A Case of Lagochilascariasis in Suriname with the Involvement of the ENT System and the Skull Base

Joeri A J Douma, Ralph A E Akrum, Rudie Tjong Tjin Joe, Mike Chan, John Codrington, Stephen Gerold S Vreden

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

We describe a case of human lagochilascariasis, with skull-base involvement and a chronic and relapsing course after treatment. This rare parasitic infection is usually manifested in the head and neck area, characterized by progressive granulomatous inflammation and the formation of abscesses. Transmission to humans most likely occurs by the consumption of undercooked meat of wild rodents. On the basis of literature studies, we propose the most likely life cycle of the parasite that involves wild feline and rodent species, with humans as accidental hosts. Even in endemic areas, it is very difficult to recognize the disease at an early stage. Progression will eventually lead to involvement of the (central) nervous system, as described in our case. Treatment is often difficult and involves resection and prolonged treatment with anthelmintic drugs. Recurrences are not uncommon and at present, long-term oral administration of ivermectin seems to be the most effective treatment.

Original languageEnglish
Pages (from-to)88-91
Number of pages4
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume95
Issue number1
DOIs
Publication statusPublished - 6 Jul 2016

Cite this

Douma, Joeri A J ; Akrum, Ralph A E ; Joe, Rudie Tjong Tjin ; Chan, Mike ; Codrington, John ; Vreden, Stephen Gerold S. / A Case of Lagochilascariasis in Suriname with the Involvement of the ENT System and the Skull Base. In: American Journal of Tropical Medicine and Hygiene. 2016 ; Vol. 95, No. 1. pp. 88-91.
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abstract = "We describe a case of human lagochilascariasis, with skull-base involvement and a chronic and relapsing course after treatment. This rare parasitic infection is usually manifested in the head and neck area, characterized by progressive granulomatous inflammation and the formation of abscesses. Transmission to humans most likely occurs by the consumption of undercooked meat of wild rodents. On the basis of literature studies, we propose the most likely life cycle of the parasite that involves wild feline and rodent species, with humans as accidental hosts. Even in endemic areas, it is very difficult to recognize the disease at an early stage. Progression will eventually lead to involvement of the (central) nervous system, as described in our case. Treatment is often difficult and involves resection and prolonged treatment with anthelmintic drugs. Recurrences are not uncommon and at present, long-term oral administration of ivermectin seems to be the most effective treatment.",
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A Case of Lagochilascariasis in Suriname with the Involvement of the ENT System and the Skull Base. / Douma, Joeri A J; Akrum, Ralph A E; Joe, Rudie Tjong Tjin; Chan, Mike; Codrington, John; Vreden, Stephen Gerold S.

In: American Journal of Tropical Medicine and Hygiene, Vol. 95, No. 1, 06.07.2016, p. 88-91.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Akrum, Ralph A E

AU - Joe, Rudie Tjong Tjin

AU - Chan, Mike

AU - Codrington, John

AU - Vreden, Stephen Gerold S

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N2 - We describe a case of human lagochilascariasis, with skull-base involvement and a chronic and relapsing course after treatment. This rare parasitic infection is usually manifested in the head and neck area, characterized by progressive granulomatous inflammation and the formation of abscesses. Transmission to humans most likely occurs by the consumption of undercooked meat of wild rodents. On the basis of literature studies, we propose the most likely life cycle of the parasite that involves wild feline and rodent species, with humans as accidental hosts. Even in endemic areas, it is very difficult to recognize the disease at an early stage. Progression will eventually lead to involvement of the (central) nervous system, as described in our case. Treatment is often difficult and involves resection and prolonged treatment with anthelmintic drugs. Recurrences are not uncommon and at present, long-term oral administration of ivermectin seems to be the most effective treatment.

AB - We describe a case of human lagochilascariasis, with skull-base involvement and a chronic and relapsing course after treatment. This rare parasitic infection is usually manifested in the head and neck area, characterized by progressive granulomatous inflammation and the formation of abscesses. Transmission to humans most likely occurs by the consumption of undercooked meat of wild rodents. On the basis of literature studies, we propose the most likely life cycle of the parasite that involves wild feline and rodent species, with humans as accidental hosts. Even in endemic areas, it is very difficult to recognize the disease at an early stage. Progression will eventually lead to involvement of the (central) nervous system, as described in our case. Treatment is often difficult and involves resection and prolonged treatment with anthelmintic drugs. Recurrences are not uncommon and at present, long-term oral administration of ivermectin seems to be the most effective treatment.

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