A state-independent network of depressive, negative and positive symptoms in male patients with schizophrenia spectrum disorders

Genetic Risk and Outcome of Psychosis investigators

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Depressive symptoms occur frequently in patients with schizophrenia. Several factor analytical studies investigated the associations between positive, negative and depressive symptoms and reported difficulties differentiating between these symptom domains. Here, we argue that a network approach may offer insights into these associations, by exploring interrelations between symptoms. The aims of current study were to I) construct a network of positive, negative and depressive symptoms in male patients with schizophrenia to investigate interactions between individual symptoms; II) identify the most central symptoms within this network and III) examine group-level differences in network connectivity between remitted and non–remitted patients. We computed a network of depressive, positive and negative symptoms in a sample of 470 male patients diagnosed with a psychotic disorder. Depressive symptoms were assessed with the Calgary Depression Rating Scale for Schizophrenia, while psychotic symptoms were assessed with the Positive and Negative Syndrome Scale. Networks of male patients who fulfilled remission criteria (Andreasen et al., 2005) and non–remitters for psychosis were compared. Our results indicate that depressive symptoms are mostly associated with suicidality and may act as moderator between psychotic symptoms and suicidality. In addition, ‘depressed mood’, ‘observed depression’, ‘poor rapport’, 'stereotyped thinking’ and ‘delusions’ were central symptoms within the network. Finally, although remitted male patients had a similar network structure compared to non-remitters the networks differed significantly in terms of global strength. In conclusion, clinical symptoms of schizophrenia were linked in a stable way, independent of symptomatic remission while the number of connections appears to be dependent on remission status.
Original languageEnglish
Pages (from-to)232-239
JournalSchizophrenia Research
Volume193
DOIs
Publication statusPublished - 2018
Externally publishedYes

Cite this

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title = "A state-independent network of depressive, negative and positive symptoms in male patients with schizophrenia spectrum disorders",
abstract = "Depressive symptoms occur frequently in patients with schizophrenia. Several factor analytical studies investigated the associations between positive, negative and depressive symptoms and reported difficulties differentiating between these symptom domains. Here, we argue that a network approach may offer insights into these associations, by exploring interrelations between symptoms. The aims of current study were to I) construct a network of positive, negative and depressive symptoms in male patients with schizophrenia to investigate interactions between individual symptoms; II) identify the most central symptoms within this network and III) examine group-level differences in network connectivity between remitted and non–remitted patients. We computed a network of depressive, positive and negative symptoms in a sample of 470 male patients diagnosed with a psychotic disorder. Depressive symptoms were assessed with the Calgary Depression Rating Scale for Schizophrenia, while psychotic symptoms were assessed with the Positive and Negative Syndrome Scale. Networks of male patients who fulfilled remission criteria (Andreasen et al., 2005) and non–remitters for psychosis were compared. Our results indicate that depressive symptoms are mostly associated with suicidality and may act as moderator between psychotic symptoms and suicidality. In addition, ‘depressed mood’, ‘observed depression’, ‘poor rapport’, 'stereotyped thinking’ and ‘delusions’ were central symptoms within the network. Finally, although remitted male patients had a similar network structure compared to non-remitters the networks differed significantly in terms of global strength. In conclusion, clinical symptoms of schizophrenia were linked in a stable way, independent of symptomatic remission while the number of connections appears to be dependent on remission status.",
author = "{Genetic Risk and Outcome of Psychosis investigators} and {van Rooijen}, Geeske and Adela-Maria Isvoranu and Kruijt, {Olle H.} and {van Borkulo}, {Claudia D.} and Meijer, {Carin J.} and Wigman, {Johanna T. W.} and Ruh{\'e}, {Henricus G.} and {de Haan}, Lieuwe and Richard Bruggeman and Wiepke Cahn and Kahn, {Ren{\'e} S.} and Inez Myin-Germeys and {van Os}, Jim and Bartels-Velthuis, {Agna A.}",
year = "2018",
doi = "10.1016/j.schres.2017.07.035",
language = "English",
volume = "193",
pages = "232--239",
journal = "Schizophrenia Research",
issn = "0920-9964",
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}

A state-independent network of depressive, negative and positive symptoms in male patients with schizophrenia spectrum disorders. / Genetic Risk and Outcome of Psychosis investigators.

