A function for the macrophage F4/80 molecule in tolerance induction

Timo K van den Berg; Georg Kraal

doi:10.1016/j.it.2005.07.008

A function for the macrophage F4/80 molecule in tolerance induction

Timo K van den Berg, Georg Kraal

Molecular cell biology and Immunology

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

The F4/80 monoclonal antibody has been used widely as a marker for mouse macrophages. The antigen (Ag) recognized by the antibody has been characterized as a member of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family, although the function of the molecule has remained elusive. A recent study provides evidence for a role of the F4/80 molecule in the induction of immunological tolerance. This study appears to provide clear evidence for a role of the F4/80 molecule in the immune system, however, what does it really tell us about the activities of the F4/80 molecule?

Original language	English
Pages (from-to)	506-9
Number of pages	4
Journal	Trends in Immunology
Volume	26
Issue number	10
DOIs	https://doi.org/10.1016/j.it.2005.07.008
Publication status	Published - Oct 2005

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10.1016/j.it.2005.07.008

Cite this

van den Berg, T. K., & Kraal, G. (2005). A function for the macrophage F4/80 molecule in tolerance induction. Trends in Immunology, 26(10), 506-9. https://doi.org/10.1016/j.it.2005.07.008

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title = "A function for the macrophage F4/80 molecule in tolerance induction",

abstract = "The F4/80 monoclonal antibody has been used widely as a marker for mouse macrophages. The antigen (Ag) recognized by the antibody has been characterized as a member of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family, although the function of the molecule has remained elusive. A recent study provides evidence for a role of the F4/80 molecule in the induction of immunological tolerance. This study appears to provide clear evidence for a role of the F4/80 molecule in the immune system, however, what does it really tell us about the activities of the F4/80 molecule?",

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AU - Kraal, Georg

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AB - The F4/80 monoclonal antibody has been used widely as a marker for mouse macrophages. The antigen (Ag) recognized by the antibody has been characterized as a member of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family, although the function of the molecule has remained elusive. A recent study provides evidence for a role of the F4/80 molecule in the induction of immunological tolerance. This study appears to provide clear evidence for a role of the F4/80 molecule in the immune system, however, what does it really tell us about the activities of the F4/80 molecule?

KW - Animals

KW - Antibodies, Monoclonal/immunology

KW - Antibody Specificity

KW - Antigens, Differentiation/physiology

KW - Glycoproteins/genetics

KW - Immune Tolerance/immunology

KW - Macrophages/immunology

KW - Mice

KW - Models, Immunological

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JO - Trends in Immunology

JF - Trends in Immunology

SN - 1471-4906

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