A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers

Y.C. Ding; L. McGuffog; S. Healey; E. Friedman; Y. Laitman; P.S. Shani; B. Kaufman; A. Liljegren; A. Lindblom; H. Olsson; U. Kristoffersson; M. Stenmark-Askmalm; B. Melin; S.M. Domchek; K.L. Nathanson; T.R. Rebbeck; A. Jakubowska; J. Lubinski; K. Jaworska; K. Durda; J. Gronwald; T. Huzarski; C. Cybulski; T. Byrski; A. Osorio; T.R. Cajal; A.V. Stavropoulou; J. Benitez; U. Hamann; M. Rookus; C.M. Aalfs; J.L. de Lange; E.J. Meijers-Heijboer; J.C. Oosterwijk; C.J. van Asperen; E.B.G. Garcia; N. Hoogerbrugge; A. Jager; R.B. van der Luijt; D.F. Easton; S. Peock; D. Frost; S.D. Ellis; R. Platte; E. Fineberg; D.G. Evans; F. Lalloo; L. Izatt; R. Eeles; J. Adlard; R. Davidson; D. Eccles; T. Cole; J. Cook; C. Brewer; M Tischkowitz; A.K. Godwin; H. Pathak; D. Stoppa-Lyonnet; O.M. Sinilnikova; S. Mazoyer; L. Barjhoux; M. Leone; M. Gauthier-Villars; V. Caux-Moncoutier; A. de Pauw; A. Hardouin; P. Berthet; H. Dreyfus; S.F. Ferrer; M.A. Collonge-Rame; J. Sokolowska; S. Buys; M. Daly; A. Miron; M.B. Terry; W. Chung; E.M. John; M. Southey; D. Goldgar; C.F. Singer; M.K.M. Tea; D. Gschwantler-Kaulich; A. Fink-Retter; T.V.O. Hansen; B. Ejlertsen; O.T. Johannsson; K. Offit; K. Sarrel; M.M. Gaudet; J. Vijai; M. Robson; M.R. Piedmonte; L. Andrews; D. Cohn; L.R. Demars; P. DiSilvestro; G. Rodriguez; A.E. Toland

doi:10.1158/1055-9965.EPI-12-0229

A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers

Y.C. Ding, L. McGuffog, S. Healey, E. Friedman, Y. Laitman, P.S. Shani, B. Kaufman, A. Liljegren, A. Lindblom, H. Olsson, U. Kristoffersson, M. Stenmark-Askmalm, B. Melin, S.M. Domchek, K.L. Nathanson, T.R. Rebbeck, A. Jakubowska, J. Lubinski, K. Jaworska, K. DurdaJ. Gronwald, T. Huzarski, C. Cybulski, T. Byrski, A. Osorio, T.R. Cajal, A.V. Stavropoulou, J. Benitez, U. Hamann, M. Rookus, C.M. Aalfs, J.L. de Lange, E.J. Meijers-Heijboer, J.C. Oosterwijk, C.J. van Asperen, E.B.G. Garcia, N. Hoogerbrugge, A. Jager, R.B. van der Luijt, D.F. Easton, S. Peock, D. Frost, S.D. Ellis, R. Platte, E. Fineberg, D.G. Evans, F. Lalloo, L. Izatt, R. Eeles, J. Adlard, R. Davidson, D. Eccles, T. Cole, J. Cook, C. Brewer, M Tischkowitz, A.K. Godwin, H. Pathak, D. Stoppa-Lyonnet, O.M. Sinilnikova, S. Mazoyer, L. Barjhoux, M. Leone, M. Gauthier-Villars, V. Caux-Moncoutier, A. de Pauw, A. Hardouin, P. Berthet, H. Dreyfus, S.F. Ferrer, M.A. Collonge-Rame, J. Sokolowska, S. Buys, M. Daly, A. Miron, M.B. Terry, W. Chung, E.M. John, M. Southey, D. Goldgar, C.F. Singer, M.K.M. Tea, D. Gschwantler-Kaulich, A. Fink-Retter, T.V.O. Hansen, B. Ejlertsen, O.T. Johannsson, K. Offit, K. Sarrel, M.M. Gaudet, J. Vijai, M. Robson, M.R. Piedmonte, L. Andrews, D. Cohn, L.R. Demars, P. DiSilvestro, G. Rodriguez, A.E. Toland

Clinical genetics

Research output: Contribution to journal › Article › Academic › peer-review

Original language	Undefined/Unknown
Pages (from-to)	1362-1370
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	21
Issue number	8
DOIs	https://doi.org/10.1158/1055-9965.EPI-12-0229
Publication status	Published - 2012

