A novel four-component reaction for the synthesis of functionalised dihydropyrimidines

Danielle J. Vugts, Helen Jansen, Rob F. Schmitz, Romano V.A. Orru*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


In a multi-component reaction (MCR) of a phosphonate, nitriles, aldehydes and isocyanates, N3-functionalised dihydropyrimidines can be synthesised efficiently via a Horner-Emmons/aza Diels-Alder pathway.

Original languageEnglish
Pages (from-to)2594-2595
Number of pages2
JournalChemical Communications
Issue number20
Publication statusPublished - 2003

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