A companion to the preclinical common data elements for physiologic data in rodent epilepsy models. A report of the TASK3 Physiology Working Group of the ILAE/AES Joint Translational Task Force

Jan A. Gorter, Erwin A. van Vliet, Stefanie Dedeurwaerdere, Gordon F. Buchanan, Daniel Friedman, Karin Borges, Heidi Grabenstatter, Katarzyna Lukasiuk, Helen E. Scharfman, Astrid Nehlig

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force created the TASK3 working groups to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve standardization of experimental designs. This article concerns the parameters that can be measured to assess the physiologic condition of the animals that are used to study rodent models of epilepsy. Here we discuss CDEs for physiologic parameters measured in adult rats and mice such as general health status, temperature, cardiac and respiratory function, and blood constituents. We provide detailed CDE tables and case report forms (CRFs), and with this companion manuscript we discuss the monitoring of different aspects of physiology of the animals. The CDEs, CRFs, and companion paper are available to all researchers, and their use will benefit the harmonization and comparability of translational preclinical epilepsy research. The ultimate hope is to facilitate the development of biomarkers and new treatments for epilepsy.
Original languageEnglish
Pages (from-to)69-89
JournalEpilepsia Open
Volume3
Issue numberS1
DOIs
Publication statusPublished - 2018
Externally publishedYes

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