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10.1158/1055-9965.EPI-12-0229

Cite this

Ding, Y. C., McGuffog, L., Healey, S., Friedman, E., Laitman, Y., Shani, P. S., ... Toland, A. E. (2012). A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers. Cancer Epidemiology Biomarkers and Prevention, 21(8), 1362-1370. https://doi.org/10.1158/1055-9965.EPI-12-0229

Ding, Y.C. ; McGuffog, L. ; Healey, S. ; Friedman, E. ; Laitman, Y. ; Shani, P.S. ; Kaufman, B. ; Liljegren, A. ; Lindblom, A. ; Olsson, H. ; Kristoffersson, U. ; Stenmark-Askmalm, M. ; Melin, B. ; Domchek, S.M. ; Nathanson, K.L. ; Rebbeck, T.R. ; Jakubowska, A. ; Lubinski, J. ; Jaworska, K. ; Durda, K. ; Gronwald, J. ; Huzarski, T. ; Cybulski, C. ; Byrski, T. ; Osorio, A. ; Cajal, T.R. ; Stavropoulou, A.V. ; Benitez, J. ; Hamann, U. ; Rookus, M. ; Aalfs, C.M. ; de Lange, J.L. ; Meijers-Heijboer, E.J. ; Oosterwijk, J.C. ; van Asperen, C.J. ; Garcia, E.B.G. ; Hoogerbrugge, N. ; Jager, A. ; van der Luijt, R.B. ; Easton, D.F. ; Peock, S. ; Frost, D. ; Ellis, S.D. ; Platte, R. ; Fineberg, E. ; Evans, D.G. ; Lalloo, F. ; Izatt, L. ; Eeles, R. ; Adlard, J. ; Davidson, R. ; Eccles, D. ; Cole, T. ; Cook, J. ; Brewer, C. ; Tischkowitz, M ; Godwin, A.K. ; Pathak, H. ; Stoppa-Lyonnet, D. ; Sinilnikova, O.M. ; Mazoyer, S. ; Barjhoux, L. ; Leone, M. ; Gauthier-Villars, M. ; Caux-Moncoutier, V. ; de Pauw, A. ; Hardouin, A. ; Berthet, P. ; Dreyfus, H. ; Ferrer, S.F. ; Collonge-Rame, M.A. ; Sokolowska, J. ; Buys, S. ; Daly, M. ; Miron, A. ; Terry, M.B. ; Chung, W. ; John, E.M. ; Southey, M. ; Goldgar, D. ; Singer, C.F. ; Tea, M.K.M. ; Gschwantler-Kaulich, D. ; Fink-Retter, A. ; Hansen, T.V.O. ; Ejlertsen, B. ; Johannsson, O.T. ; Offit, K. ; Sarrel, K. ; Gaudet, M.M. ; Vijai, J. ; Robson, M. ; Piedmonte, M.R. ; Andrews, L. ; Cohn, D. ; Demars, L.R. ; DiSilvestro, P. ; Rodriguez, G. ; Toland, A.E. / A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers. In: Cancer Epidemiology Biomarkers and Prevention. 2012 ; Vol. 21, No. 8. pp. 1362-1370.

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title = "A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers",

author = "Y.C. Ding and L. McGuffog and S. Healey and E. Friedman and Y. Laitman and P.S. Shani and B. Kaufman and A. Liljegren and A. Lindblom and H. Olsson and U. Kristoffersson and M. Stenmark-Askmalm and B. Melin and S.M. Domchek and K.L. Nathanson and T.R. Rebbeck and A. Jakubowska and J. Lubinski and K. Jaworska and K. Durda and J. Gronwald and T. Huzarski and C. Cybulski and T. Byrski and A. Osorio and T.R. Cajal and A.V. Stavropoulou and J. Benitez and U. Hamann and M. Rookus and C.M. Aalfs and {de Lange}, J.L. and E.J. Meijers-Heijboer and J.C. Oosterwijk and {van Asperen}, C.J. and E.B.G. Garcia and N. Hoogerbrugge and A. Jager and {van der Luijt}, R.B. and D.F. Easton and S. Peock and D. Frost and S.D. Ellis and R. Platte and E. Fineberg and D.G. Evans and F. Lalloo and L. Izatt and R. Eeles and J. Adlard and R. Davidson and D. Eccles and T. Cole and J. Cook and C. Brewer and M Tischkowitz and A.K. Godwin and H. Pathak and D. Stoppa-Lyonnet and O.M. Sinilnikova and S. Mazoyer and L. Barjhoux and M. Leone and M. Gauthier-Villars and V. Caux-Moncoutier and {de Pauw}, A. and A. Hardouin and P. Berthet and H. Dreyfus and S.F. Ferrer and M.A. Collonge-Rame and J. Sokolowska and S. Buys and M. Daly and A. Miron and M.B. Terry and W. Chung and E.M. John and M. Southey and D. Goldgar and C.F. Singer and M.K.M. Tea and D. Gschwantler-Kaulich and A. Fink-Retter and T.V.O. Hansen and B. Ejlertsen and O.T. Johannsson and K. Offit and K. Sarrel and M.M. Gaudet and J. Vijai and M. Robson and M.R. Piedmonte and L. Andrews and D. Cohn and L.R. Demars and P. DiSilvestro and G. Rodriguez and A.E. Toland",

