A controlled trial of methionyl growth hormone therapy in prepubertal children with short stature, subnormal growth rate and normal growth hormone response to secretagogues

J. M. Wit, D. H.F. Rietveld, S. L.S. Drop, W. Oostdijk, M. Gons, B. J. Otten, H. A. Delemarre-Van de Waal, M. Reeser, J. J.J. Waelkens, A. Bot

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Thirty short and slowly growing children with normal plasma growth hormone (GH) responses to standard provocation tests were randomly assigned to either a group (n = 20) undergoing treatment with methionyl GH (somatrem), 2 IU per m2 body surface s.c. daily, or a control group (n = 10). Twelve out of 18 children who completed the first year of treatment showed a height velocity increment of more than 2 cm/year. The mean (SD) growth velocity of the treatment group increased by 3.0 (1.9) cm/year over the first year, compared with -0.2 (0.7) cm/year in the control group. Neither parameters of endogenous GH secretion nor plasma IGF-I levels showed a significant correlation with the growth response. Of the auxological variables studied, pre-treatment growth velocity (r = -0.8) and the short-term height velocity increment (r = 0.7-0.9) showed significant correlations with the growth response in the first year of treatment. Somatrem therapy was without side effects, except in one child who developed anti-GH antibodies in combination with a poor growth response.

Original languageEnglish
Pages (from-to)426-435
Number of pages10
JournalActa Paediatrica Scandinavica
Volume78
Issue number3
Publication statusPublished - 1 Jan 1989

Cite this

Wit, J. M. ; Rietveld, D. H.F. ; Drop, S. L.S. ; Oostdijk, W. ; Gons, M. ; Otten, B. J. ; Delemarre-Van de Waal, H. A. ; Reeser, M. ; Waelkens, J. J.J. ; Bot, A. / A controlled trial of methionyl growth hormone therapy in prepubertal children with short stature, subnormal growth rate and normal growth hormone response to secretagogues. In: Acta Paediatrica Scandinavica. 1989 ; Vol. 78, No. 3. pp. 426-435.
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abstract = "Thirty short and slowly growing children with normal plasma growth hormone (GH) responses to standard provocation tests were randomly assigned to either a group (n = 20) undergoing treatment with methionyl GH (somatrem), 2 IU per m2 body surface s.c. daily, or a control group (n = 10). Twelve out of 18 children who completed the first year of treatment showed a height velocity increment of more than 2 cm/year. The mean (SD) growth velocity of the treatment group increased by 3.0 (1.9) cm/year over the first year, compared with -0.2 (0.7) cm/year in the control group. Neither parameters of endogenous GH secretion nor plasma IGF-I levels showed a significant correlation with the growth response. Of the auxological variables studied, pre-treatment growth velocity (r = -0.8) and the short-term height velocity increment (r = 0.7-0.9) showed significant correlations with the growth response in the first year of treatment. Somatrem therapy was without side effects, except in one child who developed anti-GH antibodies in combination with a poor growth response.",
author = "Wit, {J. M.} and Rietveld, {D. H.F.} and Drop, {S. L.S.} and W. Oostdijk and M. Gons and Otten, {B. J.} and {Delemarre-Van de Waal}, {H. A.} and M. Reeser and Waelkens, {J. J.J.} and A. Bot",
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Wit, JM, Rietveld, DHF, Drop, SLS, Oostdijk, W, Gons, M, Otten, BJ, Delemarre-Van de Waal, HA, Reeser, M, Waelkens, JJJ & Bot, A 1989, 'A controlled trial of methionyl growth hormone therapy in prepubertal children with short stature, subnormal growth rate and normal growth hormone response to secretagogues' Acta Paediatrica Scandinavica, vol. 78, no. 3, pp. 426-435.

A controlled trial of methionyl growth hormone therapy in prepubertal children with short stature, subnormal growth rate and normal growth hormone response to secretagogues. / Wit, J. M.; Rietveld, D. H.F.; Drop, S. L.S.; Oostdijk, W.; Gons, M.; Otten, B. J.; Delemarre-Van de Waal, H. A.; Reeser, M.; Waelkens, J. J.J.; Bot, A.

In: Acta Paediatrica Scandinavica, Vol. 78, No. 3, 01.01.1989, p. 426-435.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - A controlled trial of methionyl growth hormone therapy in prepubertal children with short stature, subnormal growth rate and normal growth hormone response to secretagogues

AU - Wit, J. M.

AU - Rietveld, D. H.F.

AU - Drop, S. L.S.

AU - Oostdijk, W.

AU - Gons, M.

AU - Otten, B. J.

AU - Delemarre-Van de Waal, H. A.

AU - Reeser, M.

AU - Waelkens, J. J.J.

AU - Bot, A.

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N2 - Thirty short and slowly growing children with normal plasma growth hormone (GH) responses to standard provocation tests were randomly assigned to either a group (n = 20) undergoing treatment with methionyl GH (somatrem), 2 IU per m2 body surface s.c. daily, or a control group (n = 10). Twelve out of 18 children who completed the first year of treatment showed a height velocity increment of more than 2 cm/year. The mean (SD) growth velocity of the treatment group increased by 3.0 (1.9) cm/year over the first year, compared with -0.2 (0.7) cm/year in the control group. Neither parameters of endogenous GH secretion nor plasma IGF-I levels showed a significant correlation with the growth response. Of the auxological variables studied, pre-treatment growth velocity (r = -0.8) and the short-term height velocity increment (r = 0.7-0.9) showed significant correlations with the growth response in the first year of treatment. Somatrem therapy was without side effects, except in one child who developed anti-GH antibodies in combination with a poor growth response.

AB - Thirty short and slowly growing children with normal plasma growth hormone (GH) responses to standard provocation tests were randomly assigned to either a group (n = 20) undergoing treatment with methionyl GH (somatrem), 2 IU per m2 body surface s.c. daily, or a control group (n = 10). Twelve out of 18 children who completed the first year of treatment showed a height velocity increment of more than 2 cm/year. The mean (SD) growth velocity of the treatment group increased by 3.0 (1.9) cm/year over the first year, compared with -0.2 (0.7) cm/year in the control group. Neither parameters of endogenous GH secretion nor plasma IGF-I levels showed a significant correlation with the growth response. Of the auxological variables studied, pre-treatment growth velocity (r = -0.8) and the short-term height velocity increment (r = 0.7-0.9) showed significant correlations with the growth response in the first year of treatment. Somatrem therapy was without side effects, except in one child who developed anti-GH antibodies in combination with a poor growth response.

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