A pilot study of the effects of running training on visuospatial memory in MS: A stronger functional embedding of the hippocampus in the default-mode network?

Marijn Huiskamp; Lousin Moumdjian; Paul van Asch; Veronica Popescu; Menno Michiel Schoonheim; Martijn D. Steenwijk; Ellen Vanzeir; Bart van Wijmeersch; Jeroen J.G. Geurts; Peter Feys; Hanneke E. Hulst

doi:10.1177/1352458519863644

A pilot study of the effects of running training on visuospatial memory in MS: A stronger functional embedding of the hippocampus in the default-mode network?

Marijn Huiskamp^*, Lousin Moumdjian, Paul van Asch, Veronica Popescu, Menno Michiel Schoonheim, Martijn D. Steenwijk, Ellen Vanzeir, Bart van Wijmeersch, Jeroen J.G. Geurts, Peter Feys, Hanneke E. Hulst

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background/objective: Endurance exercise can improve memory function in persons with multiple sclerosis (pwMS), but the effects on hippocampal functioning are currently unknown. We investigated the effects of a running intervention on memory and hippocampal functional connectivity in pwMS. Methods/results: Memory and resting-state functional magnetic resonance imaging (fMRI) data were collected in a running intervention (n = 15) and waitlist group (n = 14). Visuospatial memory improvement was correlated to increased connectivity between the hippocampus and the default-mode network (DMN) in the intervention group only. Conclusion: As a result of endurance exercise, improvements in visuospatial memory may be mediated by a stronger functional embedding of the hippocampus in the DMN.

Original language	English
Pages (from-to)	1594-1598
Number of pages	5
Journal	Multiple Sclerosis Journal
Volume	26
Issue number	12
DOIs	https://doi.org/10.1177/1352458519863644
Publication status	Published - 1 Oct 2020

Access to Document

10.1177/1352458519863644

Cite this

Huiskamp, M., Moumdjian, L., van Asch, P., Popescu, V., Schoonheim, M. M., Steenwijk, M. D., Vanzeir, E., van Wijmeersch, B., Geurts, J. J. G., Feys, P., & Hulst, H. E. (2020). A pilot study of the effects of running training on visuospatial memory in MS: A stronger functional embedding of the hippocampus in the default-mode network? Multiple Sclerosis Journal, 26(12), 1594-1598. https://doi.org/10.1177/1352458519863644

@article{6fa739a27e364b2a98833eae51e28185,

title = "A pilot study of the effects of running training on visuospatial memory in MS: A stronger functional embedding of the hippocampus in the default-mode network?",

abstract = "Background/objective: Endurance exercise can improve memory function in persons with multiple sclerosis (pwMS), but the effects on hippocampal functioning are currently unknown. We investigated the effects of a running intervention on memory and hippocampal functional connectivity in pwMS. Methods/results: Memory and resting-state functional magnetic resonance imaging (fMRI) data were collected in a running intervention (n = 15) and waitlist group (n = 14). Visuospatial memory improvement was correlated to increased connectivity between the hippocampus and the default-mode network (DMN) in the intervention group only. Conclusion: As a result of endurance exercise, improvements in visuospatial memory may be mediated by a stronger functional embedding of the hippocampus in the DMN.",

keywords = "cognitive rehabilitation, default-mode network, endurance exercise, functional connectivity, hippocampus, Multiple sclerosis",

author = "Marijn Huiskamp and Lousin Moumdjian and {van Asch}, Paul and Veronica Popescu and Schoonheim, {Menno Michiel} and Steenwijk, {Martijn D.} and Ellen Vanzeir and {van Wijmeersch}, Bart and Geurts, {Jeroen J.G.} and Peter Feys and Hulst, {Hanneke E.}",

year = "2020",

month = oct,

day = "1",

doi = "10.1177/1352458519863644",

language = "English",

volume = "26",

pages = "1594--1598",

journal = "Multiple Sclerosis",

issn = "1352-4585",

publisher = "SAGE Publications Ltd",

number = "12",

}

Huiskamp, M, Moumdjian, L, van Asch, P, Popescu, V, Schoonheim, MM , Steenwijk, MD, Vanzeir, E, van Wijmeersch, B, Geurts, JJG, Feys, P & Hulst, HE 2020, 'A pilot study of the effects of running training on visuospatial memory in MS: A stronger functional embedding of the hippocampus in the default-mode network?', Multiple Sclerosis Journal, vol. 26, no. 12, pp. 1594-1598. https://doi.org/10.1177/1352458519863644

A pilot study of the effects of running training on visuospatial memory in MS : A stronger functional embedding of the hippocampus in the default-mode network? / Huiskamp, Marijn; Moumdjian, Lousin; van Asch, Paul et al.

In: Multiple Sclerosis Journal, Vol. 26, No. 12, 01.10.2020, p. 1594-1598.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - A pilot study of the effects of running training on visuospatial memory in MS

T2 - A stronger functional embedding of the hippocampus in the default-mode network?

AU - Huiskamp, Marijn

AU - Moumdjian, Lousin

AU - van Asch, Paul

AU - Popescu, Veronica

AU - Schoonheim, Menno Michiel

AU - Steenwijk, Martijn D.

AU - Vanzeir, Ellen

AU - van Wijmeersch, Bart

AU - Geurts, Jeroen J.G.

AU - Feys, Peter

AU - Hulst, Hanneke E.

PY - 2020/10/1

Y1 - 2020/10/1

N2 - Background/objective: Endurance exercise can improve memory function in persons with multiple sclerosis (pwMS), but the effects on hippocampal functioning are currently unknown. We investigated the effects of a running intervention on memory and hippocampal functional connectivity in pwMS. Methods/results: Memory and resting-state functional magnetic resonance imaging (fMRI) data were collected in a running intervention (n = 15) and waitlist group (n = 14). Visuospatial memory improvement was correlated to increased connectivity between the hippocampus and the default-mode network (DMN) in the intervention group only. Conclusion: As a result of endurance exercise, improvements in visuospatial memory may be mediated by a stronger functional embedding of the hippocampus in the DMN.

AB - Background/objective: Endurance exercise can improve memory function in persons with multiple sclerosis (pwMS), but the effects on hippocampal functioning are currently unknown. We investigated the effects of a running intervention on memory and hippocampal functional connectivity in pwMS. Methods/results: Memory and resting-state functional magnetic resonance imaging (fMRI) data were collected in a running intervention (n = 15) and waitlist group (n = 14). Visuospatial memory improvement was correlated to increased connectivity between the hippocampus and the default-mode network (DMN) in the intervention group only. Conclusion: As a result of endurance exercise, improvements in visuospatial memory may be mediated by a stronger functional embedding of the hippocampus in the DMN.

KW - cognitive rehabilitation

KW - default-mode network

KW - endurance exercise

KW - functional connectivity

KW - hippocampus

KW - Multiple sclerosis

UR - http://www.scopus.com/inward/record.url?scp=85070293639&partnerID=8YFLogxK

U2 - 10.1177/1352458519863644

DO - 10.1177/1352458519863644

M3 - Article

C2 - 31317828

AN - SCOPUS:85070293639

VL - 26

SP - 1594

EP - 1598

JO - Multiple Sclerosis

JF - Multiple Sclerosis

SN - 1352-4585

IS - 12

ER -

A pilot study of the effects of running training on visuospatial memory in MS: A stronger functional embedding of the hippocampus in the default-mode network?

Abstract

Access to Document

Other files and links

Cite this