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1988

Mitomycin C injucted organ toxicity in wistar rats. A study with special focus in the kidney

Verwey, J., Kerpel Fronius, S., Stuurman, M., van Friet, A. J., van Hattum, A. H., de Vries, J. & Pinedo, H. M., 1988, In : Journal of Cancer Research and Clinical Oncology. 114, p. 137-141

Research output: Contribution to journalArticleAcademicpeer-review

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Morphometric study of myocardial changes during doxorubicin induced cardiomyopathy in mice

van der Vijgh, W. J. F., van Velzen, D., van der Poort, S. E. J. M., Schlüper, H. M. M., Mross, K., Feyen, J. & Pinedo, H. M., 1988, In : European Journal of Cancer and Clinical Oncology. 24, 10, p. 1603-1608

Research output: Contribution to journalArticleAcademicpeer-review

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Negative phase II trial of menogaril in advanced squamous, adeno and large cell carcinoma of the lung

Joss, R. A., Monfardini, S., Hansen, H., Dombernowsky, P., Renard, J. & Pinedo, H. M., 1988, In : European Journal of Cancer and Clinical Oncology. 24, 2, p. 263-265

Research output: Contribution to journalArticleAcademicpeer-review

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Peters, G.J. A sensitive nonradioactive assay for pyrimidine nucleoside phosphorylase using reverse phase high performance liquid chromatography

Laurensse, E., Pinedo, H. M. & Peters, G. J., 1988, In : Clinica Chimica Acta. 178, p. 71-78

Research output: Contribution to journalArticleAcademicpeer-review

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Pharmacokinetics and metabolism of epirubicin and doxorubicin in humans

Mross, K., Maessen, P., van der Vijgh, W. J. F., Gall, H., Boven, E. & Pinedo, H. M., 1988, In : Journal of Clinical Oncology. 6, p. 517-526

Research output: Contribution to journalArticleAcademicpeer-review

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Pharmacokinetics of 5 fluorouracil assesses with a sensitive mass spectrometric method in patients on a dose escalation schedule

van Groeningen, C. J., Pinedo, H. M., Heddes, J., Kok, R. M., de Jong, A. P. J. M., Wattel, E., Peters, G. J. & Lankelma, J., 1988, In : Cancer Research. 48, p. 6956-6961

Research output: Contribution to journalArticleAcademicpeer-review

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Pharmacokinetics of brequinar sodium (NSC 368390; DUP 785) in cerebrospinal Fluid

Schwartsmann, G., van der Vijgh, W. J. F., Klein, I., van Groeningen, C. J., Vermorken, J. B. & Pinedo, H. M., 1988, In : European Journal of Cancer and Clinical Oncology. 24, 12, p. 1903-1904

Research output: Contribution to journalArticleAcademicpeer-review

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Pharmacokinetics of free and total platinum species after rapid and prolonged infusions of aqua(l,l-bis(aminomethylcyclohexane) sulfatoplatinum(11) (spiroplatin) during phase I trial

van der Vijgh, W. J. F., Elferink, F., Vermorken, J. B., ten Bokkel Huinink, W. W., Klein, I., Gall, H., Simonetti, G., McVie, J. G. & Pinedo, H. M., 1988, In : European Journal of Cancer and Clinical Oncology. 24, p. 621-627

Research output: Contribution to journalArticleAcademicpeer-review

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Phase II study of Iroplatin (CHIP, JM 9) in advanced testicular cancers progressing after prior chemotherapy

Clavel, M., Montfardini, S., Gundersen, S., Kaye, S., Siegenthaler, P., Renard, J., van Glabbeke, M. & Pinedo, H. M., 1988, In : European Journal of Cancer and Clinical Oncology. 24, 8, p. 1345-1348

Research output: Contribution to journalArticleAcademicpeer-review

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Phase II study of TCNU in advanced breast cancer

Dombernowsky, P., Clavel, M., Smyth, J. F., Howell, A., van Glabekke, M., Renard, J. & Pinedo, H. M., 1988, In : European Journal of Cancer and Clinical Oncology. 24, 8, p. 1377-1378

Research output: Contribution to journalArticleAcademicpeer-review

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Pinedo, H.M. Pharmacokinetics and toxicity of mitomycin C in rodents, given alone, in combination, or after induction of microsomal drug metabolism

Kerper-Fronius, S., Verweij, J., Stuurman, M., Kanyar, B., Lelieveld, P. & Pinedo, H. M., 1988, In : Cancer Chemotherapy and Pharmacology. 22, p. 104-108

Research output: Contribution to journalArticleAcademicpeer-review

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Pinedo H.M. Monoclonal antibody JSB-l detects a highly conserved epitope on the P-glycoprotein associated with multidrug resistance.

