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• 2020

  Brain γ-Tocopherol Levels Are Associated with Presynaptic Protein Levels in Elderly Human Midfrontal Cortex

  de Leeuw, F. A., Honer, W. G., Schneider, J. A. & Morris, M. C., 2020, In : Journal of Alzheimer's disease : JAD. 77, 2, p. 619-627 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Breast cancer-induced immune suppression in the sentinel lymph node is effectively countered by CpG-B in conjunction with inhibition of the JAK2/STAT3 pathway

  van Pul, K. M., Vuylsteke, R. J. C. L. M., de Beijer, M. T. A., van de Ven, R., van den Tol, M. P., Stockmann, H. B. A. C. & de Gruijl, T. D., 12 Oct 2020, In : Journal for Immunotherapy of Cancer. 8, 2, 000761.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Breast Implant Prevalence in the Dutch Female Population Assessed by Chest Radiographs

  de Boer, M., van Middelkoop, M., Hauptmann, M., van der Bijl, N., Bosmans, J. A. W., Hendriks-Brouwer, N., Schop, S. J., de Boer, J. P., Hijmering, N. J., Overbeek, L. I. H., Lobbes, M. B. I., Klazen, C. A. H., de Jong, D., Rakhorst, H. A., van der Hulst, R. R. W. J. & van Leeuwen, F. E., 2020, In : Aesthetic Surgery Journal. 40, 2, p. 156-164 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Breath-synchronized electrical stimulation of the expiratory muscles in mechanically ventilated patients: a randomized controlled feasibility study and pooled analysis

  Jonkman, A. H., Frenzel, T., McCaughey, E. J., McLachlan, A. J., Boswell-Ruys, C. L., Collins, D. W., Gandevia, S. C., Girbes, A. R. J., Hoiting, O., Kox, M., Oppersma, E., Peters, M., Pickkers, P., Roesthuis, L. H., Schouten, J., Shi, Z-H., Veltink, P. H., de Vries, H. J., Shannon Weickert, C., Wiedenbach, C. & 5 others, Zhang, Y., Tuinman, P. R., de Man, A. M. E., Butler, J. E. & Heunks, L. M. A., 1 Dec 2020, In : Critical Care. 24, 1, 628.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Bumetanide for Core Symptoms of Autism Spectrum Disorder (BAMBI): a Single Center, Double-Blinded, Participant-Randomized, Placebo-Controlled, Phase 2, Superiority Trial

  Sprengers, J., Van Andel, D. M., Zuithoff, N. P. A., Keijzer-Veen, M. G., Schulp, A. J. A., Scheepers, F. E., Lilien, M. R., Oranje, B. & Bruining, H., 2020, (Accepted/In press) In : Journal of the American Academy of Child and Adolescent Psychiatry.

  Research output: Contribution to journal › Article › Academic › peer-review

• Can a biomarker triage test reduce colonoscopy burden in fecal immunochemical test screening?

  Greuter, M. J., Carvalho, B., Wit, M. D., Dekker, E., Spaander, M. C., Meijer, G. A., Engeland, M. V. & Coupé, V. M., 1 Jun 2020, In : Journal of comparative effectiveness research. 9, 8, p. 563-571 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Cancer risk stratification of anal intraepithelial neoplasia in HIV-positive men by validated methylation markers associated with progression to cancer

  van der Zee, R. P., Richel, O., van Noesel, C. J. M., Ciocănea-Teodorescu, I., van Splunter, A. P., Ter Braak, T. J., Nathan, M., Cuming, T., Sheaff, M., Kreuter, A., Meijer, C. J. L. M., Quint, W. G. V., de Vries, H. J. C., Prins, J. M. & Steenbergen, R. D. M., 8 Apr 2020, In : Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

  Research output: Contribution to journal › Article › Academic › peer-review

• Cannabinoids and psychotic symptoms: A potential role for a genetic variant in the P2X purinoceptor 7 (P2RX7) gene

  Boks, M. P., He, Y., Schubart, C. D., Gastel, W. V., Elkrief, L., Huguet, G., Eijk, K. V., Vinkers, C. H., Kahn, R. S., Paus, T., Conrod, P., Hol, E. M. & de Witte, L. D., 1 Jan 2020, (Accepted/In press) In : Brain, Behavior, and Immunity. 88, 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Can the PROPER intervention reduce psychotropic drug prescription in nursing home residents with dementia? Results of a cluster-randomized controlled trial

  Smeets, C. H. W., Smalbrugge, M., Koopmans, R. T. C. M., Nelissen-Vrancken, M. H. J. M. G., Van Der Spek, K., Teerenstra, S., Gerritsen, D. L. & Zuidema, S. U., 1 Jan 2020, (Accepted/In press) In : International Psychogeriatrics.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Carbamazepine en quetiapine: een onderbelichte, maar zeer relevante interactie

  van der Gaag, S., Kupka, R. W. & Bet, P. M., 1 Jan 2020, In : Tijdschrift voor Psychiatrie. 62, 9, p. 794-797 4 p.

