A Cell-Enriched Engineered Myocardial Graft Limits Infarct Size and Improves Cardiac Function: Pre-Clinical Study in the Porcine Myocardial Infarction Model

Isaac Perea-Gil, Cristina Prat-Vidal, Carolina Gálvez-Montón, Santiago Roura, Aida Llucià-Valldeperas, Carolina Soler-Botija, Oriol Iborra-Egea, Idoia Díaz-Güemes, Verónica Crisóstomo, Francisco M Sánchez-Margallo, Antoni Bayes-Genis

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Myocardial infarction (MI) remains a dreadful disease around the world, causing irreversible sequelae that shorten life expectancy and reduce quality of life despite current treatment. Here, the authors engineered a cell-enriched myocardial graft, composed of a decellularized myocardial matrix refilled with adipose tissue-derived progenitor cells (EMG-ATDPC). Once applied over the infarcted area in the swine MI model, the EMG-ATDPC improved cardiac function, reduced infarct size, attenuated fibrosis progression, and promoted neovascularization of the ischemic myocardium. The beneficial effects exerted by the EMG-ATDPC and the absence of identified adverse side effects should facilitate its clinical translation as a novel MI therapy in humans.

Original languageEnglish
Pages (from-to)360-372
Number of pages13
JournalJACC: Basic to Translational Science
Volume1
Issue number5
DOIs
Publication statusPublished - Aug 2016

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