Scheper, R. J., Bulte, W. J. M., Brakkee, J. G. P., Quak, J. J., Schoot, E. V. D., Palm, A. J. M., Meijer, C. J. L. M., Broxterman, H. J., Kuiper, C. M., Lankelma, J. & Pinedo, H. M., 1988, In : International Journal of Cancer. 42, p. 389-394

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Preclinical antitumor activity of 5-aza-2′-deoxycytidine agains human head and neck cancer xenografts

Braakhuis, B. J. M., van Dongen, G. A. M. S., van Walsum, M., Leyva, A. & Snow, G. B., 1 Dec 1988, In : Investigational New Drugs. 6, 4, p. 299-304 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Preclinical phase II studies in human tumor lines: a European multi-center study

Boven, E., Winograd, B., Fodstad, O., Lobbezoo, M. W. & Pinedo, H. M., 1988, In : European Journal of Cancer and Clinical Oncology. 24, 3, p. 567-573

Research output: Contribution to journalArticleAcademicpeer-review

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Prescription sequence analysis: A new and fast method for assessing certain adverse reactions of prescription drugs in large populations

Petri, H., De Vet, H. C. W., Naus, J. & Urquhart, J., 1 Jan 1988, In : Statistics in Medicine. 7, 11, p. 1171-1175 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Rapid diagnosis of genital herpes simplex infection by an indirect ELISA method

Skar, A. G., Middeldorp, J., Gundersen, T., Rollag, H. & Degrè, M., Dec 1988, In : NIPH annals. 11, 2, p. 59-65 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Relation between infarct size and left ventricular performance assessed in patients with first acute myocardial infarction randomized to intracoronary thrombolytic therapy or to conventional treatment

Van Der Laarse, A., Kerkhof, P. L. M., Vermeer, F., Serruys, P. W., Hermens, W. T., Verheugt, F. W. A., Bär, F. W., Krauss, X. H., Van Der Wall, E. E. & Simoons, M. L., 1 Jan 1988, In : The American Journal of Cardiology. 61, 1, p. 1-7 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Semi Quinone formation from the catechol and ortho-quinone metabolites of the antitumor agent VP l6 213

van Maanen, J. M. S., Verkerk, U. H., Broersen, J., Lafleur, M. V. M., de Vries, J., Retel, J. & Pinedo, H. M., 1988, In : Free radical research. 4, 6, p. 371-384

Research output: Contribution to journalArticleAcademicpeer-review

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Sex reassignment surgery: A study of 141 dutch transsexuals

Kuiper, B. & Cohen-Kettenis, P., 1 Oct 1988, In : Archives of Sexual Behavior. 17, 5, p. 439-457 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

Short-term patterns of pulsatile luteinizing hormone secretion do not differ between male-to-female transsexuals and heterosexual men

Spijkstra, J. J., Spinder, T. & Gooren, L. J. G., 1 Jan 1988, In : Psychoneuroendocrinology. 13, 3, p. 279-283 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Structure Bioactivation relationship of a series of podophyllotoxin derivatives

van Maanen, J. M. S., van den Akker, E., de Vries, J., Pakkenist, T. R. J., Lankelma, J., Retel, J. & Pinedo, H. M., 1988, In : European Journal of Cancer and Clinical Oncology. 24, 9, p. 1415-1419

Research output: Contribution to journalArticleAcademicpeer-review

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Swelling of metastatic tumours with high dose interleukin-2 therapy

Goey, S. H., Voerman, H. J., Strack van Schijndel, R. J. M., van der Hoeven, J. J. M., Wagstaff, J., Thijs, L. G. & Pinedo, H. M., 1988, In : New England Journal of Medicine. 318, p. 643-644

Research output: Contribution to journalArticleAcademicpeer-review

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Tetrahydro-aminoacridine: een veelbelovende 'therapie' voor de ziekte van Alzheimer?

