A pilot study of the effects of running training on visuospatial memory in MS: A stronger functional embedding of the hippocampus in the default-mode network?

Marijn Huiskamp, Lousin Moumdjian, Paul van Asch, Veronica Popescu, Menno Michiel Schoonheim, Martijn D. Steenwijk, Ellen Vanzeir, Bart van Wijmeersch, Jeroen J.G. Geurts, Peter Feys, Hanneke E. Hulst

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background/objective: Endurance exercise can improve memory function in persons with multiple sclerosis (pwMS), but the effects on hippocampal functioning are currently unknown. We investigated the effects of a running intervention on memory and hippocampal functional connectivity in pwMS. Methods/results: Memory and resting-state functional magnetic resonance imaging (fMRI) data were collected in a running intervention (n = 15) and waitlist group (n = 14). Visuospatial memory improvement was correlated to increased connectivity between the hippocampus and the default-mode network (DMN) in the intervention group only. Conclusion: As a result of endurance exercise, improvements in visuospatial memory may be mediated by a stronger functional embedding of the hippocampus in the DMN.

Original languageEnglish
JournalMultiple Sclerosis Journal
DOIs
Publication statusPublished - 1 Jan 2019

Cite this

@article{6fa739a27e364b2a98833eae51e28185,
title = "A pilot study of the effects of running training on visuospatial memory in MS: A stronger functional embedding of the hippocampus in the default-mode network?",
abstract = "Background/objective: Endurance exercise can improve memory function in persons with multiple sclerosis (pwMS), but the effects on hippocampal functioning are currently unknown. We investigated the effects of a running intervention on memory and hippocampal functional connectivity in pwMS. Methods/results: Memory and resting-state functional magnetic resonance imaging (fMRI) data were collected in a running intervention (n = 15) and waitlist group (n = 14). Visuospatial memory improvement was correlated to increased connectivity between the hippocampus and the default-mode network (DMN) in the intervention group only. Conclusion: As a result of endurance exercise, improvements in visuospatial memory may be mediated by a stronger functional embedding of the hippocampus in the DMN.",
keywords = "cognitive rehabilitation, default-mode network, endurance exercise, functional connectivity, hippocampus, Multiple sclerosis",
author = "Marijn Huiskamp and Lousin Moumdjian and {van Asch}, Paul and Veronica Popescu and Schoonheim, {Menno Michiel} and Steenwijk, {Martijn D.} and Ellen Vanzeir and {van Wijmeersch}, Bart and Geurts, {Jeroen J.G.} and Peter Feys and Hulst, {Hanneke E.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1177/1352458519863644",
language = "English",
journal = "Multiple Sclerosis",
issn = "1352-4585",
publisher = "SAGE Publications Ltd",

}

A pilot study of the effects of running training on visuospatial memory in MS : A stronger functional embedding of the hippocampus in the default-mode network? / Huiskamp, Marijn; Moumdjian, Lousin; van Asch, Paul; Popescu, Veronica; Schoonheim, Menno Michiel; Steenwijk, Martijn D.; Vanzeir, Ellen; van Wijmeersch, Bart; Geurts, Jeroen J.G.; Feys, Peter; Hulst, Hanneke E.

In: Multiple Sclerosis Journal, 01.01.2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - A pilot study of the effects of running training on visuospatial memory in MS

T2 - A stronger functional embedding of the hippocampus in the default-mode network?

AU - Huiskamp, Marijn

AU - Moumdjian, Lousin

AU - van Asch, Paul

AU - Popescu, Veronica

AU - Schoonheim, Menno Michiel

AU - Steenwijk, Martijn D.

AU - Vanzeir, Ellen

AU - van Wijmeersch, Bart

AU - Geurts, Jeroen J.G.

AU - Feys, Peter

AU - Hulst, Hanneke E.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background/objective: Endurance exercise can improve memory function in persons with multiple sclerosis (pwMS), but the effects on hippocampal functioning are currently unknown. We investigated the effects of a running intervention on memory and hippocampal functional connectivity in pwMS. Methods/results: Memory and resting-state functional magnetic resonance imaging (fMRI) data were collected in a running intervention (n = 15) and waitlist group (n = 14). Visuospatial memory improvement was correlated to increased connectivity between the hippocampus and the default-mode network (DMN) in the intervention group only. Conclusion: As a result of endurance exercise, improvements in visuospatial memory may be mediated by a stronger functional embedding of the hippocampus in the DMN.

AB - Background/objective: Endurance exercise can improve memory function in persons with multiple sclerosis (pwMS), but the effects on hippocampal functioning are currently unknown. We investigated the effects of a running intervention on memory and hippocampal functional connectivity in pwMS. Methods/results: Memory and resting-state functional magnetic resonance imaging (fMRI) data were collected in a running intervention (n = 15) and waitlist group (n = 14). Visuospatial memory improvement was correlated to increased connectivity between the hippocampus and the default-mode network (DMN) in the intervention group only. Conclusion: As a result of endurance exercise, improvements in visuospatial memory may be mediated by a stronger functional embedding of the hippocampus in the DMN.

KW - cognitive rehabilitation

KW - default-mode network

KW - endurance exercise

KW - functional connectivity

KW - hippocampus

KW - Multiple sclerosis

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U2 - 10.1177/1352458519863644

DO - 10.1177/1352458519863644

M3 - Article

JO - Multiple Sclerosis

JF - Multiple Sclerosis

SN - 1352-4585

ER -