A single exposure to amphetamine is sufficient to induce long-term behavioral, neuroendocrine, and neurochemical sensitization in rats

Louk J.M.J. Vanderschuren, E. Donné Schmidt, Taco J. De Vries, Caroline A.P. Van Moorsel, Fred J.H. Tilders, Anton N.M. Schoffelmeer

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Repeated treatment with psychostimulant drugs causes long-lasting behavioral sensitization and associated neuroadaptations. Although sensitization induced by a single psychostimulant exposure has also been reported, information on the behavioral and neurochemical consequences of a single psychostimulant exposure is sparse. Therefore, to evaluate whether behavioral sensitization evoked by single and repeated psychostimulant pretreatment regimens represent the same neurobiological phenomenon, the time-dependent expression of behavioral, neurochemical, and neuroendocrine sensitization after a single exposure to amphetamine was investigated in rats. A single exposure to amphetamine (5 mg/kg, i.p.) caused context- independent sensitization of the Iocomotor effects of amphetamine, which intensified over time. Thus, sensitization to amphetamine was marginal at 3 d after treatment and more evident after 1 week, whereas 3 weeks after treatment, profound sensitization, as well as cross-sensitization, to cocaine was observed. Amphetamine pretreatment caused an increase in the electrically evoked release of [3H]dopamine from nucleus accumbens, caudate putamen, and medial prefrontal cortex slices and of [14C]acetylcholine from accumbens and caudate slices. The hyperreactivity of dopaminergic nerve terminals appeared to parallel the development of locomotor sensitization, i.e., whereas hyperreactivity of accumbens dopaminergic terminals increased between 3 d and 3 weeks after treatment, the hyperreactivity of medial prefrontal dopaminergic terminals decreased. Pre-exposure to amphetamine also sensitized the hypothalamus-pituitary-adrenal axis response to amphetamine at 1 and 3 weeks, but not at 3 d after treatment. Because these data closely resemble those reported previously for repeated amphetamine pretreatment, it is concluded that a single exposure to amphetamine is sufficient to induce long- term behavioral, neurochemical, and neuroendocrine sensitization in rats.

Original languageEnglish
Pages (from-to)9579-9586
Number of pages8
JournalJournal of Neuroscience
Volume19
Issue number21
Publication statusPublished - 1 Nov 1999

Cite this

Vanderschuren, L. J. M. J., Donné Schmidt, E., De Vries, T. J., Van Moorsel, C. A. P., Tilders, F. J. H., & Schoffelmeer, A. N. M. (1999). A single exposure to amphetamine is sufficient to induce long-term behavioral, neuroendocrine, and neurochemical sensitization in rats. Journal of Neuroscience, 19(21), 9579-9586.
Vanderschuren, Louk J.M.J. ; Donné Schmidt, E. ; De Vries, Taco J. ; Van Moorsel, Caroline A.P. ; Tilders, Fred J.H. ; Schoffelmeer, Anton N.M. / A single exposure to amphetamine is sufficient to induce long-term behavioral, neuroendocrine, and neurochemical sensitization in rats. In: Journal of Neuroscience. 1999 ; Vol. 19, No. 21. pp. 9579-9586.
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abstract = "Repeated treatment with psychostimulant drugs causes long-lasting behavioral sensitization and associated neuroadaptations. Although sensitization induced by a single psychostimulant exposure has also been reported, information on the behavioral and neurochemical consequences of a single psychostimulant exposure is sparse. Therefore, to evaluate whether behavioral sensitization evoked by single and repeated psychostimulant pretreatment regimens represent the same neurobiological phenomenon, the time-dependent expression of behavioral, neurochemical, and neuroendocrine sensitization after a single exposure to amphetamine was investigated in rats. A single exposure to amphetamine (5 mg/kg, i.p.) caused context- independent sensitization of the Iocomotor effects of amphetamine, which intensified over time. Thus, sensitization to amphetamine was marginal at 3 d after treatment and more evident after 1 week, whereas 3 weeks after treatment, profound sensitization, as well as cross-sensitization, to cocaine was observed. Amphetamine pretreatment caused an increase in the electrically evoked release of [3H]dopamine from nucleus accumbens, caudate putamen, and medial prefrontal cortex slices and of [14C]acetylcholine from accumbens and caudate slices. The hyperreactivity of dopaminergic nerve terminals appeared to parallel the development of locomotor sensitization, i.e., whereas hyperreactivity of accumbens dopaminergic terminals increased between 3 d and 3 weeks after treatment, the hyperreactivity of medial prefrontal dopaminergic terminals decreased. Pre-exposure to amphetamine also sensitized the hypothalamus-pituitary-adrenal axis response to amphetamine at 1 and 3 weeks, but not at 3 d after treatment. Because these data closely resemble those reported previously for repeated amphetamine pretreatment, it is concluded that a single exposure to amphetamine is sufficient to induce long- term behavioral, neurochemical, and neuroendocrine sensitization in rats.",
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Vanderschuren, LJMJ, Donné Schmidt, E, De Vries, TJ, Van Moorsel, CAP, Tilders, FJH & Schoffelmeer, ANM 1999, 'A single exposure to amphetamine is sufficient to induce long-term behavioral, neuroendocrine, and neurochemical sensitization in rats' Journal of Neuroscience, vol. 19, no. 21, pp. 9579-9586.