  Research output: Contribution to journal › Article › Professional

• Carbohydrate-based adjuvants

  Garcia-Vello, P., Speciale, I., Chiodo, F., Molinaro, A. & De Castro, C., 2020, (Accepted/In press) In : Drug Discovery Today: Technologies.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access

• Carcinoembryonic antigen-specific, fluorescent image-guided cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for metastatic colorectal cancer

  Schaap, D. P., de Valk, K. S., Deken, M. M., Meijer, R. P. J., Burggraaf, J., Vahrmeijer, A. L., Kusters, M. & on behalf of the SGM-101 study group, 1 Jan 2020, In : British Journal of Surgery. 107, 4, 4 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Cardiac dysfunction in cancer patients: beyond direct cardiomyocyte damage of anticancer drugs: novel cardio-oncology insights from the joint 2019 meeting of the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart

  Tocchetti, C. G., Ameri, P., de Boer, R. A., D'Alessandra, Y., Russo, M., Sorriento, D., Ciccarelli, M., Kiss, B., Bertrand, L., Dawson, D., Falcao-Pires, I., Giacca, M., Hamdani, N., Linke, W. A., Mayr, M., van der Velden, J., Zacchigna, S., Ghigo, A., Hirsch, E., Lyon, A. R. & 5 others, Görbe, A., Ferdinandy, P., Madonna, R., Heymans, S. & Thum, T., 1 Sep 2020, In : Cardiovascular Research. 116, 11, p. 1820-1834 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• CardioMEMS: the next revolution in heart failure management?

  Handoko, M. L. & van de Bovenkamp, A. A., 1 Jan 2020, In : Netherlands Heart Journal. 28, 1, p. 14-15 2 p.

  Research output: Contribution to journal › Comment/Letter to the editor › Academic

  Open Access

• Cardiovascular Event Risk in Rheumatoid Arthritis Compared with Type 2 Diabetes: A 15-year Longitudinal Study

  Agca, R., Hopman, L. H. G. A., Laan, K. J. C., van Halm, V. P., Peters, M. J. L., Smulders, Y. M., Dekker, J. M., Nijpels, G., Stehouwer, C. D. A., Voskuyl, A. E., Boers, M., Lems, W. F. & Nurmohamed, M. T., 1 Mar 2020, In : Journal of Rheumatology. 47, 3, p. 316-324 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Cardiovascular risk after hypertensive disorders of pregnancy in women with and without inheritable Thrombophilia

  Schonewille, N. N., Abheiden, C. N. H., Bokslag, A., Thijs, A., De Groot, C. J. M., De Vries, J. I. P. & De Boer, M. A., 1 Jan 2020, (Accepted/In press) In : Hypertension in Pregnancy. 39, 2, 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Cardiovascular risk in ankylosing spondylitis and the effect of anti-TNF drugs: a narrative review

  Atzeni, F., Nucera, V., Galloway, J., Zoltán, S. & Nurmohamed, M., May 2020, In : Expert Opinion on Biological Therapy. 20, 5, p. 517-524 8 p.

  Research output: Contribution to journal › Review article › Academic › peer-review

• Cardiovascular risk in inflammatory arthritis: rheumatoid arthritis and gout

  Hansildaar, R., Vedder, D., Baniaamam, M., Tausche, A. K., Gerritsen, M. & Nurmohamed, M. T., 2020, (Accepted/In press) In : The Lancet Rheumatology.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access

• Cardiovascular risk in persons at risk of developing rheumatoid arthritis

  van Boheemen, L., van Beers-Tas, M. H., Kroese, J. M., van de Stadt, L. A., van Schaardenburg, D. & Nurmohamed, M. T., 1 Jan 2020, In : PLoS ONE. 15, 8, p. e0237072 e0237072.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Case of the month from the Netherlands Cancer Institute, Amsterdam: how to differentiate between benign and malignant prostatic cysts