Translated title of the contribution: Tetrahydroaminoacridine: a promising 'therapy' for Alzheimer's disease?Drukarch, B. & Stoof, J. C., 1 Oct 1988, In : Nederlands Tijdschrift voor Geneeskunde. 132, 40, p. 1833-5 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

The anti-ischaemic activity of the novel compound, CERM 11956, compared with that of bepridil and nifedipine in isolated guinea-pig hearts

Boddeke, E. W. G. M., Wilffert, B., Heynis, J. B., Hugtenburg, J. G., Jap, W. T. J., Veldsema-Currie, R. D. & Van Zwieten, P. A., 10 May 1988, In : European Journal of Pharmacology. 149, 3, p. 195-203 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

The interaction of interdigitating cells and lymphocytes in vitro and in vivo

Breel, M., Mebius, R. & Kraal, G., Feb 1988, In : Immunology. 63, 2, p. 331-7 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

The main steps in the development of anticancer agents

Schwartsmann, G., Winograd, B. & Pinedo, H. M., 1988, In : Radiotherapy and Oncology. 12, p. 301-313

Research output: Contribution to journalArticleAcademicpeer-review

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The pharmacokinetic plasma profile of mitomycin C, measured after sequential intermittent intravenous administration

Lankelma, J., Stuurman, M., van Hoogenhuijze, J., van Bochove, A., Vermorken, J. B., Verwey, J. & Pinedo, H. M., 1988, In : European Journal of Cancer and Clinical Oncology. 24, p. 175-180

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The quantification of gammacarboxyglutamic acid residues in plasma-osteocalcin

Soute, B. A. M., Ulrich, M. M. W., Knapen, M. H. J., van Haarlem, L. J. M. & Vermeer, C., 1 Sep 1988, In : Calcified Tissue International. 43, 3, p. 184-188 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

The role of oxygen-derived five radicals in the cytotoxicity of doxorubicin in multidrug resistant and sensitive human ovarian cancer cells

Cervantes, A., Pinedo, H. M., Lankelma, J. & Schuurhuis, G. J., 1988, In : Cancer Letters. 41, p. 169-177

Research output: Contribution to journalArticleAcademicpeer-review

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Vitamin K-dependent carboxylation. A synthetic peptide based upon the γ-carboxylation recognition site sequence of the prothrombin propeptide is an active substrate for the carboxylase in vitro

Ulrich, M. M. W., Furie, B. C., Jacobs, M. R., Vermeer, C. & Furie, B. C., 1 Jan 1988, In : Journal of Biological Chemistry. 263, 20, p. 9697-9702 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Vitamin K is no antagonist for the action of warfarin in rat osteosarcoma UMR 106

Ulrich, M. M. W., Knapen, M. H. J., Herrmann Erlee, M. P. M. & Vermeer, C., 1 Apr 1988, In : Thrombosis Research. 50, 1, p. 27-32 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

1989

A4 protein in alzheimer’s disease: Primary and secondary cellular events in extracellular amyloid deposition

Rozemuller, J. M. & Stam, F. C., 1 Jan 1989, In : Journal of Neuropathology and Experimental Neurology. 48, 6, p. 674-691 18 p.

Research output: Contribution to journalArticleAcademicpeer-review

A comparison of the cardioprotective effects of calcium antagonists from different classes upon ischaemic damage in the guinea-pig working heart

Hugtenburg, J. G., Mathy, M. J., Veldsema-Currie, R. D., Boddeke, H. W. G. M., Beekeringh, J. J. & van Zwieten, P. A., 1 Jan 1989, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 340, 1, p. 126-134 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

A controlled trial of methionyl growth hormone therapy in prepubertal children with short stature, subnormal growth rate and normal growth hormone response to secretagogues

Wit, J. M., Rietveld, D. H. F., Drop, S. L. S., Oostdijk, W., Gons, M., Otten, B. J., Delemarre-Van de Waal, H. A., Reeser, M., Waelkens, J. J. J. & Bot, A., 1 Jan 1989, In : Acta Paediatrica Scandinavica. 78, 3, p. 426-435 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Activity of the folate analog 10-ethyl, 10-deaza-aminopterin (10-EdAM) against human head and neck cancer xenografts

Brown, D. H., Braakhuis, B. J. M., Van Dongen, G. A. M. S., Van Walsum, M., Bagnay, M. & Snow, G. B., 1 Dec 1989, In : Anticancer Research. 9, 6, p. 1549-1552 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Alpha 2-adrenoceptor-mediated modulation of noradrenaline release is decreased in vas deferens but not in cerebral cortex of diabetic rats

Drukarch, B., Schepens, E., Heimans, J. J. & Stoof, J. C., Jul 1989, In : Journal of the Neurological Sciences. 91, 3, p. 293-9 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Anti‐tumor and differentiation‐inducing activity of n,n‐dimethylformamide (dmf) in head‐and‐neck cancer xenografts

