A pilot study of the effects of running training on visuospatial memory in MS: A stronger functional embedding of the hippocampus in the default-mode network?

Marijn Huiskamp*, Lousin Moumdjian, Paul van Asch, Veronica Popescu, Menno Michiel Schoonheim, Martijn D. Steenwijk, Ellen Vanzeir, Bart van Wijmeersch, Jeroen J.G. Geurts, Peter Feys, Hanneke E. Hulst

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Background/objective: Endurance exercise can improve memory function in persons with multiple sclerosis (pwMS), but the effects on hippocampal functioning are currently unknown. We investigated the effects of a running intervention on memory and hippocampal functional connectivity in pwMS. Methods/results: Memory and resting-state functional magnetic resonance imaging (fMRI) data were collected in a running intervention (n = 15) and waitlist group (n = 14). Visuospatial memory improvement was correlated to increased connectivity between the hippocampus and the default-mode network (DMN) in the intervention group only. Conclusion: As a result of endurance exercise, improvements in visuospatial memory may be mediated by a stronger functional embedding of the hippocampus in the DMN.

Original languageEnglish
Pages (from-to)1594-1598
Number of pages5
JournalMultiple Sclerosis Journal
Issue number12
Publication statusPublished - 1 Oct 2020

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