  Veerman, H., van Leeuwen, P. J., Bekers, E. & van der Poel, H. G., 1 Aug 2020, In : BJU International. 126, 2, p. 240-244 5 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Case report: Candida krusei spondylitis in an immunocompromised patient

  Overgaauw, A. J. C., de Leeuw, D. C., Stoof, S. P., van Dijk, K., Bot, J. C. J. & Hendriks, E. J., 8 Oct 2020, In : BMC Infectious Diseases. 20, 1, 739.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• CCL23: A Chemokine Associated with Progression from Mild Cognitive Impairment to Alzheimer's Disease

  Faura, J., Bustamante, A., Penalba, A., Giralt, D., Simats, A., Martínez-Sáez, E., Alcolea, D., Fortea, J., Lleó, A., Teunissen, C. E., Van Der Flier, W. M., Ibañez, L., Harari, O., Cruchaga, C., Hernández-Guillamón, M., Delgado, P. & Montaner, J., 1 Jan 2020, In : Journal of Alzheimer's Disease. 73, 4, p. 1585-1595 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• cCOG: A web-based cognitive test tool for detecting neurodegenerative disorders

  Rhodius-Meester, H. F. M., Paajanen, T., Koikkalainen, J., Mahdiani, S., Bruun, M., Baroni, M., Lemstra, A. W., Scheltens, P., Herukka, S-K., Pikkarainen, M., Hall, A., Hänninen, T., Ngandu, T., Kivipelto, M., van Gils, M., Hasselbalch, S. G., Mecocci, P., Remes, A., Soininen, H., van der Flier, W. M. & 1 others, Lötjönen, J., 2020, In : Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 12, 1, p. e12083

  Research output: Contribution to journal › Article › Academic › peer-review

• CDH6 and HAGH protein levels in plasma associate with Alzheimer’s disease in APOE ε4 carriers

  Ahmad, S., Milan, M. D. C., Hansson, O., Demirkan, A., Agustin, R., Sáez, M. E., Giagtzoglou, N., Cabrera-Socorro, A., Bakker, M. H. M., Ramirez, A., Hankemeier, T., Stomrud, E., Mattsson-Carlgren, N., Scheltens, P., van der Flier, W. M., Ikram, M. A., Malarstig, A., Teunissen, C. E., Amin, N. & van Duijn, C. M., 1 Dec 2020, In : Scientific Reports. 10, 1, 8233.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Cells derived from human long bone appear more differentiated and more actively stimulate osteoclastogenesis compared to alveolar bone-derived cells

  Kelder, C., Kleverlaan, C. J., Gilijamse, M., Bakker, A. D. & de Vries, T. J., 2 Jul 2020, In : International Journal of Molecular Sciences. 21, 14, p. 1-17 17 p., 5072.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Cellular, mitochondrial and molecular alterations associate with early left ventricular diastolic dysfunction in a porcine model of diabetic metabolic derangement

  Heinonen, I., Sorop, O., van Dalen, B. M., Wüst, R. C. I., van de Wouw, J., de Beer, V. J., Octavia, Y., van Duin, R. W. B., Hoogstrate, Y., Blonden, L., Alkio, M., Anttila, K., Stubbs, A., van der Velden, J., Merkus, D. & Duncker, D. J., 1 Dec 2020, In : Scientific Reports. 10, 1, 13173.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Cellular senescence impairs the reversibility of pulmonary arterial hypertension

  van der Feen, D. E., Bossers, G. P. L., Hagdorn, Q. A. J., Moonen, J. R., Kurakula, K., Szulcek, R., Chappell, J., Vallania, F., Donato, M., Kok, K., Kohli, J. S., Petersen, A. H., van Leusden, T., Demaria, M., Goumans, M. J. T. H., De Boer, R. A., Khatri, P., Rabinovitch, M., Berger, R. M. F. & Bartelds, B., 29 Jul 2020, In : Science Translational Medicine. 12, 554, eaaw4974.

