A 30-month worksite-based lifestyle program to promote cardiovascular health in middle-aged bank employees: Design of the TANSNIP-PESA randomized controlled trial

Jennifer K. Coffeng, Hidde P. van der Ploeg, José M. Castellano, Juan M. Fernández-Alvira, Borja Ibáñez, Inés García-Lunar, Allard J. van der Beek, Antonio Fernández-Ortiz, Agustín Mocoroa, Laura García-Leal, Evelyn Cárdenas, Carolina Rojas, María I. Martínez-Castro, Silvia Santiago-Sacristán, Miriam Fernández-Gallardo, José M. Mendiguren, Sameer Bansilal, Willem van Mechelen, Valentín Fuster*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Background Cardiovascular disease (CVD) is the leading cause of death worldwide. With atherosclerosis as the underlying cause for many CVD events, prevention or reduction of subclinical atherosclerotic plaque burden (SAPB) through a healthier lifestyle may have substantial public health benefits. Objective The objective was to describe the protocol of a randomized controlled trial investigating the effectiveness of a 30-month worksite-based lifestyle program aimed to promote cardiovascular health in participants having a high or a low degree of SAPB compared with standard care. Methods We will conduct a randomized controlled trial including middle-aged bank employees from the Progression of Early Subclinical Atherosclerosis cohort, stratified by SAPB (high SAPB n = 260, low SAPB n = 590). Within each stratum, participants will be randomized 1:1 to receive a lifestyle program or standard care. The program consists of 3 elements: (a) 12 personalized lifestyle counseling sessions using Motivational Interviewing over a 30-month period, (b) a wrist-worn physical activity tracker, and (c) a sit-stand workstation. Primary outcome measure is a composite score of blood pressure, physical activity, sedentary time, body weight, diet, and smoking (ie, adapted Fuster-BEWAT score) measured at baseline and at 1-, 2-, and 3-year follow-up. Conclusions The study will provide insights into the effectiveness of a 30-month worksite-based lifestyle program to promote cardiovascular health compared with standard care in participants with a high or low degree of SAPB.

Original languageEnglish
Pages (from-to)121-132
Number of pages12
JournalAmerican Heart Journal
Publication statusPublished - 1 Feb 2017

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