Een nieuwe klasse oncolytica

Translated title of the contribution: A new class of oncolytic agents. Farnesyltransferase inhibitors

M. Crul*, R. W M Underberg, J. H. Beijnen, J. H M Schellens

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Recent research revealed that mutations in ras genes contribute to tumorigenesis in a number of tissues. In order to achieve a biologically active state during mitosis, Ras proteins need to undergo a number of post-translational modifications of which farnesylation is the most important one. Mutation of ras genes blocks the physiological dephosphorylating process of Ras proteins. This can result in tumour development and growth. Inhibition of farnesylation by farnesyltransferase inhibitors may prevent these processes. Several types of farnesyltransferase inhibitors have been developed, each with its own unique mechanism of interference. Pre-clinical studies revealed promising tumour regression in several models as well as limited side-effects. Several phase I Studies have been completed and currently phase II and III investigations are in progress focused on pancreatic and colon cancer. However, prior to routine use of these agents more clinical research is required to demonstrate efficacy and safety.

Translated title of the contributionA new class of oncolytic agents. Farnesyltransferase inhibitors
Original languageDutch
Pages (from-to)260-265
Number of pages6
JournalPharmaceutisch Weekblad
Issue number8
Publication statusPublished - 23 Feb 2001

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