A Mapping Between Structural and Functional Brain Networks

Jil Meier, Prejaas Tewarie, Arjan Hillebrand, Linda Douw, Bob W van Dijk, Steven M Stufflebeam, Piet Van Mieghem

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The relationship between structural and functional brain networks is still highly debated. Most previous studies have used a single functional imaging modality to analyze this relationship. In this work, we use multimodal data, from functional MRI, magnetoencephalography, and diffusion tensor imaging, and assume that there exists a mapping between the connectivity matrices of the resting-state functional and structural networks. We investigate this mapping employing group averaged as well as individual data. We indeed find a significantly high goodness of fit level for this structure-function mapping. Our analysis suggests that a functional connection is shaped by all walks up to the diameter in the structural network in both modality cases. When analyzing the inverse mapping, from function to structure, longer walks in the functional network also seem to possess minor influence on the structural connection strengths. Even though similar overall properties for the structure-function mapping are found for different functional modalities, our results indicate that the structure-function relationship is modality dependent.

Original languageEnglish
Pages (from-to)298-311
Number of pages14
JournalBrain Connectivity
Volume6
Issue number4
DOIs
Publication statusPublished - 2016

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