A pilot study investigating the effects of orally administered pentoxifylline on selected immune variables in patients with multiple sclerosis

B. W. Van Oosten, M. H.G. Rep, R. A.W. Van Lier, P. E.T. Scholten, B. M.E. Von Blomberg, K. W. Pflughaupt, H. P. Hartung, H. J. Adèr, C. H. Polman

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Abstract

Multiple sclerosis is probably mainly mediated by T-helper 1 (T(H)l)-lymphocytes. T(H)1-function can be down-regulated in vitro and in animal experiments by pentoxifylline. Therefore, we included 20 multiple sclerosis patients in an open label pilot trial of pentoxifylline. Ontcome parameter was the effect of treatment on levels of various cytokines and adhesion molecules in cerebrospinal fluid and serum, on production of T(H)1- and T(H)2-cytokines using cell stimulation assays, as well as on measures of T-cell activation and proliferation. Kurtzke's EDSS was a secondary efficacy parameter. A convincing and consistent effect of pentoxifylline could not be demonstrated.

Original languageEnglish
Pages (from-to)49-55
Number of pages7
JournalJournal of Neuroimmunology
Volume66
Issue number1-2
DOIs
Publication statusPublished - 1 Jan 1996

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