Een jongen met acute cerebellaire ataxie zonder opsoclonus, door een neuroblastoom

Translated title of the contribution: A boy with acute cerebellar ataxia without opsoclonus caused by neuroblastoma

R. S. Blokker, L. M.E. Smit, C. Van Den Bos, P. C. Overberg, H. N. Caron, G. J.L. Kaspers*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


A 2-year-old boy presented with acute cerebellar ataxia without opsoclonus. The ataxia was assumed to be post-viral. After a period of 2 years a neuroblastoma was detected. Treatment with a curative intent was successful and consisted of metaiodobenzylguanidine 1131, chemotherapy, tumour resection, chemotherapy again and follow-up treatment with isotretinoin after irradiation. In the literature, 5 other children have been described with acute cerebellar ataxia without opsoclonus in whom neuroblastoma was detected eventually. The mean age of these children at initial presentation was 26 months. The mean time between initial presentation and diagnosis of neuroblastoma or ganglioneuroblastoma was 12 months. Urine concentrations of catecholamine metabolites were normal in 5 of the 6 total children; concentrations were elevated in 1 child. The tumour was located paravertebrally in 5 of the 6 children. Ataxia resolved following resection of the neuroblastoma in all patients. Each child with prolonged or recurrent acute cerebellar ataxia should be extensively investigated for the presence of neuroblastoma, even in the absence of opsoclonus.

Translated title of the contributionA boy with acute cerebellar ataxia without opsoclonus caused by neuroblastoma
Original languageDutch
Pages (from-to)799-803
Number of pages5
JournalNederlands Tijdschrift voor Geneeskunde
Issue number14
Publication statusPublished - 8 Apr 2006

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