A Cell-Enriched Engineered Myocardial Graft Limits Infarct Size and Improves Cardiac Function: Pre-Clinical Study in the Porcine Myocardial Infarction Model

Isaac Perea-Gil, Cristina Prat-Vidal, Carolina Gálvez-Montón, Santiago Roura, Aida Llucià-Valldeperas, Carolina Soler-Botija, Oriol Iborra-Egea, Idoia Díaz-Güemes, Verónica Crisóstomo, Francisco M Sánchez-Margallo, Antoni Bayes-Genis

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Myocardial infarction (MI) remains a dreadful disease around the world, causing irreversible sequelae that shorten life expectancy and reduce quality of life despite current treatment. Here, the authors engineered a cell-enriched myocardial graft, composed of a decellularized myocardial matrix refilled with adipose tissue-derived progenitor cells (EMG-ATDPC). Once applied over the infarcted area in the swine MI model, the EMG-ATDPC improved cardiac function, reduced infarct size, attenuated fibrosis progression, and promoted neovascularization of the ischemic myocardium. The beneficial effects exerted by the EMG-ATDPC and the absence of identified adverse side effects should facilitate its clinical translation as a novel MI therapy in humans.

Original languageEnglish
Pages (from-to)360-372
Number of pages13
JournalJACC: Basic to Translational Science
Volume1
Issue number5
DOIs
Publication statusPublished - Aug 2016

Cite this

Perea-Gil, Isaac ; Prat-Vidal, Cristina ; Gálvez-Montón, Carolina ; Roura, Santiago ; Llucià-Valldeperas, Aida ; Soler-Botija, Carolina ; Iborra-Egea, Oriol ; Díaz-Güemes, Idoia ; Crisóstomo, Verónica ; Sánchez-Margallo, Francisco M ; Bayes-Genis, Antoni. / A Cell-Enriched Engineered Myocardial Graft Limits Infarct Size and Improves Cardiac Function : Pre-Clinical Study in the Porcine Myocardial Infarction Model. In: JACC: Basic to Translational Science. 2016 ; Vol. 1, No. 5. pp. 360-372.
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abstract = "Myocardial infarction (MI) remains a dreadful disease around the world, causing irreversible sequelae that shorten life expectancy and reduce quality of life despite current treatment. Here, the authors engineered a cell-enriched myocardial graft, composed of a decellularized myocardial matrix refilled with adipose tissue-derived progenitor cells (EMG-ATDPC). Once applied over the infarcted area in the swine MI model, the EMG-ATDPC improved cardiac function, reduced infarct size, attenuated fibrosis progression, and promoted neovascularization of the ischemic myocardium. The beneficial effects exerted by the EMG-ATDPC and the absence of identified adverse side effects should facilitate its clinical translation as a novel MI therapy in humans.",
author = "Isaac Perea-Gil and Cristina Prat-Vidal and Carolina G{\'a}lvez-Mont{\'o}n and Santiago Roura and Aida Lluci{\`a}-Valldeperas and Carolina Soler-Botija and Oriol Iborra-Egea and Idoia D{\'i}az-G{\"u}emes and Ver{\'o}nica Cris{\'o}stomo and S{\'a}nchez-Margallo, {Francisco M} and Antoni Bayes-Genis",
year = "2016",
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Perea-Gil, I, Prat-Vidal, C, Gálvez-Montón, C, Roura, S, Llucià-Valldeperas, A, Soler-Botija, C, Iborra-Egea, O, Díaz-Güemes, I, Crisóstomo, V, Sánchez-Margallo, FM & Bayes-Genis, A 2016, 'A Cell-Enriched Engineered Myocardial Graft Limits Infarct Size and Improves Cardiac Function: Pre-Clinical Study in the Porcine Myocardial Infarction Model' JACC: Basic to Translational Science, vol. 1, no. 5, pp. 360-372. https://doi.org/10.1016/j.jacbts.2016.06.005

A Cell-Enriched Engineered Myocardial Graft Limits Infarct Size and Improves Cardiac Function : Pre-Clinical Study in the Porcine Myocardial Infarction Model. / Perea-Gil, Isaac; Prat-Vidal, Cristina; Gálvez-Montón, Carolina; Roura, Santiago; Llucià-Valldeperas, Aida; Soler-Botija, Carolina; Iborra-Egea, Oriol; Díaz-Güemes, Idoia; Crisóstomo, Verónica; Sánchez-Margallo, Francisco M; Bayes-Genis, Antoni.

In: JACC: Basic to Translational Science, Vol. 1, No. 5, 08.2016, p. 360-372.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - A Cell-Enriched Engineered Myocardial Graft Limits Infarct Size and Improves Cardiac Function

T2 - Pre-Clinical Study in the Porcine Myocardial Infarction Model

AU - Perea-Gil, Isaac

AU - Prat-Vidal, Cristina

AU - Gálvez-Montón, Carolina

AU - Roura, Santiago

AU - Llucià-Valldeperas, Aida

AU - Soler-Botija, Carolina

AU - Iborra-Egea, Oriol

AU - Díaz-Güemes, Idoia

AU - Crisóstomo, Verónica

AU - Sánchez-Margallo, Francisco M

AU - Bayes-Genis, Antoni

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AB - Myocardial infarction (MI) remains a dreadful disease around the world, causing irreversible sequelae that shorten life expectancy and reduce quality of life despite current treatment. Here, the authors engineered a cell-enriched myocardial graft, composed of a decellularized myocardial matrix refilled with adipose tissue-derived progenitor cells (EMG-ATDPC). Once applied over the infarcted area in the swine MI model, the EMG-ATDPC improved cardiac function, reduced infarct size, attenuated fibrosis progression, and promoted neovascularization of the ischemic myocardium. The beneficial effects exerted by the EMG-ATDPC and the absence of identified adverse side effects should facilitate its clinical translation as a novel MI therapy in humans.

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