TY - JOUR
T1 - A Coordinated Multi-study Analysis of the Longitudinal Association Between Handgrip Strength and Cognitive Function in Older Adults
AU - Zammit, Andrea R.
AU - Piccinin, Andrea M.
AU - Duggan, Emily C.
AU - Koval, Andriy
AU - Clouston, Sean
AU - Robitaille, Annie
AU - Brown, Cassandra L.
AU - Handschuh, Philipp
AU - Wu, Chenkai
AU - Jarry, Valérie
AU - Finkel, Deborah
AU - Graham, Raquel B.
AU - Muniz-Terrera, Graciela
AU - Praetorius Björk, Marcus
AU - Bennett, David
AU - Deeg, Dorly J.
AU - Johansson, Boo
AU - Katz, Mindy J.
AU - Kaye, Jeffrey
AU - Lipton, Richard B.
AU - Martin, Mike
AU - Pederson, Nancy L.
AU - Spiro, Avron
AU - Zimprich, Daniel
AU - Hofer, Scott M.
N1 - Publisher Copyright:
© 2019 Published by Oxford University Press on behalf of The Gerontological Society of America 2019.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/2/1
Y1 - 2021/2/1
N2 - OBJECTIVE: Handgrip strength, an indicator of overall muscle strength, has been found to be associated with slower rate of cognitive decline and decreased risk for cognitive impairment and dementia. However, evaluating the replicability of associations between aging-related changes in physical and cognitive functioning is challenging due to differences in study designs and analytical models. A multiple-study coordinated analysis approach was used to generate new longitudinal results based on comparable construct-level measurements and identical statistical models and to facilitate replication and research synthesis. METHODS: We performed coordinated analysis on 9 cohort studies affiliated with the Integrative Analysis of Longitudinal Studies of Aging and Dementia (IALSA) research network. Bivariate linear mixed models were used to examine associations among individual differences in baseline level, rate of change, and occasion-specific variation across grip strength and indicators of cognitive function, including mental status, processing speed, attention and working memory, perceptual reasoning, verbal ability, and learning and memory. Results were summarized using meta-analysis. RESULTS: After adjustment for covariates, we found an overall moderate association between change in grip strength and change in each cognitive domain for both males and females: Average correlation coefficient was 0.55 (95% CI = 0.44-0.56). We also found a high level of heterogeneity in this association across studies. DISCUSSION: Meta-analytic results from nine longitudinal studies showed consistently positive associations between linear rates of change in grip strength and changes in cognitive functioning. Future work will benefit from the examination of individual patterns of change to understand the heterogeneity in rates of aging and health-related changes across physical and cognitive biomarkers.
AB - OBJECTIVE: Handgrip strength, an indicator of overall muscle strength, has been found to be associated with slower rate of cognitive decline and decreased risk for cognitive impairment and dementia. However, evaluating the replicability of associations between aging-related changes in physical and cognitive functioning is challenging due to differences in study designs and analytical models. A multiple-study coordinated analysis approach was used to generate new longitudinal results based on comparable construct-level measurements and identical statistical models and to facilitate replication and research synthesis. METHODS: We performed coordinated analysis on 9 cohort studies affiliated with the Integrative Analysis of Longitudinal Studies of Aging and Dementia (IALSA) research network. Bivariate linear mixed models were used to examine associations among individual differences in baseline level, rate of change, and occasion-specific variation across grip strength and indicators of cognitive function, including mental status, processing speed, attention and working memory, perceptual reasoning, verbal ability, and learning and memory. Results were summarized using meta-analysis. RESULTS: After adjustment for covariates, we found an overall moderate association between change in grip strength and change in each cognitive domain for both males and females: Average correlation coefficient was 0.55 (95% CI = 0.44-0.56). We also found a high level of heterogeneity in this association across studies. DISCUSSION: Meta-analytic results from nine longitudinal studies showed consistently positive associations between linear rates of change in grip strength and changes in cognitive functioning. Future work will benefit from the examination of individual patterns of change to understand the heterogeneity in rates of aging and health-related changes across physical and cognitive biomarkers.
KW - Cognitive function
KW - Coordinated analysis
KW - Grip strength
KW - Harmonization
KW - Integrative data analysis
KW - Longitudinal studies
UR - http://www.scopus.com/inward/record.url?scp=85100125571&partnerID=8YFLogxK
U2 - 10.1093/geronb/gbz072
DO - 10.1093/geronb/gbz072
M3 - Article
C2 - 31187137
VL - 76
SP - 229
EP - 241
JO - The journals of gerontology. Series B, Psychological sciences and social sciences
JF - The journals of gerontology. Series B, Psychological sciences and social sciences
SN - 1758-5368
IS - 2
ER -