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journal = "Cancer Epidemiology Biomarkers and Prevention",

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Ding, YC, McGuffog, L, Healey, S, Friedman, E, Laitman, Y, Shani, PS, Kaufman, B, Liljegren, A, Lindblom, A, Olsson, H, Kristoffersson, U, Stenmark-Askmalm, M, Melin, B, Domchek, SM, Nathanson, KL, Rebbeck, TR, Jakubowska, A, Lubinski, J, Jaworska, K, Durda, K, Gronwald, J, Huzarski, T, Cybulski, C, Byrski, T, Osorio, A, Cajal, TR, Stavropoulou, AV, Benitez, J, Hamann, U, Rookus, M, Aalfs, CM, de Lange, JL, Meijers-Heijboer, EJ, Oosterwijk, JC, van Asperen, CJ, Garcia, EBG, Hoogerbrugge, N, Jager, A, van der Luijt, RB, Easton, DF, Peock, S, Frost, D, Ellis, SD, Platte, R, Fineberg, E, Evans, DG, Lalloo, F, Izatt, L, Eeles, R, Adlard, J, Davidson, R, Eccles, D, Cole, T, Cook, J, Brewer, C, Tischkowitz, M, Godwin, AK, Pathak, H, Stoppa-Lyonnet, D, Sinilnikova, OM, Mazoyer, S, Barjhoux, L, Leone, M, Gauthier-Villars, M, Caux-Moncoutier, V, de Pauw, A, Hardouin, A, Berthet, P, Dreyfus, H, Ferrer, SF, Collonge-Rame, MA, Sokolowska, J, Buys, S, Daly, M, Miron, A, Terry, MB, Chung, W, John, EM, Southey, M, Goldgar, D, Singer, CF, Tea, MKM, Gschwantler-Kaulich, D, Fink-Retter, A, Hansen, TVO, Ejlertsen, B, Johannsson, OT, Offit, K, Sarrel, K, Gaudet, MM, Vijai, J, Robson, M, Piedmonte, MR, Andrews, L, Cohn, D, Demars, LR, DiSilvestro, P, Rodriguez, G & Toland, AE 2012, 'A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers', Cancer Epidemiology Biomarkers and Prevention, vol. 21, no. 8, pp. 1362-1370. https://doi.org/10.1158/1055-9965.EPI-12-0229

A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers. / Ding, Y.C.; McGuffog, L.; Healey, S.; Friedman, E.; Laitman, Y.; Shani, P.S.; Kaufman, B.; Liljegren, A.; Lindblom, A.; Olsson, H.; Kristoffersson, U.; Stenmark-Askmalm, M.; Melin, B.; Domchek, S.M.; Nathanson, K.L.; Rebbeck, T.R.; Jakubowska, A.; Lubinski, J.; Jaworska, K.; Durda, K.; Gronwald, J.; Huzarski, T.; Cybulski, C.; Byrski, T.; Osorio, A.; Cajal, T.R.; Stavropoulou, A.V.; Benitez, J.; Hamann, U.; Rookus, M.; Aalfs, C.M.; de Lange, J.L.; Meijers-Heijboer, E.J.; Oosterwijk, J.C.; van Asperen, C.J.; Garcia, E.B.G.; Hoogerbrugge, N.; Jager, A.; van der Luijt, R.B.; Easton, D.F.; Peock, S.; Frost, D.; Ellis, S.D.; Platte, R.; Fineberg, E.; Evans, D.G.; Lalloo, F.; Izatt, L.; Eeles, R.; Adlard, J.; Davidson, R.; Eccles, D.; Cole, T.; Cook, J.; Brewer, C.; Tischkowitz, M; Godwin, A.K.; Pathak, H.; Stoppa-Lyonnet, D.; Sinilnikova, O.M.; Mazoyer, S.; Barjhoux, L.; Leone, M.; Gauthier-Villars, M.; Caux-Moncoutier, V.; de Pauw, A.; Hardouin, A.; Berthet, P.; Dreyfus, H.; Ferrer, S.F.; Collonge-Rame, M.A.; Sokolowska, J.; Buys, S.; Daly, M.; Miron, A.; Terry, M.B.; Chung, W.; John, E.M.; Southey, M.; Goldgar, D.; Singer, C.F.; Tea, M.K.M.; Gschwantler-Kaulich, D.; Fink-Retter, A.; Hansen, T.V.O.; Ejlertsen, B.; Johannsson, O.T.; Offit, K.; Sarrel, K.; Gaudet, M.M.; Vijai, J.; Robson, M.; Piedmonte, M.R.; Andrews, L.; Cohn, D.; Demars, L.R.; DiSilvestro, P.; Rodriguez, G.; Toland, A.E.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 21, No. 8, 2012, p. 1362-1370.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers

