TY - JOUR
T1 - A function for the macrophage F4/80 molecule in tolerance induction
AU - van den Berg, Timo K
AU - Kraal, Georg
PY - 2005/10
Y1 - 2005/10
N2 - The F4/80 monoclonal antibody has been used widely as a marker for mouse macrophages. The antigen (Ag) recognized by the antibody has been characterized as a member of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family, although the function of the molecule has remained elusive. A recent study provides evidence for a role of the F4/80 molecule in the induction of immunological tolerance. This study appears to provide clear evidence for a role of the F4/80 molecule in the immune system, however, what does it really tell us about the activities of the F4/80 molecule?
AB - The F4/80 monoclonal antibody has been used widely as a marker for mouse macrophages. The antigen (Ag) recognized by the antibody has been characterized as a member of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family, although the function of the molecule has remained elusive. A recent study provides evidence for a role of the F4/80 molecule in the induction of immunological tolerance. This study appears to provide clear evidence for a role of the F4/80 molecule in the immune system, however, what does it really tell us about the activities of the F4/80 molecule?
KW - Animals
KW - Antibodies, Monoclonal/immunology
KW - Antibody Specificity
KW - Antigens, Differentiation/physiology
KW - Glycoproteins/genetics
KW - Immune Tolerance/immunology
KW - Macrophages/immunology
KW - Mice
KW - Models, Immunological
U2 - 10.1016/j.it.2005.07.008
DO - 10.1016/j.it.2005.07.008
M3 - Review article
C2 - 16087400
VL - 26
SP - 506
EP - 509
JO - Trends in Immunology
JF - Trends in Immunology
SN - 1471-4906
IS - 10
ER -