In: Schizophrenia Research, Vol. 193, 2018, p. 232-239.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - A state-independent network of depressive, negative and positive symptoms in male patients with schizophrenia spectrum disorders

AU - Genetic Risk and Outcome of Psychosis investigators

AU - van Rooijen, Geeske

AU - Isvoranu, Adela-Maria

AU - Kruijt, Olle H.

AU - van Borkulo, Claudia D.

AU - Meijer, Carin J.

AU - Wigman, Johanna T. W.

AU - Ruhé, Henricus G.

AU - de Haan, Lieuwe

AU - Bruggeman, Richard

AU - Cahn, Wiepke

AU - Kahn, René S.

AU - Myin-Germeys, Inez

AU - van Os, Jim

AU - Bartels-Velthuis, Agna A.

PY - 2018

Y1 - 2018

N2 - Depressive symptoms occur frequently in patients with schizophrenia. Several factor analytical studies investigated the associations between positive, negative and depressive symptoms and reported difficulties differentiating between these symptom domains. Here, we argue that a network approach may offer insights into these associations, by exploring interrelations between symptoms. The aims of current study were to I) construct a network of positive, negative and depressive symptoms in male patients with schizophrenia to investigate interactions between individual symptoms; II) identify the most central symptoms within this network and III) examine group-level differences in network connectivity between remitted and non–remitted patients. We computed a network of depressive, positive and negative symptoms in a sample of 470 male patients diagnosed with a psychotic disorder. Depressive symptoms were assessed with the Calgary Depression Rating Scale for Schizophrenia, while psychotic symptoms were assessed with the Positive and Negative Syndrome Scale. Networks of male patients who fulfilled remission criteria (Andreasen et al., 2005) and non–remitters for psychosis were compared. Our results indicate that depressive symptoms are mostly associated with suicidality and may act as moderator between psychotic symptoms and suicidality. In addition, ‘depressed mood’, ‘observed depression’, ‘poor rapport’, 'stereotyped thinking’ and ‘delusions’ were central symptoms within the network. Finally, although remitted male patients had a similar network structure compared to non-remitters the networks differed significantly in terms of global strength. In conclusion, clinical symptoms of schizophrenia were linked in a stable way, independent of symptomatic remission while the number of connections appears to be dependent on remission status.

AB - Depressive symptoms occur frequently in patients with schizophrenia. Several factor analytical studies investigated the associations between positive, negative and depressive symptoms and reported difficulties differentiating between these symptom domains. Here, we argue that a network approach may offer insights into these associations, by exploring interrelations between symptoms. The aims of current study were to I) construct a network of positive, negative and depressive symptoms in male patients with schizophrenia to investigate interactions between individual symptoms; II) identify the most central symptoms within this network and III) examine group-level differences in network connectivity between remitted and non–remitted patients. We computed a network of depressive, positive and negative symptoms in a sample of 470 male patients diagnosed with a psychotic disorder. Depressive symptoms were assessed with the Calgary Depression Rating Scale for Schizophrenia, while psychotic symptoms were assessed with the Positive and Negative Syndrome Scale. Networks of male patients who fulfilled remission criteria (Andreasen et al., 2005) and non–remitters for psychosis were compared. Our results indicate that depressive symptoms are mostly associated with suicidality and may act as moderator between psychotic symptoms and suicidality. In addition, ‘depressed mood’, ‘observed depression’, ‘poor rapport’, 'stereotyped thinking’ and ‘delusions’ were central symptoms within the network. Finally, although remitted male patients had a similar network structure compared to non-remitters the networks differed significantly in terms of global strength. In conclusion, clinical symptoms of schizophrenia were linked in a stable way, independent of symptomatic remission while the number of connections appears to be dependent on remission status.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85028308369&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/28844638

U2 - 10.1016/j.schres.2017.07.035

DO - 10.1016/j.schres.2017.07.035

M3 - Article

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SP - 232

EP - 239

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

ER -