A comparison of the in vitro cytotoxicity of daunorubicin and liposomal daunorubicin in pediatric acute leukemia

Bianca F. Goemans*, Christian M. Zwaan, Dirk Reinhardt, Brenda E.S. Gibson, K. Hählen, Gert Jan L. Kaspers

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Anthracyclines are effective in the treatment of leukemia, but their use is limited because of cardiotoxicity. Liposomal daunorubicin (L-DNR) is potentially less cardiotoxic than daunorubicin (DNR). We compared in vitro cytotoxicity in pediatric acute leukemia samples and found no significant differences between cytotoxicity of DNR and L-DNR.

Original languageEnglish
Pages (from-to)1573-1574
Number of pages2
JournalHaematologica
Volume91
Issue number11
Publication statusPublished - Nov 2006

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