A novel t(6;14)(q25∼q27;q32) in acute myelocytic leukemia involves the BCL11B gene

Vladimir Bezrookove, Shama L. Van Zelderen-Bhola, Antoinette Brink, Károly Szuhai, Anton K. Raap, Renee Barge, Geoffrey C. Beverstock, Carla Rosenberg*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Cytogenetic studies in a patient with acute myelocytic leukemia (AML) revealed as the sole karyotypic alteration a half-cryptic rearrangement, identified with 48-color combined binary ratio-labeled fluorescence in situ hybridization (pq-COBRA-FISH) as a reciprocal t(6;14)(q?;q?). The breakpoints were later assigned on the basis of G-banding to t(6;14)(q25∼q26;q32). FISH experiments using genomic probes showed that the breakpoint on 14q32.2 was within bacterial artificial chromosome RP11-782I5 and revealed BCL11B as the only candidate gene in the region. BCL11B is a homolog to BCL11A (2p13), a highly conserved gene implicated in mouse and human leukemias. To our knowledge, this is the first report implicating BCL11B in hematological malignancies. Because of lack of material, the translocation partner remains unknown.

Original languageEnglish
Pages (from-to)72-76
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume149
Issue number1
DOIs
Publication statusPublished - Feb 2004

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