormone-resistance.

de Voogt, H. J., Rao, R. B. & Geldof, A. A., 1 Jan 1989, In : Progress in clinical and biological research. 303, p. 325-329 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

15 Downloads (Pure)

Human pharmacokinetics of carboplatin after oral administration

Pinedo, H. M., van Hennik, M. B., van der Vijgh, W. J. F., Klein, I. & Vermorken, J. B., 1989, In : Cancer Chemotherapy and Pharmacology. 23, p. 126-127

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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Identification of a membrane-associated folate-binding protein in human leukemic CCRF-CEM cells with transport-related methotrexate resistance

Jansen, G., Westerhof, G. R., Kathmann, I., Rademaker, B. C., Rijksen, G. & Schornagel, J. H., 1 May 1989, In : Cancer Research. 49, 9, p. 2455-9 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

17 Downloads (Pure)

Immunohistochemical detection and quantitation of p-glycoprotein in multiple drug-resistant human myeloma cells: association with level of drug resistance and drug accumulation

Dalton, W. S., Grogan, T. M., Rybski, J. A., Scheper, R. J., Richter, L., Kailey, J., Broxterman, H. J. & Pinedo, H. M., 1989, In : Blood. 73, 3, p. 747-752

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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23 Downloads (Pure)

Immunohistochemical detection of P glycoprotein in human tumor cells with a low degree of drug resistance

Broxterman, H. J., Pinedo, H. M., Kuiper, C. M., van der Hoeven, J. M., de Lange, P., Quak, J. J., Scheper, R. J., Keizer, H. G., Schuurhuis, G. J. & Lankelma, J., 1989, In : International Journal of Cancer. 43, p. 340-343

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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Improved detection of acute myocardial infarction by magnetic resonance imaging using Gadolinium-DTPA

van Dijkman, P. R. M., Doornbos, J., de Roos, A., van der Laarse, A., Postema, S., Matheijssen, N. A. A., Bruschke, A. V. G., Voorthuisen, A. E. V., Cats, V. M. & van der Wall, E. E., 1 Mar 1989, In : The International Journal of Cardiac Imaging. 5, 1, p. 1-8 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Influence of the mesocortical dopaminergic system on activity, food hoarding, social-agonistic behavior, and spatial delayed alternation in male rats

Stam, C. J., de Bruin, J. P., van Haelst, A. M., van der Gugten, J. & Kalsbeek, A., Feb 1989, In : Behavioral Neuroscience. 103, 1, p. 24-35 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Interaction of N-hydroxy(sulfo) succinimide active esters with the reduced folate/methotrexate transport system from human leukemic CCRF-CEM cells

Jansen, G., Westerhof, G. R., Rijksen, G. & Schornagel, J. H., 3 Nov 1989, In : Biochimica et Biophysica Acta. Reviews on Cancer. 985, 3, p. 266-70 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Interferon-gamma-increased adherence of lymphocytes to high endothelial venules

Hendriks, H. R., Korn, C., Mebius, R. E. & Kraal, G., Oct 1989, In : Immunology. 68, 2, p. 221-6 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

17 Downloads (Pure)

In vitro and in vivo inhibition of thymidylate synthase of human colon cancer by 5-fluorouracil

Peters, G. J., Laurensse, E., van Groeningen, C. J., Meijer, S. & Pinedo, H. M., 1989, In : Advances in Experimental Medicine and Biology. 253A, p. 439-445

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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19 Downloads (Pure)

Lack of effectiveness of combined 5 fluorouracil and leucovorin in patients with 5 fluorouracil resistant advanced colorectal cancer

van Groeningen, C. J., Peters, G. & Pinedo, H. M., 1989, In : European Journal of Cancer and Clinical Oncology. 25, p. 45-49

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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Localization and imaging of radiolabelled monoclonal antibody against squamous‐cell carcinoma of the head and neck in tumor‐bearing nude mice

Quak, J. J., Balm, A. J. M., Brakkee, J. G. P., Scheper, R. J., Haisma, H. J., Braakhuis, B. J. M., Meijer, C. J. L. M. & Snow, G. B., 1 Jan 1989, In : International Journal of Cancer. 44, 3, p. 534-538 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Matrix structure representation of a medical knowledge base

Kerkhof, P. L. M., 1 Dec 1989, p. 1832-1833. 2 p.

Research output: Contribution to conferencePaperAcademic

Medical applications of artificial intelligence and information systems.

Finkelstein, S. M., Kerkhof, P. L. & Okada, M., 1 May 1989, In : IEEE Transactions on Biomedical Engineering. 36, 5, p. 501-502 2 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Metastasis of prostate tumor cells to bronchus associated lymphoid tissue

Geldof, A. A. & Rao, B. R., 1 Jan 1989, In : In vivo. 3, 2, p. 87-91 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Downloads (Pure)

Mucocutaneous side effects of brequinar sodium

Schwartsmann, G., Bork, E., Vermorken, J. B., Nieboer, C., Dodion, P., ten Bokkel Huinink, W. W., Hansen, N., Armand, J. P., Winograd, B., Gall, H., Pinedo, H. M. & Seldenrijk, A., 1989, In : Cancer. 63, p. 243-248

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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New anti-ischaemic drugs: cytoprotective action with no primary haemodynamic effects

Boddeke, E., Hugtenburg, J., Jap, W., Heynis, J. & Zwieten, P. V., 1 Jan 1989, In : Trends in Pharmacological Sciences. 10, 10, p. 397-400 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Nucleotide sequence comparison of five human pepsinogen A (PGA) genes: evolution of the PGA multigene family

Evers, M. P., Zelle, B., Bebelman, J. P., van Beusechem, V., Kraakman, L., Hoffer, M. J., Pronk, J. C., Mager, W. H., Planta, R. J., Eriksson, A. W. & Frants, R., Apr 1989, In : Genomics. 4, 3, p. 232-9 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

OVULATION INDUCTION, IN-VITRO FERTILISATION, AND NEURAL TUBE DEFECTS

Cornel, M. C., Ten Kate, L. P. & Te Meerman, G. J., 30 Dec 1989, In : The Lancet. 334, 8678-8679, 1 p.

Research output: Contribution to journalLetterAcademicpeer-review

OVULATION INDUCTION AND NEURAL TUBE DEFECTS

Cornel, M. C., Ten Kate, L. P., Graham Dukes, M. N., de Jong-VD Berg, L. T. W., Meyboom, R. H. B., Garbis, H. & Peters, P. W. J., 17 Jun 1989, In : The Lancet. 333, 8651, 1 p.

Research output: Contribution to journalLetterAcademicpeer-review