A child with severe hearing loss associated with maternal cisplatin treatment during pregnancy

Eric C T Geijteman, Celesta W M Wensveen, Johannes J Duvekot, Lia van Zuylen

Research output: Contribution to journalArticleAcademicpeer-review


BACKGROUND: Cisplatin is considered safe to use during the second and third trimesters of pregnancy in patients with cancer.

CASE: A 34-year-old pregnant woman was diagnosed with cervical cancer. She received five weekly dosages of cisplatin and paclitaxel, starting at 26 5/7 weeks of gestation. An elective cesarean delivery was performed at 34 4/7 weeks of gestation. After birth, the neonate was diagnosed with severe bilateral perceptive hearing loss.

CONCLUSION: Cisplatin during the second and third trimesters of pregnancy may lead to fetal ototoxicity.

Original languageEnglish
Pages (from-to)454-6
Number of pages3
JournalObstetrics and Gynecology
Issue number2 Pt 2 Suppl 1
Publication statusPublished - Aug 2014
Externally publishedYes

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