A high proportion of novel mutations in BRCA1 with strong founder effects among Dutch and Belgian hereditary breast and ovarian cancer families

T Peelen, M van Vliet, A Petrij-Bosch, R Mieremet, C Szabo, A M van den Ouweland, F Hogervorst, R Brohet, M J Ligtenberg, E Teugels, R van der Luijt, A H van der Hout, J J Gille, G Pals, I Jedema, R Olmer, I van Leeuwen, B Newman, M Plandsoen, M van der EstG Brink, S Hageman, P J Arts, M M Bakker, P Devilee

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

We have identified 79 mutations in BRCA1 in a set of 643 Dutch and 23 Belgian hereditary breast and ovarian cancer families collected either for research or for clinical diagnostic purposes. Twenty-eight distinct mutations have been observed, 18 of them not previously reported and 12 of them occurring more than once. Most conspicuously, a 2804delAA mutation has been found 19 times and has never been reported outside the Netherlands. A common haplotype spanning > or = 375 kb could be identified for each of the nine examined recurrent mutations, indicating the presence of multiple BRCA1 founder mutations in the Dutch population. The 2804delAA mutation has been estimated to have originated approximately 32 generations ago. No specific breast or ovarian cancer phenotype could be assigned to any of the common mutations, and the ovarian cancer incidence among 18 families with the 2804delAA mutation was heterogeneous.

Original languageEnglish
Pages (from-to)1041-9
Number of pages9
JournalAmerican journal of human genetics
Volume60
Issue number5
Publication statusPublished - May 1997

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