  Research output: Contribution to journal › Article › Academic › peer-review

• Cerebral blood flow and cognitive functioning in patients with disorders along the heart–brain axis: Cerebral blood flow and the heart–brain axis

  Leeuwis, A. E., Hooghiemstra, A. M., Bron, E. E., Kuipers, S., Oudeman, E. A., Kalay, T., Brunner-La Rocca, H. P., Kappelle, L. J., van Oostenbrugge, R. J., Greving, J. P., Niessen, W. J., van Buchem, M. A., van Osch, M. J. P., van Rossum, A. C., Prins, N. D., Biessels, G. J., Barkhof, F., van der Flier, W. M. & Heart–Brain Connection consortium, 1 Jan 2020, (Accepted/In press) In : Alzheimer's and Dementia: Translational Research and Clinical Interventions.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Cerebral Blood Flow in Patients with Severe Aortic Valve Stenosis Undergoing Transcatheter Aortic Valve Implantation

  Vlastra, W., van Nieuwkerk, A. C., Bronzwaer, A-S. G. T., Versteeg, A., Bron, E. E., Niessen, W. J., Mutsaerts, H. J. M. M., van der Ster, B. J. P., Majoie, C. B. L. M., Biessels, G. J., Nederveen, A. J., Daemen, M. J. A. P., van Osch, M. J. P., Baan, J., Piek, J. J., van Lieshout, J. J. & Delewi, R., 2020, In : Journal of the American Geriatrics Society.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Cerebral cortical microinfarcts: A novel MRI marker of vascular brain injury in patients with heart failure

  Ferro, D., van den Brink, H., Amier, R., van Buchem, M., de Bresser, J., Bron, E., Brunner-La Rocca, H. P., Hooghiemstra, A., Marcks, N., van Rossum, A., Biessels, G. J. & Heart-Brain Connection Consortium, 1 Jan 2020, (Accepted/In press) In : International Journal of Cardiology. 310, 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Cerebral effects of glucagon-like peptide-1 receptor blockade before and after Roux-en-Y gastric bypass surgery in obese women: A proof-of-concept resting-state functional MRI study

  van Duinkerken, E., Bernardes, G., van Bloemendaal, L., Veltman, D. J., Barkhof, F., Mograbi, D. C., Gerdes, V. E. A., Deacon, C. F., Holst, J. J., Drent, M. L., Diamant, M., Ten Kulve, J. & Ijzerman, R. G., 20 Oct 2020, In : Diabetes, Obesity and Metabolism.

  Research output: Contribution to journal › Article › Academic › peer-review

• Cerebral Microangiopathy in Leukoencephalopathy With Cerebral Calcifications and Cysts: A Pathological Description

  Helman, G., Viaene, A. N., Takanohashi, A., Breur, M., Berger, R., Woidill, S., Cottrell, J. R., Schiffmann, R., Crow, Y. J., Simons, C., Bugiani, M. & Vanderver, A., 2020, In : Journal of Child Neurology.

  Research output: Contribution to journal › Article › Academic › peer-review

• Cerebral Organoids: A Human Model for AAV Capsid Selection and Therapeutic Transgene Efficacy in the Brain

  Depla, J. A., Sogorb-Gonzalez, M., Mulder, L. A., Heine, V. M., Konstantinova, P., van Deventer, S. J., Wolthers, K. C., Pajkrt, D., Sridhar, A. & Evers, M. M., 11 Sep 2020, In : Molecular Therapy - Methods and Clinical Development. 18, p. 167-175 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Cerebroplacental ratio in predicting adverse perinatal outcome: a meta-analysis of individual participant data

  Vollgraff Heidweiller-Schreurs, C. A., van Osch, I. R., Heymans, M. W., Ganzevoort, W., Schoonmade, L. J., Bax, C. J., Mol, B. W. J., de Groot, C. J. M., Bossuyt, P. M. M., de Boer, M. A. & the CPR IPD Study Group, 1 Jan 2020, (Accepted/In press) In : BJOG: An International Journal of Obstetrics and Gynaecology.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Challenges for immunotherapy in multiple myeloma: Bone marrow microenvironment-mediated immune suppression and immune resistance

  Holthof, L. C. & Mutis, T., Apr 2020, In : Cancers. 12, 4, 988.

  Research output: Contribution to journal › Review article › Academic › peer-review

  Open Access

• Challenges in timing puberty suppression for gender-Nonconforming adolescents

  de Vries, A. L. C., 1 Dec 2020, In : Pediatrics. 146, 4, e2020010611.

  Research output: Contribution to journal › Comment/Letter to the editor › Academic

• Challenging listening environments in higher education: an analysis of academic classroom acoustics

  van den Heuij, K., Goverts, T., Neijenhuis, K. & Coene, M., 2020, In : Journal of Applied Research in Higher Education.

  Research output: Contribution to journal › Article › Academic › peer-review

• Changes in countermovement jump performance and subjective readiness-to-train scores following a simulated soccer match

  Lombard, W., Starling, L., Wewege, L. & Lambert, M., 1 Jan 2020, (Accepted/In press) In : European Journal of Sport Science.