AU - Ding, Y.C.

AU - McGuffog, L.

AU - Healey, S.

AU - Friedman, E.

AU - Laitman, Y.

AU - Shani, P.S.

AU - Kaufman, B.

AU - Liljegren, A.

AU - Lindblom, A.

AU - Olsson, H.

AU - Kristoffersson, U.

AU - Stenmark-Askmalm, M.

AU - Melin, B.

AU - Domchek, S.M.

AU - Nathanson, K.L.

AU - Rebbeck, T.R.

AU - Jakubowska, A.

AU - Lubinski, J.

AU - Jaworska, K.

AU - Durda, K.

AU - Gronwald, J.

AU - Huzarski, T.

AU - Cybulski, C.

AU - Byrski, T.

AU - Osorio, A.

AU - Cajal, T.R.

AU - Stavropoulou, A.V.

AU - Benitez, J.

AU - Hamann, U.

AU - Rookus, M.

AU - Aalfs, C.M.

AU - de Lange, J.L.

AU - Meijers-Heijboer, E.J.

AU - Oosterwijk, J.C.

AU - van Asperen, C.J.

AU - Garcia, E.B.G.

AU - Hoogerbrugge, N.

AU - Jager, A.

AU - van der Luijt, R.B.

AU - Easton, D.F.

AU - Peock, S.

AU - Frost, D.

AU - Ellis, S.D.

AU - Platte, R.

AU - Fineberg, E.

AU - Evans, D.G.

AU - Lalloo, F.

AU - Izatt, L.

AU - Eeles, R.

AU - Adlard, J.

AU - Davidson, R.

AU - Eccles, D.

AU - Cole, T.

AU - Cook, J.

AU - Brewer, C.

AU - Tischkowitz, M

AU - Godwin, A.K.

AU - Pathak, H.

AU - Stoppa-Lyonnet, D.

AU - Sinilnikova, O.M.

AU - Mazoyer, S.

AU - Barjhoux, L.

AU - Leone, M.

AU - Gauthier-Villars, M.

AU - Caux-Moncoutier, V.

AU - de Pauw, A.

AU - Hardouin, A.

AU - Berthet, P.

AU - Dreyfus, H.

AU - Ferrer, S.F.

AU - Collonge-Rame, M.A.

AU - Sokolowska, J.

AU - Buys, S.

AU - Daly, M.

AU - Miron, A.

AU - Terry, M.B.

AU - Chung, W.

AU - John, E.M.

AU - Southey, M.

AU - Goldgar, D.

AU - Singer, C.F.

AU - Tea, M.K.M.

AU - Gschwantler-Kaulich, D.

AU - Fink-Retter, A.

AU - Hansen, T.V.O.

AU - Ejlertsen, B.

AU - Johannsson, O.T.

AU - Offit, K.

AU - Sarrel, K.

AU - Gaudet, M.M.

AU - Vijai, J.

AU - Robson, M.

AU - Piedmonte, M.R.

AU - Andrews, L.

AU - Cohn, D.

AU - Demars, L.R.

AU - DiSilvestro, P.

AU - Rodriguez, G.

AU - Toland, A.E.

PY - 2012

Y1 - 2012

U2 - 10.1158/1055-9965.EPI-12-0229

DO - 10.1158/1055-9965.EPI-12-0229

M3 - Article

C2 - 22729394

VL - 21

SP - 1362

EP - 1370

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1055-9965

IS - 8

ER -