A single exposure to amphetamine is sufficient to induce long-term behavioral, neuroendocrine, and neurochemical sensitization in rats. / Vanderschuren, Louk J.M.J.; Donné Schmidt, E.; De Vries, Taco J.; Van Moorsel, Caroline A.P.; Tilders, Fred J.H.; Schoffelmeer, Anton N.M.

In: Journal of Neuroscience, Vol. 19, No. 21, 01.11.1999, p. 9579-9586.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - A single exposure to amphetamine is sufficient to induce long-term behavioral, neuroendocrine, and neurochemical sensitization in rats

AU - Vanderschuren, Louk J.M.J.

AU - Donné Schmidt, E.

AU - De Vries, Taco J.

AU - Van Moorsel, Caroline A.P.

AU - Tilders, Fred J.H.

AU - Schoffelmeer, Anton N.M.

PY - 1999/11/1

Y1 - 1999/11/1

N2 - Repeated treatment with psychostimulant drugs causes long-lasting behavioral sensitization and associated neuroadaptations. Although sensitization induced by a single psychostimulant exposure has also been reported, information on the behavioral and neurochemical consequences of a single psychostimulant exposure is sparse. Therefore, to evaluate whether behavioral sensitization evoked by single and repeated psychostimulant pretreatment regimens represent the same neurobiological phenomenon, the time-dependent expression of behavioral, neurochemical, and neuroendocrine sensitization after a single exposure to amphetamine was investigated in rats. A single exposure to amphetamine (5 mg/kg, i.p.) caused context- independent sensitization of the Iocomotor effects of amphetamine, which intensified over time. Thus, sensitization to amphetamine was marginal at 3 d after treatment and more evident after 1 week, whereas 3 weeks after treatment, profound sensitization, as well as cross-sensitization, to cocaine was observed. Amphetamine pretreatment caused an increase in the electrically evoked release of [3H]dopamine from nucleus accumbens, caudate putamen, and medial prefrontal cortex slices and of [14C]acetylcholine from accumbens and caudate slices. The hyperreactivity of dopaminergic nerve terminals appeared to parallel the development of locomotor sensitization, i.e., whereas hyperreactivity of accumbens dopaminergic terminals increased between 3 d and 3 weeks after treatment, the hyperreactivity of medial prefrontal dopaminergic terminals decreased. Pre-exposure to amphetamine also sensitized the hypothalamus-pituitary-adrenal axis response to amphetamine at 1 and 3 weeks, but not at 3 d after treatment. Because these data closely resemble those reported previously for repeated amphetamine pretreatment, it is concluded that a single exposure to amphetamine is sufficient to induce long- term behavioral, neurochemical, and neuroendocrine sensitization in rats.

AB - Repeated treatment with psychostimulant drugs causes long-lasting behavioral sensitization and associated neuroadaptations. Although sensitization induced by a single psychostimulant exposure has also been reported, information on the behavioral and neurochemical consequences of a single psychostimulant exposure is sparse. Therefore, to evaluate whether behavioral sensitization evoked by single and repeated psychostimulant pretreatment regimens represent the same neurobiological phenomenon, the time-dependent expression of behavioral, neurochemical, and neuroendocrine sensitization after a single exposure to amphetamine was investigated in rats. A single exposure to amphetamine (5 mg/kg, i.p.) caused context- independent sensitization of the Iocomotor effects of amphetamine, which intensified over time. Thus, sensitization to amphetamine was marginal at 3 d after treatment and more evident after 1 week, whereas 3 weeks after treatment, profound sensitization, as well as cross-sensitization, to cocaine was observed. Amphetamine pretreatment caused an increase in the electrically evoked release of [3H]dopamine from nucleus accumbens, caudate putamen, and medial prefrontal cortex slices and of [14C]acetylcholine from accumbens and caudate slices. The hyperreactivity of dopaminergic nerve terminals appeared to parallel the development of locomotor sensitization, i.e., whereas hyperreactivity of accumbens dopaminergic terminals increased between 3 d and 3 weeks after treatment, the hyperreactivity of medial prefrontal dopaminergic terminals decreased. Pre-exposure to amphetamine also sensitized the hypothalamus-pituitary-adrenal axis response to amphetamine at 1 and 3 weeks, but not at 3 d after treatment. Because these data closely resemble those reported previously for repeated amphetamine pretreatment, it is concluded that a single exposure to amphetamine is sufficient to induce long- term behavioral, neurochemical, and neuroendocrine sensitization in rats.

KW - Acetylcholine release

KW - Amphetamine

KW - Caudate putamen

KW - Dopamine release

KW - Hypothalamus-pituitary-adrenal axis

KW - Locomotor sensitization

KW - Medial prefrontal cortex

KW - Nucleus accumbens

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Vanderschuren LJMJ, Donné Schmidt E, De Vries TJ, Van Moorsel CAP, Tilders FJH, Schoffelmeer ANM. A single exposure to amphetamine is sufficient to induce long-term behavioral, neuroendocrine, and neurochemical sensitization in rats. Journal of Neuroscience. 1999 Nov 1;19(21):9579-9586.