Van Dongen, G. A. M. S., Braakhuis, B. J. M., Leyva, A., Hendriks, H. R., Kipp, B. B. A., Bagnay, M. & Snow, G. B., 1 Jan 1989, In : International Journal of Cancer. 43, 2, p. 285-292 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

A peptidoglycan protein complex purified from M. leprae cell walls contains most or all immunodominant M. leprae T-cell antigens

Mutis, T., Van Schooten, W. C. A. & De Vries, R. R. P., 1 Jan 1989, In : International Journal of Leprosy. 57, 4, p. 788-793 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

A progress report of a phase I study of interferon-gamma and interleukin-2 and some comments on the mechanism of the toxicity due to Interleukin-2

Wagstaff, J., Vermorken, J. B., Schwartsmann, G., Scheper, R. J., Hack, C. E., Nuijens, J. H., Eerenberg-Belmer, A. J. M. & Pinedo, H. M., 1989, In : Cancer Treatment Reviews. 16, Suppl. A, p. 105-109

Research output: Contribution to journalArticleAcademicpeer-review

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A theoretical and experimental investigation of acid catalyzed rearrangements of small [n]cyclophanes

Kostermans, G. B. M., Kwakman, P. J., Pouwels, P. J. W., Somsen, G., De Wolf, W. H. & Bicklehaupt, F., 1 Jan 1989, In : Journal of Physical Organic Chemistry. 2, 4, p. 331-348 18 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cardioprotective effect of trimetazidine and nifedipine in guinea-pig hearts subjected to ischaemia

Hugtenburg, J. G., Jap, T. J. W., Mathy, M. J., Van Heiningen, P. N. M., Bohnenn, V. A., Heijnis, J. B., Boddeke, H. W. G. M. & Van Zwieten, P. A., 1 Jan 1989, In : Archives Internationales de Pharmacodynamie et de Therapie. 300, p. 186-208 23 p.

Research output: Contribution to journalArticleAcademicpeer-review

Chemotherapy in advanced soft tissue sarcomas

Verwey, J., van Groeningen, C. J. & Pinedo, H. M., 1989, Treatment of soft tissue sarcomas. Kluwer Academic Publishers, p. 75-92

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

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Cloning and expression in Escherichia coli of Haemophilus influenzae fimbrial genes establishes adherence to oropharyngeal epithelial cells

Van Ham, S. M., Mooi, F. R., Sindhunata, M. G., Maris, W. R. & Van Alphen, L., 1 Jan 1989, In : EMBO Journal. 8, 11, p. 3535-3540 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Collaboration between general practitioners and specialists in patients with cancer

Van der Wouden, J. C. & Dokter, H. J., 1 Jan 1989, In : Huisarts en Wetenschap. 32, 2, p. 51-55 5 p.

Research output: Contribution to journalArticleProfessional

Correlation of multidrug distribution, and increased P-glycoprotein expression in cultured SW-1573 human lung tumor cells

Keizer, H. G., Schuurhuis, G. J., Broxterman, H. J., Lankelma, J., Schoonen, W. G. E. J., van Rijn, J., Pinedo, H. M. & Joenje, H., 1989, In : Cancer Research. 49, p. 2988-2993

Research output: Contribution to journalArticleAcademicpeer-review

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Cytotoxicity of methotrexate and trimetrexate and its reversal by folinic acid in human leukemic CCRF-CEM cells with carrier-mediated and receptor-mediated folate uptake

van der Veer, L. J., Westerhof, G. R., Rijksen, G., Schornagel, J. H. & Jansen, G., 1989, In : Leukemia Research. 13, 11, p. 981-7 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Differences between negative inotropic and vasodilator effects of calcium antagonists acting on extra- and intracellular calcium movements in rat and guinea-pig cardiac preparations

Hugtenburg, J. G., Mathy, M. J., Boddeke, H. W. G. M., Beckeringh, J. J. & van Zwieten, P. A., 1 Jan 1989, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 340, 5, p. 567-575 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Doppler studies in red cell isoimmunization

Bilardo, C. M., Nicolaides, K. H. & Campbell, S., 1989, In : Clinical Obstetrics and Gynecology. 32, 4, p. 719-727

Research output: Contribution to journalArticleAcademicpeer-review

Effect of artificial electron acceptors on the cytotoxicity of mitomycin C and doxorubicin in human lung tumor cells

Keizer, H. G., de Leeuw, J., van Rijn, J., Pinedo, H. M. & Joenje, H., 1989, In : European Journal of Cancer and Clinical Oncology. 25, 7, p. 1113-1118

Research output: Contribution to journalArticleAcademicpeer-review

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