A function for the macrophage F4/80 molecule in tolerance induction

Timo K van den Berg, Georg Kraal

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

The F4/80 monoclonal antibody has been used widely as a marker for mouse macrophages. The antigen (Ag) recognized by the antibody has been characterized as a member of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family, although the function of the molecule has remained elusive. A recent study provides evidence for a role of the F4/80 molecule in the induction of immunological tolerance. This study appears to provide clear evidence for a role of the F4/80 molecule in the immune system, however, what does it really tell us about the activities of the F4/80 molecule?

Original languageEnglish
Pages (from-to)506-9
Number of pages4
JournalTrends in Immunology
Volume26
Issue number10
DOIs
Publication statusPublished - Oct 2005

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