  Research output: Contribution to journal › Article › Academic › peer-review

• Changes in gastric anatomy after delivery of breath-hold MR-guided SABR for adrenal metastases

  van Sörnsen de Koste, J. R., Palacios, M. A., Chen, H., Schneiders, F. L., Bruynzeel, A. M. E., Slotman, B. J., Haasbeek, C. J. A. & Senan, S., 1 Nov 2020, In : Radiotherapy and Oncology. 152, p. 26-29 4 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Characteristics and help-seeking behavior of people failing a smart device self-test for hearing

  Schönborn, D., Asmail, F. M., De Sousa, K. C., Laplante-Lévesque, A., Moore, D. R., Smits, C. & Swanepoel, D. W., 1 Jan 2020, In : American Journal of Audiology. 29, 3, p. 365-374 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Characterization of Macrophage Galactose-type Lectin (MGL) Ligands in Colorectal Cancer Cell Lines

  Pirro, M., Rombouts, Y., Stella, A., Neyrolles, O., Burlet-Schiltz, O., van Vliet, SJ., de Ru, A., Mohammed, Y., Wuhrer, M., van Veelen, P. A. & Hensbergen, P., 2020, In : Biochimica et Biophysica Acta (BBA) - General Subjects. 1864, 4, 129513.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Characterization of Mechanical Signature of Eutopic Endometrial Stromal Cells of Endometriosis Patients

  Altayyeb, A., Othman, E., Khashbah, M., Esmaeel, A., El-Mokhtar, M., Lambalk, C., Mijatovic, V. & Abdelgawad, M., 1 Jan 2020, In : Reproductive Sciences. 27, 1, p. 364-374 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Characterizing diversity in the tumor-immune microenvironment of distinct subclasses of gastroesophageal adenocarcinomas

  Derks, S., de Klerk, L. K., Xu, X., Fleitas, T., Liu, K. X., Liu, Y., Dietlein, F., Margolis, C., Chiaravalli, A. M., Da Silva, A. C., Ogino, S., Akarca, F. G., Freeman, G. J., Rodig, S. J., Hornick, J. L., van Allen, E., Li, B., Liu, S. X., Thorsson, V. & Bass, A. J., Aug 2020, In : Annals of Oncology. 31, 8, p. 1011-1020 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Chemical synthesis of glycans up to a 128-mer relevant to the O-antigen of Bacteroides vulgatus

  Chiodo, F., 18 Aug 2020, In : Nature Communications. 11, 1, 4142.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Child and parent perceived determinants of children’s inadequate sleep health. A concept mapping study

  Belmon, L. S., Busch, V., van Stralen, M. M., Stijnman, D. P. M., Hidding, L. M., Harmsen, I. A. & Chinapaw, M. J. M., 1 Mar 2020, In : International Journal of Environmental Research and Public Health. 17, 5, 1583.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Childbirth Experience Associated With Maternal and Paternal Stress During the First Year, but Not Child Attachment

  Holopainen, A., Verhage, M. L. & Oosterman, M., 8 Sep 2020, In : Frontiers in Psychiatry. 11, 562394.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Child development at 6 years after maternal cancer diagnosis and treatment during pregnancy

  The International Network on Cancer, Infertility and Pregnancy (INCIP), 1 Oct 2020, In : European Journal of Cancer. 138, p. 57-67 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Childhood overweight and obesity and the risk of depression across the lifespan

  Gibson-Smith, D., Halldorsson, T. I., Bot, M., Brouwer, I. A., Visser, M., Thorsdottir, I., Birgisdottir, B. E., Gudnason, V., Eiriksdottir, G., Launer, L. J., Harris, T. B. & Gunnarsdottir, I., 21 Jan 2020, In : BMC Pediatrics. 20, 1, p. 25 1 p., 25.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Childhood trauma and attachment style predict the four-year course of obsessive compulsive disorder: Findings from the Netherlands obsessive compulsive disorder study

  Tibi, L., van Oppen, P., van Balkom, A. J. L. M., Eikelenboom, M., Hendriks, G-J. & Anholt, G. E., 2020, In : Journal of Affective Disorders. 264, p. 206-214 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Childhood trauma and dysregulation of multiple biological stress systems in adulthood: Results from the Netherlands Study of Depression and Anxiety (NESDA)

  Kuzminskaite, E., Vinkers, C. H., Elzinga, B. M., Wardenaar, K. J., Giltay, E. J. & Penninx, B. W. J. H., 1 Nov 2020, In : Psychoneuroendocrinology. 121, 104835.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access